| Schedule of Significant Expense Categories Reviewed by CODM |
The following table summarizes the significant expense categories regularly reviewed by the CODM for the three and six months ended June 30, 2026 and 2025.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three months ended June 30, |
|
|
Six months ended June 30, |
|
(in thousands) |
|
2026 |
|
|
2025 |
|
|
2026 |
|
|
2025 |
|
Revenue |
|
$ |
5,704 |
|
|
$ |
— |
|
|
$ |
10,284 |
|
|
$ |
— |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
|
|
|
|
|
|
|
|
|
|
|
JAK2 V617F |
|
|
2,266 |
|
|
|
1,881 |
|
|
|
3,678 |
|
|
|
3,056 |
|
KAT6A |
|
|
2,085 |
|
|
|
795 |
|
|
|
2,876 |
|
|
|
1,301 |
|
Discovery programs |
|
|
229 |
|
|
|
612 |
|
|
|
283 |
|
|
|
1,399 |
|
Other |
|
|
14 |
|
|
|
6,804 |
|
|
|
852 |
|
|
|
16,705 |
|
General costs, including personnel related |
|
|
11,537 |
|
|
|
15,692 |
|
|
|
22,043 |
|
|
|
32,139 |
|
Total research and development |
|
|
16,131 |
|
|
|
25,784 |
|
|
|
29,732 |
|
|
|
54,600 |
|
General and administrative |
|
|
5,027 |
|
|
|
6,410 |
|
|
|
10,183 |
|
|
|
12,200 |
|
Total operating expenses |
|
$ |
21,158 |
|
|
$ |
32,194 |
|
|
$ |
39,915 |
|
|
$ |
66,800 |
|
Loss from operations |
|
|
(15,454 |
) |
|
|
(32,194 |
) |
|
|
(29,631 |
) |
|
|
(66,800 |
) |
Other income, net |
|
|
1,533 |
|
|
|
963 |
|
|
|
5,325 |
|
|
|
3,484 |
|
Net loss |
|
$ |
(13,921 |
) |
|
$ |
(31,231 |
) |
|
$ |
(24,306 |
) |
|
$ |
(63,316 |
) |
|