Segments - Schedule of Significant Expense Categories Reviewed by CODM (Details) - USD ($) $ in Thousands |
3 Months Ended | 6 Months Ended | ||||
|---|---|---|---|---|---|---|
Jun. 30, 2026 |
Mar. 31, 2026 |
Jun. 30, 2025 |
Mar. 31, 2025 |
Jun. 30, 2026 |
Jun. 30, 2025 |
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| Segment Reporting [Line Items] | ||||||
| Revenue | $ 5,704 | $ 0 | $ 10,284 | $ 0 | ||
| Operating expenses: | ||||||
| Research and development | 16,131 | 25,784 | 29,732 | 54,600 | ||
| General and administrative | 5,027 | 6,410 | 10,183 | 12,200 | ||
| Total operating expenses | 21,158 | 32,194 | 39,915 | 66,800 | ||
| Loss from operations | (15,454) | (32,194) | (29,631) | (66,800) | ||
| Other income, net | 1,533 | 963 | 5,325 | 3,484 | ||
| Net loss | (13,921) | $ (10,385) | (31,231) | $ (32,085) | (24,306) | (63,316) |
| JAK2 V617F | ||||||
| Operating expenses: | ||||||
| Research and development | 2,266 | 1,881 | 3,678 | 3,056 | ||
| KAT6A | ||||||
| Operating expenses: | ||||||
| Research and development | 2,085 | 795 | 2,876 | 1,301 | ||
| Discovery Programs | ||||||
| Operating expenses: | ||||||
| Research and development | 229 | 612 | 283 | 1,399 | ||
| Other | ||||||
| Operating expenses: | ||||||
| Research and development | 14 | 6,804 | 852 | 16,705 | ||
| General Costs, Including Personnel Related | ||||||
| Operating expenses: | ||||||
| Research and development | $ 11,537 | $ 15,692 | $ 22,043 | $ 32,139 | ||
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- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- References No definition available.
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- Definition The net result for the period of deducting operating expenses from operating revenues. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of income (expense) related to nonoperating activities, classified as other. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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