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Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Equity Agreement [Member] Represents the equity agreement. mnpr_OwnershipInterestLicenseAgreement Ownership Interest, License Agreement The percentage of ownership interest from the license agreement. Common stock, par value of $0.001 per share, 40,000,000 shares authorized, 6,712,172 and 6,692,140 shares issued and outstanding at June 30, 2026, and December 31, 2025, respectively mnpr_AdditionalCashPaymentForLicenseAgreement Additional Cash Payment for License Agreement Represents the additional cash paid for the license agreement. 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License Agreement [Member] Represents the license agreement. us-gaap_DisclosureTextBlockAbstract Notes to Financial Statements us-gaap_TableTextBlock Notes Tables mnpr_ClassOfPrewarrantOrRightMaximumBeneficialOwnershipPercentage Class of Pre-Warrant or Right, Maximum Beneficial Ownership Percentage Maximum percentage of beneficial ownership for prefunded warrant. Document Fiscal Period Focus us-gaap_ProceedsFromIssuanceOfWarrants Proceeds from Issuance of Warrants Document Fiscal Year Focus us-gaap_ComprehensiveIncomeNetOfTax Comprehensive income (loss) mnpr_ClassOfPrewarrantOrRightPricePerShare Class of Pre-Warrant or Right, Price Per Share (in dollars per share) Per share price of pre-funded warrant. 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Entity Current Reporting Status Supplemental Balance Sheet Lease Information [Table Text Block] Tabular disclosure of balance sheet lease information. Entity Incorporation, State or Country Code Current Fiscal Year End Date mnpr_RoyaltyPaymentsPercentageOfNetSales Royalty Payments, Percentage of Net Sales Amount of royalty payments as percentage of net sales. Research and development Research and Development Expense Entity Filer Category Entity Shell Company Entity Emerging Growth Company Entity Small Business us-gaap_OperatingIncomeLoss Income (loss) from operations Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Unvested options outstanding expected to vest(3) (in shares) us-gaap_Revenues Revenues mnpr_RoyaltyPaymentsPercentageOfSublicensingIncome Royalty Payments, Percentage of Sublicensing Income Amount of royalty payments as percentage of sublicensing income. Entity Address, State or Province Loss Contingencies [Table] Statement of Stockholders' Equity [Abstract] Entity Address, City or Town Retained earnings (accumulated deficit) Retained Earnings (Accumulated Deficit) Entity Address, Address Line One Class of Warrant or Right [Axis] Unvested options outstanding expected to vest(3), exercise price (in dollars per share) Class of Warrant or Right [Domain] Statement of Cash Flows [Abstract] City Area Code us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation Taxes paid related to net share settlement of vested restricted stock units Local Phone Number Entity Address, Postal Zip Code Other comprehensive income (loss) Title of 12(b) Security Equity Components [Axis] Security Exchange Name Trading Symbol Share-Based Payment Arrangement [Policy Text Block] Cash proceeds from the issuance of stock upon exercise of stock options Class of Stock [Axis] Equity Component [Domain] us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) Fair Value, Inputs, Level 2 [Member] Equity [Text Block] Fair Value, Inputs, Level 1 [Member] Other comprehensive income (loss): AOCI Attributable to Parent [Member] Entity Common Stock, Shares Outstanding us-gaap_ClassOfWarrantOrRightOutstanding Class of Warrant or Right, Outstanding (in shares) Additional Paid-in Capital [Member] Retained Earnings [Member] Earnings Per Share [Text Block] Other current assets Foreign Currency Transactions and Translations Policy [Policy Text Block] Lower exercise price (in dollars per share) Unrealized gain (loss) on investments, net Weighted average shares outstanding: mnpr_PolicyTable Debt Securities, Held-to-Maturity [Table Text Block] Aggregate fair value Subsequent Event [Table] mnpr_OwnershipPercentage Ownership Percentage The percentage of ownership of common stock. Sale of Stock [Axis] Investments Classified by Contractual Maturity Date [Table Text Block] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share (in dollars per share) Pre-funded Warrants [Member] Pertains to pre-funded warrants. Stock-based compensation Basis of Accounting, Policy [Policy Text Block] mnpr_InsurancePremiumsDuesSubscriptionAndSoftwareCostPaidInAdvance Insurance Premiums Dues Subscription and Software Cost Paid In Advance Represents insurance premiums dues subscription and software cost paid in advance. License Agreement, Value of Common Stock [Member] Pertains to the value of common shares. Patent Costs [Policy Text Block] Disclosure of accounting policy for patent costs. Other income (loss) mnpr_StockIssuedDuringPeriodSharesAntidilutionProvisions Stock Issued During Period, Shares, Antidilution Provisions (in shares) Represents the shares issued for the antidilutive provisions. Prepaid Expenses [Policy Text Block] Disclosure of accounting policy for prepaid expenses. Foreign currency translation gain (loss), net Licensing Agreements [Policy Text Block] Disclosure of accounting policy for licensing agreements. License Agreement, Upfront Payments [Member] Pertains to upfront payments. Clinical Trial Accrual [Policy Text Block] Disclosure of accounting policy for clinical trial accrual. Fair Value Measurements, Recurring and Nonrecurring [Table Text Block] Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Sale of Stock [Domain] Share-Based Payment Arrangement, Option, Activity [Table Text Block] us-gaap_Assets Total assets Cash and Cash Equivalents, Policy [Policy Text Block] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block] mnpr_CashEquivalentsAndInvestmentsFairValue Total Represents fair value of cash equivalents and investments. Cash and cash equivalents Share-Based Payment Arrangement, Option [Member] Supplemental disclosure of non-cash investing and financing activities: mnpr_ClassOfWarrantOrRightIssued Class of Warrant or Right, Issued (in shares) Number of warrants or rights issued. Current liabilities: us-gaap_LiabilitiesCurrent Total current liabilities us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments Net amortization of investment discounts and premiums Underwriting Agreement [Member] Pertains to the type of arrangement. Amortized cost Amortized cost Monopar Therapeutics Inc. 2026 Stock Incentive Plan [Member] Represents information pertaining to the Monopar Therapeutics Inc. 2026 Stock Incentive Plan. Vesting Quarterly Over Half One Year [Member] Represents information pertaining to vesting quarterly over half of one year. Kim Tsuchimoto [Member] Represents information pertaining to Kim Tsuchimoto. Patrice Rioux [Member] Represents information pertaining to Patrice Rioux. Chandler Robinson [Member] Represents information pertaining to Chandler Robinson. Christopher Starr [Member] Represents information pertaining to Christopher Starr. Lease, Cost [Table Text Block] Quan Vu [Member] Represents information pertaining to Quan Vu. Suite 100 at 1000 Skokie Blvd in the Village of Wilmette, Illinois [Member] Represents information pertaining to Suite 100 at 1000 Skokie Blvd in the Village of Wilmette, Illinois. Vesting 6/48ths on Six-months and 1/48th After [Member] Relating to vesting 1/64ths on six-months and 1/48th after. Monopar Therapeutics Inc. 2016 Stock Incentive Plan [Member] Relating to the Monopar Therapeutics Inc. 2016 Stock Incentive Plan. Vesting Monthly Over One Year [Member] Relating to vesting monthly over one year. mnpr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOutstandingAggregateIntrinsicValue Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Outstanding, Aggregate Intrinsic Value Amount by which current fair value of underlying stock exceeds exercise price of nonvested options outstanding. Interest income (loss) mnpr_ProceedsFromIssuanceOfCommonStockNet Proceeds from Issuance of Common Stock, Net The cash inflow from the additional capital contribution to the entity net of issuance costs and legal fees. Raymond Anderson [Member] Represents information pertaining to Raymond Anderson. Price Range 2 [Member] Relating to price range 2. Lessee, Leases [Policy Text Block] Price Range 1 [Member] Relating to price range 1. Individual [Axis] Price Range 4 [Member] Relating to price range 4. Price Range 3 [Member] Relating to price range 3. mnpr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestOutstandingWeightedAverageExercisePrice Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expected to Vest, Outstanding, Weighted Average Exercise Price (in dollars per share) Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur. Accumulated other comprehensive income (loss) mnpr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedOutstandingWeightedAverageExercisePrice Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Outstanding, Weighted Average Exercise Price (in dollars per share) Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur. 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Stock, Class of Stock [Table] mnpr_ProceedsFromIssuanceOfWarrantsNet Proceeds from Issuance of Warrants, Net The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt). mnpr_OperatingLeasesMonthlyRentExpense Operating Leases, Monthly Rent Expense Monthly rental expense under operating leases. Weighted-average remaining contractual term (Year) us-gaap_PaymentsToAcquireShortTermInvestments Purchase of short-term investments Weighted-average remaining contractual term, exercisable (Year) Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes Aggregate value of stock related to vested Restricted Stock Awards. Current assets: Money Market Funds [Member] Operating lease right-of-use asset Total ROU asset Issuance of common stock upon exercise of stock options us-gaap_AssetsCurrent Total current assets ecd_Rule10b51ArrTrmntdFlag Rule 10b5-1 Arrangement Terminated [Flag] ecd_Rule10b51ArrAdoptedFlag Rule 10b5-1 Arrangement Adopted [Flag] Share Purchase Agreement With Tactic Pharma [Member] Relating to share purchase agreement with Tactic Pharma. mnpr_IncreaseDecreaseInOperatingLeaseRightOfUseAssetsAndLiabilities Operating lease right-of-use assets and liabilities, net Amount of increase (decrease) in operating lease right of use assets and liabilities, net. us-gaap_StockIssuedDuringPeriodSharesNewIssues Stock Issued During Period, Shares, New Issues (in shares) Commitments and contingencies (Note 8) Restricted Stock Units (RSUs) [Member]