August 10, 2026 SANRECO Phase 2 Topline Results in Polycythemia Vera Exhibit 99.2

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Introduction Iain Ross, Chairman and Interim Principal Executive Officer

Silence – siRNA Platform Company with Compelling Clinical Data Across Multiple Programs GOLD PLATFORM Proven GalNAc siRNA technology with broad utility Potent, durable and highly specific gene silencing Infrequent dosing enabled by durable pharmacology Strong and growing IP portfolio CLINICAL RESULTS Four clinical-stage assets targeting large unmet needs in rare and cardiometabolic diseases Compelling clinical data generated across multiple programs FRANCHISE OPPORTUNITY Divesiran: first-in-class siRNA for PV ~150K U.S. / ~3.5M global PV population1 Potential best-in-class profile Additional pipeline opportunities beyond PV 1. Using 44/100,000 global population: 7,800m, Kattamis, A. et al. Eur J Haematol (2020)

PV: Large Unmet Need and Proven Market Value Create Significant Upside for a Best-in-Class Therapy Large Underserved Population 2-5 Many PV patients remain phlebotomy-dependent Persistent burden reflects inadequate control Broad addressable population needs better therapy Current Options are Limited 2-5 Limitations in efficacy, safety and tolerability Chronic treatment burden and poor experience Jakafi generates ~$1B annually in PV despite later-line label limitations and treatment tradeoffs1 Compelling Product Profile Robust efficacy Favorable safety Infrequent dosing Better patient experience A best-in-class PV therapy could unlock blockbuster potential in a large underserved market 1. According to Incyte financial disclosures and market share data 2. Verstovsek S, et al. Ann Hematol. 2023 Mar;102(3):571-581; 3. Verstovsek S, et al. Leuk Res. 2017;56:5259.doi:10.1016/j.leukres.2017.01.032.; 4. McMullin MF, et. al. Br J Haematol. 2019 Jan; 184(2): 176-191.; 5. Mesa, R. Clin Adv Hematol Oncol (2017) 

SANRECO Results Support Potential Best-in-Class Treatment for Phlebotomy-Dependent PV Patients Efficacy Endpoints Safety Endpoints Infrequent Dosing

SANRECO Phase 2 Topline Results Steven Romano, MD, Chief R&D Officer

Preclinical Phase I Phase II Key Milestones Divesiran (TMPRSS6) Divesiran Clinical Development Program Polycythemia Vera PV is a rare myeloproliferative neoplasm characterized by excessive production of red blood cells Elevated hematocrit (Hct) >45% Primary treatment goal is to maintain Hct <45% HEMATOLOGY Topline 36-Wk Primary EP Results Completed Completed SANRECO Phase 2, n= 48 SANRECO Phase 1, n= 21 GEMINI HV Study, n= 24 Polycythemia Vera (PV) Divesiran has orphan drug and fast track status in PV

Phase 2 SANRECO Study is a Global Trial: 9 Countries / 4 Continents

Phase 2 SANRECO Study: Clinical Study Design

SANRECO Phase 2 Study Overview Design 36-week, placebo-controlled, double-blind period followed by a 3-year, double-blind and open-label extension period evaluating divesiran in 48 phlebotomy-dependent PV patients Key Inclusion Criteria PV diagnosis At least 3 phlebotomies in the last 6 months or 5 in the last year prior to screening Stable dose of cytoreductive agents allowed HCT level <45% prior to dosing Dosing & Administration Divesiran 6 mg vs. placebo Administered s.c. at Q6W and Q12W intervals Key Objectives Primary endpoint: proportion of patients who maintain HCT levels below 45% without phlebotomies between weeks 18 and 36 Secondary endpoints include safety and tolerability, pharmacokinetics, and quality of life changes

SANRECO: Primary Efficacy Endpoint - Response Rate The primary endpoint was met: Significantly higher proportion of clinical responders among the divesiran treated PV patients (88%) compared to those who received placebo (19%) during weeks 18-36; p<0.0001 Placebo adjusted response rate = 69% Note: Response is defined as HCT remaining below 45% and no phlebotomies received during weeks (18-36)

SANRECO: Primary Efficacy Endpoint by Dose Groups Note: Response is defined as HCT remaining below 45% and no phlebotomies received during weeks 18-36 18.8% 81.3% 93.8%

SANRECO: Response Rate Sensitivity Analysis (n=40)* Significantly higher proportion of clinical responders among the divesiran treated PV patients (89%) compared to those who received placebo (8%) during weeks 18-36; p<0.0001 Placebo adjusted response rate = 81% Note: Response is defined as HCT remaining below 45% and no phlebotomies received during weeks 18-36 *All patients who met the Phase 1 criterion of a minimum of 3 phlebotomies in the previous 3 months or 5 in the previous 12 months 7.7% 88.9%

SANRECO: Key Secondary Endpoint - Phlebotomy Rate Mean number of phlebotomies in the divesiran arm was 0.2 compared to 2.1 phlebotomies in the placebo arm during weeks 0-36 (p<0.0001) 12.5% 90.6%

SANRECO: Other Secondary Endpoints Divesiran groups also showed improvements in: Hematocrit control Iron markers, including ferritin Patient reported outcomes using MPN-SAF Total Symptom Score (MPN-SAF TSS)

Summary of Adverse Events (Weeks 0-36) Divesiran was generally well tolerated Safety profile was in line with previous divesiran trials; no new safety findings Injection site reactions were infrequent and self-limiting There were two investigator reported grade 1 anemia adverse event cases

Next Steps Phase 2 SANRECO full results Submitted abstract to ASH Congress (Dec 12-15, New Orleans) End of Phase 2 meeting by year end Initiate Phase 3 study in 1H 2027

SANRECO Results Support Potential Best-in-Class Treatment for Phlebotomy-Dependent PV Patients Phase 2 profile supports potential best-in-class positioning in phlebotomy-dependent PV

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