<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f8ff8-7f51-7ad6-b25d-1529a26a1fd1,g:abc0e227-1b9e-4d9e-aad2-33f827269290-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://intensitytherapeutics.com/role/Cover" xlink:type="simple" xlink:href="intensity-20260811.xsd#Cover"/>
  <link:presentationLink xlink:role="http://intensitytherapeutics.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019f8ff8-7f51-730c-abbc-39514e05c4a9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_DocumentType_019f8ff8-7f51-730c-abbc-39514e05c4a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019f8ff8-7f51-79ef-b957-a42a021e91c7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_DocumentPeriodEndDate_019f8ff8-7f51-79ef-b957-a42a021e91c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019f8ff8-7f51-77fc-8762-313d1572322b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityRegistrantName_019f8ff8-7f51-77fc-8762-313d1572322b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019f8ff8-7f51-70fb-b7fc-f2801a2a623d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019f8ff8-7f51-70fb-b7fc-f2801a2a623d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019f8ff8-7f51-796e-a3d9-73ea031ce6cb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityFileNumber_019f8ff8-7f51-796e-a3d9-73ea031ce6cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019f8ff8-7f51-76a1-b4e0-b549670937e3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityTaxIdentificationNumber_019f8ff8-7f51-76a1-b4e0-b549670937e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019f8ff8-7f51-7ce1-b385-1c09ebb92aff" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityAddressAddressLine1_019f8ff8-7f51-7ce1-b385-1c09ebb92aff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019f8ff8-7f51-75ad-b650-db95b7a219d4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityAddressAddressLine2_019f8ff8-7f51-75ad-b650-db95b7a219d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019f8ff8-7f51-76d4-a522-a02b3f8d8bf9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityAddressCityOrTown_019f8ff8-7f51-76d4-a522-a02b3f8d8bf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019f8ff8-7f51-7d00-a5aa-d1fd7ffde4f1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityAddressStateOrProvince_019f8ff8-7f51-7d00-a5aa-d1fd7ffde4f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019f8ff8-7f51-72a8-aa1d-a61c10c5622b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityAddressPostalZipCode_019f8ff8-7f51-72a8-aa1d-a61c10c5622b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019f8ff8-7f51-79a1-b366-b5b664488080" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_CityAreaCode_019f8ff8-7f51-79a1-b366-b5b664488080" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019f8ff8-7f51-75a1-9249-ca9939c9b12c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_LocalPhoneNumber_019f8ff8-7f51-75a1-9249-ca9939c9b12c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019f8ff8-7f51-77e6-aa93-0bf40f5be271" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_WrittenCommunications_019f8ff8-7f51-77e6-aa93-0bf40f5be271" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019f8ff8-7f51-7189-ad28-c07b3c090c9d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_SolicitingMaterial_019f8ff8-7f51-7189-ad28-c07b3c090c9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019f8ff8-7f51-7e20-92c1-3f4b0d918a80" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_PreCommencementTenderOffer_019f8ff8-7f51-7e20-92c1-3f4b0d918a80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019f8ff8-7f51-7e68-a0f3-8a36652bb1b8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019f8ff8-7f51-7e68-a0f3-8a36652bb1b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019f8ff8-7f51-7be2-96b8-f639e75fae36" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_Security12bTitle_019f8ff8-7f51-7be2-96b8-f639e75fae36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019f8ff8-7f51-7f11-8bf4-c23e8a9efebd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_TradingSymbol_019f8ff8-7f51-7f11-8bf4-c23e8a9efebd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019f8ff8-7f51-7548-afcc-790e3efd2653" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_SecurityExchangeName_019f8ff8-7f51-7548-afcc-790e3efd2653" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019f8ff8-7f51-7f5a-913f-7ea066419286" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityEmergingGrowthCompany_019f8ff8-7f51-7f5a-913f-7ea066419286" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019f8ff8-7f51-75c7-87b3-1646b80f6277" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityExTransitionPeriod_019f8ff8-7f51-75c7-87b3-1646b80f6277" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019f8ff8-7f51-702d-83df-7d77479f8ee8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_EntityCentralIndexKey_019f8ff8-7f51-702d-83df-7d77479f8ee8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019f8ff8-7f51-7932-8e79-906124c05a05" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f8ff8-7f51-7658-9faa-ff29c6bd9b27" xlink:to="loc_dei_AmendmentFlag_019f8ff8-7f51-7932-8e79-906124c05a05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
