v3.26.1
Nature of Business, Basis of Presentation and Segment Information (Detail)
$ in Thousands
6 Months Ended 12 Months Ended
Oct. 11, 2026
USD ($)
Sep. 10, 2026
USD ($)
Jun. 30, 2026
USD ($)
Segment
Oct. 10, 2026
USD ($)
Dec. 31, 2025
USD ($)
Product Information [Line Items]          
Accumulated deficit     $ 1,848,914   $ 1,759,499
Cash, cash equivalents and investments     $ 65,100    
Number of operating segments | Segment     1    
Number of reportable segments | Segment     1    
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]     srt:ChiefExecutiveOfficerMember    
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description     net loss as reported on the condensed consolidated statements of operations to monitor budget versus actual results and to ensure we have sufficient capital resources to develop and seek regulatory approval of our product candidates.    
Scenario, Forecast [Member]          
Product Information [Line Items]          
Minimum liquidity covenant amount $ 25,000     $ 25,000  
2028 Notes and 2029 Notes | Senior Secured Term Loan Facility [Member] | Scenario, Forecast [Member]          
Product Information [Line Items]          
Aggregate interest payments due   $ 10,100      
Line of Credit [Member] | Senior Secured Term Loan Facility [Member] | Scenario, Forecast [Member]          
Product Information [Line Items]          
Principal payment due under our senior secured term loan   15,800      
Minimum liquidity covenant amount   $ 10,000