<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e4145-afa4-7b3d-b0ab-eec41d3d5f5c,g:43da6873-dfb2-4d6b-a3f5-d96b283778fb-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://darebioscience.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="dare-20260630.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e4145-b132-7c37-9ac2-06e45a8c7029" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_StatementTable_019e4145-b132-7c37-9ac2-06e45a8c7029" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e4145-b132-76ba-8e70-cfdfabae8fcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e4145-b132-7c37-9ac2-06e45a8c7029" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e4145-b132-76ba-8e70-cfdfabae8fcb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e4145-b132-76ba-8e70-cfdfabae8fcb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e4145-b132-76ba-8e70-cfdfabae8fcb" xlink:to="loc_us-gaap_ClassOfStockDomain_019e4145-b132-76ba-8e70-cfdfabae8fcb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e4145-b132-736b-ae5e-da2af37ee692" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e4145-b132-76ba-8e70-cfdfabae8fcb" xlink:to="loc_us-gaap_ClassOfStockDomain_019e4145-b132-736b-ae5e-da2af37ee692" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_019e4145-b132-783a-bfb0-02394f589293" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e4145-b132-736b-ae5e-da2af37ee692" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_019e4145-b132-783a-bfb0-02394f589293" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e4145-b132-7695-b5a2-00771dbe278b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e4145-b132-7695-b5a2-00771dbe278b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019e4145-b132-71bf-8e2d-bb4a342bc7a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019e4145-b132-71bf-8e2d-bb4a342bc7a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_019e4145-b132-7b38-9a72-07c2ae127887" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_PreferredStockSharesIssued_019e4145-b132-7b38-9a72-07c2ae127887" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_019e4145-b132-77fe-9656-fbb1f40f2477" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_019e4145-b132-77fe-9656-fbb1f40f2477" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_019e4145-b132-73b7-9e4c-2d525741ef85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_019e4145-b132-73b7-9e4c-2d525741ef85" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019e4145-b132-7dee-b1e1-e520000ae5de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019e4145-b132-7dee-b1e1-e520000ae5de" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019e4145-b132-78e2-8ac5-281ba0356e66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019e4145-b132-78e2-8ac5-281ba0356e66" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019e4145-b132-72f8-80b2-404495f02f59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_CommonStockSharesIssued_019e4145-b132-72f8-80b2-404495f02f59" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e4145-b132-7b13-a191-0a826e69229e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7ce0-8b10-dbbe53c23315" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019e4145-b132-7b13-a191-0a826e69229e" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited" xlink:type="simple" xlink:href="dare-20260630.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019f26fb-e090-770b-b1e4-2933e2d5de03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_StatementTable_019f26fb-e090-770b-b1e4-2933e2d5de03" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019f26fb-e091-7fce-be05-a1d4b9dda21c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019f26fb-e090-770b-b1e4-2933e2d5de03" xlink:to="loc_srt_ProductOrServiceAxis_019f26fb-e091-7fce-be05-a1d4b9dda21c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019f26fb-e091-7fce-be05-a1d4b9dda21c_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019f26fb-e091-7fce-be05-a1d4b9dda21c" xlink:to="loc_srt_ProductsAndServicesDomain_019f26fb-e091-7fce-be05-a1d4b9dda21c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019f26fb-e091-7752-bb19-3f1d688cef85" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019f26fb-e091-7fce-be05-a1d4b9dda21c" xlink:to="loc_srt_ProductsAndServicesDomain_019f26fb-e091-7752-bb19-3f1d688cef85" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_019f26fb-e091-7bd9-8b37-061b493439f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019f26fb-e091-7752-bb19-3f1d688cef85" xlink:to="loc_us-gaap_RoyaltyMember_019f26fb-e091-7bd9-8b37-061b493439f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019e4145-b132-721a-9f92-5d0d3e74b0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_RevenuesAbstract_019e4145-b132-721a-9f92-5d0d3e74b0dc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4145-b132-7199-9479-f79f8a2b445d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e4145-b132-721a-9f92-5d0d3e74b0dc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4145-b132-7199-9479-f79f8a2b445d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax_019fd888-fedb-7cc0-b1f0-c78ac0eca853" xlink:href="dare-20260630.xsd#dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e4145-b132-721a-9f92-5d0d3e74b0dc" xlink:to="loc_dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax_019fd888-fedb-7cc0-b1f0-c78ac0eca853" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e4145-b132-72a0-951c-b518f6f90aba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_CostOfRevenue_019e4145-b132-72a0-951c-b518f6f90aba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_019e4145-b132-7019-822f-e3f4e8d5837f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_OperatingExpensesAbstract_019e4145-b132-7019-822f-e3f4e8d5837f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4145-b132-7498-a254-a5ea993e009f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b132-7019-822f-e3f4e8d5837f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4145-b132-7498-a254-a5ea993e009f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e4145-b132-7003-9a6b-bf165bbc21d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b132-7019-822f-e3f4e8d5837f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e4145-b132-7003-9a6b-bf165bbc21d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e4145-b132-719e-ac31-ed5f2de8f43f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b132-7019-822f-e3f4e8d5837f" xlink:to="loc_us-gaap_OperatingExpenses_019e4145-b132-719e-ac31-ed5f2de8f43f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e4145-b132-700b-87aa-1a3d39674e5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e4145-b132-700b-87aa-1a3d39674e5e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4145-b132-7197-8f3c-462c0e98fdf3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4145-b132-7197-8f3c-462c0e98fdf3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e4145-b132-7850-8863-709c0abf351b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_NetIncomeLoss_019e4145-b132-7850-8863-709c0abf351b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4145-b132-7c93-a9f0-2e4d2f4431e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4145-b132-7c93-a9f0-2e4d2f4431e2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e4145-b132-7052-b29f-fc3a65139126" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e4145-b132-7052-b29f-fc3a65139126" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019e4145-b132-7f04-8962-b92bc3add3d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_EarningsPerShareBasic_019e4145-b132-7f04-8962-b92bc3add3d9" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019e4145-b132-7067-94a9-c1a10d314eef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_EarningsPerShareDiluted_019e4145-b132-7067-94a9-c1a10d314eef" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_019e4145-b132-75e3-8be4-139a61cb4dfd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019f26fb-e091-70a7-9624-ba95d4b0fd74" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_019e4145-b132-75e3-8be4-139a61cb4dfd" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e4145-b132-7af8-913d-0c18ad936d4a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_019e4145-b132-75e3-8be4-139a61cb4dfd" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e4145-b132-7af8-913d-0c18ad936d4a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e4145-b132-7bfc-ac4d-4ba1efee8a8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_019e4145-b132-75e3-8be4-139a61cb4dfd" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e4145-b132-7bfc-ac4d-4ba1efee8a8f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited" xlink:type="simple" xlink:href="dare-20260630.xsd#CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e4145-b132-7906-b3aa-476824b7d816" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e4145-b132-75d0-8cbb-6808fdf77705" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7906-b3aa-476824b7d816" xlink:to="loc_us-gaap_StatementTable_019e4145-b132-75d0-8cbb-6808fdf77705" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019e4145-b132-700a-8ccc-7a2c2aa00d8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e4145-b132-75d0-8cbb-6808fdf77705" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019e4145-b132-700a-8ccc-7a2c2aa00d8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e4145-b132-700a-8ccc-7a2c2aa00d8f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e4145-b132-700a-8ccc-7a2c2aa00d8f" xlink:to="loc_us-gaap_EquityComponentDomain_019e4145-b132-700a-8ccc-7a2c2aa00d8f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e4145-b132-700a-8ccc-7a2c2aa00d8f" xlink:to="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SeriesANonVotingConvertiblePreferredStockMember_019e4145-b132-7976-869c-02c07aa5b6e1" xlink:href="dare-20260630.xsd#dare_SeriesANonVotingConvertiblePreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:to="loc_dare_SeriesANonVotingConvertiblePreferredStockMember_019e4145-b132-7976-869c-02c07aa5b6e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019e4145-b132-7e7a-a725-e283070f0c79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:to="loc_us-gaap_CommonStockMember_019e4145-b132-7e7a-a725-e283070f0c79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019e4145-b132-72ef-b121-58baed6e29ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019e4145-b132-72ef-b121-58baed6e29ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e4145-b132-71c6-ac84-ff437d7ec1b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e4145-b132-71c6-ac84-ff437d7ec1b7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019e4145-b132-72d1-9199-4e229694bb39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e4145-b132-7b7f-aa29-2d3b61590c14" xlink:to="loc_us-gaap_RetainedEarningsMember_019e4145-b132-72d1-9199-4e229694bb39" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e4145-b132-7906-b3aa-476824b7d816" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e4145-b132-7df5-9cd0-0a0f8b86362e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019e4145-b132-7df5-9cd0-0a0f8b86362e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e4145-b132-7797-9d25-8816628fa42b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_StockholdersEquity_019e4145-b132-7797-9d25-8816628fa42b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019e4145-b132-72d9-9438-1a3690ddec17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019e4145-b132-72d9-9438-1a3690ddec17" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares_019e4145-b132-785e-85ad-36b29ad7c859" xlink:href="dare-20260630.xsd#dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares_019e4145-b132-785e-85ad-36b29ad7c859" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue_019e4145-b132-73c2-8753-f99584e43d4c" xlink:href="dare-20260630.xsd#dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue_019e4145-b132-73c2-8753-f99584e43d4c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019f89d9-9da8-799d-b5ab-84ea782ac4cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019f89d9-9da8-799d-b5ab-84ea782ac4cc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_019f89d9-d1df-75db-bb86-d421bcefba65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_019f89d9-d1df-75db-bb86-d421bcefba65" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019e4145-b132-7f23-8766-352319af6a4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019e4145-b132-7f23-8766-352319af6a4f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019e4145-b132-76e9-a511-bba242d58dda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019e4145-b132-76e9-a511-bba242d58dda" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e4145-b132-7a90-8566-c7cc2cf42c73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_NetIncomeLoss_019e4145-b132-7a90-8566-c7cc2cf42c73" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4145-b132-7e82-b09b-7f00ec4b161a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e4145-b132-7b5b-9672-7a613d411fc2" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4145-b132-7e82-b09b-7f00ec4b161a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e4145-b132-72e9-bc93-93e9ae99ae63" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e4145-b132-7bb9-9002-e7696b9a2324" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:to="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:to="loc_srt_RangeMember_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:to="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e81ab-d9ec-797a-ac6c-d633133ad575" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:to="loc_srt_MinimumMember_019e81ab-d9ec-797a-ac6c-d633133ad575" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e81ab-d9ec-7d86-9f28-332f16c88bd7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:to="loc_srt_MaximumMember_019e81ab-d9ec-7d86-9f28-332f16c88bd7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-7887-8793-bd1815cc654b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-7887-8793-bd1815cc654b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreeclampsiaAgreementMember_019e81ac-0bb9-72cf-84fc-6b57e14e2eec" xlink:href="dare-20260630.xsd#dare_PreeclampsiaAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_PreeclampsiaAgreementMember_019e81ac-0bb9-72cf-84fc-6b57e14e2eec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e81ac-0bb9-7285-855b-65711c49f0d6" xlink:href="dare-20260630.xsd#dare_ContraceptiveLandscapeReviewAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e81ac-0bb9-7285-855b-65711c49f0d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentServicesMember_019e81ac-0bb9-71f8-a635-bb26aedbf8c1" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_ResearchAndDevelopmentServicesMember_019e81ac-0bb9-71f8-a635-bb26aedbf8c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e81ac-0bb9-7a1b-9cbc-94ab738ff53d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e81ac-0bb9-7a1b-9cbc-94ab738ff53d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e81ab-d9ec-7403-a8de-54d7aaf99377" xlink:href="dare-20260630.xsd#dare_GrantAwardsIndirectCostAllowancePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e81ab-d9ec-7403-a8de-54d7aaf99377" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_019e81ab-d9ec-7046-9f37-df64d8037029" xlink:href="dare-20260630.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_DeferredGrantFundingCurrent_019e81ab-d9ec-7046-9f37-df64d8037029" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e81ab-d9ec-71dc-ab74-ef751f4403c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e81ab-d9ec-71dc-ab74-ef751f4403c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WorkingCapitalIncreaseDeficit_019e81ab-d9ec-7e36-8ac1-59b69afe332a" xlink:href="dare-20260630.xsd#dare_WorkingCapitalIncreaseDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_WorkingCapitalIncreaseDeficit_019e81ab-d9ec-7e36-8ac1-59b69afe332a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e81ab-d9ec-74cb-81fe-1683b511ef11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e81ab-d9ec-74cb-81fe-1683b511ef11" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e81ab-d9ec-7fb1-9778-49ff453fdb21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NetIncomeLoss_019e81ab-d9ec-7fb1-9778-49ff453fdb21" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e81ab-d9ec-7ecf-9533-5bbc0d3e0ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e81ab-d9ec-7ecf-9533-5bbc0d3e0ed6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_019e81ac-0bb9-7f10-9046-7b179f74d945" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NumberOfOperatingSegments_019e81ac-0bb9-7f10-9046-7b179f74d945" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019e81ac-0bb9-7fe2-8fb5-1c568e6eac10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NumberOfReportableSegments_019e81ac-0bb9-7fe2-8fb5-1c568e6eac10" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements_019fede0-86fe-76f4-8f1b-65e354eb17c3" xlink:href="dare-20260630.xsd#dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements_019fede0-86fe-76f4-8f1b-65e354eb17c3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e81ac-0bb9-722b-8941-0f66fea607c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e81ac-0bb9-722b-8941-0f66fea607c6" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e81ac-0bb9-782b-a54f-1c5a74d6c13b" xlink:href="dare-20260630.xsd#dare_TransactionPriceAllocatedToRemainingPerformanceObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e81ac-0bb9-782b-a54f-1c5a74d6c13b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OutstandingAdvancesRepaymentPeriod_019e81ac-0bb9-7f76-af91-40102fd659ee" xlink:href="dare-20260630.xsd#dare_OutstandingAdvancesRepaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_OutstandingAdvancesRepaymentPeriod_019e81ac-0bb9-7f76-af91-40102fd659ee" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesOnInventoryPurchases_019e81ac-0bb9-742a-9d22-83248342f942" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdvancesOnInventoryPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_AdvancesOnInventoryPurchases_019e81ac-0bb9-742a-9d22-83248342f942" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivables_019e81ac-0bb9-7924-a896-8802732f0b1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_OtherReceivables_019e81ac-0bb9-7924-a896-8802732f0b1a" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e81ac-3dce-74ec-8136-34d96eedf064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e81ac-3dce-74ec-8136-34d96eedf064" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails_1" xlink:type="simple" xlink:href="dare-20260630.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails_1"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:to="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:to="loc_srt_RangeMember_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e81ab-d9ec-7f43-aa20-4c2fd7e371e9" xlink:to="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e81ab-d9ec-797a-ac6c-d633133ad575" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:to="loc_srt_MinimumMember_019e81ab-d9ec-797a-ac6c-d633133ad575" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e81ab-d9ec-7d86-9f28-332f16c88bd7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81ab-d9ec-7f34-b00b-03e32751e508" xlink:to="loc_srt_MaximumMember_019e81ab-d9ec-7d86-9f28-332f16c88bd7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-7643-8983-d198a4261558" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-7887-8793-bd1815cc654b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-7887-8793-bd1815cc654b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81ac-0bb9-7887-8793-bd1815cc654b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreeclampsiaAgreementMember_019e81ac-0bb9-72cf-84fc-6b57e14e2eec" xlink:href="dare-20260630.xsd#dare_PreeclampsiaAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_PreeclampsiaAgreementMember_019e81ac-0bb9-72cf-84fc-6b57e14e2eec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e81ac-0bb9-7285-855b-65711c49f0d6" xlink:href="dare-20260630.xsd#dare_ContraceptiveLandscapeReviewAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e81ac-0bb9-7285-855b-65711c49f0d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentServicesMember_019e81ac-0bb9-71f8-a635-bb26aedbf8c1" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81ac-0bb9-74dd-8451-dd46528cd429" xlink:to="loc_dare_ResearchAndDevelopmentServicesMember_019e81ac-0bb9-71f8-a635-bb26aedbf8c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e81ab-d9ec-7403-a8de-54d7aaf99377" xlink:href="dare-20260630.xsd#dare_GrantAwardsIndirectCostAllowancePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e81ab-d9ec-7403-a8de-54d7aaf99377" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_019e81ab-d9ec-7046-9f37-df64d8037029" xlink:href="dare-20260630.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_DeferredGrantFundingCurrent_019e81ab-d9ec-7046-9f37-df64d8037029" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e81ab-d9ec-71dc-ab74-ef751f4403c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e81ab-d9ec-71dc-ab74-ef751f4403c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WorkingCapitalIncreaseDeficit_019e81ab-d9ec-7e36-8ac1-59b69afe332a" xlink:href="dare-20260630.xsd#dare_WorkingCapitalIncreaseDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_WorkingCapitalIncreaseDeficit_019e81ab-d9ec-7e36-8ac1-59b69afe332a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e81ab-d9ec-74cb-81fe-1683b511ef11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e81ab-d9ec-74cb-81fe-1683b511ef11" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e81ab-d9ec-7fb1-9778-49ff453fdb21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NetIncomeLoss_019e81ab-d9ec-7fb1-9778-49ff453fdb21" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e81ab-d9ec-7ecf-9533-5bbc0d3e0ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e81ab-d9ec-7ecf-9533-5bbc0d3e0ed6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_019e81ac-0bb9-7f10-9046-7b179f74d945" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NumberOfOperatingSegments_019e81ac-0bb9-7f10-9046-7b179f74d945" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019e81ac-0bb9-7fe2-8fb5-1c568e6eac10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_NumberOfReportableSegments_019e81ac-0bb9-7fe2-8fb5-1c568e6eac10" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements_019fede0-86fe-76f4-8f1b-65e354eb17c3" xlink:href="dare-20260630.xsd#dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_CollaborativeArrangementAndArrangementOtherThanCollaborativeNumberOfServicesAgreements_019fede0-86fe-76f4-8f1b-65e354eb17c3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e81ac-0bb9-722b-8941-0f66fea607c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e81ac-0bb9-722b-8941-0f66fea607c6" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e81ac-0bb9-782b-a54f-1c5a74d6c13b" xlink:href="dare-20260630.xsd#dare_TransactionPriceAllocatedToRemainingPerformanceObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e81ac-0bb9-782b-a54f-1c5a74d6c13b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OutstandingAdvancesRepaymentPeriod_019e81ac-0bb9-7f76-af91-40102fd659ee" xlink:href="dare-20260630.xsd#dare_OutstandingAdvancesRepaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_dare_OutstandingAdvancesRepaymentPeriod_019e81ac-0bb9-7f76-af91-40102fd659ee" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesOnInventoryPurchases_019e81ac-0bb9-742a-9d22-83248342f942" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdvancesOnInventoryPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_AdvancesOnInventoryPurchases_019e81ac-0bb9-742a-9d22-83248342f942" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivables_019e81ac-0bb9-7924-a896-8802732f0b1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_OtherReceivables_019e81ac-0bb9-7924-a896-8802732f0b1a" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e81ac-3dce-74ec-8136-34d96eedf064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e81ab-d9ec-7634-bbae-12e61ba3b2fe" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e81ac-3dce-74ec-8136-34d96eedf064" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e4145-b132-7c19-b35a-67e93edc89de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-75bc-a5a0-71dca7e40c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e4145-b132-7c19-b35a-67e93edc89de" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-75bc-a5a0-71dca7e40c5b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e4145-b132-7ebd-99de-af35941511da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e4145-b132-75bc-a5a0-71dca7e40c5b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e4145-b132-7ebd-99de-af35941511da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7ebd-99de-af35941511da_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e4145-b132-7ebd-99de-af35941511da" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7ebd-99de-af35941511da_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7d03-9fe1-cc74638130bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e4145-b132-7ebd-99de-af35941511da" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7d03-9fe1-cc74638130bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019e4145-b132-7542-b939-546b421fae82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7d03-9fe1-cc74638130bb" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019e4145-b132-7542-b939-546b421fae82" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019e4145-b132-7b2a-9b11-e5e04cf9b34f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7d03-9fe1-cc74638130bb" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019e4145-b132-7b2a-9b11-e5e04cf9b34f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019e4145-b132-787b-bc8b-7ef760295fe4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e4145-b132-7d03-9fe1-cc74638130bb" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019e4145-b132-787b-bc8b-7ef760295fe4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e4145-b132-7252-9c7d-215961b56903" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e4145-b132-7c19-b35a-67e93edc89de" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e4145-b132-7252-9c7d-215961b56903" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StrategicAgreementsDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StrategicAgreementsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StrategicAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e81c8-49b1-7282-8f02-a25b4154d461" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_srt_CounterpartyNameAxis_019e81c8-49b1-7282-8f02-a25b4154d461" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7282-8f02-a25b4154d461_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e81c8-49b1-7282-8f02-a25b4154d461" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7282-8f02-a25b4154d461_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e81c8-49b1-7282-8f02-a25b4154d461" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OrganonMember_019e81c8-49b1-799c-9556-d8e6f5d69a89" xlink:href="dare-20260630.xsd#dare_OrganonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:to="loc_dare_OrganonMember_019e81c8-49b1-799c-9556-d8e6f5d69a89" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BayerHealthcareLLCMember_019e81c8-83c7-71f2-9831-ecf002e4e2ea" xlink:href="dare-20260630.xsd#dare_BayerHealthcareLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:to="loc_dare_BayerHealthcareLLCMember_019e81c8-83c7-71f2-9831-ecf002e4e2ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FormerStockholdersOfMBIMember_019e81ca-5320-7026-85f2-038a87509a8e" xlink:href="dare-20260630.xsd#dare_FormerStockholdersOfMBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:to="loc_dare_FormerStockholdersOfMBIMember_019e81ca-5320-7026-85f2-038a87509a8e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CatalentAndMilanaPharmMember_019e81cd-b245-762c-8348-9fcb460ab48c" xlink:href="dare-20260630.xsd#dare_CatalentAndMilanaPharmMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81c8-49b1-7722-85ad-754d06224ac4" xlink:to="loc_dare_CatalentAndMilanaPharmMember_019e81cd-b245-762c-8348-9fcb460ab48c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e81c8-83c7-7b26-8407-da28624552c1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_srt_ProductOrServiceAxis_019e81c8-83c7-7b26-8407-da28624552c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e81c8-83c7-7b26-8407-da28624552c1_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e81c8-83c7-7b26-8407-da28624552c1" xlink:to="loc_srt_ProductsAndServicesDomain_019e81c8-83c7-7b26-8407-da28624552c1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e81c8-83c7-7932-bd12-179865d036f9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e81c8-83c7-7b26-8407-da28624552c1" xlink:to="loc_srt_ProductsAndServicesDomain_019e81c8-83c7-7932-bd12-179865d036f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRevenueMember_019e81c8-83c7-7294-8eb4-9bdb368b9e27" xlink:href="dare-20260630.xsd#dare_RoyaltyRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e81c8-83c7-7932-bd12-179865d036f9" xlink:to="loc_dare_RoyaltyRevenueMember_019e81c8-83c7-7294-8eb4-9bdb368b9e27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e81c8-83c7-727a-bdef-d4ddee1ace56" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e81c8-83c7-727a-bdef-d4ddee1ace56" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-727a-bdef-d4ddee1ace56_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81c8-83c7-727a-bdef-d4ddee1ace56" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-727a-bdef-d4ddee1ace56_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e81c8-83c7-727a-bdef-d4ddee1ace56" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_019e81c8-83c7-7631-a836-134ff172d1b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_us-gaap_CollaborativeArrangementMember_019e81c8-83c7-7631-a836-134ff172d1b7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DouglasLicenseAgreementMember_019e81ca-5320-7436-83bb-bad87aa663a0" xlink:href="dare-20260630.xsd#dare_DouglasLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_DouglasLicenseAgreementMember_019e81ca-5320-7436-83bb-bad87aa663a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_HennepinLicenseAgreementMember_019e81ca-5320-70c5-a124-f5afdb1efb36" xlink:href="dare-20260630.xsd#dare_HennepinLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_HennepinLicenseAgreementMember_019e81ca-5320-70c5-a124-f5afdb1efb36" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_019e81cc-1f95-7873-aac9-d4a553bc117a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_us-gaap_LicensingAgreementsMember_019e81cc-1f95-7873-aac9-d4a553bc117a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AssignmentAgreementMember_019e81cc-1f95-7e17-9850-36a9118568a0" xlink:href="dare-20260630.xsd#dare_AssignmentAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_AssignmentAgreementMember_019e81cc-1f95-7e17-9850-36a9118568a0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MergerAgreementMember_019e81cc-1f95-7886-be2d-e7069570a17a" xlink:href="dare-20260630.xsd#dare_MergerAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_MergerAgreementMember_019e81cc-1f95-7886-be2d-e7069570a17a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PearTreePharmaceuticalsIncMember_019e81cc-1f95-7461-afad-49c1ee530734" xlink:href="dare-20260630.xsd#dare_PearTreePharmaceuticalsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_PearTreePharmaceuticalsIncMember_019e81cc-1f95-7461-afad-49c1ee530734" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_JuniperPharmaceuticalsInc.Member_019e81cd-b245-72a5-9b15-95496c98f777" xlink:href="dare-20260630.xsd#dare_JuniperPharmaceuticalsInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_JuniperPharmaceuticalsInc.Member_019e81cd-b245-72a5-9b15-95496c98f777" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndCollaborationAgreementMember_019e81cd-b245-7629-9a3a-f475ee0af94e" xlink:href="dare-20260630.xsd#dare_LicenseAndCollaborationAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e81c8-83c7-74e6-b1be-378da801a5f5" xlink:to="loc_dare_LicenseAndCollaborationAgreementMember_019e81cd-b245-7629-9a3a-f475ee0af94e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_019e81ca-5320-741a-8d45-c462effe20ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_019e81ca-5320-741a-8d45-c462effe20ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-741a-8d45-c462effe20ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019e81ca-5320-741a-8d45-c462effe20ef" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-741a-8d45-c462effe20ef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019e81ca-5320-741a-8d45-c462effe20ef" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainDevelopmentMilestonesMember_019e81ca-5320-79ec-98ca-a00d8ddfd1ec" xlink:href="dare-20260630.xsd#dare_UponAchievingCertainDevelopmentMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:to="loc_dare_UponAchievingCertainDevelopmentMilestonesMember_019e81ca-5320-79ec-98ca-a00d8ddfd1ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainCommercialMilestonesMember_019e81ca-5320-7b74-a9b5-27c3d447259e" xlink:href="dare-20260630.xsd#dare_UponAchievingCertainCommercialMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:to="loc_dare_UponAchievingCertainCommercialMilestonesMember_019e81ca-5320-7b74-a9b5-27c3d447259e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember_019e81cc-1f95-7d99-9612-42ffe39b3688" xlink:href="dare-20260630.xsd#dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:to="loc_dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember_019e81cc-1f95-7d99-9612-42ffe39b3688" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember_019e81cc-1f95-7c94-8eaf-5f65b492a41b" xlink:href="dare-20260630.xsd#dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019e81ca-5320-745b-a207-5d7d6d78aa80" xlink:to="loc_dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember_019e81cc-1f95-7c94-8eaf-5f65b492a41b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019e81ca-5320-7284-bbd2-549999a66ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019e81ca-5320-7284-bbd2-549999a66ddd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-7284-bbd2-549999a66ddd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019e81ca-5320-7284-bbd2-549999a66ddd" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-7284-bbd2-549999a66ddd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-79d4-96ad-93b1cfea8cba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019e81ca-5320-7284-bbd2-549999a66ddd" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-79d4-96ad-93b1cfea8cba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClinicalAndRegulatoryMilestonesMember_019e81ca-5320-7fec-a53e-83057eff7d3b" xlink:href="dare-20260630.xsd#dare_ClinicalAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-79d4-96ad-93b1cfea8cba" xlink:to="loc_dare_ClinicalAndRegulatoryMilestonesMember_019e81ca-5320-7fec-a53e-83057eff7d3b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SalesMilestonesMember_019e81ca-5320-7932-b814-c2a0235ff27b" xlink:href="dare-20260630.xsd#dare_SalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-79d4-96ad-93b1cfea8cba" xlink:to="loc_dare_SalesMilestonesMember_019e81ca-5320-7932-b814-c2a0235ff27b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ADVATecAgreementMember_019e81ce-5773-7862-b767-69674cb4596b" xlink:href="dare-20260630.xsd#dare_ADVATecAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019e81ca-5320-79d4-96ad-93b1cfea8cba" xlink:to="loc_dare_ADVATecAgreementMember_019e81ce-5773-7862-b767-69674cb4596b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019e81ca-5320-78a7-b84a-0a66e93713c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019e81ca-5320-78a7-b84a-0a66e93713c1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e81ca-5320-78a7-b84a-0a66e93713c1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019e81ca-5320-78a7-b84a-0a66e93713c1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e81ca-5320-78a7-b84a-0a66e93713c1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e81ca-5320-70d0-9e82-666f3d020aac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019e81ca-5320-78a7-b84a-0a66e93713c1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e81ca-5320-70d0-9e82-666f3d020aac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MicrochipsBiotechInc.Member_019e81ca-5320-7bce-ae0d-c62b8dc8dc72" xlink:href="dare-20260630.xsd#dare_MicrochipsBiotechInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e81ca-5320-70d0-9e82-666f3d020aac" xlink:to="loc_dare_MicrochipsBiotechInc.Member_019e81ca-5320-7bce-ae0d-c62b8dc8dc72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_019e81ca-5320-781f-b5a7-64d851d76927" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_019e81ca-5320-781f-b5a7-64d851d76927" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_019e81ca-5320-781f-b5a7-64d851d76927_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_019e81ca-5320-781f-b5a7-64d851d76927" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_019e81ca-5320-781f-b5a7-64d851d76927_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_019e81ca-5320-7cd5-b5ec-50a3b843c51a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_019e81ca-5320-781f-b5a7-64d851d76927" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_019e81ca-5320-7cd5-b5ec-50a3b843c51a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019e81ca-5320-7b8a-8fe1-4f5a21cd00a3" xlink:href="dare-20260630.xsd#dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_019e81ca-5320-7cd5-b5ec-50a3b843c51a" xlink:to="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019e81ca-5320-7b8a-8fe1-4f5a21cd00a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e81cc-1f95-75bf-b475-4f66630330af" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_srt_RangeAxis_019e81cc-1f95-75bf-b475-4f66630330af" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81cc-1f95-75bf-b475-4f66630330af_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e81cc-1f95-75bf-b475-4f66630330af" xlink:to="loc_srt_RangeMember_019e81cc-1f95-75bf-b475-4f66630330af_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81cc-1f95-7675-b0dc-32bea79680ef" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e81cc-1f95-75bf-b475-4f66630330af" xlink:to="loc_srt_RangeMember_019e81cc-1f95-7675-b0dc-32bea79680ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e81cc-1f95-7323-a2af-1403947938cf" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81cc-1f95-7675-b0dc-32bea79680ef" xlink:to="loc_srt_MaximumMember_019e81cc-1f95-7323-a2af-1403947938cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e81ce-5773-7e9c-b746-a161246bec90" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81cc-1f95-7675-b0dc-32bea79680ef" xlink:to="loc_srt_MinimumMember_019e81ce-5773-7e9c-b746-a161246bec90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019e81cc-1f95-7e0e-aa66-1078988fc101" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019e81cc-1f95-7e0e-aa66-1078988fc101" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019e81cc-1f95-7e0e-aa66-1078988fc101_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019e81cc-1f95-7e0e-aa66-1078988fc101" xlink:to="loc_us-gaap_RelatedPartyDomain_019e81cc-1f95-7e0e-aa66-1078988fc101_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019e81cc-1f95-7d69-bca6-279dbd0e0cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019e81cc-1f95-7e0e-aa66-1078988fc101" xlink:to="loc_us-gaap_RelatedPartyDomain_019e81cc-1f95-7d69-bca6-279dbd0e0cb6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyMember_019e81cc-1f95-722d-846c-9a3f3efb6ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019e81cc-1f95-7d69-bca6-279dbd0e0cb6" xlink:to="loc_us-gaap_RelatedPartyMember_019e81cc-1f95-722d-846c-9a3f3efb6ed0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019e81ce-5773-7b6e-ba2f-5ac2200453ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e4145-b132-713b-b256-f012bc1b7fda" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019e81ce-5773-7b6e-ba2f-5ac2200453ec" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProjectMember_019e81ce-5773-7b6e-ba2f-5ac2200453ec_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019e81ce-5773-7b6e-ba2f-5ac2200453ec" xlink:to="loc_us-gaap_ProjectMember_019e81ce-5773-7b6e-ba2f-5ac2200453ec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProjectMember_019e81ce-5773-73ad-b22b-f02822789f7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019e81ce-5773-7b6e-ba2f-5ac2200453ec" xlink:to="loc_us-gaap_ProjectMember_019e81ce-5773-73ad-b22b-f02822789f7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019e81ce-5773-7b63-86fc-9944435bc26c" xlink:href="dare-20260630.xsd#dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProjectMember_019e81ce-5773-73ad-b22b-f02822789f7f" xlink:to="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019e81ce-5773-7b63-86fc-9944435bc26c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponReachingCertainWorldwideNetSalesMilestonesMember_019e81ce-5773-717d-b579-aa3768c49783" xlink:href="dare-20260630.xsd#dare_UponReachingCertainWorldwideNetSalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProjectMember_019e81ce-5773-73ad-b22b-f02822789f7f" xlink:to="loc_dare_UponReachingCertainWorldwideNetSalesMilestonesMember_019e81ce-5773-717d-b579-aa3768c49783" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UpfrontLicenseFeeAmountPaid_019e81c8-49b1-76dd-9710-72b28223b484" xlink:href="dare-20260630.xsd#dare_UpfrontLicenseFeeAmountPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_UpfrontLicenseFeeAmountPaid_019e81c8-49b1-76dd-9710-72b28223b484" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount_019e81c8-83c7-75dc-b2bf-7a2b172d8946" xlink:href="dare-20260630.xsd#dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount_019e81c8-83c7-75dc-b2bf-7a2b172d8946" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses_019e81c8-83c7-7ff9-b30c-c9db0ecdb597" xlink:href="dare-20260630.xsd#dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses_019e81c8-83c7-7ff9-b30c-c9db0ecdb597" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount_019e81c8-83c7-7727-8bd6-44c9288dfc7d" xlink:href="dare-20260630.xsd#dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount_019e81c8-83c7-7727-8bd6-44c9288dfc7d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod_019e81c8-83c7-7ad4-9d1e-4f56c68b6127" xlink:href="dare-20260630.xsd#dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod_019e81c8-83c7-7ad4-9d1e-4f56c68b6127" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MaximumPotentialMilestonePayments_019e81ca-5320-7304-a69a-527753f0f709" xlink:href="dare-20260630.xsd#dare_MaximumPotentialMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_MaximumPotentialMilestonePayments_019e81ca-5320-7304-a69a-527753f0f709" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentMilestonePayment_019e81ca-5320-7926-adf9-b8d9412dc621" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentMilestonePayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_ResearchAndDevelopmentMilestonePayment_019e81ca-5320-7926-adf9-b8d9412dc621" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AssetAcquisitionContingentConsiderationCurrent_019e81ca-5320-7446-9aa1-93e9d92b941c" xlink:href="dare-20260630.xsd#dare_AssetAcquisitionContingentConsiderationCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_AssetAcquisitionContingentConsiderationCurrent_019e81ca-5320-7446-9aa1-93e9d92b941c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PaymentOfAdditionalConsiderationInBusinessCombination_019e81ca-5320-72a1-8e9c-bf62e2fa99b2" xlink:href="dare-20260630.xsd#dare_PaymentOfAdditionalConsiderationInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_PaymentOfAdditionalConsiderationInBusinessCombination_019e81ca-5320-72a1-8e9c-bf62e2fa99b2" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PaymentsToStockholdersRepresentativeInBusinessCombination_019e81ca-5320-72e8-90f6-736161793f0b" xlink:href="dare-20260630.xsd#dare_PaymentsToStockholdersRepresentativeInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_PaymentsToStockholdersRepresentativeInBusinessCombination_019e81ca-5320-72e8-90f6-736161793f0b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmount_019e81cc-1f95-7ed2-bc35-3c941230a610" xlink:href="dare-20260630.xsd#dare_MilestonePaymentsContingentAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_MilestonePaymentsContingentAmount_019e81cc-1f95-7ed2-bc35-3c941230a610" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter_019e81cd-b245-728c-a58b-1ea2a06443dc" xlink:href="dare-20260630.xsd#dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter_019e81cd-b245-728c-a58b-1ea2a06443dc" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRatePercentage_019e81ce-5773-7928-ae6e-432f89b206f0" xlink:href="dare-20260630.xsd#dare_RoyaltyRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e81c8-49b1-7f86-ac95-00aab947c5c8" xlink:to="loc_dare_RoyaltyRatePercentage_019e81ce-5773-7928-ae6e-432f89b206f0" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockholdersEquityAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e81d3-820b-7d29-91c3-9a517c51e5f5" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_srt_CounterpartyNameAxis_019e81d3-820b-7d29-91c3-9a517c51e5f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-7d29-91c3-9a517c51e5f5_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e81d3-820b-7d29-91c3-9a517c51e5f5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-7d29-91c3-9a517c51e5f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-785a-a540-5048a84564f6" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e81d3-820b-7d29-91c3-9a517c51e5f5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-785a-a540-5048a84564f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LincolnParkCapitalFundLLCMember_019e81d3-820b-7160-8633-7539af931f72" xlink:href="dare-20260630.xsd#dare_LincolnParkCapitalFundLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-785a-a540-5048a84564f6" xlink:to="loc_dare_LincolnParkCapitalFundLLCMember_019e81d3-820b-7160-8633-7539af931f72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DigitalOfferingLLCMember_019e81d4-2c26-71c0-8e53-e1d04861abb0" xlink:href="dare-20260630.xsd#dare_DigitalOfferingLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e81d3-820b-785a-a540-5048a84564f6" xlink:to="loc_dare_DigitalOfferingLLCMember_019e81d4-2c26-71c0-8e53-e1d04861abb0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e81d3-820b-7e36-80aa-625a4d0d0b95" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_srt_RangeAxis_019e81d3-820b-7e36-80aa-625a4d0d0b95" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81d3-820b-7e36-80aa-625a4d0d0b95_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e81d3-820b-7e36-80aa-625a4d0d0b95" xlink:to="loc_srt_RangeMember_019e81d3-820b-7e36-80aa-625a4d0d0b95_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e81d3-820b-7879-be8e-5fa56318b2fb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e81d3-820b-7e36-80aa-625a4d0d0b95" xlink:to="loc_srt_RangeMember_019e81d3-820b-7879-be8e-5fa56318b2fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e81d3-820b-7460-9d1f-ebe836eb3859" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81d3-820b-7879-be8e-5fa56318b2fb" xlink:to="loc_srt_MaximumMember_019e81d3-820b-7460-9d1f-ebe836eb3859" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e81d3-820b-7569-8160-87f91f1b8cc0" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e81d3-820b-7879-be8e-5fa56318b2fb" xlink:to="loc_srt_MinimumMember_019e81d3-820b-7569-8160-87f91f1b8cc0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019e81d3-820b-785f-ba47-ba290658e6ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019e81d3-820b-785f-ba47-ba290658e6ed" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e81d3-820b-785f-ba47-ba290658e6ed_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e81d3-820b-785f-ba47-ba290658e6ed" xlink:to="loc_us-gaap_EquityComponentDomain_019e81d3-820b-785f-ba47-ba290658e6ed_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e81d3-820b-7f3b-8a13-5319529839e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e81d3-820b-785f-ba47-ba290658e6ed" xlink:to="loc_us-gaap_EquityComponentDomain_019e81d3-820b-7f3b-8a13-5319529839e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019e81d3-820b-7218-9d30-bcf6dfc2230d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e81d3-820b-7f3b-8a13-5319529839e2" xlink:to="loc_us-gaap_CommonStockMember_019e81d3-820b-7218-9d30-bcf6dfc2230d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019e81d3-820b-75c3-a53b-104cc3943f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019e81d3-820b-75c3-a53b-104cc3943f3f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-75c3-a53b-104cc3943f3f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019e81d3-820b-75c3-a53b-104cc3943f3f" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-75c3-a53b-104cc3943f3f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-76a1-9143-b236a9ff17e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019e81d3-820b-75c3-a53b-104cc3943f3f" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-76a1-9143-b236a9ff17e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PurchaseAndRegistrationRightsAgreementMember_019e81d3-820b-7744-a7d7-9cb8259c910c" xlink:href="dare-20260630.xsd#dare_PurchaseAndRegistrationRightsAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-76a1-9143-b236a9ff17e3" xlink:to="loc_dare_PurchaseAndRegistrationRightsAgreementMember_019e81d3-820b-7744-a7d7-9cb8259c910c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_March2023AtTheMarketSalesAgreementMember_019e81d3-ab87-7419-9146-2d1a687e1f99" xlink:href="dare-20260630.xsd#dare_March2023AtTheMarketSalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-76a1-9143-b236a9ff17e3" xlink:to="loc_dare_March2023AtTheMarketSalesAgreementMember_019e81d3-ab87-7419-9146-2d1a687e1f99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RegulationAOfferingMember_019e81d4-2c26-7bd2-9386-6d96cf98dc9a" xlink:href="dare-20260630.xsd#dare_RegulationAOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e81d3-820b-76a1-9143-b236a9ff17e3" xlink:to="loc_dare_RegulationAOfferingMember_019e81d4-2c26-7bd2-9386-6d96cf98dc9a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e81d3-ab87-7fe3-89db-330db7fadd98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_us-gaap_AwardTypeAxis_019e81d3-ab87-7fe3-89db-330db7fadd98" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e81d3-ab87-7fe3-89db-330db7fadd98_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e81d3-ab87-7fe3-89db-330db7fadd98" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e81d3-ab87-7fe3-89db-330db7fadd98_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e81d3-ab87-7081-ae63-56559256e276" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e81d3-ab87-7fe3-89db-330db7fadd98" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e81d3-ab87-7081-ae63-56559256e276" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019e81d3-ab87-7844-a6e9-3acaa95f0d08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e81d3-ab87-7081-ae63-56559256e276" xlink:to="loc_us-gaap_WarrantMember_019e81d3-ab87-7844-a6e9-3acaa95f0d08" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e81d3-ab87-75a1-8c78-8930306acd68" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e81d3-ab87-75a1-8c78-8930306acd68" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-75a1-8c78-8930306acd68_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e81d3-ab87-75a1-8c78-8930306acd68" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-75a1-8c78-8930306acd68_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e81d3-ab87-75a1-8c78-8930306acd68" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019e81d3-ab87-79f4-8062-9aec5887acd0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:to="loc_us-gaap_WarrantMember_019e81d3-ab87-79f4-8062-9aec5887acd0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_InvestorWarrantsMember_019e81d4-2c26-7e7b-afcb-30e303d786ae" xlink:href="dare-20260630.xsd#dare_InvestorWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:to="loc_dare_InvestorWarrantsMember_019e81d4-2c26-7e7b-afcb-30e303d786ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AgentUnitWarrantsMember_019e81d4-4b40-74d8-85cd-8b75063e2fe7" xlink:href="dare-20260630.xsd#dare_AgentUnitWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:to="loc_dare_AgentUnitWarrantsMember_019e81d4-4b40-74d8-85cd-8b75063e2fe7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AgentCommonWarrantMember_019e81d4-4b40-7e36-b055-fa700059a4dc" xlink:href="dare-20260630.xsd#dare_AgentCommonWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e81d3-ab87-7d74-94c1-cceb6c264e16" xlink:to="loc_dare_AgentCommonWarrantMember_019e81d4-4b40-7e36-b055-fa700059a4dc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e81d4-04f7-7871-9f6a-bbcd24254bba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7062-8dc4-fd86ad23354f" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e81d4-04f7-7871-9f6a-bbcd24254bba" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-7871-9f6a-bbcd24254bba_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e81d4-04f7-7871-9f6a-bbcd24254bba" xlink:to="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-7871-9f6a-bbcd24254bba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-79a4-8b8c-140ee6b665ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e81d4-04f7-7871-9f6a-bbcd24254bba" xlink:to="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-79a4-8b8c-140ee6b665ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_019e81d4-04f7-7e39-8113-087d515f8188" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-79a4-8b8c-140ee6b665ea" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_019e81d4-04f7-7e39-8113-087d515f8188" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SeriesAConvertiblePreferredStockMember_019f89f7-0502-7974-9e76-5043fc7f183b" xlink:href="dare-20260630.xsd#dare_SeriesAConvertiblePreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e81d4-04f7-79a4-8b8c-140ee6b665ea" xlink:to="loc_dare_SeriesAConvertiblePreferredStockMember_019f89f7-0502-7974-9e76-5043fc7f183b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockAuthorizedAmount_019e81d3-820b-74d0-8fe9-edafe26bf5d5" xlink:href="dare-20260630.xsd#dare_SaleOfStockAuthorizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_SaleOfStockAuthorizedAmount_019e81d3-820b-74d0-8fe9-edafe26bf5d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_019e81d3-820b-7567-a38d-ba3c225f190a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesIssuedPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_019e81d3-820b-7567-a38d-ba3c225f190a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019e81d3-820b-7a43-a304-ce630f95f5af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019e81d3-820b-7a43-a304-ce630f95f5af" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfLowestSalePrices_019e81d3-820b-7ca2-bfa2-58cbc10b58a2" xlink:href="dare-20260630.xsd#dare_NumberOfLowestSalePrices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_NumberOfLowestSalePrices_019e81d3-820b-7ca2-bfa2-58cbc10b58a2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfProceedingBusinessPeriod_019e81d3-820b-71d9-83c3-90ad6d0dad71" xlink:href="dare-20260630.xsd#dare_NumberOfProceedingBusinessPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_NumberOfProceedingBusinessPeriod_019e81d3-820b-71d9-83c3-90ad6d0dad71" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PurchaseCommitmentMaximumAmountCommitted_019e81d3-820b-776e-b606-f1a8204dddcf" xlink:href="dare-20260630.xsd#dare_PurchaseCommitmentMaximumAmountCommitted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PurchaseCommitmentMaximumAmountCommitted_019e81d3-820b-776e-b606-f1a8204dddcf" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightExtentHolderOwnPercentage_019e81d3-ab87-7a91-b4c8-d41890f72513" xlink:href="dare-20260630.xsd#dare_ClassOfWarrantOrRightExtentHolderOwnPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_ClassOfWarrantOrRightExtentHolderOwnPercentage_019e81d3-ab87-7a91-b4c8-d41890f72513" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BeneficialOwnershipPercentage_019e81d3-ab87-7956-99b9-849d9a41bfee" xlink:href="dare-20260630.xsd#dare_BeneficialOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_BeneficialOwnershipPercentage_019e81d3-ab87-7956-99b9-849d9a41bfee" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019e81d3-ab87-7d36-8660-9127df2c4185" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019e81d3-ab87-7d36-8660-9127df2c4185" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019e81d3-ab87-725a-a561-a51c496bb6b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019e81d3-ab87-725a-a561-a51c496bb6b8" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_019fa7c7-99c1-7807-ad24-bc3f44e442ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WriteOffOfDeferredDebtIssuanceCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_019fa7c7-99c1-7807-ad24-bc3f44e442ee" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PercentageOfAggregateCommission_019e81d3-ab87-7261-9bfd-d2251c768a3b" xlink:href="dare-20260630.xsd#dare_PercentageOfAggregateCommission"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PercentageOfAggregateCommission_019e81d3-ab87-7261-9bfd-d2251c768a3b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019e81d3-ab87-7d33-b397-aca0be51bec2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019e81d3-ab87-7d33-b397-aca0be51bec2" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e81d3-ab87-76df-980e-9b487ba3830e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e81d3-ab87-76df-980e-9b487ba3830e" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019e81d4-04f7-75b3-b838-e580e33a433a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019e81d4-04f7-75b3-b838-e580e33a433a" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e81d4-04f7-7fdd-976e-9e1be5c2b9d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e81d4-04f7-7fdd-976e-9e1be5c2b9d5" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockInitialStatedValuePerShare_019e81d4-2c26-71d4-a380-9fbd375499e7" xlink:href="dare-20260630.xsd#dare_PreferredStockInitialStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockInitialStatedValuePerShare_019e81d4-2c26-71d4-a380-9fbd375499e7" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockConvertibleConversionPrice_019e81d4-2c26-76b9-918a-2d9860458dee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockConvertibleConversionPrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_PreferredStockConvertibleConversionPrice_019e81d4-2c26-76b9-918a-2d9860458dee" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleSharePriceTrigger_019e81d4-2c26-7c4b-802e-80872c7baee0" xlink:href="dare-20260630.xsd#dare_PreferredStockConvertibleSharePriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockConvertibleSharePriceTrigger_019e81d4-2c26-7c4b-802e-80872c7baee0" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleThresholdTradingDays_019e81d4-2c26-7995-a541-1a11a1544311" xlink:href="dare-20260630.xsd#dare_PreferredStockConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockConvertibleThresholdTradingDays_019e81d4-2c26-7995-a541-1a11a1544311" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleThresholdConsecutiveTradingDays_019e81d4-2c26-7857-b014-1147f7abec34" xlink:href="dare-20260630.xsd#dare_PreferredStockConvertibleThresholdConsecutiveTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockConvertibleThresholdConsecutiveTradingDays_019e81d4-2c26-7857-b014-1147f7abec34" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertiblePublicOfferingProceedsTrigger_019e81d4-2c26-7488-b41b-b388b81494c0" xlink:href="dare-20260630.xsd#dare_PreferredStockConvertiblePublicOfferingProceedsTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockConvertiblePublicOfferingProceedsTrigger_019e81d4-2c26-7488-b41b-b388b81494c0" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger_019e81d4-2c26-7a54-847d-199e1f430d2a" xlink:href="dare-20260630.xsd#dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger_019e81d4-2c26-7a54-847d-199e1f430d2a" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockNonCompoundedRateOfReturnPercentage_019e81d4-2c26-7206-a306-515fbf14392c" xlink:href="dare-20260630.xsd#dare_PreferredStockNonCompoundedRateOfReturnPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockNonCompoundedRateOfReturnPercentage_019e81d4-2c26-7206-a306-515fbf14392c" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockPercentageOfStatedValuePerShare_019e81d4-2c26-7efb-b21a-c2936ed33b1e" xlink:href="dare-20260630.xsd#dare_PreferredStockPercentageOfStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_PreferredStockPercentageOfStatedValuePerShare_019e81d4-2c26-7efb-b21a-c2936ed33b1e" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019e81d4-2c26-7fcb-8abd-d32245a8f1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019e81d4-2c26-7fcb-8abd-d32245a8f1b5" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight_019e81d4-2c26-7645-b988-fe7b3cbe6007" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight_019e81d4-2c26-7645-b988-fe7b3cbe6007" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_019e81d4-2c26-77d7-8864-656e9d7c069b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_SharePrice_019e81d4-2c26-77d7-8864-656e9d7c069b" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_019e81d4-2c26-7b33-9832-925141455235" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_019e81d4-2c26-7b33-9832-925141455235" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockPlacementFeePercentage_019e81d4-2c26-70d0-9297-ad8f502dd77f" xlink:href="dare-20260630.xsd#dare_SaleOfStockPlacementFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_SaleOfStockPlacementFeePercentage_019e81d4-2c26-70d0-9297-ad8f502dd77f" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockPercentageOfWarrantsIssuable_019e81d4-2c26-7c35-8a2b-6893e489f25a" xlink:href="dare-20260630.xsd#dare_SaleOfStockPercentageOfWarrantsIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_SaleOfStockPercentageOfWarrantsIssuable_019e81d4-2c26-7c35-8a2b-6893e489f25a" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_019e81d4-2c26-7354-b9e6-23fc8394533c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_019e81d4-2c26-7354-b9e6-23fc8394533c" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts_019e81d4-2c26-7ac2-84e5-cd6d0ba21544" xlink:href="dare-20260630.xsd#dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts_019e81d4-2c26-7ac2-84e5-cd6d0ba21544" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_019e81d4-2c26-7826-9888-e70a170c19ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstandingTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_019e81d4-2c26-7826-9888-e70a170c19ed" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise_019e81d4-2c26-7dfc-a334-8d320ef73524" xlink:href="dare-20260630.xsd#dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise_019e81d4-2c26-7dfc-a334-8d320ef73524" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e81d4-4b40-775c-96e6-2e422f9e23ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e81d4-4b40-775c-96e6-2e422f9e23ea" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpenseOfferingCost_019e81d4-4b40-7751-b00d-9ec79bc2b1de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoninterestExpenseOfferingCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_NoninterestExpenseOfferingCost_019e81d4-4b40-7751-b00d-9ec79bc2b1de" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesIssued1_019f89f7-db5e-7cc8-9da4-ce068a3e59ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConversionOfStockSharesIssued1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ConversionOfStockSharesIssued1_019f89f7-db5e-7cc8-9da4-ce068a3e59ca" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_019f89f7-0502-7633-9179-2d217e081723" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConversionOfStockSharesConverted1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_019f89f7-0502-7633-9179-2d217e081723" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_019f89f7-db5e-716c-a996-e015b3e940a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e81d3-820b-7f01-a507-09dc9c684457" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_019f89f7-db5e-716c-a996-e015b3e940a5" xlink:type="arc" order="39"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityScheduleofWarrantActivityDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockholdersEquityScheduleofWarrantActivityDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityScheduleofWarrantActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019e4145-b132-718c-96d0-4fec6ba67c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7e3d-a38d-a98a7cff8009" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e4145-b132-718c-96d0-4fec6ba67c0b" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7e3d-a38d-a98a7cff8009" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-7843-99b1-b32b65ff64cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7e3d-a38d-a98a7cff8009" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-7843-99b1-b32b65ff64cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7843-99b1-b32b65ff64cc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-7843-99b1-b32b65ff64cc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7843-99b1-b32b65ff64cc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7222-84fd-86fce4b26112" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-7843-99b1-b32b65ff64cc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7222-84fd-86fce4b26112" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7222-84fd-86fce4b26112" xlink:to="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_December2023WarrantsMember_019e4145-b132-759b-bcbc-954c2bba0fcd" xlink:href="dare-20260630.xsd#dare_December2023WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:to="loc_dare_December2023WarrantsMember_019e4145-b132-759b-bcbc-954c2bba0fcd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_September2023WarrantsMember_019e4145-b132-7039-a133-ad68bae26580" xlink:href="dare-20260630.xsd#dare_September2023WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:to="loc_dare_September2023WarrantsMember_019e4145-b132-7039-a133-ad68bae26580" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_October2016WarrantsMember_019e4145-b132-7dcd-baed-0a481bc68505" xlink:href="dare-20260630.xsd#dare_October2016WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:to="loc_dare_October2016WarrantsMember_019e4145-b132-7dcd-baed-0a481bc68505" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RegulationAOfferingInvestorWarrantsMember_019e4145-b132-756d-aa46-f7b6152a5e0c" xlink:href="dare-20260630.xsd#dare_RegulationAOfferingInvestorWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019e4145-b132-7f68-90ea-05f846564671" xlink:to="loc_dare_RegulationAOfferingInvestorWarrantsMember_019e4145-b132-756d-aa46-f7b6152a5e0c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019fa821-ff56-7f7f-a508-b9a64d9674c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019e4145-b132-7e3d-a38d-a98a7cff8009" xlink:to="loc_us-gaap_AwardTypeAxis_019fa821-ff56-7f7f-a508-b9a64d9674c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019fa821-ff56-7f7f-a508-b9a64d9674c2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019fa821-ff56-7f7f-a508-b9a64d9674c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019fa821-ff56-7f7f-a508-b9a64d9674c2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019fa821-ff56-725c-925b-3ee6a057a4c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019fa821-ff56-7f7f-a508-b9a64d9674c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019fa821-ff56-725c-925b-3ee6a057a4c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019fa822-563c-7813-90a2-094083473bed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019fa821-ff56-725c-925b-3ee6a057a4c8" xlink:to="loc_us-gaap_WarrantMember_019fa822-563c-7813-90a2-094083473bed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019e4145-b132-73d8-bf55-5c67f5bc3d61" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e4145-b132-718c-96d0-4fec6ba67c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019e4145-b132-73d8-bf55-5c67f5bc3d61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e4145-b132-73e6-a96c-a5bd91472c86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e4145-b132-718c-96d0-4fec6ba67c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e4145-b132-73e6-a96c-a5bd91472c86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019fa821-ff56-7c8c-a9c1-27defd911934" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019e4145-b132-718c-96d0-4fec6ba67c0b" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019fa821-ff56-7c8c-a9c1-27defd911934" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b132-73e4-a606-796b9d530bcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b132-73e4-a606-796b9d530bcb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-79d9-8f86-b0924c2bd372" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b132-73e4-a606-796b9d530bcb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-79d9-8f86-b0924c2bd372" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-79d9-8f86-b0924c2bd372_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-79d9-8f86-b0924c2bd372" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-79d9-8f86-b0924c2bd372_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7d98-bbf8-0630e81af9c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e4145-b132-79d9-8f86-b0924c2bd372" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7d98-bbf8-0630e81af9c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WarrantsMember_019e4145-b132-7916-ba20-d44a87c10571" xlink:href="dare-20260630.xsd#dare_WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e4145-b132-7d98-bbf8-0630e81af9c4" xlink:to="loc_dare_WarrantsMember_019e4145-b132-7916-ba20-d44a87c10571" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019e4145-b132-7ddb-8f79-94fe1a92a776" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019e4145-b132-7ddb-8f79-94fe1a92a776" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_019e4145-b132-7ec1-9ba7-be3a0e59ec64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_019e4145-b132-7ec1-9ba7-be3a0e59ec64" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_019e4145-b132-78bc-b08b-84682c84f952" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_019e4145-b132-78bc-b08b-84682c84f952" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations_019e4145-b132-70e7-a58d-cd3e48a5ac70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019e4145-b132-7a38-a051-d6717af21612" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations_019e4145-b132-70e7-a58d-cd3e48a5ac70" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019e4145-b132-7762-95bf-30f065bf7ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e4145-b132-7cbf-8cbf-12594a6a2814" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e4145-b132-7cbf-8cbf-12594a6a2814" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e4145-b132-773c-b36c-8d361e0c6f89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e4145-b132-773c-b36c-8d361e0c6f89" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue_019e4145-b132-7e17-8772-db27c945a583" xlink:href="dare-20260630.xsd#dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:to="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue_019e4145-b132-7e17-8772-db27c945a583" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue_019e4145-b132-76ca-ae61-8be10966910f" xlink:href="dare-20260630.xsd#dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019e4145-b132-7f51-ab4c-1b91820d70b7" xlink:to="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue_019e4145-b132-76ca-ae61-8be10966910f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e4145-b132-7b00-a09b-a4e069668022" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019e4145-b132-7608-ad34-7f3d7e6bcdd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019e4145-b132-7608-ad34-7f3d7e6bcdd2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_019e4145-b132-7df2-80ba-fb96e1b360ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019e4145-b132-7608-ad34-7f3d7e6bcdd2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_019e4145-b132-7df2-80ba-fb96e1b360ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019e4145-b132-76f7-97e1-450d236c8670" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b132-763b-963f-6d315fe53124" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019e4145-b132-76f7-97e1-450d236c8670" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_019e4145-b132-7775-873b-302cdafc4497" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019e4145-b132-76f7-97e1-450d236c8670" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_019e4145-b132-7775-873b-302cdafc4497" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockBasedCompensationAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7790-b36e-99db3145c4ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7790-b36e-99db3145c4ef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019f3d7e-f991-7fc1-998c-a1774219730a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7790-b36e-99db3145c4ef" xlink:to="loc_us-gaap_PlanNameAxis_019f3d7e-f991-7fc1-998c-a1774219730a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7fc1-998c-a1774219730a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019f3d7e-f991-7fc1-998c-a1774219730a" xlink:to="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7fc1-998c-a1774219730a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019f3d7e-f991-7fc1-998c-a1774219730a" xlink:to="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember_019f3d7e-f991-7b9f-9a5b-1f68ff80dc18" xlink:href="dare-20260630.xsd#dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:to="loc_dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember_019f3d7e-f991-7b9f-9a5b-1f68ff80dc18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019f3d7e-f991-7374-962d-d91aa74242ab" xlink:href="dare-20260630.xsd#dare_TwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:to="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019f3d7e-f991-7374-962d-d91aa74242ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019f3d7e-f991-7ac9-a58c-918bc8a8b45e" xlink:href="dare-20260630.xsd#dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:to="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019f3d7e-f991-7ac9-a58c-918bc8a8b45e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember_019f3d7e-f991-726b-9fad-08b3d382dee6" xlink:href="dare-20260630.xsd#dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:to="loc_dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember_019f3d7e-f991-726b-9fad-08b3d382dee6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember_019f3d7e-f991-7f7d-b351-499c976da1d1" xlink:href="dare-20260630.xsd#dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019f3d7e-f991-7379-9f05-cd422d168ade" xlink:to="loc_dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember_019f3d7e-f991-7f7d-b351-499c976da1d1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019f3d7e-f991-7b6b-85e4-6c61812650c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7790-b36e-99db3145c4ef" xlink:to="loc_us-gaap_AwardTypeAxis_019f3d7e-f991-7b6b-85e4-6c61812650c6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-7b6b-85e4-6c61812650c6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019f3d7e-f991-7b6b-85e4-6c61812650c6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-7b6b-85e4-6c61812650c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019f3d7e-f991-7b6b-85e4-6c61812650c6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019f3d7e-f991-7489-a8d0-01514ba36754" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019f3d7e-f991-7489-a8d0-01514ba36754" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019f3d7f-1a21-7fa4-a679-10284dd9d69f" xlink:href="dare-20260630.xsd#dare_TwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:to="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019f3d7f-1a21-7fa4-a679-10284dd9d69f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019f3d7f-6031-7d4f-a57c-39596da731cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019f3d7f-6031-7d4f-a57c-39596da731cd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_019f3d7f-7b6e-76be-b91c-cc3d0b529080" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f3d7e-f991-765b-809c-63662ee69d3d" xlink:to="loc_us-gaap_RestrictedStockMember_019f3d7f-7b6e-76be-b91c-cc3d0b529080" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019f3d7e-f991-711f-93b0-139eca3113b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019f3d7e-f991-711f-93b0-139eca3113b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019f3d7e-f991-7935-927f-ef9c7f6635e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019f3d7e-f991-7935-927f-ef9c7f6635e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019f3d7e-f991-7853-a814-73af6153a934" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019f3d7e-f991-7853-a814-73af6153a934" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019f3d7f-1a21-7519-9a66-7bdfb8e3810f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019f3d7f-1a21-7519-9a66-7bdfb8e3810f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019f3d7f-1a21-748d-ba3a-f9ce9848cfe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019f3d7f-1a21-748d-ba3a-f9ce9848cfe9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WeightedAverageAmortizationPeriod_019f3d88-0875-7f97-9cc1-f05a431491cc" xlink:href="dare-20260630.xsd#dare_WeightedAverageAmortizationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_dare_WeightedAverageAmortizationPeriod_019f3d88-0875-7f97-9cc1-f05a431491cc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f3d7f-45fc-705f-8ef4-1feb8d2c0d89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f3d7f-45fc-705f-8ef4-1feb8d2c0d89" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019f3d7f-6031-7812-b5a0-36ffefdf4b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019f3d7f-6031-7812-b5a0-36ffefdf4b3e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfNonEmployeeDirectors_019fdd5b-8032-7599-b4d5-165f501b014b" xlink:href="dare-20260630.xsd#dare_NumberOfNonEmployeeDirectors"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_dare_NumberOfNonEmployeeDirectors_019fdd5b-8032-7599-b4d5-165f501b014b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsRightToReceive_019fdd5c-ac16-78be-90fe-78538723c763" xlink:href="dare-20260630.xsd#dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsRightToReceive"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsRightToReceive_019fdd5c-ac16-78be-90fe-78538723c763" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f41b6-a160-773d-8d1d-d6b25f1ba3f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f41b6-a160-773d-8d1d-d6b25f1ba3f0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019f3d7f-7b6e-7de9-b5b2-adcb35507cc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019f3d7f-7b6e-7de9-b5b2-adcb35507cc4" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019f3d7f-7b6f-7683-a706-c68d3a3c0590" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019f3d7f-7b6f-7683-a706-c68d3a3c0590" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_019f3d88-0875-72ee-a30d-b68a49503def" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f3d7e-f991-7363-ae6d-492b42a6f71b" xlink:to="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_019f3d88-0875-72ee-a30d-b68a49503def" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7181-b237-975cdebc9fed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7181-b237-975cdebc9fed" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019e4145-b132-7012-a888-a6f87935b107" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7181-b237-975cdebc9fed" xlink:to="loc_us-gaap_PlanNameAxis_019e4145-b132-7012-a888-a6f87935b107" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019e4145-b132-7012-a888-a6f87935b107_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019e4145-b132-7012-a888-a6f87935b107" xlink:to="loc_us-gaap_PlanNameDomain_019e4145-b132-7012-a888-a6f87935b107_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019e4145-b132-78be-bda7-83cfdf79b6fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019e4145-b132-7012-a888-a6f87935b107" xlink:to="loc_us-gaap_PlanNameDomain_019e4145-b132-78be-bda7-83cfdf79b6fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019e4145-b132-75e0-893b-ef340f26d693" xlink:href="dare-20260630.xsd#dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019e4145-b132-78be-bda7-83cfdf79b6fa" xlink:to="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019e4145-b132-75e0-893b-ef340f26d693" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e4145-b132-70d3-83c1-741eed4be99d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e4145-b132-7181-b237-975cdebc9fed" xlink:to="loc_us-gaap_AwardTypeAxis_019e4145-b132-70d3-83c1-741eed4be99d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e4145-b132-70d3-83c1-741eed4be99d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e4145-b132-70d3-83c1-741eed4be99d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e4145-b132-70d3-83c1-741eed4be99d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e4145-b132-706c-b983-c60362b15474" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e4145-b132-70d3-83c1-741eed4be99d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e4145-b132-706c-b983-c60362b15474" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e4145-b132-71b2-9e2a-515587a5031e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e4145-b132-706c-b983-c60362b15474" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e4145-b132-71b2-9e2a-515587a5031e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e4145-b132-7b53-9f89-59b0a8815dd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e4145-b132-7b53-9f89-59b0a8815dd1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019e4145-b132-750b-81cc-c08f7eb1496d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019e4145-b132-750b-81cc-c08f7eb1496d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019e4145-b132-770d-a792-b9cc1a49a4c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019e4145-b132-770d-a792-b9cc1a49a4c3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019e4145-b132-7db5-99ff-2f6cfd8340ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019e4145-b132-7db5-99ff-2f6cfd8340ff" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_019e4145-b132-7c57-a829-d334bc5f5637" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e4145-b132-7aca-8476-a9e67af5b449" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_019e4145-b132-7c57-a829-d334bc5f5637" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e4145-b132-7066-8ac7-158d8a485c59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019e4145-b132-7380-b791-34decd5605d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019e4145-b132-7380-b791-34decd5605d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e4145-b132-7dde-aee4-9f165f86d08d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e4145-b132-7dde-aee4-9f165f86d08d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019e4145-b132-7cfa-99c6-36f4d55dbe4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019e4145-b132-7cfa-99c6-36f4d55dbe4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019e4145-b132-773c-ab4c-4c38ec64de81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019e4145-b132-773c-ab4c-4c38ec64de81" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019e4145-b132-79ce-a9ec-034ed887b1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019e4145-b132-79ce-a9ec-034ed887b1b5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_019e4145-b132-7ab4-9236-2254118996a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e4145-b132-737c-9160-a126bbe112fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_019e4145-b132-7ab4-9236-2254118996a5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e4145-b132-7525-9182-d527c7111639" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019e4145-b132-7601-819f-40d434f57218" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e4145-b132-7860-ba09-7ab482c4488f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019e4145-b132-7601-819f-40d434f57218" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e4145-b132-797f-9d1e-6b0d23b281c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e4145-b132-797f-9d1e-6b0d23b281c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:to="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-7a77-9768-0d1790a8c891_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-7a77-9768-0d1790a8c891_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e821c-d54d-73ec-b20b-921cfb2f595c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e821c-d54d-73ec-b20b-921cfb2f595c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e4145-b132-78d7-94f7-1da2799532d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e4145-b132-78d7-94f7-1da2799532d1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails_1" xlink:type="simple" xlink:href="dare-20260630.xsd#StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails_1"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e4145-b132-7726-afc3-9767ec2067bd" xlink:to="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-7a77-9768-0d1790a8c891_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-7a77-9768-0d1790a8c891_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e821c-d54d-7a77-9768-0d1790a8c891" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e821c-d54d-73ec-b20b-921cfb2f595c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e821c-d54d-75f2-9a5a-fcdbab6947d0" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e821c-d54d-73ec-b20b-921cfb2f595c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e4145-b132-78d7-94f7-1da2799532d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e4145-b132-74ad-bf87-abaec29df9fe" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e4145-b132-78d7-94f7-1da2799532d1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#StockBasedCompensationScheduleofRSUActivityDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f2740-660c-7df2-ac29-7f77752e2f69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019f2740-660b-77fd-a3a7-b2c0538ff03f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f2740-660c-7df2-ac29-7f77752e2f69" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019f2740-660b-77fd-a3a7-b2c0538ff03f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019f2740-660b-70db-8c81-d997a2547f4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019f2740-660b-77fd-a3a7-b2c0538ff03f" xlink:to="loc_us-gaap_AwardTypeAxis_019f2740-660b-70db-8c81-d997a2547f4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f2740-660b-70db-8c81-d997a2547f4d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019f2740-660b-70db-8c81-d997a2547f4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f2740-660b-70db-8c81-d997a2547f4d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f2740-660c-72ae-827a-5ea3ddaad886" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019f2740-660b-70db-8c81-d997a2547f4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f2740-660c-72ae-827a-5ea3ddaad886" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019f2740-660c-7c37-9792-5eb425a1f440" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019f2740-660c-72ae-827a-5ea3ddaad886" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019f2740-660c-7c37-9792-5eb425a1f440" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f2740-660c-7df2-ac29-7f77752e2f69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019f2740-660c-7437-ba6e-e2102df67e79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019f2740-660c-7437-ba6e-e2102df67e79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019f2740-660c-726a-8bd0-dd8862dc4006" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019f2740-660c-726a-8bd0-dd8862dc4006" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019f2740-660c-72ee-8f5c-839bc5653e10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019f2740-660c-72ee-8f5c-839bc5653e10" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019f2740-660c-7702-bbcb-e59501c8ea57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019f2744-1f2e-747a-8d99-98d4189ae9a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019f2740-660c-7702-bbcb-e59501c8ea57" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019f2743-2b76-7845-b93e-4c7d45fea4c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019f2740-660c-7df2-ac29-7f77752e2f69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019f2740-660c-77d6-99fb-fbf190fcf4d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019f2740-660c-77d6-99fb-fbf190fcf4d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f2740-660c-72ae-bd01-b8536de2bee9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019f2740-660c-72ae-bd01-b8536de2bee9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019f2740-660c-72fe-ba98-b393ae9915f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019f2740-660c-72fe-ba98-b393ae9915f7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019f2740-660c-7cc9-98ad-549b1e2b0154" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019f2746-d5f5-7263-9a5f-67321b4bede3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019f2740-660c-7cc9-98ad-549b1e2b0154" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019f3d7d-0d71-73e4-89bd-c92322a53402" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#LeasedPropertiesAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_019e4145-b132-7648-9cac-11dc63251cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:to="loc_us-gaap_LeaseContractualTermAxis_019e4145-b132-7648-9cac-11dc63251cf3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019e4145-b132-7648-9cac-11dc63251cf3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019e4145-b132-7648-9cac-11dc63251cf3" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019e4145-b132-7648-9cac-11dc63251cf3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019e820b-2330-798b-ba5b-a367d1797f75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019e4145-b132-7648-9cac-11dc63251cf3" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019e820b-2330-798b-ba5b-a367d1797f75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CleanRoomSpaceMember_019e820b-2330-761b-bce3-51e686ffa54f" xlink:href="dare-20260630.xsd#dare_CleanRoomSpaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_019e820b-2330-798b-ba5b-a367d1797f75" xlink:to="loc_dare_CleanRoomSpaceMember_019e820b-2330-761b-bce3-51e686ffa54f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e820b-2330-7f47-842e-da1a1e3874c0" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:to="loc_srt_ProductOrServiceAxis_019e820b-2330-7f47-842e-da1a1e3874c0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e820b-2330-7f47-842e-da1a1e3874c0_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e820b-2330-7f47-842e-da1a1e3874c0" xlink:to="loc_srt_ProductsAndServicesDomain_019e820b-2330-7f47-842e-da1a1e3874c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e820b-2330-723b-aa5f-826c9a7da304" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e820b-2330-7f47-842e-da1a1e3874c0" xlink:to="loc_srt_ProductsAndServicesDomain_019e820b-2330-723b-aa5f-826c9a7da304" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseMember_019e820b-2330-7798-9a58-1d8ea61c6985" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LicenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e820b-2330-723b-aa5f-826c9a7da304" xlink:to="loc_us-gaap_LicenseMember_019e820b-2330-7798-9a58-1d8ea61c6985" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e820b-2330-7e89-a67e-725fa87514d8" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:to="loc_srt_RangeAxis_019e820b-2330-7e89-a67e-725fa87514d8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e820b-2330-7e89-a67e-725fa87514d8_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e820b-2330-7e89-a67e-725fa87514d8" xlink:to="loc_srt_RangeMember_019e820b-2330-7e89-a67e-725fa87514d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e820b-2330-79da-a644-cb1635958b07" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e820b-2330-7e89-a67e-725fa87514d8" xlink:to="loc_srt_RangeMember_019e820b-2330-79da-a644-cb1635958b07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e820b-2330-798f-9f8e-799b7896d61d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e820b-2330-79da-a644-cb1635958b07" xlink:to="loc_srt_MaximumMember_019e820b-2330-798f-9f8e-799b7896d61d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_019e820b-2330-7bc6-afca-38f2293c0445" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019e4145-b132-78eb-81b2-397bf1884db2" xlink:to="loc_dei_LegalEntityAxis_019e820b-2330-7bc6-afca-38f2293c0445" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019e820b-2330-7bc6-afca-38f2293c0445_default" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_019e820b-2330-7bc6-afca-38f2293c0445" xlink:to="loc_dei_EntityDomain_019e820b-2330-7bc6-afca-38f2293c0445_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019e820b-2330-70bc-b471-5d6d3adb1a2a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_019e820b-2330-7bc6-afca-38f2293c0445" xlink:to="loc_dei_EntityDomain_019e820b-2330-70bc-b471-5d6d3adb1a2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MBIMember_019e820b-2330-7992-ae64-dd01bfe2e829" xlink:href="dare-20260630.xsd#dare_MBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_019e820b-2330-70bc-b471-5d6d3adb1a2a" xlink:to="loc_dare_MBIMember_019e820b-2330-7992-ae64-dd01bfe2e829" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementTerm_019e820b-2330-7312-a7c8-42024f4068b8" xlink:href="dare-20260630.xsd#dare_LicenseAndServicesAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_dare_LicenseAndServicesAgreementTerm_019e820b-2330-7312-a7c8-42024f4068b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementAmountPayableUponExecution_019e820b-2330-770f-9628-ed80be70870e" xlink:href="dare-20260630.xsd#dare_LicenseAndServicesAgreementAmountPayableUponExecution"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_dare_LicenseAndServicesAgreementAmountPayableUponExecution_019e820b-2330-770f-9628-ed80be70870e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage_019e820b-2330-7559-a664-a3f3dd9dabb8" xlink:href="dare-20260630.xsd#dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage_019e820b-2330-7559-a664-a3f3dd9dabb8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019e820b-2330-7fe9-bfff-92f86ef327ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_019e820b-2330-7fe9-bfff-92f86ef327ae" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019e820b-2330-7cb8-aebe-4a95a242fb92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_FinanceLeaseLiability_019e820b-2330-7cb8-aebe-4a95a242fb92" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_019e820b-2330-70ba-99b1-151f95e95ef0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_019e820b-2330-70ba-99b1-151f95e95ef0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FinanceLeaseIncrementalBorrowingRatePrimeRate_019e820b-2330-720f-9e6c-eba388af2ad4" xlink:href="dare-20260630.xsd#dare_FinanceLeaseIncrementalBorrowingRatePrimeRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_dare_FinanceLeaseIncrementalBorrowingRatePrimeRate_019e820b-2330-720f-9e6c-eba388af2ad4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_019e820b-2330-7abc-bbeb-f391f7a8f01b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_019e820b-2330-7abc-bbeb-f391f7a8f01b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetRentableArea_019e820b-2330-76cf-8f85-97d4feefa9d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetRentableArea"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_NetRentableArea_019e820b-2330-76cf-8f85-97d4feefa9d0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019e820b-2330-7b53-ada6-5223611961ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019e820b-2330-7b53-ada6-5223611961ab" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OperatingLeaseIncrementalBorrowingRatePrimeRate_019e820b-45bb-7f4d-bf94-01c253c1ebbc" xlink:href="dare-20260630.xsd#dare_OperatingLeaseIncrementalBorrowingRatePrimeRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019e820b-2330-7a8b-95fb-04fc5e2672b3" xlink:to="loc_dare_OperatingLeaseIncrementalBorrowingRatePrimeRate_019e820b-45bb-7f4d-bf94-01c253c1ebbc" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyInterestFinancingAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#RoyaltyInterestFinancingAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyInterestFinancingAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e8215-63c3-7c74-a484-f241c9b0588e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:to="loc_srt_CounterpartyNameAxis_019e8215-63c3-7c74-a484-f241c9b0588e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8215-63c3-7c74-a484-f241c9b0588e_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e8215-63c3-7c74-a484-f241c9b0588e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8215-63c3-7c74-a484-f241c9b0588e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8215-63c3-722c-8d3a-d969602c595b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e8215-63c3-7c74-a484-f241c9b0588e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8215-63c3-722c-8d3a-d969602c595b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnitedInEndeavorLLCMember_019e8215-63c3-7164-83b6-5a87ea750f1d" xlink:href="dare-20260630.xsd#dare_UnitedInEndeavorLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8215-63c3-722c-8d3a-d969602c595b" xlink:to="loc_dare_UnitedInEndeavorLLCMember_019e8215-63c3-7164-83b6-5a87ea750f1d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e8215-63c3-7d96-ae90-1d41686153e0" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:to="loc_srt_RangeAxis_019e8215-63c3-7d96-ae90-1d41686153e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8215-63c3-7d96-ae90-1d41686153e0_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e8215-63c3-7d96-ae90-1d41686153e0" xlink:to="loc_srt_RangeMember_019e8215-63c3-7d96-ae90-1d41686153e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8215-63c3-7ce6-9f5f-8b9a440205bd" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e8215-63c3-7d96-ae90-1d41686153e0" xlink:to="loc_srt_RangeMember_019e8215-63c3-7ce6-9f5f-8b9a440205bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e8215-63c3-76a3-b604-5f636ed17d5d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8215-63c3-7ce6-9f5f-8b9a440205bd" xlink:to="loc_srt_MinimumMember_019e8215-63c3-76a3-b604-5f636ed17d5d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e8215-63c3-70c4-b350-7b4bbf31b600" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8215-63c3-7ce6-9f5f-8b9a440205bd" xlink:to="loc_srt_MaximumMember_019e8215-63c3-70c4-b350-7b4bbf31b600" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8215-8dc3-7673-9dc9-a15e106638dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8215-8dc3-7673-9dc9-a15e106638dc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8215-8dc3-7673-9dc9-a15e106638dc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8215-8dc3-7673-9dc9-a15e106638dc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8215-8dc3-7673-9dc9-a15e106638dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8215-8dc3-7bae-8615-824680e4340e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8215-8dc3-7673-9dc9-a15e106638dc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8215-8dc3-7bae-8615-824680e4340e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019e8215-8dc3-7246-9d4f-3dce848219d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8215-8dc3-7bae-8615-824680e4340e" xlink:to="loc_us-gaap_WarrantMember_019e8215-8dc3-7246-9d4f-3dce848219d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_019e8215-8dc3-7dae-84ff-1ba30e6db1f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-7c2d-8e05-62d25e7ff1fb" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_019e8215-8dc3-7dae-84ff-1ba30e6db1f7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e8215-8dc3-7dae-84ff-1ba30e6db1f7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019e8215-8dc3-7dae-84ff-1ba30e6db1f7" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e8215-8dc3-7dae-84ff-1ba30e6db1f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019edf60-0b48-7bc9-a435-d899e90b5385" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019e8215-8dc3-7dae-84ff-1ba30e6db1f7" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019edf60-0b48-7bc9-a435-d899e90b5385" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e8215-8dc3-72a9-8c53-aa63a430210e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019edf60-0b48-7bc9-a435-d899e90b5385" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e8215-8dc3-72a9-8c53-aa63a430210e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019e8215-8dc3-7dc9-aa4c-418b09301e2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e8215-8dc3-72a9-8c53-aa63a430210e" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019e8215-8dc3-7dc9-aa4c-418b09301e2c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e8215-63c3-711f-ab61-130097eca77a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e8215-63c3-711f-ab61-130097eca77a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNumberOfAdditionalPayments_019e8215-63c3-7488-ae7a-94046949c945" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementNumberOfAdditionalPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementNumberOfAdditionalPayments_019e8215-63c3-7488-ae7a-94046949c945" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementSupplementInvestmentPayment_019e8215-63c3-7307-827d-5e862f43d227" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementSupplementInvestmentPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementSupplementInvestmentPayment_019e8215-63c3-7307-827d-5e862f43d227" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementInternalRateOfReturn_019e8215-63c3-7f84-a142-f120fee17ac4" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementInternalRateOfReturn"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementInternalRateOfReturn_019e8215-63c3-7f84-a142-f120fee17ac4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementHardCapPercentage_019e8215-63c3-792c-bcca-c8c6f9423943" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementHardCapPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementHardCapPercentage_019e8215-63c3-792c-bcca-c8c6f9423943" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019e8215-63c3-7673-a4f5-aa9df14832ce" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019e8215-63c3-7673-a4f5-aa9df14832ce" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019e8215-63c3-7265-aeff-94c3b7c90f74" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementMilestonePaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019e8215-63c3-7265-aeff-94c3b7c90f74" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementQuarterlyPaymentsPeriod_019e8215-63c3-7800-a9cf-fd01b040e89d" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementQuarterlyPaymentsPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementQuarterlyPaymentsPeriod_019e8215-63c3-7800-a9cf-fd01b040e89d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage_019e8215-8dc3-7fe2-b459-9d4fde96f434" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage_019e8215-8dc3-7fe2-b459-9d4fde96f434" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation_019e8215-8dc3-7cd9-bbb6-ac966c3a3a8a" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation_019e8215-8dc3-7cd9-bbb6-ac966c3a3a8a" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued_019e8215-8dc3-7007-a0b6-ce8a224a5413" xlink:href="dare-20260630.xsd#dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued_019e8215-8dc3-7007-a0b6-ce8a224a5413" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightSupplementInvestment_019e8215-8dc3-7dbd-8740-cbd2f6ef4dc3" xlink:href="dare-20260630.xsd#dare_ClassOfWarrantOrRightSupplementInvestment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_ClassOfWarrantOrRightSupplementInvestment_019e8215-8dc3-7dbd-8740-cbd2f6ef4dc3" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount_019e8215-8dc3-76a7-9f93-9149633aa9e2" xlink:href="dare-20260630.xsd#dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount_019e8215-8dc3-76a7-9f93-9149633aa9e2" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_019e8215-8dc3-7368-9903-efd9513f8953" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8215-63c3-78af-9689-c882c0a55b3e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_019e8215-8dc3-7368-9903-efd9513f8953" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-70f1-8c30-7a2538fab971" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-70f1-8c30-7a2538fab971" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e4145-b133-71d9-aeb2-a3a8087c0475" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e4145-b133-70f1-8c30-7a2538fab971" xlink:to="loc_srt_ProductOrServiceAxis_019e4145-b133-71d9-aeb2-a3a8087c0475" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e4145-b133-71d9-aeb2-a3a8087c0475_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e4145-b133-71d9-aeb2-a3a8087c0475" xlink:to="loc_srt_ProductsAndServicesDomain_019e4145-b133-71d9-aeb2-a3a8087c0475_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e4145-b133-7691-8cf5-08d02dd527b1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e4145-b133-71d9-aeb2-a3a8087c0475" xlink:to="loc_srt_ProductsAndServicesDomain_019e4145-b133-7691-8cf5-08d02dd527b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_019e4145-b133-7f22-a746-5fcaf68fcd3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-7691-8cf5-08d02dd527b1" xlink:to="loc_us-gaap_RoyaltyMember_019e4145-b133-7f22-a746-5fcaf68fcd3f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e4145-b133-7353-9ac7-6649d4aecddd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e4145-b133-7353-9ac7-6649d4aecddd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019e4145-b133-7c0b-91c6-06d91395f86d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019e4145-b133-7c0b-91c6-06d91395f86d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_019e4145-b133-7522-b277-9ceb26d8e2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_019e4145-b133-7522-b277-9ceb26d8e2f1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRoyalties_019e4145-b133-755d-9aa1-986d699ba6df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_us-gaap_PaymentsForRoyalties_019e4145-b133-755d-9aa1-986d699ba6df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties_019e4145-b133-71b7-ac60-2c55fb27f429" xlink:href="dare-20260630.xsd#dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties_019e4145-b133-71b7-ac60-2c55fb27f429" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyGuaranteesCommitmentsGrossAmount_019e4145-b133-78ac-9a5c-4bf59ec082c7" xlink:href="dare-20260630.xsd#dare_RoyaltyGuaranteesCommitmentsGrossAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e4145-b133-7b27-82bf-3bc5c7c5cba4" xlink:to="loc_dare_RoyaltyGuaranteesCommitmentsGrossAmount_019e4145-b133-78ac-9a5c-4bf59ec082c7" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyPurchaseAgreementsDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#RoyaltyPurchaseAgreementsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyPurchaseAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:href="dare-20260630.xsd#dare_CommitmentsAndContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:href="dare-20260630.xsd#dare_CommitmentsAndContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e8222-0f0a-7d09-87ae-3e7168a9c5eb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:to="loc_srt_CounterpartyNameAxis_019e8222-0f0a-7d09-87ae-3e7168a9c5eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7d09-87ae-3e7168a9c5eb_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e8222-0f0a-7d09-87ae-3e7168a9c5eb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7d09-87ae-3e7168a9c5eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7739-999c-48dc9b1879c7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e8222-0f0a-7d09-87ae-3e7168a9c5eb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7739-999c-48dc9b1879c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_XOMAUSLLCMember_019e8222-0f0a-7ee1-8135-bdbc62e845e8" xlink:href="dare-20260630.xsd#dare_XOMAUSLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7739-999c-48dc9b1879c7" xlink:to="loc_dare_XOMAUSLLCMember_019e8222-0f0a-7ee1-8135-bdbc62e845e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BayerHealthcareLLCMember_019e8222-2a7d-71ce-9653-3e2eeb722fe9" xlink:href="dare-20260630.xsd#dare_BayerHealthcareLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8222-0f0a-7739-999c-48dc9b1879c7" xlink:to="loc_dare_BayerHealthcareLLCMember_019e8222-2a7d-71ce-9653-3e2eeb722fe9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e8222-0f0a-7e51-a5c6-ff7fa6273592" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e8222-0f0a-7e51-a5c6-ff7fa6273592" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8222-0f0a-7e51-a5c6-ff7fa6273592_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8222-0f0a-7e51-a5c6-ff7fa6273592" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8222-0f0a-7e51-a5c6-ff7fa6273592_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8222-0f0a-7358-9fa8-1366c7f7a599" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8222-0f0a-7e51-a5c6-ff7fa6273592" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8222-0f0a-7358-9fa8-1366c7f7a599" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyPurchaseAgreementMember_019e8222-0f0a-728e-a709-4aa108a389e4" xlink:href="dare-20260630.xsd#dare_RoyaltyPurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8222-0f0a-7358-9fa8-1366c7f7a599" xlink:to="loc_dare_RoyaltyPurchaseAgreementMember_019e8222-0f0a-728e-a709-4aa108a389e4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e8222-2a7d-716d-a577-6562a3874629" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:to="loc_srt_ProductOrServiceAxis_019e8222-2a7d-716d-a577-6562a3874629" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-716d-a577-6562a3874629_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e8222-2a7d-716d-a577-6562a3874629" xlink:to="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-716d-a577-6562a3874629_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e8222-2a7d-716d-a577-6562a3874629" xlink:to="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_XACIATOMember_019e8222-2a7d-7907-8319-a582d1d0bac6" xlink:href="dare-20260630.xsd#dare_XACIATOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:to="loc_dare_XACIATOMember_019e8222-2a7d-7907-8319-a582d1d0bac6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OvapreneMember_019e8222-2a7d-7a9c-a980-9e48dc607179" xlink:href="dare-20260630.xsd#dare_OvapreneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:to="loc_dare_OvapreneMember_019e8222-2a7d-7a9c-a980-9e48dc607179" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream2.0Member_019e8222-2a7d-7fff-982c-35f776e06155" xlink:href="dare-20260630.xsd#dare_SildenafilCream2.0Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:to="loc_dare_SildenafilCream2.0Member_019e8222-2a7d-7fff-982c-35f776e06155" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream3.6Member_019e8222-2a7d-7e2a-8e8c-a4f7544feaa9" xlink:href="dare-20260630.xsd#dare_SildenafilCream3.6Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:to="loc_dare_SildenafilCream3.6Member_019e8222-2a7d-7e2a-8e8c-a4f7544feaa9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SyntheticMember_019e8222-2a7d-739a-8b09-cd235eec4d31" xlink:href="dare-20260630.xsd#dare_SyntheticMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8222-2a7d-7742-9b9b-e1b7e3b6aa66" xlink:to="loc_dare_SyntheticMember_019e8222-2a7d-739a-8b09-cd235eec4d31" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e8222-2a7d-7493-8916-8e2e7842b5fe" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019e4145-b133-76de-9179-578e1e4c1870" xlink:to="loc_srt_RangeAxis_019e8222-2a7d-7493-8916-8e2e7842b5fe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8222-2a7d-7493-8916-8e2e7842b5fe_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e8222-2a7d-7493-8916-8e2e7842b5fe" xlink:to="loc_srt_RangeMember_019e8222-2a7d-7493-8916-8e2e7842b5fe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8222-2a7d-7f73-a162-a9f8c9527665" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e8222-2a7d-7493-8916-8e2e7842b5fe" xlink:to="loc_srt_RangeMember_019e8222-2a7d-7f73-a162-a9f8c9527665" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e8222-2a7d-7ce4-86e6-859a49e481d2" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8222-2a7d-7f73-a162-a9f8c9527665" xlink:to="loc_srt_MaximumMember_019e8222-2a7d-7ce4-86e6-859a49e481d2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e8222-2a7d-74cd-89f8-5d7b4bf89afb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8222-2a7d-7f73-a162-a9f8c9527665" xlink:to="loc_srt_MinimumMember_019e8222-2a7d-74cd-89f8-5d7b4bf89afb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e8222-0f0a-76dc-a9ab-1c457174f64f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019e8222-0f0a-76dc-a9ab-1c457174f64f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMaximumRoyaltyPayments_019e8222-0f0a-7167-aa8e-8b7e45438ddf" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementMaximumRoyaltyPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementMaximumRoyaltyPayments_019e8222-0f0a-7167-aa8e-8b7e45438ddf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementContingentPurchasePricePayments_019e8222-0f0a-79b5-9eae-518ae53e780b" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementContingentPurchasePricePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementContingentPurchasePricePayments_019e8222-0f0a-79b5-9eae-518ae53e780b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount_019e8222-0f0a-72c7-ad21-0f3e9664c82e" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount_019e8222-0f0a-72c7-ad21-0f3e9664c82e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019e8222-2a7d-708f-9749-da6f46df7b1f" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementMilestonePaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019e8222-2a7d-708f-9749-da6f46df7b1f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones_019e8222-2a7d-78c6-ae36-ab6a7ac620ac" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones_019e8222-2a7d-78c6-ae36-ab6a7ac620ac" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMaximumPotentialMilestonePayments_019e8222-2a7d-741d-82f4-876bd983f43c" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementMaximumPotentialMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementMaximumPotentialMilestonePayments_019e8222-2a7d-741d-82f4-876bd983f43c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019e8222-2a7d-7e7b-80be-1691d695b82c" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019e8222-2a7d-7e7b-80be-1691d695b82c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementFutureNetSalesPercentage_019e8222-2a7d-7f6d-b326-e058ec19e662" xlink:href="dare-20260630.xsd#dare_RoyaltyAgreementFutureNetSalesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyAgreementFutureNetSalesPercentage_019e8222-2a7d-7f6d-b326-e058ec19e662" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRatePercentage_019e8222-2a7d-7ae4-9025-627fd07081f4" xlink:href="dare-20260630.xsd#dare_RoyaltyRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_RoyaltyRatePercentage_019e8222-2a7d-7ae4-9025-627fd07081f4" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights_019e8222-2a7d-7962-8326-a14395e71352" xlink:href="dare-20260630.xsd#dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights_019e8222-2a7d-7962-8326-a14395e71352" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts_019e8222-2a7d-77a0-8c2e-76705d74591e" xlink:href="dare-20260630.xsd#dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019e8222-0f0a-7022-b61e-1df5e089e822" xlink:to="loc_dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts_019e8222-2a7d-77a0-8c2e-76705d74591e" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/GrantAwardsDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#GrantAwardsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/GrantAwardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e4145-b133-7110-a2a6-ac1cb95137eb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:to="loc_srt_CounterpartyNameAxis_019e4145-b133-7110-a2a6-ac1cb95137eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e4145-b133-7110-a2a6-ac1cb95137eb_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e4145-b133-7110-a2a6-ac1cb95137eb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e4145-b133-7110-a2a6-ac1cb95137eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8228-4ca0-7fa2-872b-7890e90a9e56" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e4145-b133-7110-a2a6-ac1cb95137eb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8228-4ca0-7fa2-872b-7890e90a9e56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019e8228-4ca0-7868-a3cb-08cf243815e8" xlink:href="dare-20260630.xsd#dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8228-4ca0-7fa2-872b-7890e90a9e56" xlink:to="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019e8228-4ca0-7868-a3cb-08cf243815e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FoundationMember_019e8228-9277-71a2-be5d-0a6bb53bd290" xlink:href="dare-20260630.xsd#dare_FoundationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8228-4ca0-7fa2-872b-7890e90a9e56" xlink:to="loc_dare_FoundationMember_019e8228-9277-71a2-be5d-0a6bb53bd290" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e8228-4ca0-707e-b0a4-cb68b89b4a57" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:to="loc_srt_ProductOrServiceAxis_019e8228-4ca0-707e-b0a4-cb68b89b4a57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-707e-b0a4-cb68b89b4a57_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e8228-4ca0-707e-b0a4-cb68b89b4a57" xlink:to="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-707e-b0a4-cb68b89b4a57_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e8228-4ca0-707e-b0a4-cb68b89b4a57" xlink:to="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FederalSubawardMember_019e8228-4ca0-7d47-9285-628371da3c44" xlink:href="dare-20260630.xsd#dare_FederalSubawardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:to="loc_dare_FederalSubawardMember_019e8228-4ca0-7d47-9285-628371da3c44" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DAREHPVMember_019e8228-72b7-7439-9555-00364ca91925" xlink:href="dare-20260630.xsd#dare_DAREHPVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:to="loc_dare_DAREHPVMember_019e8228-72b7-7439-9555-00364ca91925" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_GrantDAREPTB1Member_019e8228-72b7-7eed-9aa0-cf9cffa717f7" xlink:href="dare-20260630.xsd#dare_GrantDAREPTB1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:to="loc_dare_GrantDAREPTB1Member_019e8228-72b7-7eed-9aa0-cf9cffa717f7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraceptiveProductGrantAgreementMember_019e8228-9277-71ac-b874-5f454c84d3f9" xlink:href="dare-20260630.xsd#dare_ContraceptiveProductGrantAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:to="loc_dare_ContraceptiveProductGrantAgreementMember_019e8228-9277-71ac-b874-5f454c84d3f9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DARELARC1Member_019e8228-9277-7d42-ba24-04157ac3c2c9" xlink:href="dare-20260630.xsd#dare_DARELARC1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8228-4ca0-7d3e-b3dd-8e7f329bb62f" xlink:to="loc_dare_DARELARC1Member_019e8228-9277-7d42-ba24-04157ac3c2c9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e8228-72b7-763f-96a4-1b78de0a8b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e8228-72b7-763f-96a4-1b78de0a8b7f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8228-72b7-763f-96a4-1b78de0a8b7f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8228-72b7-763f-96a4-1b78de0a8b7f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8228-72b7-763f-96a4-1b78de0a8b7f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8228-72b7-74ac-9220-f3243829d74b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8228-72b7-763f-96a4-1b78de0a8b7f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8228-72b7-74ac-9220-f3243829d74b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PhaseIISegmentMember_019e8228-72b7-7295-8e26-9ec0cafc5866" xlink:href="dare-20260630.xsd#dare_PhaseIISegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8228-72b7-74ac-9220-f3243829d74b" xlink:to="loc_dare_PhaseIISegmentMember_019e8228-72b7-7295-8e26-9ec0cafc5866" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e8228-72b7-7294-9f6f-32d99e532851" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019e4145-b133-7d4d-bdd2-9d9524fe3c09" xlink:to="loc_srt_RangeAxis_019e8228-72b7-7294-9f6f-32d99e532851" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8228-72b7-7294-9f6f-32d99e532851_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e8228-72b7-7294-9f6f-32d99e532851" xlink:to="loc_srt_RangeMember_019e8228-72b7-7294-9f6f-32d99e532851_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8228-72b7-7494-be5a-794168e5e9a7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e8228-72b7-7294-9f6f-32d99e532851" xlink:to="loc_srt_RangeMember_019e8228-72b7-7494-be5a-794168e5e9a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e8228-72b7-7c2a-809b-5acc0b209f6b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8228-72b7-7494-be5a-794168e5e9a7" xlink:to="loc_srt_MinimumMember_019e8228-72b7-7c2a-809b-5acc0b209f6b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e8228-72b7-7893-b517-850574e1b396" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8228-72b7-7494-be5a-794168e5e9a7" xlink:to="loc_srt_MaximumMember_019e8228-72b7-7893-b517-850574e1b396" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromAwardOfGrants_019e8228-4ca0-7250-8370-6860edf589d8" xlink:href="dare-20260630.xsd#dare_ProceedsFromAwardOfGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ProceedsFromAwardOfGrants_019e8228-4ca0-7250-8370-6860edf589d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentArrangementPerformancePeriod_019e8228-4ca0-79af-a1b1-30a1934635d9" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentArrangementPerformancePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ResearchAndDevelopmentArrangementPerformancePeriod_019e8228-4ca0-79af-a1b1-30a1934635d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage_019e8228-4ca0-7416-82f9-13f2628648c3" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage_019e8228-4ca0-7416-82f9-13f2628648c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment_019e8228-72b7-7594-b809-6836efecdf0d" xlink:href="dare-20260630.xsd#dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment_019e8228-72b7-7594-b809-6836efecdf0d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred_019e8228-72b7-75c6-b5af-bd1269378d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred_019e8228-72b7-75c6-b5af-bd1269378d2e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_019e8228-72b7-70e6-ac8f-bf728730f37d" xlink:href="dare-20260630.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_DeferredGrantFundingCurrent_019e8228-72b7-70e6-ac8f-bf728730f37d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromAwardOfGrantsInitialAmount_019f1204-ef2a-71fa-9627-dac2a9614ec6" xlink:href="dare-20260630.xsd#dare_ProceedsFromAwardOfGrantsInitialAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ProceedsFromAwardOfGrantsInitialAmount_019f1204-ef2a-71fa-9627-dac2a9614ec6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ReceivableForExpensesEligibleForReimbursement_019e8228-72b7-7c8f-ac43-2e7aa9c8e1f8" xlink:href="dare-20260630.xsd#dare_ReceivableForExpensesEligibleForReimbursement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_ReceivableForExpensesEligibleForReimbursement_019e8228-72b7-7c8f-ac43-2e7aa9c8e1f8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NonDilutiveGrantFundingPercentageExcluded_019e8228-72b7-73f4-bef6-ff0a7d6a6953" xlink:href="dare-20260630.xsd#dare_NonDilutiveGrantFundingPercentageExcluded"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_dare_NonDilutiveGrantFundingPercentageExcluded_019e8228-72b7-73f4-bef6-ff0a7d6a6953" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantsReceivable_019e8228-9277-79f1-a298-cbf1edea3eb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrantsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_us-gaap_GrantsReceivable_019e8228-9277-79f1-a298-cbf1edea3eb4" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e8228-9277-7a59-87b1-e601c77f7683" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019e8228-4ca0-7293-a5e3-c86007bd996f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e8228-9277-7a59-87b1-e601c77f7683" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/NetLossPerShareDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#NetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/NetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e4145-b133-7028-81ce-01993bd7adb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e4145-b133-7727-9ffe-6fff50a7a8e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e4145-b133-7028-81ce-01993bd7adb0" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e4145-b133-7727-9ffe-6fff50a7a8e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e4145-b133-7b3b-8678-6ecfc68f1462" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e4145-b133-7727-9ffe-6fff50a7a8e4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e4145-b133-7b3b-8678-6ecfc68f1462" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7b3b-8678-6ecfc68f1462_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e4145-b133-7b3b-8678-6ecfc68f1462" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7b3b-8678-6ecfc68f1462_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e4145-b133-7b3b-8678-6ecfc68f1462" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_StockOptionsMember_019fa7e0-40c0-7fe0-a7f8-ebcc22fef7e1" xlink:href="dare-20260630.xsd#dare_StockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:to="loc_dare_StockOptionsMember_019fa7e0-40c0-7fe0-a7f8-ebcc22fef7e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CommonStockWarrantsMember_019fdd13-9374-7168-be95-03ed77cb94b6" xlink:href="dare-20260630.xsd#dare_CommonStockWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:to="loc_dare_CommonStockWarrantsMember_019fdd13-9374-7168-be95-03ed77cb94b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019fa7e2-a63b-712b-8d92-1c0b5ecf37b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019fa7e2-a63b-712b-8d92-1c0b5ecf37b2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockMember_019e4145-b133-764a-996d-9ea99ac40537" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:to="loc_us-gaap_PreferredStockMember_019e4145-b133-764a-996d-9ea99ac40537" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SellingAgentUnitWarrantsMember_019e4145-b133-732a-98b9-18673d08edd2" xlink:href="dare-20260630.xsd#dare_SellingAgentUnitWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e4145-b133-7ca2-b69a-92e69cb63439" xlink:to="loc_dare_SellingAgentUnitWarrantsMember_019e4145-b133-732a-98b9-18673d08edd2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e4145-b133-7478-b67f-7fd439c21b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e4145-b133-7028-81ce-01993bd7adb0" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e4145-b133-7478-b67f-7fd439c21b8d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/SegmentInformationDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#SegmentInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/SegmentInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e4145-b133-79ce-8b9a-47ac0da13f80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e4145-b133-7afd-aeb7-7ab200616ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e4145-b133-79ce-8b9a-47ac0da13f80" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e4145-b133-7afd-aeb7-7ab200616ed7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e4145-b133-7044-97f1-12d4d28cc6b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e4145-b133-7afd-aeb7-7ab200616ed7" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e4145-b133-7044-97f1-12d4d28cc6b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e4145-b133-7044-97f1-12d4d28cc6b7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e4145-b133-7044-97f1-12d4d28cc6b7" xlink:to="loc_us-gaap_SegmentDomain_019e4145-b133-7044-97f1-12d4d28cc6b7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e4145-b133-7d5f-8987-07ae43f4b137" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e4145-b133-7044-97f1-12d4d28cc6b7" xlink:to="loc_us-gaap_SegmentDomain_019e4145-b133-7d5f-8987-07ae43f4b137" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ReportableSegmentMember_019e4145-b133-733a-9cb3-52684d7602ee" xlink:href="dare-20260630.xsd#dare_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e4145-b133-7d5f-8987-07ae43f4b137" xlink:to="loc_dare_ReportableSegmentMember_019e4145-b133-733a-9cb3-52684d7602ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e4145-b133-7060-924d-4afbaf964c58" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e4145-b133-7afd-aeb7-7ab200616ed7" xlink:to="loc_srt_ProductOrServiceAxis_019e4145-b133-7060-924d-4afbaf964c58" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e4145-b133-7060-924d-4afbaf964c58_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e4145-b133-7060-924d-4afbaf964c58" xlink:to="loc_srt_ProductsAndServicesDomain_019e4145-b133-7060-924d-4afbaf964c58_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e4145-b133-7060-924d-4afbaf964c58" xlink:to="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_019e4145-b133-796e-b626-c23b7d61f0f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_us-gaap_RoyaltyMember_019e4145-b133-796e-b626-c23b7d61f0f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OvapreneMember_019e4145-b133-77b2-9cc3-4ebedbdb077b" xlink:href="dare-20260630.xsd#dare_OvapreneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_OvapreneMember_019e4145-b133-77b2-9cc3-4ebedbdb077b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream3.6Member_019e4145-b133-7ae6-82b4-2a2953734822" xlink:href="dare-20260630.xsd#dare_SildenafilCream3.6Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_SildenafilCream3.6Member_019e4145-b133-7ae6-82b4-2a2953734822" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OtherAdvancedClinicalStageProgramsMember_019e4145-b133-74c4-9fb1-3ea98b88f179" xlink:href="dare-20260630.xsd#dare_OtherAdvancedClinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_OtherAdvancedClinicalStageProgramsMember_019e4145-b133-74c4-9fb1-3ea98b88f179" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_Phase1AndPhase1ReadyClinicalStageProgramsMember_019e4145-b133-778a-b96e-da2af4c80a7d" xlink:href="dare-20260630.xsd#dare_Phase1AndPhase1ReadyClinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_Phase1AndPhase1ReadyClinicalStageProgramsMember_019e4145-b133-778a-b96e-da2af4c80a7d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreclinicalStageProgramsMember_019e4145-b133-768e-b1db-bfcab51276c9" xlink:href="dare-20260630.xsd#dare_PreclinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_PreclinicalStageProgramsMember_019e4145-b133-768e-b1db-bfcab51276c9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PersonnelRelatedIncludingStockBasedCompensationMember_019e4145-b133-7c6d-8216-295d8af5d7dc" xlink:href="dare-20260630.xsd#dare_PersonnelRelatedIncludingStockBasedCompensationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_PersonnelRelatedIncludingStockBasedCompensationMember_019e4145-b133-7c6d-8216-295d8af5d7dc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OtherIndirectCostsMember_019e4145-b133-7d22-8ccf-2befd8ffb8da" xlink:href="dare-20260630.xsd#dare_OtherIndirectCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e4145-b133-76dd-80b6-b058302345ac" xlink:to="loc_dare_OtherIndirectCostsMember_019e4145-b133-7d22-8ccf-2befd8ffb8da" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_019ff6ce-f3c4-7241-b776-24ac6260ded0" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e4145-b133-7afd-aeb7-7ab200616ed7" xlink:to="loc_srt_ConsolidationItemsAxis_019ff6ce-f3c4-7241-b776-24ac6260ded0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019ff6ce-f3c4-7241-b776-24ac6260ded0_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_019ff6ce-f3c4-7241-b776-24ac6260ded0" xlink:to="loc_srt_ConsolidationItemsDomain_019ff6ce-f3c4-7241-b776-24ac6260ded0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019ff6ce-f3c4-72ea-8f40-6b5ff7204fee" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_019ff6ce-f3c4-7241-b776-24ac6260ded0" xlink:to="loc_srt_ConsolidationItemsDomain_019ff6ce-f3c4-72ea-8f40-6b5ff7204fee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_019ff6cf-3646-7b14-b172-cf56b7b70aaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019ff6ce-f3c4-72ea-8f40-6b5ff7204fee" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_019ff6cf-3646-7b14-b172-cf56b7b70aaa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019e4145-b133-7a2b-b5ca-f8a47c13fa5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e4145-b133-79ce-8b9a-47ac0da13f80" xlink:to="loc_us-gaap_RevenuesAbstract_019e4145-b133-7a2b-b5ca-f8a47c13fa5a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4145-b133-7f77-be1f-b2fc59003834" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e4145-b133-7a2b-b5ca-f8a47c13fa5a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4145-b133-7f77-be1f-b2fc59003834" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax_019fdd4e-43f8-728a-b225-439074c1f1fe" xlink:href="dare-20260630.xsd#dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e4145-b133-7a2b-b5ca-f8a47c13fa5a" xlink:to="loc_dare_RevenueTrueUpFromContractWithCustomerExcludingAssessedTax_019fdd4e-43f8-728a-b225-439074c1f1fe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e4145-b133-7227-b353-85a30d99e425" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e4145-b133-7a2b-b5ca-f8a47c13fa5a" xlink:to="loc_us-gaap_CostOfRevenue_019e4145-b133-7227-b353-85a30d99e425" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e4145-b133-79ce-8b9a-47ac0da13f80" xlink:to="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019e4145-b133-7303-9e8c-52b180a1d8d5" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentDirectProgramCostsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:to="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019e4145-b133-7303-9e8c-52b180a1d8d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCosts_019e4145-b133-7d22-b7cb-22d9dd8e72fd" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentExpenseDirectProgramCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019e4145-b133-7303-9e8c-52b180a1d8d5" xlink:to="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCosts_019e4145-b133-7d22-b7cb-22d9dd8e72fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019e4145-b133-73ad-b1ef-34d1dd0b7d77" xlink:href="dare-20260630.xsd#dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019e4145-b133-7303-9e8c-52b180a1d8d5" xlink:to="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019e4145-b133-73ad-b1ef-34d1dd0b7d77" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet_019e4145-b133-7605-8e76-60a8b1c55df7" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019e4145-b133-7303-9e8c-52b180a1d8d5" xlink:to="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet_019e4145-b133-7605-8e76-60a8b1c55df7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019e4145-b133-77be-9f6d-97cc4e5c5a3c" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentIndirectCostsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:to="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019e4145-b133-77be-9f6d-97cc4e5c5a3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseIndirectCosts_019e4145-b133-7b01-9285-a0b01c2114b5" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentExpenseIndirectCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019e4145-b133-77be-9f6d-97cc4e5c5a3c" xlink:to="loc_dare_ResearchAndDevelopmentExpenseIndirectCosts_019e4145-b133-7b01-9285-a0b01c2114b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseIndirectCosts_019e4145-b133-79de-abd7-8d33afbf4d9b" xlink:href="dare-20260630.xsd#dare_ContraResearchAndDevelopmentExpenseIndirectCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019e4145-b133-77be-9f6d-97cc4e5c5a3c" xlink:to="loc_dare_ContraResearchAndDevelopmentExpenseIndirectCosts_019e4145-b133-79de-abd7-8d33afbf4d9b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseIndirectCostsNet_019e4145-b133-73b5-8510-9362f620d620" xlink:href="dare-20260630.xsd#dare_ResearchAndDevelopmentExpenseIndirectCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019e4145-b133-77be-9f6d-97cc4e5c5a3c" xlink:to="loc_dare_ResearchAndDevelopmentExpenseIndirectCostsNet_019e4145-b133-73b5-8510-9362f620d620" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e4145-b133-7d92-b132-8c8e3c7e3444" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e4145-b133-7d92-b132-8c8e3c7e3444" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4145-b133-70b4-8d78-df677021a081" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4145-b133-70b4-8d78-df677021a081" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e4145-b133-78aa-8c36-cacb2de5fda2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019e4145-b133-7572-92ac-9abdee224127" xlink:to="loc_us-gaap_OperatingExpenses_019e4145-b133-78aa-8c36-cacb2de5fda2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e4145-b133-7272-b265-150563c8388d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e4145-b133-7272-b265-150563c8388d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e4145-b133-7b27-bb98-3fdb8218d32a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e4145-b133-7b27-bb98-3fdb8218d32a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019e4145-b133-7363-9505-0e16281162b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019e4145-b133-7363-9505-0e16281162b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4145-b133-7537-8f13-22060d837779" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4145-b133-7537-8f13-22060d837779" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e4145-b133-7cd0-83b8-928d6ab15d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e4145-b133-7880-b05c-fea1209a172e" xlink:to="loc_us-gaap_NetIncomeLoss_019e4145-b133-7cd0-83b8-928d6ab15d2e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019e4145-b133-7236-96d4-dfd2634e46e2" xlink:href="dare-20260630.xsd#dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="dare-20260630.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_019e4145-b133-792d-a12f-2478b53ad279" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_SubsequentEventTable_019e4145-b133-792d-a12f-2478b53ad279" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019fb608-2eac-79f1-a3c0-6e90299d7b48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019e4145-b133-792d-a12f-2478b53ad279" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019fb608-2eac-79f1-a3c0-6e90299d7b48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019fb608-2eac-79f1-a3c0-6e90299d7b48_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019fb608-2eac-79f1-a3c0-6e90299d7b48" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019fb608-2eac-79f1-a3c0-6e90299d7b48_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019fb608-2eac-7f0b-a293-3edf658a2e77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019fb608-2eac-79f1-a3c0-6e90299d7b48" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019fb608-2eac-7f0b-a293-3edf658a2e77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019fb608-2eac-7e07-8812-105bfbd194a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019fb608-2eac-7f0b-a293-3edf658a2e77" xlink:to="loc_us-gaap_SubsequentEventMember_019fb608-2eac-7e07-8812-105bfbd194a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019fb608-2eac-75e6-85be-9475b70fb907" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019e4145-b133-792d-a12f-2478b53ad279" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019fb608-2eac-75e6-85be-9475b70fb907" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019fb608-2eac-75e6-85be-9475b70fb907_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019fb608-2eac-75e6-85be-9475b70fb907" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019fb608-2eac-75e6-85be-9475b70fb907_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019fb608-2eac-7b19-ba46-13989e4d8c6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019fb608-2eac-75e6-85be-9475b70fb907" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019fb608-2eac-7b19-ba46-13989e4d8c6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PurchaseAgreementMember_019fb608-4a15-7cb4-bed6-bf3e818012f0" xlink:href="dare-20260630.xsd#dare_PurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019fb608-2eac-7b19-ba46-13989e4d8c6f" xlink:to="loc_dare_PurchaseAgreementMember_019fb608-4a15-7cb4-bed6-bf3e818012f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019fb608-4a15-7526-93ae-da1dce6d762f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019e4145-b133-792d-a12f-2478b53ad279" xlink:to="loc_us-gaap_DebtInstrumentAxis_019fb608-4a15-7526-93ae-da1dce6d762f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fb608-4a15-7526-93ae-da1dce6d762f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fb608-4a15-7526-93ae-da1dce6d762f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fb608-4a15-7526-93ae-da1dce6d762f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fb608-4a15-7ac1-b0e6-3cc9c8e7db99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fb608-4a15-7526-93ae-da1dce6d762f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fb608-4a15-7ac1-b0e6-3cc9c8e7db99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_InsuranceFinancingMember_019fb608-4a15-78b2-b366-c433bc2d4986" xlink:href="dare-20260630.xsd#dare_InsuranceFinancingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fb608-4a15-7ac1-b0e6-3cc9c8e7db99" xlink:to="loc_dare_InsuranceFinancingMember_019fb608-4a15-78b2-b366-c433bc2d4986" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019fdd27-7baf-7bfe-a365-9e378b5c0fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019fdd27-7baf-7bfe-a365-9e378b5c0fb8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fdd28-22ca-7155-a8f1-4c95022fe108" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fdd28-22ca-7155-a8f1-4c95022fe108" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019fb608-2eac-77a9-bbf4-ba2aa63ca375" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019fb608-2eac-77a9-bbf4-ba2aa63ca375" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019fb608-4a15-7c7a-bcb3-34b680fce871" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019fb608-4a15-7c7a-bcb3-34b680fce871" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockConsiderationReceivedOnTransactionNetOfCommissions_019fb608-4a15-7c8c-b458-cecc33a7098c" xlink:href="dare-20260630.xsd#dare_SaleOfStockConsiderationReceivedOnTransactionNetOfCommissions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_dare_SaleOfStockConsiderationReceivedOnTransactionNetOfCommissions_019fb608-4a15-7c8c-b458-cecc33a7098c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpenseOfferingCost_019fdd29-9988-7532-bd76-da0470cb216a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoninterestExpenseOfferingCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019fb608-2eac-786f-b9be-8f10e8e9ad75" xlink:to="loc_us-gaap_NoninterestExpenseOfferingCost_019fdd29-9988-7532-bd76-da0470cb216a" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
