v3.26.1
Leases - Additional Information (Detail)
3 Months Ended 6 Months Ended
Jun. 30, 2026
USD ($)
Lease
Jun. 30, 2025
USD ($)
Jun. 30, 2026
USD ($)
Lease
Jun. 30, 2025
USD ($)
Dec. 31, 2025
Lessee Lease Description [Line Items]          
Number of operating leases | Lease 2   2    
Lessee, operating lease, expiration period     We currently have two operating leases for administrative and research and development office and lab space in San Diego, California and Boston, Massachusetts that expire between July 2031 and May 2033.    
Lease agreement additional extended lease term 5 years   5 years    
Weighted-average discount rate 12.30%   12.30%   12.30%
Weighted-average remaining lease term 6 years 2 months 12 days   6 years 2 months 12 days   6 years 4 months 24 days
Total cash received for amounts included in the measurement of lease liabilities $ 300,000 $ 400,000      
Total cash paid for amounts included in the measurement of lease liabilities     $ 3,000,000 $ 900,000  
ROU assets obtained in exchange for operating lease liabilities     0 2,700,000  
ASC 842          
Lessee Lease Description [Line Items]          
Total operating lease rent expense 600,000 $ 800,000 1,200,000 $ 1,600,000  
Boston Lease          
Lessee Lease Description [Line Items]          
Reimbursements for tenant improvements and rent credits     1,400,000    
2025 San Diego Corporate Headquarters Lease          
Lessee Lease Description [Line Items]          
Rent credit to be applied as credit, in equal monthly installments     2,400,000    
Lease allowance $ 6,200,000   $ 6,200,000