0001427925 2026-08-12 2026-08-12 0001427925 1 2026-08-12 2026-08-12 0001427925 2 2026-08-12 2026-08-12 iso4217:USD pure shares S-8 S-8 EX-FILING FEES 0001427925 TALPHERA, INC. N/A false false S-8 TALPHERA, INC. Equity Common Stock, $0.001 par value per share, 2020 Equity Incentive Plan true 4000000 1.39 5560000.00 0.0001381 767.84 Equity Common Stock, $0.001 par value per share, 2011 Employee Stock Purchase Plan true 100000 1.39 139000.00 0.0001381 19.20 5699000.00 787.04 0.00 787.04 (1) Pursuant to Rule 416(a) promulgated under the Securities Act, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of common stock that become issuable under the Registrant's 2020 Equity Incentive Plan and 2011 Employee Stock Purchase Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of the Registrant's common stock, as applicable. (2) Estimated pursuant to Rules 457(c) and 457(h) under the Securities Act, solely for the purposes of calculating the registration fee and based on the average of the high and low prices of the Registrant's common stock as reported on The Nasdaq Capital Market on August 5, 2026, which date is within five business days prior to the filing of this Registration Statement. (3) Represents 4,000,000 additional shares of the Registrant's common stock that are or that may become issuable under the Registrant's 2020 Equity Incentive Plan. (1) Pursuant to Rule 416(a) promulgated under the Securities Act, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of common stock that become issuable under the Registrant's 2020 Equity Incentive Plan and 2011 Employee Stock Purchase Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of the Registrant's common stock, as applicable. (2) Estimated pursuant to Rules 457(c) and 457(h) under the Securities Act, solely for the purposes of calculating the registration fee and based on the average of the high and low prices of the Registrant's common stock as reported on The Nasdaq Capital Market on August 5, 2026, which date is within five business days prior to the filing of this Registration Statement. (4) Represents 100,000 additional shares of the Registrant's common stock that are or that may become issuable under the Registrant's 2011 Employee Stock Purchase Plan.