0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Condensed Consolidated Statements of Operations (Unaudited) link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Condensed Consolidated Statements of Operations (Unaudited) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Condensed Consolidated Statements of Comprehensive Loss (Unaudited) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Condensed Consolidated Statements of Redeemable Convertible Noncontrolling Interests and Stockholders' Deficit (Unaudited) link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows (Unaudited) link:presentationLink link:calculationLink link:definitionLink 9952158 - Statement - Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Organization and Description of Business link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Equity Method Investments link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Intangible Assets, net link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Deferred Royalty Obligations, Net link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - License and Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - In-licensing and Other Research and Development Agreements link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Public Offerings and Share Repurchase Program link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Restructuring, Impairment and Related Charges link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Intangible Assets, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Deferred Royalty Obligations, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Organization and Description of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Summary of Significant Accounting Policies - Schedule of Concentration, Percentage of Gross Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Summary of Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Summary of Segment Information for Revenue, Significant Operating Expenses and Other Income (Expense), and Net Loss (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Schedule of Inventories Presented on Condensed Consolidated Balance Sheet (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Fair Value Measurements - Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Fair Value Measurements - Schedule of Aggregate Face Values and Fair Values of Notes (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Cash Equivalent and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Cash Equivalents and Marketable Securities - Schedule of Cash Equivalent and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Cash Equivalents and Marketable Securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Equity Method Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Intangible Assets, net - Summary of Recognized Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Intangible Assets, net - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Commitments and Contingencies - Schedule of Potential Milestone Amounts and Accruals (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Debt - 2027 Notes Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Debt - 2029 Notes Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Debt - 2031 Notes Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Debt - 2033 Notes Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Debt - Schedule of Outstanding Notes Balances (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Debt - Schedule of Total Interest Expense Recognized Related to Notes (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Debt - Schedule of Interest Payable (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Debt - Schedule of Future Minimum Payments under Notes (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Debt - Schedule of Share Repurchase Transactions with Respect to the Notes (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Debt - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Deferred Royalty Obligations, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Deferred Royalty Obligations, Net - Schedule of Deferred Royalty Obligations, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - License and Collaboration Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - In-licensing and Other Research and Development Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Leases - Components of Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Leases - Schedule of Supplemental Cash Flow Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Leases - Schedule of Future Minimum Lease Payments for Noncancelable Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Leases - Schedule of Future Minimum Lease Payments for Noncancelable Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Public Offerings and Share Repurchase Program (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Stock-Based Compensation - Summary of Stock Based Compensation for Employees and Non Employees (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Stock-Based Compensation - Summary of Stock Based Compensation for Employees and Non Employees (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Net Loss Per Share - Schedule of Common Stock Equivalents were Excluded from Computation of Diluted Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Subsequent Event (Details) link:presentationLink link:calculationLink link:definitionLink