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  <xsd:element id="cmre_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsDiscontinuedOperation" name="GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_GlassertonLocktonWalstonStewartonLentonAndAltonShippingCoMember" name="GlassertonLocktonWalstonStewartonLentonAndAltonShippingCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_IncreaseDecreaseInAccruedCharterRevenue" name="IncreaseDecreaseInAccruedCharterRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestCostsCapitalizedDuringPeriod" name="InterestCostsCapitalizedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_InvestmentAgreedAmount" name="InvestmentAgreedAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_JointVentureOwnershipPercent" name="JointVentureOwnershipPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_KalamataShippingCorporationEtAlMember" name="KalamataShippingCorporationEtAlMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KempMaritimeCoLoanAgreementMember" name="KempMaritimeCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KonstantakopoulosFamilyMember" name="KonstantakopoulosFamilyMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_LesseeAndLessorFinanceLeasesTextBlock" name="LesseeAndLessorFinanceLeasesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesMember" name="LoanAgreementWith11CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_LoanAgreementsWithBarkleyAndConleyShippingCosAndBertrandAndSchofieldMaritimeCosMember" name="LoanAgreementsWithBarkleyAndConleyShippingCosAndBertrandAndSchofieldMaritimeCosMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_LoanAgreementsWithBeardmoreAndFairbankMaritimeCompaniesMember" name="LoanAgreementsWithBeardmoreAndFairbankMaritimeCompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" name="LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" name="LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermDebtGrossCurrentMaturities" name="LongtermDebtGrossCurrentMaturities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermPurchaseCommitmentToBePaidYearFour" name="LongtermPurchaseCommitmentToBePaidYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_LongtermPurchaseCommitmentToBePaidYearThree" name="LongtermPurchaseCommitmentToBePaidYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_LongtermPurchaseCommitmentToBePaidYearTwo" name="LongtermPurchaseCommitmentToBePaidYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MaerskPueloAndSixNewbuildContainerVesselsMember" name="MaerskPueloAndSixNewbuildContainerVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MaerskPueloMember" name="MaerskPueloMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerAMember" name="MajorCustomerAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerBMember" name="MajorCustomerBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_MajorCustomerEMember" name="MajorCustomerEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomersABCDAndEMember" name="MajorCustomersABCDAndEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVessel" name="ManagementFeePerDayPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" name="ManagementFeePerDayPerVesselUnderBareboatCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeesRelatedParties" name="ManagementFeesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeesRelatedPartiesDiscontinuedOperation" name="ManagementFeesRelatedPartiesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan10Member" name="NMLLoan10Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan11Member" name="NMLLoan11Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan12Member" name="NMLLoan12Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan13Member" name="NMLLoan13Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan15Member" name="NMLLoan15Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan16Member" name="NMLLoan16Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan17Member" name="NMLLoan17Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan18Member" name="NMLLoan18Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan19Member" name="NMLLoan19Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan20Member" name="NMLLoan20Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan2Member" name="NMLLoan2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan3Member" name="NMLLoan3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan4Member" name="NMLLoan4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan5Member" name="NMLLoan5Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan6Member" name="NMLLoan6Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan7Member" name="NMLLoan7Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan8Member" name="NMLLoan8Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan9Member" name="NMLLoan9Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NavilandsMember" name="NavilandsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneGlobalFinanceLtdNgfMember" name="NeptuneGlobalFinanceLtdNgfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneMaritimeLeasingLimitedNmlMember" name="NeptuneMaritimeLeasingLimitedNmlMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneMember" name="NeptuneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NetBookValueMember" name="NetBookValueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NmlLoan14Member" name="NmlLoan14Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NmlLoan21Member" name="NmlLoan21Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NoncontrollingInterestIncreaseDecreaseFromIssuanceOfSubsidiarySharesToNoncontrollingInterestHolders" name="NoncontrollingInterestIncreaseDecreaseFromIssuanceOfSubsidiarySharesToNoncontrollingInterestHolders" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NonoperatingIncomeExpenseDiscontinuedOperation" name="NonoperatingIncomeExpenseDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Note10a2Member" name="Note10a2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Note10bMember" name="Note10bMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfContainerVessels" name="NumberOfContainerVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompanies" name="NumberOfControlledCompanies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsOwned" name="NumberOfControlledCompaniesDryBulkVesselsOwned" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsPreviouslyOwnedOrTobesold" name="NumberOfControlledCompaniesDryBulkVesselsPreviouslyOwnedOrTobesold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsTobeacquired" name="NumberOfControlledCompaniesDryBulkVesselsTobeacquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDryBulkVessels" name="NumberOfDryBulkVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfHandysizeBulkersSold" name="NumberOfHandysizeBulkersSold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfInterestRateDerivativesTerminated" name="NumberOfInterestRateDerivativesTerminated" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfMajorityOwnedSubsidiaries" name="NumberOfMajorityOwnedSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfPlatformSupplyVesselsOrdered" name="NumberOfPlatformSupplyVesselsOrdered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSubsidiaries" name="NumberOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSubsidiariesInvolvedInArbitration" name="NumberOfSubsidiariesInvolvedInArbitration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVessels" name="NumberOfVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsAcquired" name="NumberOfVesselsAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsCompletedDdDuringPeriod" name="NumberOfVesselsCompletedDdDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" name="NumberOfVesselsProvidedAsCollateralsToSecureLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsSurveyInProcess" name="NumberOfVesselsSurveyInProcess" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsUnderConstruction" name="NumberOfVesselsUnderConstruction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsUnderConstructionThroughNml" name="NumberOfVesselsUnderConstructionThroughNml" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsUnderSaleAndLeasebackAgreements" name="NumberOfVesselsUnderSaleAndLeasebackAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_O2024Q4DividendsMember" name="O2024Q4DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q4October152024ToJanuary142025DividendsMember" name="O2024Q4October152024ToJanuary142025DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q1DividendsMember" name="O2025Q1DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q1January152025ToApril142025DividendsMember" name="O2025Q1January152025ToApril142025DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q4DividendsMember" name="O2025Q4DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q4October152025ToJanuary142026DividendsMember" name="O2025Q4October152025ToJanuary142026DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2026Q1DividendsMember" name="O2026Q1DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2026Q1january152026ToApril142026DividendsMember" name="O2026Q1january152026ToApril142026DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2026Q3DividendsMember" name="O2026Q3DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OfficersCompensationChargedPeriodEnd" name="OfficersCompensationChargedPeriodEnd" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OtherComprehensiveIncomeLossDerivativeEffectivePortionOfChangesInFairValueNet" name="OtherComprehensiveIncomeLossDerivativeEffectivePortionOfChangesInFairValueNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherFinancingArrangementsMember" name="OtherFinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OtherNonoperatingIncomeExpenseDiscontinuedOperation" name="OtherNonoperatingIncomeExpenseDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherThirdpartyManagersMember" name="OtherThirdpartyManagersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsForInvestmentsInLeasebackVesselsInvestingActivities" name="PaymentsForInvestmentsInLeasebackVesselsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsToAcquireVessels" name="PaymentsToAcquireVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PercentageOwnership" name="PercentageOwnership" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_PlangeShippingCoAndSixOtherCompaniesLoanAgreementMember" name="PlangeShippingCoAndSixOtherCompaniesLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_PolarBrasilMember" name="PolarBrasilMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_PortoKagioAndPortoGermenoMember" name="PortoKagioAndPortoGermenoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PreferredStockVotesPerShare" name="PreferredStockVotesPerShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedParties" name="QuarterlyFeeToRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedPartiesShares" name="QuarterlyFeeToRelatedPartiesShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_QuentinShippingCoAndSanderShippingCo2Member" name="QuentinShippingCoAndSanderShippingCo2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingCo3Member" name="ReddickShippingCoAndVerandiShippingCo3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceLoanWithSchofieldMaritimeCoAndEightOtherCompaniesMember" name="RefinanceLoanWithSchofieldMaritimeCoAndEightOtherCompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForQuentinShippingAndSanderShippingMember" name="RefinanceTermLoanForQuentinShippingAndSanderShippingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForReddickShippingAndVerandiShippingMember" name="RefinanceTermLoanForReddickShippingAndVerandiShippingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForTenCompaniesMember" name="RefinanceTermLoanForTenCompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" name="RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoansOf17CompaniesMember" name="RefinanceTermLoansOf17CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RevenueDaysPerAnnum" name="RevenueDaysPerAnnum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselPolarBrasilSlMember" name="SaleLeasebackTransactionsRegardingTheVesselPolarBrasilSlMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SalestypeLeaseNetInvestmentInLeaseTableTextBlock" name="SalestypeLeaseNetInvestmentInLeaseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDeferredChargesTableTextBlock" name="ScheduleOfDeferredChargesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" name="ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" name="ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" name="ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfFinancingCostsTableTextBlock" name="ScheduleOfFinancingCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" name="ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" name="ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfVesselsAndAdvancesNetTableTextBlock" name="ScheduleOfVesselsAndAdvancesNetTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SecondGroupOfSixNewbuildContainerVesselsMember" name="SecondGroupOfSixNewbuildContainerVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SixNewbuildContainerVesselsMember" name="SixNewbuildContainerVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SixPreAndPostdeliveryFinancialAgreements2Member" name="SixPreAndPostdeliveryFinancialAgreements2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SixPreAndPostdeliveryFinancialAgreementsMember" name="SixPreAndPostdeliveryFinancialAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SubscriptionFeesMember" name="SubscriptionFeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SwapInterestExpenseNet" name="SwapInterestExpenseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SykesMaritimeCoMember" name="SykesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TermLoanAndOtherFinancingArrangementsMember" name="TermLoanAndOtherFinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TermLoanValueMaintenanceClauses" name="TermLoanValueMaintenanceClauses" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_TimeCharterArrangementsRemainingTermsPeriod" name="TimeCharterArrangementsRemainingTermsPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TimeCharterAssumedAmortizationPeriod" name="TimeCharterAssumedAmortizationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Two2001built5610TeuSecondhandContainerVesselsMember" name="Two2001built5610TeuSecondhandContainerVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" name="USRelatedGrossTransportationIncomeThatTaxApplies" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnamortizedDeferredRentMember" name="UnamortizedDeferredRentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" name="UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" name="UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VelaAndVulpeculaMember" name="VelaAndVulpeculaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselAcquisitionsAdvancesAndOtherVesselsCosts" name="VesselAcquisitionsAdvancesAndOtherVesselsCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VesselCostMember" name="VesselCostMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselImpairmentLossDiscontinuedOperation" name="VesselImpairmentLossDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAndAdvancesNetTextBlock" name="VesselsAndAdvancesNetTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAtCost" name="VesselsAtCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsImpairmentLoss" name="VesselsImpairmentLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsNet" name="VesselsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsSalesTransfersAndOtherMovementsAccumulatedDepreciation" name="VesselsSalesTransfersAndOtherMovementsAccumulatedDepreciation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsSalesTransfersAndOtherMovementsCost" name="VesselsSalesTransfersAndOtherMovementsCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsSalesTransfersAndOtherMovementsNet" name="VesselsSalesTransfersAndOtherMovementsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsUnderTimeCharter" name="VesselsUnderTimeCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpenses" name="VoyageExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesDiscontinuedOperation" name="VoyageExpensesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedParties" name="VoyageExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedPartiesDiscontinuedOperation" name="VoyageExpensesRelatedPartiesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageRevenues" name="VoyageRevenues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_WalstonShippingCoMember" name="WalstonShippingCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WorkingCapitalSecurity" name="WorkingCapitalSecurity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WorkingCapitalSecurityPerVessel" name="WorkingCapitalSecurityPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" name="statement-statement-note-1-basis-of-presentation-and-general-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" name="statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" name="statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" name="statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-tables" name="statement-statement-note-10-longterm-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-maturity-of-salestype-lease-receivables-details" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-maturity-of-salestype-lease-receivables-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-salestype-lease-details" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-salestype-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-tables" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-schedule-of-capital-commitments-details" name="statement-statement-note-13-commitments-and-contingencies-schedule-of-capital-commitments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" name="statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-tables" name="statement-statement-note-13-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-15-earnings-per-share-schedule-of-earnings-per-share-details" name="statement-statement-note-15-earnings-per-share-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-15-earnings-per-share-tables" name="statement-statement-note-15-earnings-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" name="statement-statement-note-16-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-interest-and-finance-costs-tables" name="statement-statement-note-16-interest-and-finance-costs-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" name="statement-statement-note-18-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-effect-of-derivative-instruments-details" name="statement-statement-note-18-derivatives-effect-of-derivative-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-tables" name="statement-statement-note-18-derivatives-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-financial-instruments-fair-value-of-assets-and-liabilities-details" name="statement-statement-note-19-financial-instruments-fair-value-of-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-financial-instruments-tables" name="statement-statement-note-19-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-3-discontinued-operations-components-details" name="statement-statement-note-3-discontinued-operations-components-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-3-discontinued-operations-tables" name="statement-statement-note-3-discontinued-operations-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-5-segmental-financial-information-summary-of-reportable-segments-details" name="statement-statement-note-5-segmental-financial-information-summary-of-reportable-segments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-5-segmental-financial-information-tables" name="statement-statement-note-5-segmental-financial-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-vessels-and-advances-net-summary-of-vessels-details" name="statement-statement-note-8-vessels-and-advances-net-summary-of-vessels-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-vessels-and-advances-net-tables" name="statement-statement-note-8-vessels-and-advances-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-deferred-charges-net-schedule-of-deferred-charges-net-details" name="statement-statement-note-9-deferred-charges-net-schedule-of-deferred-charges-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-deferred-charges-net-tables" name="statement-statement-note-9-deferred-charges-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
