<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019eb40c-b11e-7132-bc10-7b4a9a013002,g:653572b1-4cea-4781-8f48-78687ad58586-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://allogene.com/role/CondensedBalanceSheets" xlink:type="simple" xlink:href="allo-20260630.xsd#CondensedBalanceSheets"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CondensedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-79c7-a56e-ffd3c935e32d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-79c7-a56e-ffd3c935e32d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019eb40c-b1f3-7179-af6b-3943d96ade99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019eb40c-b1f3-7179-af6b-3943d96ade99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019eb40c-b1f3-7d32-9769-be92029fb16e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019eb40c-b1f3-7d32-9769-be92029fb16e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019eb40c-b1f3-738c-b1cb-43a55b566890" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019eb40c-b1f3-738c-b1cb-43a55b566890" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019eb40c-b1f3-7e7c-bc59-fe9f8390f200" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019eb40c-b1f3-7e7c-bc59-fe9f8390f200" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019eb40c-b1f3-7f34-80b4-fc10180cd533" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019eb40c-b1f3-7f34-80b4-fc10180cd533" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EscrowDeposit_019eb40c-b1f3-7ae2-aceb-c537ac2b613c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EscrowDeposit"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019eb40c-b1f3-742c-b47b-bcf34be8b719" xlink:to="loc_us-gaap_EscrowDeposit_019eb40c-b1f3-7ae2-aceb-c537ac2b613c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019eb40c-b1f3-77c0-bf14-3ee988cbc30e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019eb40c-b1f3-7644-aab7-2992060b31aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019eb40c-b1f3-77c0-bf14-3ee988cbc30e" xlink:to="loc_us-gaap_AccountsPayableCurrent_019eb40c-b1f3-7644-aab7-2992060b31aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_AccruedAndOtherLiabilitiesCurrent_019eb40c-b1f3-7b31-ac54-79071d15f038" xlink:href="allo-20260630.xsd#allo_AccruedAndOtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019eb40c-b1f3-77c0-bf14-3ee988cbc30e" xlink:to="loc_allo_AccruedAndOtherLiabilitiesCurrent_019eb40c-b1f3-7b31-ac54-79071d15f038" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019eb40c-b1f3-725d-93b9-1a71bcf45a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019eb40c-b1f3-75bd-aa8e-280efeeb95c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019eb40c-b1f3-725d-93b9-1a71bcf45a2d" xlink:to="loc_us-gaap_LiabilitiesCurrent_019eb40c-b1f3-75bd-aa8e-280efeeb95c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019eb40c-b1f3-7c33-8777-efd5bbbf9868" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019eb40c-b1f3-725d-93b9-1a71bcf45a2d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019eb40c-b1f3-7c33-8777-efd5bbbf9868" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019eb40c-b1f3-7330-8fb0-f543a1279b68" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019eb40c-b1f3-725d-93b9-1a71bcf45a2d" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019eb40c-b1f3-7330-8fb0-f543a1279b68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019eb40c-b1f3-7a8c-a5c0-0ee3e5401a47" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019eb40c-b1f3-7796-94a2-c8d298865251" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019eb40c-b1f3-7a8c-a5c0-0ee3e5401a47" xlink:to="loc_us-gaap_Liabilities_019eb40c-b1f3-7796-94a2-c8d298865251" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019eb40c-b1f3-7ef8-bb0c-84c7fc5d3a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019eb40c-b1f3-7a8c-a5c0-0ee3e5401a47" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019eb40c-b1f3-7ef8-bb0c-84c7fc5d3a8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-78cf-8898-d1cd62213d5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019eb40c-b1f3-7a8c-a5c0-0ee3e5401a47" xlink:to="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-78cf-8898-d1cd62213d5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-7d2e-83c8-f10f29a8e214" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019eb40c-b1f3-7f6b-a9ad-9327f9037ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-7d2e-83c8-f10f29a8e214" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019eb40c-b1f3-7f6b-a9ad-9327f9037ae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019eb40c-b1f3-7cb5-ae34-17fb224c4035" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-7d2e-83c8-f10f29a8e214" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019eb40c-b1f3-7cb5-ae34-17fb224c4035" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019eb40c-b1f3-7498-8c4c-48b702826eda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019eb40c-b1f3-7d2e-83c8-f10f29a8e214" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019eb40c-b1f3-7498-8c4c-48b702826eda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019eb40c-b1f3-7dae-897c-2f01622e2d78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:to="loc_us-gaap_PreferredStockValue_019eb40c-b1f3-7dae-897c-2f01622e2d78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019eb40c-b1f3-7f1f-97a1-cc5cdc6e78de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:to="loc_us-gaap_CommonStockValue_019eb40c-b1f3-7f1f-97a1-cc5cdc6e78de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019eb40c-b1f3-7c3a-9af7-fdd516703e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019eb40c-b1f3-7c3a-9af7-fdd516703e4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019eb40c-b1f3-7922-9237-b01c8becfa6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019eb40c-b1f3-7922-9237-b01c8becfa6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019eb40c-b1f3-7277-b76d-477c079c28f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019eb40c-b1f3-76fd-95f0-2e70ac120028" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019eb40c-b1f3-7277-b76d-477c079c28f4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/CondensedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="allo-20260630.xsd#CondensedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CondensedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019eb40c-b1f3-7e5c-8b0d-96043a726983" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed008-0e72-7283-8619-650b02266678" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019eb40c-b1f3-7e5c-8b0d-96043a726983" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed008-0e72-7283-8619-650b02266678" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7f82-a606-25a30197b267" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019eb40c-b1f3-7e5c-8b0d-96043a726983" xlink:to="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7f82-a606-25a30197b267" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019eb40c-b1f3-7efb-b107-17bc7695e5b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019eb40c-b1f3-76ed-9777-df9e317e555a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019eb40c-b1f3-7efb-b107-17bc7695e5b7" xlink:to="loc_us-gaap_NetIncomeLoss_019eb40c-b1f3-76ed-9777-df9e317e555a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019eb40c-b1f3-7d92-b279-765fb31c1c04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019eb40c-b1f3-7efb-b107-17bc7695e5b7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019eb40c-b1f3-7d92-b279-765fb31c1c04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7706-a54e-aa43079f33d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019eb40c-b1f3-79fa-9cb6-0959fe3a60b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7706-a54e-aa43079f33d9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019eb40c-b1f3-79fa-9cb6-0959fe3a60b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019eb40c-b1f3-7829-8ade-d2f00981277a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7706-a54e-aa43079f33d9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019eb40c-b1f3-7829-8ade-d2f00981277a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019eca95-68b2-7703-b8b8-04efd82ba067" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfLongLivedAssetsHeldForUse"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b1f3-7706-a54e-aa43079f33d9" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019eca95-68b2-7703-b8b8-04efd82ba067" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019eb40c-b1f3-76e2-b576-6630f1aff0eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019eb40c-b1f3-7411-a828-15bd1d36cba7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019eb40c-b1f3-76e2-b576-6630f1aff0eb" xlink:to="loc_us-gaap_OperatingIncomeLoss_019eb40c-b1f3-7411-a828-15bd1d36cba7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-735d-a680-a757ea340c7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019eb40c-b1f3-76e2-b576-6630f1aff0eb" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-735d-a680-a757ea340c7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-7a03-aec9-a7e3a2b3e2eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019eb40c-b1f3-72eb-9b66-fc828f518526" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-7a03-aec9-a7e3a2b3e2eb" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019eb40c-b1f3-72eb-9b66-fc828f518526" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndOtherIncome_019eb40c-b1f3-7d24-b1e5-6dae234ee7a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestAndOtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-7a03-aec9-a7e3a2b3e2eb" xlink:to="loc_us-gaap_InterestAndOtherIncome_019eb40c-b1f3-7d24-b1e5-6dae234ee7a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019eb40c-b1f3-7cd2-8563-732637f6b819" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019eb40c-b1f3-7a03-aec9-a7e3a2b3e2eb" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019eb40c-b1f3-7cd2-8563-732637f6b819" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/CondensedStatementsofCashFlows" xlink:type="simple" xlink:href="allo-20260630.xsd#CondensedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CondensedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019eb40c-b1f3-7cca-9e68-558c4097becb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7e77-84ad-e59b30f9c92a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019eb40c-b1f3-7cca-9e68-558c4097becb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7e77-84ad-e59b30f9c92a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-71b7-a107-b939fdb93a11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019eb40c-b1f3-7cca-9e68-558c4097becb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-71b7-a107-b939fdb93a11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7736-823f-331f0c7a2d6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019eb40c-b1f3-7cca-9e68-558c4097becb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7736-823f-331f0c7a2d6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019eb40c-b1f3-7b14-97c2-715ed0513664" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_ProfitLoss_019eb40c-b1f3-7b14-97c2-715ed0513664" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019eb40c-b1f3-7784-b815-3befda9234a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_ShareBasedCompensation_019eb40c-b1f3-7784-b815-3befda9234a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019eb40c-b1f3-7ba1-af5c-820a9a995e57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019eb40c-b1f3-7ba1-af5c-820a9a995e57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_019eb40c-b1f3-7cc9-9c43-b1c824fe41a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_019eb40c-b1f3-7cc9-9c43-b1c824fe41a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_019eb40c-b1f3-7cf9-91f3-ab56dca2ac48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_OperatingLeaseExpense_019eb40c-b1f3-7cf9-91f3-ab56dca2ac48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDepositOtherAssets_019eb40c-b1f3-7147-99dc-9b7ff0d62116" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDepositOtherAssets"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInDepositOtherAssets_019eb40c-b1f3-7147-99dc-9b7ff0d62116" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019eb40c-b1f3-7b4b-88d1-39576794b2e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019eb40c-b1f3-7b4b-88d1-39576794b2e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019eb40c-b1f3-7966-8191-8760e60a3715" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019eb40c-b1f3-7966-8191-8760e60a3715" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019eb40c-b1f3-7b5d-944a-8faa859d2a5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019eb40c-b1f3-7b5d-944a-8faa859d2a5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019eb40c-b1f3-771c-8e9c-a3d99af9e021" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019eb40c-b1f3-771c-8e9c-a3d99af9e021" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019eb40c-b1f3-7477-aa5b-552f9583138a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019eb40c-b1f3-7477-aa5b-552f9583138a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019eb40c-b1f3-7150-ab6b-a3ee41423903" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019eb40c-b1f3-7150-ab6b-a3ee41423903" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019ecaa8-d453-7c12-9947-22dbde85c9f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfLongLivedAssetsHeldForUse"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019ecaa8-d453-7c12-9947-22dbde85c9f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_NoncashCollaborationRevenue_019face0-0017-786a-937a-0d3eefb2ab1f" xlink:href="allo-20260630.xsd#allo_NoncashCollaborationRevenue"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019eb40c-b1f3-7fd1-b850-8a9768170711" xlink:to="loc_allo_NoncashCollaborationRevenue_019face0-0017-786a-937a-0d3eefb2ab1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-7407-94c1-7290edf1f9c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019eb40c-b1f3-7bab-9ac3-c5eb7dd22230" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-7407-94c1-7290edf1f9c5" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019eb40c-b1f3-7bab-9ac3-c5eb7dd22230" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019eb40c-b1f3-7e4a-9c9f-c870360edb70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-7407-94c1-7290edf1f9c5" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019eb40c-b1f3-7e4a-9c9f-c870360edb70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_019eb40c-b1f3-7b84-9e2e-6097a84baab1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019eb40c-b1f3-7407-94c1-7290edf1f9c5" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_019eb40c-b1f3-7b84-9e2e-6097a84baab1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7f3f-9560-c3f83c006b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019eb40c-b1f3-7edb-9738-d7f06f666fcc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7f3f-9560-c3f83c006b6a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019eb40c-b1f3-7edb-9738-d7f06f666fcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_ProceedsFromGrantAwards_019eb40c-b1f3-762e-b385-27ae83c4162b" xlink:href="allo-20260630.xsd#allo_ProceedsFromGrantAwards"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7f3f-9560-c3f83c006b6a" xlink:to="loc_allo_ProceedsFromGrantAwards_019eb40c-b1f3-762e-b385-27ae83c4162b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019eb40c-b1f3-7cf2-92ae-2a3468080127" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7f3f-9560-c3f83c006b6a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019eb40c-b1f3-7cf2-92ae-2a3468080127" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019eb40c-b1f3-7c2a-a60e-31c2c06b9f2b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019eb40c-b1f3-7f3f-9560-c3f83c006b6a" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019eb40c-b1f3-7c2a-a60e-31c2c06b9f2b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/FinancialInstrumentsScheduleofCashEquivalentsRestrictedCashandInvestmentsClassifiedasAvailableforSaleSecuritiesDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#FinancialInstrumentsScheduleofCashEquivalentsRestrictedCashandInvestmentsClassifiedasAvailableforSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/FinancialInstrumentsScheduleofCashEquivalentsRestrictedCashandInvestmentsClassifiedasAvailableforSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_allo_CashEquivalentsAndShortTermInvestments_019eb40c-b2bd-7306-9192-ef68bc373460" xlink:href="allo-20260630.xsd#allo_CashEquivalentsAndShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019eb40c-b2bd-78a5-bfb6-4d3625d54d05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_allo_CashEquivalentsAndShortTermInvestments_019eb40c-b2bd-7306-9192-ef68bc373460" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_019eb40c-b2bd-78a5-bfb6-4d3625d54d05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019eb40c-b2bd-7e09-9370-7c83922d5117" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_allo_CashEquivalentsAndShortTermInvestments_019eb40c-b2bd-7306-9192-ef68bc373460" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019eb40c-b2bd-7e09-9370-7c83922d5117" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019eb40c-b2bd-7ebb-ba4d-01b91f982928" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_allo_CashEquivalentsAndShortTermInvestments_019eb40c-b2bd-7306-9192-ef68bc373460" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019eb40c-b2bd-7ebb-ba4d-01b91f982928" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019eb40c-b2bd-7805-bd7b-cbbe76c10af0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019eb40c-b2bd-7b79-b379-59dbc8581e81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019eb40c-b2bd-7805-bd7b-cbbe76c10af0" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019eb40c-b2bd-7b79-b379-59dbc8581e81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019eb40c-b2bd-7683-8684-46ffc20c42b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019eb40c-b2bd-7805-bd7b-cbbe76c10af0" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019eb40c-b2bd-7683-8684-46ffc20c42b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019eb40c-b2bd-7e3c-b6da-09dd618b6877" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019eb40c-b2bd-7805-bd7b-cbbe76c10af0" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019eb40c-b2bd-7e3c-b6da-09dd618b6877" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019eb40c-b2be-7d4a-9c0d-67a1d2d009ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019eb40c-b2be-7821-8384-0bf9c7c2cace" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019eb40c-b2be-7d4a-9c0d-67a1d2d009ce" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019eb40c-b2be-7821-8384-0bf9c7c2cace" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019eb40c-b2be-79ac-ac48-a7a3f0f732bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019eb40c-b2be-7d4a-9c0d-67a1d2d009ce" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019eb40c-b2be-79ac-ac48-a7a3f0f732bb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/CommitmentsandContingenciesLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#CommitmentsandContingenciesLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CommitmentsandContingenciesLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019eb40c-b2be-790e-9c91-ecc70b02ca70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019eb40c-b2be-7973-ab90-9b417158ec7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019eb40c-b2be-790e-9c91-ecc70b02ca70" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019eb40c-b2be-7973-ab90-9b417158ec7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019eb40c-b2be-7b2f-aa43-558a1b3b91e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019eb40c-b2be-790e-9c91-ecc70b02ca70" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019eb40c-b2be-7b2f-aa43-558a1b3b91e4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/CommitmentsandContingenciesLeaseCostsDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#CommitmentsandContingenciesLeaseCostsDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CommitmentsandContingenciesLeaseCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019eb40c-b2be-74a5-8cdd-17292b0db4c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019eb40c-b2be-7aa7-a538-548c41a97791" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019eb40c-b2be-74a5-8cdd-17292b0db4c9" xlink:to="loc_us-gaap_OperatingLeaseCost_019eb40c-b2be-7aa7-a538-548c41a97791" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019eb40c-b2be-7a83-9568-64b0ee790aa1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019eb40c-b2be-74a5-8cdd-17292b0db4c9" xlink:to="loc_us-gaap_VariableLeaseCost_019eb40c-b2be-7a83-9568-64b0ee790aa1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/CommitmentsandContingenciesUndiscountedFutureLeasePaymentsDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#CommitmentsandContingenciesUndiscountedFutureLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/CommitmentsandContingenciesUndiscountedFutureLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019eb40c-b2be-7af4-b1ec-80c4c0d1e302" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019eb40c-b2be-7af4-b1ec-80c4c0d1e302" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019eb40c-b2be-769b-819f-7142ede724a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019eb40c-b2be-769b-819f-7142ede724a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019eb40c-b2be-7a4d-84fa-32a5943820aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019eb40c-b2be-7a4d-84fa-32a5943820aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019eb40c-b2be-7003-a091-2bb9b5cfc834" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019eb40c-b2be-7003-a091-2bb9b5cfc834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019eb40c-b2be-7c77-a970-f7dfe9fbc26c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019eb40c-b2be-7c77-a970-f7dfe9fbc26c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour_019eb40c-b2be-77d5-a97d-e9acbaa6c630" xlink:href="allo-20260630.xsd#allo_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019eb40c-b2be-791d-8360-d1cacfc626f8" xlink:to="loc_allo_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour_019eb40c-b2be-77d5-a97d-e9acbaa6c630" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://allogene.com/role/SegmentReportingSegmentProfitorLossandSegmentExpensesDetails" xlink:type="simple" xlink:href="allo-20260630.xsd#SegmentReportingSegmentProfitorLossandSegmentExpensesDetails"/>
  <link:calculationLink xlink:role="http://allogene.com/role/SegmentReportingSegmentProfitorLossandSegmentExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019eb40c-b2be-7d37-ad1d-30124ecc26c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019eb40c-b2be-7092-a083-6c8048eceebb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019eb40c-b2be-7d37-ad1d-30124ecc26c7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019eb40c-b2be-7092-a083-6c8048eceebb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019eb40c-b2be-7b98-bc74-7409c8b11794" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019eb40c-b2be-7d37-ad1d-30124ecc26c7" xlink:to="loc_us-gaap_OperatingExpenses_019eb40c-b2be-7b98-bc74-7409c8b11794" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fdd87-d1c0-783c-8eed-d472611537be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019eb40c-b2be-7d37-ad1d-30124ecc26c7" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019fdd87-d1c0-783c-8eed-d472611537be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_ResearchAndDevelopmentExpenseOtherDevelopmentCosts_019eb40c-b2be-750e-ae0b-91a73bc89025" xlink:href="allo-20260630.xsd#allo_ResearchAndDevelopmentExpenseOtherDevelopmentCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_allo_ResearchAndDevelopmentExpenseOtherDevelopmentCosts_019eb40c-b2be-750e-ae0b-91a73bc89025" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_019eb40c-b2be-7ee7-898c-d451ad2517e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_019eb40c-b2be-7ee7-898c-d451ad2517e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_SupportingExternalSpendExpense_019eb40c-b2be-7dac-bc91-4e73330a284d" xlink:href="allo-20260630.xsd#allo_SupportingExternalSpendExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_allo_SupportingExternalSpendExpense_019eb40c-b2be-7dac-bc91-4e73330a284d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019eb40c-b2be-728d-8203-c142a03e86bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019eb40c-b2be-728d-8203-c142a03e86bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_ResearchAndDevelopmentExpenseCemaCel_019eb40c-b2be-74a4-b45e-a9aaf94373d0" xlink:href="allo-20260630.xsd#allo_ResearchAndDevelopmentExpenseCemaCel"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_allo_ResearchAndDevelopmentExpenseCemaCel_019eb40c-b2be-74a4-b45e-a9aaf94373d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_allo_FacilitiesAndITRelatedExpense_019eb40c-b2be-7af5-80ea-fd02b0ba38b7" xlink:href="allo-20260630.xsd#allo_FacilitiesAndITRelatedExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019eb40c-b2be-774c-8e44-93d343001c91" xlink:to="loc_allo_FacilitiesAndITRelatedExpense_019eb40c-b2be-7af5-80ea-fd02b0ba38b7" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
