The following table summarizes share-based compensation expense for all share-based compensation arrangements, in thousands:


	Three Months Ended June 30,				Six Months Ended June 30,
	2026		2025		2026		2025
Research and development	$	3,238	$	2,714	$	6,453	$	6,041
Selling, general and administrative		4,971		4,235		10,172		8,750
Total share-based compensation expense	$	8,209	$	6,949	$	16,625	$	14,791

As of June 30, 2026, unrecognized estimated compensation expense related to stock options, RSUs and PSUs was approximately $48.7 million, $19.5 million, and $0.5 million, respectively, which is expected to be recognized over a weighted average period of approximately 2.7 years, 2.9 years, and 0.3 years, respectively. As of June 30, 2026, the vesting of PSUs covering 436,667 shares of common stock were determined to not be probable and have not been included in share-based compensation expense or unrecognized estimated compensation expense.