The Securities and Exchange Commission has not necessarily
reviewed the information in this filing and has not determined
if it is accurate and complete.
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Agios Pharmaceutical, Inc. | Common | 00847X104 | 3,527,602 | 95,058 | SH | DFND | 1 | 95,058 | 0 | 0 | |
| Alkermes PLC | Common | G01767105 | 6,379,563 | 121,759 | SH | DFND | 1 | 121,759 | 0 | 0 | |
| AllianceBernstein Holding L.P. | Common | 01881G106 | 1,690,560 | 48,000 | SH | DFND | 1 | 48,000 | 0 | 0 | |
| Alphabet Inc CL A | Common | 02079k305 | 107,211 | 300 | SH | DFND | 1 | 300 | 0 | 0 | |
| Alphabet Inc-Cl C | Common | 02079K107 | 32,223,696 | 91,200 | SH | DFND | 1 | 91,200 | 0 | 0 | |
| Alphabet Inc-Cl C | Common | 02079K107 | 77,733 | 220 | SH | DFND | 1 | 220 | 0 | 0 | |
| Amazon.com Inc. | Common | 023135106 | 71,502 | 300 | SH | DFND | 1 | 300 | 0 | 0 | |
| Apollo Global Management, Inc. | Common | 03769M106 | 26,619,750 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | |
| Apple Inc. | Common | 037833100 | 721,664 | 2,494 | SH | DFND | 1 | 2,494 | 0 | 0 | |
| Arcus Biosciences, Inc. | Common | 03969F109 | 2,504,660 | 81,241 | SH | DFND | 1 | 81,241 | 0 | 0 | |
| Ardelyx, Inc. | Common | 039697107 | 1,342,157 | 263,168 | SH | DFND | 1 | 263,168 | 0 | 0 | |
| AtriCure, Inc. | Common | 04963C209 | 1,438,172 | 51,400 | SH | DFND | 1 | 51,400 | 0 | 0 | |
| Biogen Inc. | Common | 09062X103 | 864,240 | 4,000 | SH | DFND | 1 | 4,000 | 0 | 0 | |
| Blackstone Group LP | Common | 09260d107 | 24,711 | 210 | SH | DFND | 1 | 210 | 0 | 0 | |
| Boston Scientific Corporation | Common | 101137107 | 256,080 | 6,000 | SH | DFND | 1 | 6,000 | 0 | 0 | |
| Bridgebio Pharma, Inc. | Common | 10806X102 | 6,915,468 | 92,850 | SH | DFND | 1 | 92,850 | 0 | 0 | |
| Bristol-Myers Squibb Company | Common | 110122108 | 115,240 | 2,000 | SH | DFND | 1 | 2,000 | 0 | 0 | |
| Broadcom, Inc. | Common | 11135F101 | 268,202 | 710 | SH | DFND | 1 | 710 | 0 | 0 | |
| Canadian Natural Resources Limited | Common | 136385101 | 663,600 | 16,800 | SH | DFND | 1 | 16,800 | 0 | 0 | |
| CareDx, Inc. | Common | 14167L103 | 388,455 | 13,630 | SH | DFND | 1 | 13,630 | 0 | 0 | |
| Catalyst Pharmaceuticals, Inc. | Common | 14888L101 | 3,583,020 | 114,000 | SH | DFND | 1 | 114,000 | 0 | 0 | |
| Cogent Biosciences Inc. | Common | 19240Q201 | 4,298,835 | 111,081 | SH | DFND | 1 | 111,081 | 0 | 0 | |
| Connect Biopharma Holdings Limited | Common | G23549101 | 1,058,772 | 444,862 | SH | DFND | 1 | 444,862 | 0 | 0 | |
| Corteva, Inc. | Common | 22052L104 | 102,136 | 1,206 | SH | DFND | 1 | 1,206 | 0 | 0 | |
| Cullinan Therapeutics, Inc. | Common | 230031106 | 1,259,804 | 69,182 | SH | DFND | 1 | 69,182 | 0 | 0 | |
| Cybin Inc | Common | 23256X407 | 2,445,700 | 370,000 | SH | DFND | 1 | 370,000 | 0 | 0 | |
| Danaher Corporation | Common | 235851102 | 34,286 | 180 | SH | DFND | 1 | 180 | 0 | 0 | |
| DocGo, Inc. | Common | 256086109 | 1,378,426 | 2,670,850 | SH | DFND | 1 | 2,670,850 | 0 | 0 | |
| Dow Inc. | Common | 260557103 | 32,996 | 1,206 | SH | DFND | 1 | 1,206 | 0 | 0 | |
| DuPont de Nemours, Inc. | Common | 36614N201 | 510,956 | 3,767 | SH | DFND | 1 | 3,767 | 0 | 0 | |
| Eastern Bankshares Inc | Common | 27627N105 | 111,200 | 5,000 | SH | DFND | 1 | 5,000 | 0 | 0 | |
| Enliven Therapeutics, Inc. | Common | 29337E102 | 313,787 | 6,183 | SH | DFND | 1 | 6,183 | 0 | 0 | |
| FS KKR Capital Corp. | Common | 302635206 | 30,187 | 2,875 | SH | DFND | 1 | 2,875 | 0 | 0 | |
| GE HealthCare Technologies Inc | Common | 36266G107 | 3,200 | 50 | SH | DFND | 1 | 50 | 0 | 0 | |
| Insmed Incorporated | Common | 457669307 | 453,455 | 4,253 | SH | DFND | 1 | 4,253 | 0 | 0 | |
| International Business Machines | Common | 459200101 | 602,352 | 2,142 | SH | DFND | 1 | 2,142 | 0 | 0 | |
| International Game Technology PLC | Common | G4863A108 | 26,800 | 2,500 | SH | DFND | 1 | 2,500 | 0 | 0 | |
| Invivyd, Inc. | Common | 00534A102 | 87,240 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| Iovance Biotherapeutics, Inc. | Common | 462260100 | 6,656,000 | 1,600,000 | SH | DFND | 1 | 1,600,000 | 0 | 0 | |
| iShares Biotechnology ETF | Common | 464287556 | 1,046,045 | 5,500 | SH | DFND | 1 | 5,500 | 0 | 0 | |
| iShares Russell Mid-Cap Growth | Common | 464287481 | 101,755 | 695 | SH | DFND | 1 | 695 | 0 | 0 | |
| Janus Henderson AAA CLO ETF | Common | 47103U845 | 4,722,229 | 93,528 | SH | DFND | 1 | 93,528 | 0 | 0 | |
| Johnson & Johnson | Common | 478160104 | 1,015,880 | 4,000 | SH | DFND | 1 | 4,000 | 0 | 0 | |
| Johnson & Johnson | Common | 478160104 | 234,161 | 922 | SH | DFND | 1 | 922 | 0 | 0 | |
| JPMorgan Chase & Co. | Common | 46625H100 | 5,924,018 | 18,098 | SH | DFND | 1 | 18,098 | 0 | 0 | |
| Kimberly-Clark Corporation | Common | 494368103 | 263,448 | 2,400 | SH | DFND | 1 | 2,400 | 0 | 0 | |
| Kura Oncology, Inc. | Common | 50127T109 | 578,854 | 52,767 | SH | DFND | 1 | 52,767 | 0 | 0 | |
| Kyndryl Holdings Inc. | Common | 50155Q100 | 4,841 | 428 | SH | DFND | 1 | 428 | 0 | 0 | |
| LB Pharmaceuticals, Inc. | Common | 50180M108 | 420,779 | 12,965 | SH | DFND | 1 | 12,965 | 0 | 0 | |
| Legacy Housing Corporation | Common | 52472M101 | 105,080 | 4,000 | SH | DFND | 1 | 4,000 | 0 | 0 | |
| LPL Financial Holdings Inc. | Common | 52012V100 | 4,647,720 | 16,500 | SH | DFND | 1 | 16,500 | 0 | 0 | |
| Madrigal Pharmaaceuticals, Inc. | Common | 558868105 | 1,610,850 | 3,000 | SH | DFND | 1 | 3,000 | 0 | 0 | |
| Microsoft Corporation | Common | 594918104 | 596,832 | 1,600 | SH | DFND | 1 | 1,600 | 0 | 0 | |
| Mondelez International, Inc. | Common | 609207105 | 173,520 | 3,000 | SH | DFND | 1 | 3,000 | 0 | 0 | |
| Nvidia Corp | Common | 67066G104 | 256,115 | 1,280 | SH | DFND | 1 | 1,280 | 0 | 0 | |
| Occidental Petroleum Corporation | Common | 674599105 | 22,779 | 469 | SH | DFND | 1 | 469 | 0 | 0 | |
| Occidential Pertro Wts exp. 8/3/27 | Common | 674599162 | 4,268 | 194 | SH | DFND | 1 | 194 | 0 | 0 | |
| Orchestra Biomed Holdings, Inc. | Common | 68572M106 | 1,094,504 | 253,651 | SH | DFND | 1 | 253,651 | 0 | 0 | |
| Pelthos Therapeutics, Inc. | Common | 171126204 | 623,783 | 22,073 | SH | DFND | 1 | 22,073 | 0 | 0 | |
| Pfizer Inc. | Common | 717081103 | 778,675 | 32,337 | SH | DFND | 1 | 32,337 | 0 | 0 | |
| Protagonist Therapeutics, Inc | Common | 74366E102 | 7,722,540 | 63,000 | SH | DFND | 1 | 63,000 | 0 | 0 | |
| Q32 Bio Inc | Common | 746964105 | 387,449 | 30,412 | SH | DFND | 1 | 30,412 | 0 | 0 | |
| Quanta Services, Inc. | Common | 74762E102 | 126,727 | 176 | SH | DFND | 1 | 176 | 0 | 0 | |
| Rain Enhancement Technologies Holdco Inc | Common | 75080J103 | 210,490 | 101,686 | SH | DFND | 1 | 101,686 | 0 | 0 | |
| Relmada Therapeutics, Inc. | Common | 75955J402 | 3,120,920 | 451,000 | SH | DFND | 1 | 451,000 | 0 | 0 | |
| Rezolute, Inc. | Common | 76200L309 | 1,924,000 | 370,000 | SH | DFND | 1 | 370,000 | 0 | 0 | |
| Ryman Hospitality Properties, Inc. | Common | 78377T107 | 308,520 | 2,400 | SH | DFND | 1 | 2,400 | 0 | 0 | |
| Salesforce, Inc. | Common | 79466L302 | 12,063 | 77 | SH | DFND | 1 | 77 | 0 | 0 | |
| Solid Bioscience Inc. | Common | 83422E204 | 561,518 | 56,208 | SH | DFND | 1 | 56,208 | 0 | 0 | |
| SPDR S&P Biotech ETF | Common | 78464A870 | 2,373,750 | 15,000 | SH | DFND | 1 | 15,000 | 0 | 0 | |
| Spruce Biosciences, Inc. | Common | 85209E208 | 1,080,000 | 20,000 | SH | DFND | 1 | 20,000 | 0 | 0 | |
| Starwood Property Trust, Inc. | Common | 85571B105 | 6,552 | 400 | SH | DFND | 1 | 400 | 0 | 0 | |
| Syndax Pharmaceutical, Inc. | Common | 87164F105 | 9,558,176 | 437,245 | SH | DFND | 1 | 437,245 | 0 | 0 | |
| TG Therapeutics, Inc. | Common | 88322Q108 | 3,672,135 | 66,839 | SH | DFND | 1 | 66,839 | 0 | 0 | |
| The Panagram BBB-B CLO ETF | Common | 81752T528 | 1,263,061 | 47,807 | SH | DFND | 1 | 47,807 | 0 | 0 | |
| Thermo Fisher Scientific, Inc. | Common | 883556102 | 22,561 | 45 | SH | DFND | 1 | 45 | 0 | 0 | |
| Travere Therapeutics, Inc. | Common | 89422G107 | 8,367,090 | 147,282 | SH | DFND | 1 | 147,282 | 0 | 0 | |
| Ultragenyx Pharmaceutical Inc. | Common | 90400D108 | 1,271,124 | 38,069 | SH | DFND | 1 | 38,069 | 0 | 0 | |
| United Healthcare Corp. | Common | 91324p102 | 23,691 | 57 | SH | DFND | 1 | 57 | 0 | 0 | |
| United Rental, Inc. | Common | 911363109 | 88,365 | 78 | SH | DFND | 1 | 78 | 0 | 0 | |
| Vera Therapeutics, Inc. | Common | 92337R101 | 1,115,660 | 26,000 | SH | DFND | 1 | 26,000 | 0 | 0 | |
| Verastem Inc. | Common | 92337C203 | 592,100 | 155,000 | SH | DFND | 1 | 155,000 | 0 | 0 | |
| Viridian Therapeutics, Inc. | Common | 92790C104 | 3,324,970 | 181,000 | SH | DFND | 1 | 181,000 | 0 | 0 | |
| Wabtec Corporation | Common | 929740108 | 1,618 | 6 | SH | DFND | 1 | 6 | 0 | 0 | |
| Wave Life Science Ltd. | Common | Y95308105 | 232,400 | 40,000 | SH | DFND | 1 | 40,000 | 0 | 0 | |
| Xeris Biopharma Holdings, Inc. | Common | 98422E103 | 8,395,200 | 1,060,000 | SH | DFND | 1 | 1,060,000 | 0 | 0 | |