0001006281 2026-08-11 2026-08-11 0001006281 1 2026-08-11 2026-08-11 iso4217:USD pure shares S-8 S-8 EX-FILING FEES 0001006281 Protalix BioTherapeutics, Inc. N/A false S-8 Protalix BioTherapeutics, Inc. Equity Common Stock, par value $0.001 per share true 3500000 2.45 8575000.00 0.0001381 1184.21 8575000.00 1184.21 0.00 1184.21 a) Registrant is registering 3,500,000 shares under the Protalix BioTherapeutics, Inc. Amended and Restated 2006 Stock Incentive Plan (the "Plan"), pursuant to this Registration Statement on Form S-8 (this "Registration Statement"). b) This Registration Statement also registers additional securities to be offered or issued upon adjustments or changes made to registered securities by reason of any stock splits, stock dividends or similar transactions as permitted by Rule 416(a) and Rule 416(b) under the Securities Act of 1933, as amended. c) Estimated in accordance with Rules 457(h) and Rule 457(c) solely for purposes of calculating the registration fee. The maximum price per Security and the maximum aggregate offering price are based on the average of the high and low sale price of the Registrant's common stock as reported on the NYSE American on August 7, 2026, which date is within five business days of the filing of this Registration Statement.