<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fece3-fe67-79d3-8b69-1a5e9c57850b,g:a0892d2b-1787-472f-b0da-7dcfbfcfed3c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://acumenpharm.com/role/Cover" xlink:type="simple" xlink:href="abos-20260812.xsd#Cover"/>
  <link:presentationLink xlink:role="http://acumenpharm.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019fece3-fe67-76cb-a004-38092bae5fa6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_DocumentType_019fece3-fe67-76cb-a004-38092bae5fa6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fece3-fe67-786f-8885-1c3f3bf98c97" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_DocumentPeriodEndDate_019fece3-fe67-786f-8885-1c3f3bf98c97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019fece3-fe67-7581-b89f-a6dd33c6cb18" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityRegistrantName_019fece3-fe67-7581-b89f-a6dd33c6cb18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019fece3-fe67-7d0e-b4ce-8d04f4f6bcea" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019fece3-fe67-7d0e-b4ce-8d04f4f6bcea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019fece3-fe67-7e1e-928e-369b46c78a2b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityFileNumber_019fece3-fe67-7e1e-928e-369b46c78a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019fece3-fe67-7fcf-85f6-62d6e2893f98" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityTaxIdentificationNumber_019fece3-fe67-7fcf-85f6-62d6e2893f98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019fece3-fe67-7ed1-84c3-731ad4dc437f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityAddressAddressLine1_019fece3-fe67-7ed1-84c3-731ad4dc437f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019fece3-fe67-7886-a638-1e22d675db24" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityAddressAddressLine2_019fece3-fe67-7886-a638-1e22d675db24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019fece3-fe67-7e28-987c-8b8120f919a3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityAddressCityOrTown_019fece3-fe67-7e28-987c-8b8120f919a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019fece3-fe67-7cbd-959c-6964ea48b95e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityAddressStateOrProvince_019fece3-fe67-7cbd-959c-6964ea48b95e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019fece3-fe67-7336-b198-54388d3b9304" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityAddressPostalZipCode_019fece3-fe67-7336-b198-54388d3b9304" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019fece3-fe67-78b0-bf37-1f9ca73bc279" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_CityAreaCode_019fece3-fe67-78b0-bf37-1f9ca73bc279" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019fece3-fe67-7f20-a4d6-3734d8d5e439" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_LocalPhoneNumber_019fece3-fe67-7f20-a4d6-3734d8d5e439" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019fece3-fe67-7961-9a95-59291eaa43d5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_WrittenCommunications_019fece3-fe67-7961-9a95-59291eaa43d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019fece3-fe67-7fa9-bb9a-61f202ed33b2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_SolicitingMaterial_019fece3-fe67-7fa9-bb9a-61f202ed33b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019fece3-fe67-76d9-9452-ad66f34826d6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_PreCommencementTenderOffer_019fece3-fe67-76d9-9452-ad66f34826d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019fece3-fe67-70b3-95e5-f6084ab37dc0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019fece3-fe67-70b3-95e5-f6084ab37dc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019fece3-fe67-78c2-9f12-cf6b2825d47b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_Security12bTitle_019fece3-fe67-78c2-9f12-cf6b2825d47b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019fece3-fe67-784d-a0df-063ec2529a52" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_TradingSymbol_019fece3-fe67-784d-a0df-063ec2529a52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019fece3-fe67-7418-9584-76c0bc127357" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_SecurityExchangeName_019fece3-fe67-7418-9584-76c0bc127357" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019fece3-fe67-7431-9795-9c4385492aee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityEmergingGrowthCompany_019fece3-fe67-7431-9795-9c4385492aee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019fece3-fe67-7601-bf31-d4cbdf7c7cda" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityExTransitionPeriod_019fece3-fe67-7601-bf31-d4cbdf7c7cda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019fece3-fe67-74e7-ad22-2b598edb0fd7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_EntityCentralIndexKey_019fece3-fe67-74e7-ad22-2b598edb0fd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019fece3-fe67-7d28-a418-813dbbee0c6f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fece3-fe67-77f3-8d25-8fba6d1b4581" xlink:to="loc_dei_AmendmentFlag_019fece3-fe67-7d28-a418-813dbbee0c6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
