v3.26.1
Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Cash flows from operating activities:    
Net loss $ (110,709) $ (118,081)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation on property and equipment 4,370 4,075
Amortization of intangible assets 979 570
Inventory reserves and write-offs 3,100 3,244
Loss on disposal of property and equipment 2 3
Share-based compensation net of amounts capitalized 8,160 7,160
Interest expense accrued on liabilities related to future royalties and milestones, net 8,306 3,294
Accretion of available-for-sale securities (1,227) (5,103)
Foreign exchange differences 3,403 (5,702)
Non-cash operating lease expense 1,764 1,943
Impairment of operating lease right-of-use assets and related property and equipment 293 0
Deferred income tax 772 871
Changes in operating assets and liabilities:    
Decrease in prepaid expenses and other current assets 20,489 5,452
Decrease (increase) in prepaid expenses and other non-current assets 82 (4,701)
Increase in inventories, net (3,734) (21,538)
Increase in accounts receivable, net (20,375) (26,726)
(Decrease) increase in accounts payable (1,840) 3,395
Increase in deferred revenue 0 2,100
Decrease in accrued expenses and other liabilities (5,552) (5,237)
Increase in operating lease liability 1,331 6,635
Net cash used in operating activities (90,386) (148,346)
Cash flows from investing activities:    
Acquisition of property and equipment (3,601) (15,520)
Purchases of marketable securities: available-for-sale debt securities (14,721) (119,299)
Proceeds from maturities and redemptions of marketable securities: available-for-sale debt securities 182,373 171,187
Net cash provided by investing activities 164,051 36,368
Cash flows from financing activities:    
Proceeds from the exercise of share options 3 0
Payments of liabilities related to future royalties and milestones, net (4,206) (768)
Net cash used in financing activities (4,203) (768)
Effect of exchange rate changes on cash, cash equivalents and restricted cash (2,188) 9,273
Net increase (decrease) in cash, cash equivalents and restricted cash 67,274 (103,473)
Cash, cash equivalents and restricted cash, beginning of period 105,636 228,805
Cash, cash equivalents and restricted cash, end of period 172,910 125,332
Unaudited supplemental cash flow information    
Cash paid for income taxes 1,307 1,038
Unaudited supplemental non-cash flow information    
Property and equipment purchases included in accounts payable or accrued expenses 158 2,114
Leased assets obtained in exchange for operating lease liabilities 11,654 0
Capitalized implementation costs included in accounts payable and accrued expenses 209 494
Reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets:    
Cash and cash equivalents 171,414 123,825
Restricted cash 1,496 1,507
Total cash, cash equivalents and restricted cash $ 172,910 $ 125,332