<?xml version="1.0" encoding="us-ascii"?>
<!-- XBRL document created with Praxa -->
<!-- Copyright (c) 2026 Praxa LLC. All Rights Reserved.-->
<!-- Creation Date: 2026-08-10T21:19:16.6092+00:00 -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/notAll" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#notAll" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/OtherIncomeNetScheduleofOtherIncomeNetDetails" xlink:href="ormp-20260630.xsd#OtherIncomeNetScheduleofOtherIncomeNetDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" xlink:href="ormp-20260630.xsd#InterimCondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/SignificantAccountingPoliciesDetails" xlink:href="ormp-20260630.xsd#SignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/SignificantAccountingPoliciesScheduleofFairValueMeasurementsonaRecurringBasisDetails" xlink:href="ormp-20260630.xsd#SignificantAccountingPoliciesScheduleofFairValueMeasurementsonaRecurringBasisDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/GeneralDetails" xlink:href="ormp-20260630.xsd#GeneralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/LoanAgreementMeasuredinFairValueDetails" xlink:href="ormp-20260630.xsd#LoanAgreementMeasuredinFairValueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueDetails" xlink:href="ormp-20260630.xsd#InvestmentinAssociateatFairValueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/CommitmentsDetails" xlink:href="ormp-20260630.xsd#CommitmentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofAssumptionsandEstimatesValueDetails" xlink:href="ormp-20260630.xsd#InvestmentsatFairValueScheduleofAssumptionsandEstimatesValueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueCompositionDetails" xlink:href="ormp-20260630.xsd#InvestmentsatFairValueScheduleofFairValueCompositionDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofRefinancingTransactionDetails" xlink:href="ormp-20260630.xsd#InvestmentsatFairValueScheduleofRefinancingTransactionDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueDetails" xlink:href="ormp-20260630.xsd#InvestmentsatFairValueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/MarketableSecuritiesDetails" xlink:href="ormp-20260630.xsd#MarketableSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofValuationoftheWarrantsDetails" xlink:href="ormp-20260630.xsd#InvestmentinAssociateatFairValueScheduleofValuationoftheWarrantsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/LoantoanEquityMethodInvesteeDetails" xlink:href="ormp-20260630.xsd#LoantoanEquityMethodInvesteeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofFinancialInformationDetails" xlink:href="ormp-20260630.xsd#InvestmentinAssociateatFairValueScheduleofFinancialInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/StockholdersEquityDetails" xlink:href="ormp-20260630.xsd#StockholdersEquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/RelatedPartyTransactionsDetails" xlink:href="ormp-20260630.xsd#RelatedPartyTransactionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/SubsequentEventsDetails" xlink:href="ormp-20260630.xsd#SubsequentEventsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/FinancialIncomeNetScheduleofFinancialIncomeNetDetails" xlink:href="ormp-20260630.xsd#FinancialIncomeNetScheduleofFinancialIncomeNetDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedBalanceSheetsUnaudited" xlink:href="ormp-20260630.xsd#InterimCondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/MarketableSecuritiesScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesDetails" xlink:href="ormp-20260630.xsd#MarketableSecuritiesScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueBreakdownDetails" xlink:href="ormp-20260630.xsd#InvestmentsatFairValueScheduleofFairValueBreakdownDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://oramed.com/20260630/role/IncomePerShareofCommonStockDetails" xlink:href="ormp-20260630.xsd#IncomePerShareofCommonStockDetails" xlink:type="simple" />
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/OtherIncomeNetScheduleofOtherIncomeNetDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AlphaTauWarrantMember" xlink:label="ormp_AlphaTauWarrantMember_2361" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_CapitalGainFromSaleOfIPMember" xlink:label="ormp_CapitalGainFromSaleOfIPMember_2363" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ClinicalTrialManagementAgreementMember" xlink:label="ormp_ClinicalTrialManagementAgreementMember_2368" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MedicoxLicenseAgreementsMember" xlink:label="ormp_MedicoxLicenseAgreementsMember_2364" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIncomeAndExpensesAbstract" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract_2357" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis" xlink:label="srt_ProductOrServiceAxis_2359" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain" xlink:label="srt_ProductsAndServicesDomain_2360" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfOtherIncomeNetLineItems" xlink:label="ormp_ScheduleOfOtherIncomeNetLineItems_2365" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIncome" xlink:label="us-gaap_OtherIncome_2366" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_OtherIncomeNetTable" xlink:label="ormp_OtherIncomeNetTable_2367" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain" xlink:label="srt_ProductsAndServicesDomain_2360_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ProductsAndServicesDomain_2360" xlink:to="ormp_AlphaTauWarrantMember_2361" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ProductsAndServicesDomain_2360" xlink:to="ormp_CapitalGainFromSaleOfIPMember_2363" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ProductsAndServicesDomain_2360" xlink:to="ormp_ClinicalTrialManagementAgreementMember_2368" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ProductsAndServicesDomain_2360" xlink:to="ormp_MedicoxLicenseAgreementsMember_2364" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_OtherIncomeNetTable_2367" xlink:to="srt_ProductOrServiceAxis_2359" />
    <link:definitionArc xlink:type="arc" order="242.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_ProductOrServiceAxis_2359" xlink:to="srt_ProductsAndServicesDomain_2360" />
    <link:definitionArc xlink:type="arc" order="248.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_ScheduleOfOtherIncomeNetLineItems_2365" xlink:to="us-gaap_OtherIncome_2366" />
    <link:definitionArc xlink:type="arc" order="249.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="ormp_ScheduleOfOtherIncomeNetLineItems_2365" xlink:to="ormp_OtherIncomeNetTable_2367" />
    <link:definitionArc xlink:type="arc" order="242.00000" priority="1" xbrldt:closed="true" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_ProductOrServiceAxis_2359" xlink:to="srt_ProductsAndServicesDomain_2360_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InterimCondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyMember" xlink:label="us-gaap_RelatedPartyMember_2201" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ConvertibleNoteCurrent" xlink:label="ormp_ConvertibleNoteCurrent_1029" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent_1031" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="us-gaap_AssetsNoncurrentAbstract_1032" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepositsAssetsNoncurrent" xlink:label="us-gaap_DepositsAssetsNoncurrent_1033" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentOwnedAtFairValue" xlink:label="us-gaap_InvestmentOwnedAtFairValue_1035" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent_1052" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent" xlink:label="us-gaap_ContractWithCustomerLiabilityNoncurrent_1054" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncome" xlink:label="us-gaap_DeferredIncome_1055" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_1025" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepositsAssetsCurrent" xlink:label="us-gaap_DepositsAssetsCurrent_1026" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures" xlink:label="us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_1036" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestmentsFairValueDisclosure" xlink:label="us-gaap_EquityMethodInvestmentsFairValueDisclosure_1037" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFVNINoncurrent" xlink:label="us-gaap_EquitySecuritiesFVNINoncurrent_1040" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsNoncurrent" xlink:label="us-gaap_AssetsNoncurrent_1044" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets_1045" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="us-gaap_LiabilitiesCurrentAbstract_1046" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_1047" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent" xlink:label="us-gaap_ContractWithCustomerLiabilityCurrent_1049" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableCurrent" xlink:label="us-gaap_DividendsPayableCurrent_1050" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity_1067" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="us-gaap_EquitySecuritiesFvNi_1028" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="us-gaap_AssetsCurrentAbstract_1024" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_EmployeeRightsUponRetirementNoncurrent" xlink:label="ormp_EmployeeRightsUponRetirementNoncurrent_1056" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="us-gaap_DividendsPayableCurrentAndNoncurrent_1058" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="us-gaap_DeferredIncomeTaxLiabilitiesNet_1059" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies_1061" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue_1063" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock_1064" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1030" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesNoncurrent" xlink:label="us-gaap_MarketableSecuritiesNoncurrent_1034" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivablesNetCurrent" xlink:label="us-gaap_OtherReceivablesNetCurrent_2195" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable_2197" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems_2198" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2199" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_2200" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_1051" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="us-gaap_LiabilitiesNoncurrentAbstract_1053" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="us-gaap_MarketableSecuritiesCurrent_1027" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLongTermInvestments" xlink:label="us-gaap_OtherLongTermInvestments_1039" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent_1041" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_1042" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_1043" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NotesPayableCurrent" xlink:label="us-gaap_NotesPayableCurrent_1048" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_1065" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1066" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="us-gaap_StatementOfFinancialPositionAbstract_1023" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_1057" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="us-gaap_LiabilitiesNoncurrent_1060" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="us-gaap_StockholdersEquityAbstract_1062" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_2200_default" />
    <link:definitionArc xlink:type="arc" order="115.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_2200" xlink:to="us-gaap_RelatedPartyMember_2201" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="ormp_ConvertibleNoteCurrent_1029" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_AssetsCurrent_1031" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_AssetsNoncurrentAbstract_1032" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_DepositsAssetsNoncurrent_1033" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_InvestmentOwnedAtFairValue_1035" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_LiabilitiesCurrent_1052" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_ContractWithCustomerLiabilityNoncurrent_1054" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_DeferredIncome_1055" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue_1025" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_DepositsAssetsCurrent_1026" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_1036" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_EquityMethodInvestmentsFairValueDisclosure_1037" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_EquitySecuritiesFVNINoncurrent_1040" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_AssetsNoncurrent_1044" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_Assets_1045" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_LiabilitiesCurrentAbstract_1046" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_1047" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_ContractWithCustomerLiabilityCurrent_1049" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_DividendsPayableCurrent_1050" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StockholdersEquityAbstract_1062" xlink:to="us-gaap_LiabilitiesAndStockholdersEquity_1067" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_EquitySecuritiesFvNi_1028" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_AssetsCurrentAbstract_1024" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="ormp_EmployeeRightsUponRetirementNoncurrent_1056" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_DividendsPayableCurrentAndNoncurrent_1058" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_DeferredIncomeTaxLiabilitiesNet_1059" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_CommitmentsAndContingencies_1061" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StockholdersEquityAbstract_1062" xlink:to="us-gaap_CommonStockValue_1063" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StockholdersEquityAbstract_1062" xlink:to="us-gaap_AdditionalPaidInCapitalCommonStock_1064" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1030" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_MarketableSecuritiesNoncurrent_1034" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_OtherReceivablesNetCurrent_2195" />
    <link:definitionArc xlink:type="arc" order="113.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_StatementTable_2197" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_StatementTable_2197" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2199" />
    <link:definitionArc xlink:type="arc" order="114.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2199" xlink:to="us-gaap_RelatedPartyDomain_2200" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent_1051" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_LiabilitiesNoncurrentAbstract_1053" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsCurrentAbstract_1024" xlink:to="us-gaap_MarketableSecuritiesCurrent_1027" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_OtherLongTermInvestments_1039" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_OtherAssetsNoncurrent_1041" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_PropertyPlantAndEquipmentNet_1042" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AssetsNoncurrentAbstract_1032" xlink:to="us-gaap_OperatingLeaseRightOfUseAsset_1043" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract_1046" xlink:to="us-gaap_NotesPayableCurrent_1048" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StockholdersEquityAbstract_1062" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit_1065" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StockholdersEquityAbstract_1062" xlink:to="us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1066" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent_1057" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract_1053" xlink:to="us-gaap_LiabilitiesNoncurrent_1060" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_2198" xlink:to="us-gaap_StockholdersEquityAbstract_1062" />
    <link:definitionArc xlink:type="arc" order="114.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_2199" xlink:to="us-gaap_RelatedPartyDomain_2200_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InterimCondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember_1095" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="us-gaap_AdditionalPaidInCapitalMember_1096" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember" xlink:label="us-gaap_RetainedEarningsMember_1097" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParentMember" xlink:label="us-gaap_ParentMember_1098" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="us-gaap_NoncontrollingInterestMember_1099" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="us-gaap_StatementEquityComponentsAxis_1094" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1100" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract_1092" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable_1093" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1102" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:label="us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_1104" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation" xlink:label="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_1105" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares" xlink:label="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_2203" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue" xlink:label="us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_2205" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems_1101" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="us-gaap_CommonStockSharesOutstanding_1103" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_1106" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AccumulatedDeficitForfeitedDividend" xlink:label="ormp_AccumulatedDeficitForfeitedDividend_1107" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss_1108" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_StockIssuedDuringPeriodValueStockBasedCompensationOfSubsidiary" xlink:label="ormp_StockIssuedDuringPeriodValueStockBasedCompensationOfSubsidiary_2211" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_StockIssuedDuringPeriodSharesStockBasedCompensationOfSubsidiary" xlink:label="ormp_StockIssuedDuringPeriodSharesStockBasedCompensationOfSubsidiary_2212" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1100_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1100" xlink:to="us-gaap_CommonStockMember_1095" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1100" xlink:to="us-gaap_AdditionalPaidInCapitalMember_1096" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1100" xlink:to="us-gaap_RetainedEarningsMember_1097" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1100" xlink:to="us-gaap_ParentMember_1098" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1100" xlink:to="us-gaap_NoncontrollingInterestMember_1099" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_StatementTable_1093" xlink:to="us-gaap_StatementEquityComponentsAxis_1094" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementEquityComponentsAxis_1094" xlink:to="us-gaap_EquityComponentDomain_1100" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StatementTable_1093" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1102" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_1104" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_1105" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_2203" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_2205" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_CommonStockSharesOutstanding_1103" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_1106" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="ormp_AccumulatedDeficitForfeitedDividend_1107" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="us-gaap_ProfitLoss_1108" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="ormp_StockIssuedDuringPeriodValueStockBasedCompensationOfSubsidiary_2211" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems_1101" xlink:to="ormp_StockIssuedDuringPeriodSharesStockBasedCompensationOfSubsidiary_2212" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementEquityComponentsAxis_1094" xlink:to="us-gaap_EquityComponentDomain_1100_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/SignificantAccountingPoliciesDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AlphaTauMember" xlink:label="ormp_AlphaTauMember_1539" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1541" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MedicoxLicenseAgreementMember" xlink:label="ormp_MedicoxLicenseAgreementMember_1543" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ClinicalTrialManagementAgreementWithOratechLtdMember" xlink:label="ormp_ClinicalTrialManagementAgreementWithOratechLtdMember_2237" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember" xlink:label="us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember_2241" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_OraTechLtdMember" xlink:label="ormp_OraTechLtdMember_2244" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1534" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1535" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1536" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AlphaTauMember" xlink:label="ormp_AlphaTauMember_1546" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="srt_EquityMethodInvesteeNameDomain_1538" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1540" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1544" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncome" xlink:label="us-gaap_DeferredIncome_1553" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_StraightlineIncomeRecognition" xlink:label="ormp_StraightlineIncomeRecognition_1554" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfAssets1" xlink:label="us-gaap_GainLossOnDispositionOfAssets1_1555" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NonRefundableConsideration" xlink:label="ormp_NonRefundableConsideration_1556" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIncome" xlink:label="us-gaap_OtherIncome_1557" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="srt_ConsolidatedEntitiesAxis_2239" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="srt_ConsolidatedEntitiesDomain_2240" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestReceivable" xlink:label="us-gaap_InterestReceivable_2242" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Cash" xlink:label="us-gaap_Cash_2245" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ExcessCost" xlink:label="ormp_ExcessCost_2247" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ServiceExpenses" xlink:label="ormp_ServiceExpenses_2253" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage_1558" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_1537" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1545" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ChangeInAccountingEstimateLineItems" xlink:label="us-gaap_ChangeInAccountingEstimateLineItems_1547" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1548" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_1549" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncome" xlink:label="us-gaap_OtherNoncashIncome_1550" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="us-gaap_OtherNoncashIncomeExpense_1551" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeRevenueRecognized" xlink:label="us-gaap_DeferredIncomeRevenueRecognized_1552" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="us-gaap_AccountingPoliciesAbstract_1531" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SignificantAccountingPoliciesDetailsTable" xlink:label="ormp_SignificantAccountingPoliciesDetailsTable_1532" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1533" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1541_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1534_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="srt_EquityMethodInvesteeNameDomain_1538_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="srt_ConsolidatedEntitiesDomain_2240_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1545_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_EquityMethodInvesteeNameDomain_1538" xlink:to="ormp_AlphaTauMember_1539" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1540" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1541" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1541" xlink:to="ormp_MedicoxLicenseAgreementMember_1543" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1545" xlink:to="ormp_ClinicalTrialManagementAgreementWithOratechLtdMember_2237" />
    <link:definitionArc xlink:type="arc" order="146.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ConsolidatedEntitiesDomain_2240" xlink:to="us-gaap_VariableInterestEntityNotPrimaryBeneficiaryMember_2241" />
    <link:definitionArc xlink:type="arc" order="149.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1545" xlink:to="ormp_OraTechLtdMember_2244" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1533" xlink:to="srt_RangeMember_1534" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1534" xlink:to="srt_MinimumMember_1535" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1534" xlink:to="srt_MaximumMember_1536" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1545" xlink:to="ormp_AlphaTauMember_1546" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_1537" xlink:to="srt_EquityMethodInvesteeNameDomain_1538" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SignificantAccountingPoliciesDetailsTable_1532" xlink:to="us-gaap_TypeOfArrangementAxis_1540" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SignificantAccountingPoliciesDetailsTable_1532" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1544" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_DeferredIncome_1553" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="ormp_StraightlineIncomeRecognition_1554" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_GainLossOnDispositionOfAssets1_1555" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="ormp_NonRefundableConsideration_1556" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_OtherIncome_1557" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SignificantAccountingPoliciesDetailsTable_1532" xlink:to="srt_ConsolidatedEntitiesAxis_2239" />
    <link:definitionArc xlink:type="arc" order="145.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_ConsolidatedEntitiesAxis_2239" xlink:to="srt_ConsolidatedEntitiesDomain_2240" />
    <link:definitionArc xlink:type="arc" order="147.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_InterestReceivable_2242" />
    <link:definitionArc xlink:type="arc" order="150.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_Cash_2245" />
    <link:definitionArc xlink:type="arc" order="152.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="ormp_ExcessCost_2247" />
    <link:definitionArc xlink:type="arc" order="156.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="ormp_ServiceExpenses_2253" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage_1558" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SignificantAccountingPoliciesDetailsTable_1532" xlink:to="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_1537" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1544" xlink:to="us-gaap_RelatedPartyDomain_1545" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1548" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_FairValueAdjustmentOfWarrants_1549" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_OtherNoncashIncome_1550" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_OtherNoncashIncomeExpense_1551" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="us-gaap_DeferredIncomeRevenueRecognized_1552" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ChangeInAccountingEstimateLineItems_1547" xlink:to="ormp_SignificantAccountingPoliciesDetailsTable_1532" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SignificantAccountingPoliciesDetailsTable_1532" xlink:to="srt_RangeAxis_1533" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1540" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1541_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1533" xlink:to="srt_RangeMember_1534_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_1537" xlink:to="srt_EquityMethodInvesteeNameDomain_1538_default" />
    <link:definitionArc xlink:type="arc" order="145.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_ConsolidatedEntitiesAxis_2239" xlink:to="srt_ConsolidatedEntitiesDomain_2240_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1544" xlink:to="us-gaap_RelatedPartyDomain_1545_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/SignificantAccountingPoliciesScheduleofFairValueMeasurementsonaRecurringBasisDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_EightyThreeWytheLoanMember" xlink:label="ormp_EightyThreeWytheLoanMember_2250" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_DNAMember" xlink:label="ormp_DNAMember_1272" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ConvertibleNoteMember" xlink:label="ormp_ConvertibleNoteMember_1287" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="us-gaap_FairValueMeasurementsRecurringMember_1264" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="us-gaap_FairValueInputsLevel1Member_1267" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="us-gaap_FairValueInputsLevel2Member_1268" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_EnteraMember" xlink:label="ormp_EnteraMember_1273" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PelthosMember" xlink:label="ormp_PelthosMember_1274" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanoMember" xlink:label="ormp_NanoMember_1275" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanosPutOptionsAndWrittenCallOptionsNetMember" xlink:label="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember_1276" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RubyCapitalMember" xlink:label="ormp_RubyCapitalMember_1277" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RoyaltyPurchaseAgreementMember" xlink:label="ormp_RoyaltyPurchaseAgreementMember_1278" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInAlphaTausSharesMember" xlink:label="ormp_InvestmentInAlphaTausSharesMember_1285" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanToAnEquityMethodInvesteeMember" xlink:label="ormp_LoanToAnEquityMethodInvesteeMember_1286" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInSharesMember" xlink:label="ormp_InvestmentInSharesMember_2314" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInARPreFundedWarrantsMember" xlink:label="ormp_InvestmentInARPreFundedWarrantsMember_2315" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInARWarrantsMember" xlink:label="ormp_InvestmentInARWarrantsMember_2316" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInARNoteAndNoteWarrantsMember" xlink:label="ormp_InvestmentInARNoteAndNoteWarrantsMember_2317" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="us-gaap_FairValueInputsLevel3Member_1269" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheANoteMember" xlink:label="ormp_TrancheANoteMember_1279" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBNoteMember" xlink:label="ormp_TrancheBNoteMember_1280" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_WarrantsNoteBMember" xlink:label="ormp_WarrantsNoteBMember_1281" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInAlphaTausWarrantsMember" xlink:label="ormp_InvestmentInAlphaTausWarrantsMember_1282" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ProfitSharingLoanAgreementMember" xlink:label="ormp_ProfitSharingLoanAgreementMember_1283" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanAgreementMeasuredInFairValueMember" xlink:label="ormp_LoanAgreementMeasuredInFairValueMember_1284" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_WarrenAtBayLoanMember" xlink:label="ormp_WarrenAtBayLoanMember_2249" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract" xlink:label="ormp_ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract_1261" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1262" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis_1263" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_1265" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInSharesAndOtherInstruments" xlink:label="ormp_InvestmentInSharesAndOtherInstruments_2321" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1288" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesAbstract" xlink:label="us-gaap_MarketableSecuritiesAbstract_1289" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract" xlink:label="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract_2312" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain_2182" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InformationByCategoryOfDebtSecurityAxis" xlink:label="us-gaap_InformationByCategoryOfDebtSecurityAxis_1270" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InformationByCategoryOfDebtSecurityDomainDomain" xlink:label="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosureAbstract" xlink:label="us-gaap_InvestmentsFairValueDisclosureAbstract_1291" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosure" xlink:label="us-gaap_InvestmentsFairValueDisclosure_1292" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecurities" xlink:label="us-gaap_MarketableSecurities_1290" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain_2182_default" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InformationByCategoryOfDebtSecurityDomainDomain" xlink:label="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271_default" />
    <link:definitionArc xlink:type="arc" order="23.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_EightyThreeWytheLoanMember_2250" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_DNAMember_1272" />
    <link:definitionArc xlink:type="arc" order="28.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_ConvertibleNoteMember_1287" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementFrequencyDomain_2182" xlink:to="us-gaap_FairValueMeasurementsRecurringMember_1264" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266" xlink:to="us-gaap_FairValueInputsLevel1Member_1267" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266" xlink:to="us-gaap_FairValueInputsLevel2Member_1268" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_EnteraMember_1273" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_PelthosMember_1274" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_NanoMember_1275" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember_1276" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_RubyCapitalMember_1277" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_RoyaltyPurchaseAgreementMember_1278" />
    <link:definitionArc xlink:type="arc" order="26.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInAlphaTausSharesMember_1285" />
    <link:definitionArc xlink:type="arc" order="27.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_LoanToAnEquityMethodInvesteeMember_1286" />
    <link:definitionArc xlink:type="arc" order="29.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInSharesMember_2314" />
    <link:definitionArc xlink:type="arc" order="30.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInARPreFundedWarrantsMember_2315" />
    <link:definitionArc xlink:type="arc" order="31.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInARWarrantsMember_2316" />
    <link:definitionArc xlink:type="arc" order="32.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInARNoteAndNoteWarrantsMember_2317" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266" xlink:to="us-gaap_FairValueInputsLevel3Member_1269" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_TrancheANoteMember_1279" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_TrancheBNoteMember_1280" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_WarrantsNoteBMember_1281" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_InvestmentInAlphaTausWarrantsMember_1282" />
    <link:definitionArc xlink:type="arc" order="24.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_ProfitSharingLoanAgreementMember_1283" />
    <link:definitionArc xlink:type="arc" order="25.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_LoanAgreementMeasuredInFairValueMember_1284" />
    <link:definitionArc xlink:type="arc" order="22.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" xlink:to="ormp_WarrenAtBayLoanMember_2249" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1288" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1262" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1262" xlink:to="us-gaap_FairValueByMeasurementFrequencyAxis_1263" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1262" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis_1265" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis_1265" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266" />
    <link:definitionArc xlink:type="arc" order="217.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract_2312" xlink:to="ormp_InvestmentInSharesAndOtherInstruments_2321" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1288" xlink:to="us-gaap_MarketableSecuritiesAbstract_1289" />
    <link:definitionArc xlink:type="arc" order="209.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1288" xlink:to="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract_2312" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByMeasurementFrequencyAxis_1263" xlink:to="us-gaap_FairValueMeasurementFrequencyDomain_2182" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1262" xlink:to="us-gaap_InformationByCategoryOfDebtSecurityAxis_1270" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InformationByCategoryOfDebtSecurityAxis_1270" xlink:to="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1288" xlink:to="us-gaap_InvestmentsFairValueDisclosureAbstract_1291" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentsFairValueDisclosureAbstract_1291" xlink:to="us-gaap_InvestmentsFairValueDisclosure_1292" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesAbstract_1289" xlink:to="us-gaap_MarketableSecurities_1290" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis_1265" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1266_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByMeasurementFrequencyAxis_1263" xlink:to="us-gaap_FairValueMeasurementFrequencyDomain_2182_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InformationByCategoryOfDebtSecurityAxis_1270" xlink:to="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1271_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/GeneralDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SeniorSecuredConvertibleNotesMember" xlink:label="ormp_SeniorSecuredConvertibleNotesMember_1509" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalSecuritiesPurchaseAgreementMember" xlink:label="ormp_AdditionalSecuritiesPurchaseAgreementMember_2233" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember" xlink:label="us-gaap_ConvertibleDebtMember_1512" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardOrdinarySharesMember" xlink:label="ormp_LifewardOrdinarySharesMember_1493" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SharePurchaseAgreementMember" xlink:label="ormp_SharePurchaseAgreementMember_1497" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardNotesPurchaseAgreementMember" xlink:label="ormp_LifewardNotesPurchaseAgreementMember_1498" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_OraTechLtdMember" xlink:label="ormp_OraTechLtdMember_1501" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PrefundedWarrantsMember" xlink:label="ormp_PrefundedWarrantsMember_1504" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SharePurchaseWarrantsMember" xlink:label="ormp_SharePurchaseWarrantsMember_1505" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NoteWarrantsMember" xlink:label="ormp_NoteWarrantsMember_1506" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_1519" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfRevenueSharingPayments" xlink:label="ormp_PercentageOfRevenueSharingPayments_1520" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardRevenueShareTerm" xlink:label="ormp_LifewardRevenueShareTerm_1521" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1489" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_GeneralDetailsTable" xlink:label="ormp_GeneralDetailsTable_1490" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis_1507" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1508" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="us-gaap_LongtermDebtTypeAxis_1510" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ConsecutiveTradingDays" xlink:label="ormp_ConsecutiveTradingDays_1529" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_1511" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationDateOfIncorporation" xlink:label="dei_EntityIncorporationDateOfIncorporation_1514" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfPreFundedWarrants" xlink:label="ormp_PercentageOfPreFundedWarrants_1522" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod" xlink:label="ormp_ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod_1524" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentIssuedPrincipal" xlink:label="us-gaap_DebtInstrumentIssuedPrincipal_1525" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="us-gaap_DebtInstrumentConvertibleConversionPrice1_1526" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_WarrantsExpirationTerm" xlink:label="ormp_WarrantsExpirationTerm_1527" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_IncreaseInWarrantPercentage" xlink:label="ormp_IncreaseInWarrantPercentage_1528" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis_1491" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain_1492" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1495" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="us-gaap_RelatedPartyTransactionAxis_1499" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1500" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_1502" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1503" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities" xlink:label="ormp_FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities_1515" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesOther" xlink:label="us-gaap_StockIssuedDuringPeriodSharesOther_1516" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_OutstandingPercentage" xlink:label="ormp_OutstandingPercentage_1517" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1518" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1508_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_1511_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain_1492_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1500_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1503_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1508" xlink:to="ormp_SeniorSecuredConvertibleNotesMember_1509" />
    <link:definitionArc xlink:type="arc" order="139.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496" xlink:to="ormp_AdditionalSecuritiesPurchaseAgreementMember_2233" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LongtermDebtTypeDomain_1511" xlink:to="us-gaap_ConvertibleDebtMember_1512" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain_1492" xlink:to="ormp_LifewardOrdinarySharesMember_1493" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1495" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496" xlink:to="ormp_SharePurchaseAgreementMember_1497" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496" xlink:to="ormp_LifewardNotesPurchaseAgreementMember_1498" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1500" xlink:to="ormp_OraTechLtdMember_1501" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1503" xlink:to="ormp_PrefundedWarrantsMember_1504" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1503" xlink:to="ormp_SharePurchaseWarrantsMember_1505" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1503" xlink:to="ormp_NoteWarrantsMember_1506" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_1519" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_PercentageOfRevenueSharingPayments_1520" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_LifewardRevenueShareTerm_1521" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_GeneralDetailsTable_1490" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_DebtInstrumentAxis_1507" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DebtInstrumentAxis_1507" xlink:to="us-gaap_DebtInstrumentNameDomain_1508" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_LongtermDebtTypeAxis_1510" />
    <link:definitionArc xlink:type="arc" order="25.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_ConsecutiveTradingDays_1529" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_LongtermDebtTypeAxis_1510" xlink:to="us-gaap_LongtermDebtTypeDomain_1511" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="dei_EntityIncorporationDateOfIncorporation_1514" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_PercentageOfPreFundedWarrants_1522" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod_1524" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="us-gaap_DebtInstrumentIssuedPrincipal_1525" />
    <link:definitionArc xlink:type="arc" order="22.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="us-gaap_DebtInstrumentConvertibleConversionPrice1_1526" />
    <link:definitionArc xlink:type="arc" order="23.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_WarrantsExpirationTerm_1527" />
    <link:definitionArc xlink:type="arc" order="24.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_IncreaseInWarrantPercentage_1528" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_StatementClassOfStockAxis_1491" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis_1491" xlink:to="us-gaap_ClassOfStockDomain_1492" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_TypeOfArrangementAxis_1495" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_RelatedPartyTransactionAxis_1499" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionAxis_1499" xlink:to="us-gaap_RelatedPartyTransactionDomain_1500" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_GeneralDetailsTable_1490" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_1502" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1502" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1503" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities_1515" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="us-gaap_StockIssuedDuringPeriodSharesOther_1516" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="ormp_OutstandingPercentage_1517" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1513" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1518" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1495" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1496_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_DebtInstrumentAxis_1507" xlink:to="us-gaap_DebtInstrumentNameDomain_1508_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_LongtermDebtTypeAxis_1510" xlink:to="us-gaap_LongtermDebtTypeDomain_1511_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis_1491" xlink:to="us-gaap_ClassOfStockDomain_1492_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionAxis_1499" xlink:to="us-gaap_RelatedPartyTransactionDomain_1500_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1502" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1503_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/LoanAgreementMeasuredinFairValueDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember" xlink:label="us-gaap_ConvertibleDebtMember_1706" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1690" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1691" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1692" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1694" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TovaChochmaImNachalaLtdMember" xlink:label="ormp_TovaChochmaImNachalaLtdMember_1703" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanAgreementMember" xlink:label="ormp_LoanAgreementMember_1695" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanAgreementMember" xlink:label="ormp_LoanAgreementMember_1698" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanExtensionMember" xlink:label="ormp_LoanExtensionMember_1699" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NewTalpiotLtdMember" xlink:label="ormp_NewTalpiotLtdMember_1702" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="us-gaap_LongtermDebtTypeAxis_1704" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_1705" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="us-gaap_DebtInstrumentLineItems_1707" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="us-gaap_DebtInstrumentFaceAmount_1708" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_1709" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MortgagesHeldForSaleFairValueDisclosure" xlink:label="us-gaap_MortgagesHeldForSaleFairValueDisclosure_1710" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLoansPayable" xlink:label="us-gaap_OtherLoansPayable_1719" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromLoans" xlink:label="us-gaap_ProceedsFromLoans_1712" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfDebt" xlink:label="us-gaap_RepaymentsOfDebt_1713" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtConversionOriginalDebtAmount1" xlink:label="us-gaap_DebtConversionOriginalDebtAmount1_1714" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod_1715" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AccruedInterest" xlink:label="ormp_AccruedInterest_1716" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RefundedAmount" xlink:label="ormp_RefundedAmount_1717" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfWeightedAverageCashflowsOfLoanDiscounted" xlink:label="ormp_PercentageOfWeightedAverageCashflowsOfLoanDiscounted_1718" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FinancialIncomeRecognized" xlink:label="ormp_FinancialIncomeRecognized_2224" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="us-gaap_DebtDisclosureAbstract_1687" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanAgreementMeasuredinFairValueDetailsTable" xlink:label="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1689" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1693" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis_1696" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1697" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1700" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1701" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MaturityDaysOfLoan" xlink:label="ormp_MaturityDaysOfLoan_1711" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1690_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1694_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_1705_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1697_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1701_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LongtermDebtTypeDomain_1705" xlink:to="us-gaap_ConvertibleDebtMember_1706" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1689" xlink:to="srt_RangeMember_1690" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1690" xlink:to="srt_MinimumMember_1691" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1690" xlink:to="srt_MaximumMember_1692" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1693" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1694" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1701" xlink:to="ormp_TovaChochmaImNachalaLtdMember_1703" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1694" xlink:to="ormp_LoanAgreementMember_1695" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1697" xlink:to="ormp_LoanAgreementMember_1698" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1697" xlink:to="ormp_LoanExtensionMember_1699" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1701" xlink:to="ormp_NewTalpiotLtdMember_1702" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" xlink:to="us-gaap_LongtermDebtTypeAxis_1704" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_LongtermDebtTypeAxis_1704" xlink:to="us-gaap_LongtermDebtTypeDomain_1705" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_DebtInstrumentFaceAmount_1708" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_DebtInstrumentInterestRateStatedPercentage_1709" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_MortgagesHeldForSaleFairValueDisclosure_1710" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_OtherLoansPayable_1719" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_ProceedsFromLoans_1712" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_RepaymentsOfDebt_1713" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_DebtConversionOriginalDebtAmount1_1714" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="us-gaap_DebtInstrumentInterestRateDuringPeriod_1715" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_AccruedInterest_1716" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_RefundedAmount_1717" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_PercentageOfWeightedAverageCashflowsOfLoanDiscounted_1718" />
    <link:definitionArc xlink:type="arc" order="130.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_FinancialIncomeRecognized_2224" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" xlink:to="srt_RangeAxis_1689" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" xlink:to="us-gaap_TypeOfArrangementAxis_1693" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" xlink:to="us-gaap_DebtInstrumentAxis_1696" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DebtInstrumentAxis_1696" xlink:to="us-gaap_DebtInstrumentNameDomain_1697" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoanAgreementMeasuredinFairValueDetailsTable_1688" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1700" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1700" xlink:to="us-gaap_RelatedPartyDomain_1701" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentLineItems_1707" xlink:to="ormp_MaturityDaysOfLoan_1711" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1689" xlink:to="srt_RangeMember_1690_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1693" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1694_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_LongtermDebtTypeAxis_1704" xlink:to="us-gaap_LongtermDebtTypeDomain_1705_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_DebtInstrumentAxis_1696" xlink:to="us-gaap_DebtInstrumentNameDomain_1697_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1700" xlink:to="us-gaap_RelatedPartyDomain_1701_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1724" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1725" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1726" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AlphaTauMember" xlink:label="ormp_AlphaTauMember_1735" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="us-gaap_ConvertibleDebtSecuritiesMember_2396" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1728" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SharePurchaseAgreementMember" xlink:label="ormp_SharePurchaseAgreementMember_1729" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ALPHATauWarrantsMember" xlink:label="ormp_ALPHATauWarrantsMember_1732" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardOrdinarySharesMember" xlink:label="ormp_LifewardOrdinarySharesMember_2375" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NoteWarrantsMember" xlink:label="ormp_NoteWarrantsMember_2376" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteeMember" xlink:label="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteeMember_2377" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_2379" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NasdaqCapitalMarketMember" xlink:label="ormp_NasdaqCapitalMarketMember_2380" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AmendedAndRestatedPreFundWarrantMember" xlink:label="ormp_AmendedAndRestatedPreFundWarrantMember_2383" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AmendedAndRestatedWarrantMember" xlink:label="ormp_AmendedAndRestatedWarrantMember_2384" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PrefundedWarrantsMember" xlink:label="ormp_PrefundedWarrantsMember_2392" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SecuredPromissoryNoteMember" xlink:label="ormp_SecuredPromissoryNoteMember_2393" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosureAbstract" xlink:label="us-gaap_InvestmentsFairValueDisclosureAbstract_1721" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentinAssociateatFairValueDetailsTable" xlink:label="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1723" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1727" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentInAffiliateActivityLineItems" xlink:label="us-gaap_InvestmentInAffiliateActivityLineItems_1736" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1737" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfOrdinaryShares" xlink:label="ormp_PercentageOfOrdinaryShares_1738" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="us-gaap_SaleOfStockPricePerShare_1739" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_1740" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NonRefundableFee" xlink:label="ormp_NonRefundableFee_1741" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_2395" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PromissoryNote" xlink:label="ormp_PromissoryNote_2397" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalPrincipalAmount" xlink:label="ormp_AdditionalPrincipalAmount_2398" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AnnumAndSecuredInterestPercentage" xlink:label="ormp_AnnumAndSecuredInterestPercentage_2399" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAdditionalCapital" xlink:label="us-gaap_OtherAdditionalCapital_2400" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalCashPayment" xlink:label="ormp_AdditionalCashPayment_2401" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="us-gaap_OtherNoncashIncomeExpense_2402" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfDiscountRate" xlink:label="ormp_PercentageOfDiscountRate_2403" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_1730" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1731" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockOtherSharesOutstanding" xlink:label="us-gaap_CommonStockOtherSharesOutstanding_2373" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_OrdinarySharesClosingPercentage" xlink:label="ormp_OrdinarySharesClosingPercentage_2374" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis_2378" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:label="us-gaap_FairValueOptionChangesInFairValueGainLoss1_2381" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFairValue" xlink:label="us-gaap_DebtInstrumentFairValue_2382" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardRevenue" xlink:label="ormp_LifewardRevenue_2385" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleNotesPayable" xlink:label="us-gaap_ConvertibleNotesPayable_2386" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfBearingInterestPerAnnum" xlink:label="ormp_PercentageOfBearingInterestPerAnnum_2387" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentMaturityDate" xlink:label="us-gaap_InvestmentMaturityDate_2388" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="us-gaap_DebtInstrumentConvertibleConversionPrice1_2389" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1733" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1734" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1742" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_1743" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosure" xlink:label="us-gaap_InvestmentsFairValueDisclosure_1744" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="us-gaap_SharesIssuedPricePerShare_1745" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfVotingInterest" xlink:label="ormp_PercentageOfVotingInterest_1746" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_1747" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UnrealizedGainLossOnInvestments" xlink:label="us-gaap_UnrealizedGainLossOnInvestments_1748" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis_2390" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_2391" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="us-gaap_LongtermDebtTypeAxis_2394" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1724_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1728_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_2379_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain_2395_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1731_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1734_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_2391_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1723" xlink:to="srt_RangeMember_1724" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1724" xlink:to="srt_MinimumMember_1725" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1724" xlink:to="srt_MaximumMember_1726" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1734" xlink:to="ormp_AlphaTauMember_1735" />
    <link:definitionArc xlink:type="arc" order="273.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LongtermDebtTypeDomain_2395" xlink:to="us-gaap_ConvertibleDebtSecuritiesMember_2396" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1727" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1728" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1728" xlink:to="ormp_SharePurchaseAgreementMember_1729" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1731" xlink:to="ormp_ALPHATauWarrantsMember_1732" />
    <link:definitionArc xlink:type="arc" order="254.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1734" xlink:to="ormp_LifewardOrdinarySharesMember_2375" />
    <link:definitionArc xlink:type="arc" order="255.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1734" xlink:to="ormp_NoteWarrantsMember_2376" />
    <link:definitionArc xlink:type="arc" order="256.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1734" xlink:to="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteeMember_2377" />
    <link:definitionArc xlink:type="arc" order="258.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InvestmentTypeAxis_2378" xlink:to="us-gaap_InvestmentTypeCategorizationMember_2379" />
    <link:definitionArc xlink:type="arc" order="259.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_2379" xlink:to="ormp_NasdaqCapitalMarketMember_2380" />
    <link:definitionArc xlink:type="arc" order="260.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1731" xlink:to="ormp_AmendedAndRestatedPreFundWarrantMember_2383" />
    <link:definitionArc xlink:type="arc" order="261.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1731" xlink:to="ormp_AmendedAndRestatedWarrantMember_2384" />
    <link:definitionArc xlink:type="arc" order="269.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_2391" xlink:to="ormp_PrefundedWarrantsMember_2392" />
    <link:definitionArc xlink:type="arc" order="270.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_2391" xlink:to="ormp_SecuredPromissoryNoteMember_2393" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="srt_RangeAxis_1723" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_TypeOfArrangementAxis_1727" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1737" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_PercentageOfOrdinaryShares_1738" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_SaleOfStockPricePerShare_1739" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_StockIssuedDuringPeriodValueNewIssues_1740" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_NonRefundableFee_1741" />
    <link:definitionArc xlink:type="arc" order="272.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_LongtermDebtTypeAxis_2394" xlink:to="us-gaap_LongtermDebtTypeDomain_2395" />
    <link:definitionArc xlink:type="arc" order="274.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_PromissoryNote_2397" />
    <link:definitionArc xlink:type="arc" order="275.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_AdditionalPrincipalAmount_2398" />
    <link:definitionArc xlink:type="arc" order="276.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_AnnumAndSecuredInterestPercentage_2399" />
    <link:definitionArc xlink:type="arc" order="277.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_OtherAdditionalCapital_2400" />
    <link:definitionArc xlink:type="arc" order="278.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_AdditionalCashPayment_2401" />
    <link:definitionArc xlink:type="arc" order="279.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_OtherNoncashIncomeExpense_2402" />
    <link:definitionArc xlink:type="arc" order="280.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_PercentageOfDiscountRate_2403" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_1730" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1730" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1731" />
    <link:definitionArc xlink:type="arc" order="22.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_CommonStockOtherSharesOutstanding_2373" />
    <link:definitionArc xlink:type="arc" order="253.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_OrdinarySharesClosingPercentage_2374" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_InvestmentTypeAxis_2378" />
    <link:definitionArc xlink:type="arc" order="254.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_FairValueOptionChangesInFairValueGainLoss1_2381" />
    <link:definitionArc xlink:type="arc" order="255.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_DebtInstrumentFairValue_2382" />
    <link:definitionArc xlink:type="arc" order="262.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_LifewardRevenue_2385" />
    <link:definitionArc xlink:type="arc" order="263.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_ConvertibleNotesPayable_2386" />
    <link:definitionArc xlink:type="arc" order="264.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_PercentageOfBearingInterestPerAnnum_2387" />
    <link:definitionArc xlink:type="arc" order="265.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_InvestmentMaturityDate_2388" />
    <link:definitionArc xlink:type="arc" order="266.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_DebtInstrumentConvertibleConversionPrice1_2389" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1733" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1733" xlink:to="us-gaap_RelatedPartyDomain_1734" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1742" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_1743" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_InvestmentsFairValueDisclosure_1744" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_SharesIssuedPricePerShare_1745" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="ormp_PercentageOfVotingInterest_1746" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_FairValueAdjustmentOfWarrants_1747" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentInAffiliateActivityLineItems_1736" xlink:to="us-gaap_UnrealizedGainLossOnInvestments_1748" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_DebtInstrumentAxis_2390" />
    <link:definitionArc xlink:type="arc" order="268.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DebtInstrumentAxis_2390" xlink:to="us-gaap_DebtInstrumentNameDomain_2391" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentinAssociateatFairValueDetailsTable_1722" xlink:to="us-gaap_LongtermDebtTypeAxis_2394" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1723" xlink:to="srt_RangeMember_1724_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1727" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1728_default" />
    <link:definitionArc xlink:type="arc" order="258.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InvestmentTypeAxis_2378" xlink:to="us-gaap_InvestmentTypeCategorizationMember_2379_default" />
    <link:definitionArc xlink:type="arc" order="272.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_LongtermDebtTypeAxis_2394" xlink:to="us-gaap_LongtermDebtTypeDomain_2395_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1730" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1731_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1733" xlink:to="us-gaap_RelatedPartyDomain_1734_default" />
    <link:definitionArc xlink:type="arc" order="268.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_DebtInstrumentAxis_2390" xlink:to="us-gaap_DebtInstrumentNameDomain_2391_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/CommitmentsDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MedicoxLicenseAgreementMember" xlink:label="ormp_MedicoxLicenseAgreementMember_1799" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1794" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1795" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1796" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1798" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherCommitmentsLineItems" xlink:label="us-gaap_OtherCommitmentsLineItems_1803" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetAcquisitionConsiderationTransferred" xlink:label="us-gaap_AssetAcquisitionConsiderationTransferred_1804" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1791" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_CommitmentsDetailsTable" xlink:label="ormp_CommitmentsDetailsTable_1792" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1793" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_1797" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense_1805" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseDiscountRate" xlink:label="us-gaap_LesseeOperatingLeaseDiscountRate_1810" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1794_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1798_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1798" xlink:to="ormp_MedicoxLicenseAgreementMember_1799" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1793" xlink:to="srt_RangeMember_1794" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1794" xlink:to="srt_MinimumMember_1795" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1794" xlink:to="srt_MaximumMember_1796" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_1797" xlink:to="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1798" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems_1803" xlink:to="us-gaap_AssetAcquisitionConsiderationTransferred_1804" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_OtherCommitmentsLineItems_1803" xlink:to="ormp_CommitmentsDetailsTable_1792" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_CommitmentsDetailsTable_1792" xlink:to="srt_RangeAxis_1793" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_CommitmentsDetailsTable_1792" xlink:to="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_1797" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems_1803" xlink:to="us-gaap_ResearchAndDevelopmentExpense_1805" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems_1803" xlink:to="us-gaap_LesseeOperatingLeaseDiscountRate_1810" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1793" xlink:to="srt_RangeMember_1794_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_1797" xlink:to="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1798_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/LoantoanEquityMethodInvesteeDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RoyaltyVestMember" xlink:label="ormp_RoyaltyVestMember_1679" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromInvestments" xlink:label="us-gaap_PaymentsForProceedsFromInvestments_1685" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanNetLoss" xlink:label="ormp_LoanNetLoss_2323" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="us-gaap_PaymentsToAcquireEquityMethodInvestments_1684" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_2190" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfIssuedAndOutstandingCapitalStock" xlink:label="ormp_PercentageOfIssuedAndOutstandingCapitalStock_1681" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestments" xlink:label="us-gaap_EquityMethodInvestments_1682" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoanToAnEquityMethodInvesteeAbstract" xlink:label="ormp_LoanToAnEquityMethodInvesteeAbstract_1676" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LoantoanEquityMethodInvesteeDetailsTable" xlink:label="ormp_LoantoanEquityMethodInvesteeDetailsTable_1677" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameAxis" xlink:label="us-gaap_InvestmentIssuerNameAxis_1678" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_2190_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentIssuerNameDomain_2190" xlink:to="ormp_RoyaltyVestMember_1679" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="us-gaap_PaymentsForProceedsFromInvestments_1685" />
    <link:definitionArc xlink:type="arc" order="219.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="ormp_LoanNetLoss_2323" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="us-gaap_PaymentsToAcquireEquityMethodInvestments_1684" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InvestmentIssuerNameAxis_1678" xlink:to="us-gaap_InvestmentIssuerNameDomain_2190" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="ormp_PercentageOfIssuedAndOutstandingCapitalStock_1681" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="us-gaap_EquityMethodInvestments_1682" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1680" xlink:to="ormp_LoantoanEquityMethodInvesteeDetailsTable_1677" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_LoantoanEquityMethodInvesteeDetailsTable_1677" xlink:to="us-gaap_InvestmentIssuerNameAxis_1678" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InvestmentIssuerNameAxis_1678" xlink:to="us-gaap_InvestmentIssuerNameDomain_2190_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofAssumptionsandEstimatesValueDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExercisePriceMember" xlink:label="us-gaap_MeasurementInputExercisePriceMember_1319" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputOptionVolatilityMember" xlink:label="us-gaap_MeasurementInputOptionVolatilityMember_1320" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="us-gaap_MeasurementInputRiskFreeInterestRateMember_1321" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MeasurementInputYieldMember" xlink:label="ormp_MeasurementInputYieldMember_1322" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExpectedTermMember" xlink:label="us-gaap_MeasurementInputExpectedTermMember_1323" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExpectedDividendRateMember" xlink:label="us-gaap_MeasurementInputExpectedDividendRateMember_1324" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBMember" xlink:label="ormp_TrancheBMember_2283" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1312" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1313" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1314" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputSharePriceMember" xlink:label="us-gaap_MeasurementInputSharePriceMember_1316" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputConversionPriceMember" xlink:label="us-gaap_MeasurementInputConversionPriceMember_1317" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MeasurementInputFloorRateMember" xlink:label="ormp_MeasurementInputFloorRateMember_1318" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBWarrantsMember" xlink:label="ormp_TrancheBWarrantsMember_2319" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfAssumptionsAndEstimatesValuationAbstract" xlink:label="ormp_ScheduleOfAssumptionsAndEstimatesValuationAbstract_1309" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable" xlink:label="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable_1310" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_2183" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingAxis" xlink:label="us-gaap_VestingAxis_2288" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2289" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1311" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="us-gaap_MeasurementInputTypeAxis_1315" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems" xlink:label="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems_1328" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_1329" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1312_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_2183_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2289_default" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputExercisePriceMember_1319" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputOptionVolatilityMember_1320" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputRiskFreeInterestRateMember_1321" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="ormp_MeasurementInputYieldMember_1322" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputExpectedTermMember_1323" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputExpectedDividendRateMember_1324" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_2289" xlink:to="ormp_TrancheBMember_2283" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1311" xlink:to="srt_RangeMember_1312" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1312" xlink:to="srt_MinimumMember_1313" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1312" xlink:to="srt_MaximumMember_1314" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputSharePriceMember_1316" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="us-gaap_MeasurementInputConversionPriceMember_1317" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2183" xlink:to="ormp_MeasurementInputFloorRateMember_1318" />
    <link:definitionArc xlink:type="arc" order="215.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_2289" xlink:to="ormp_TrancheBWarrantsMember_2319" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems_1328" xlink:to="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable_1310" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_MeasurementInputTypeAxis_1315" xlink:to="us-gaap_MeasurementInputTypeDomain_2183" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable_1310" xlink:to="us-gaap_VestingAxis_2288" />
    <link:definitionArc xlink:type="arc" order="187.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VestingAxis_2288" xlink:to="us-gaap_VestingDomain_2289" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable_1310" xlink:to="srt_RangeAxis_1311" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable_1310" xlink:to="us-gaap_MeasurementInputTypeAxis_1315" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems_1328" xlink:to="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_1329" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1311" xlink:to="srt_RangeMember_1312_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_MeasurementInputTypeAxis_1315" xlink:to="us-gaap_MeasurementInputTypeDomain_2183_default" />
    <link:definitionArc xlink:type="arc" order="187.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VestingAxis_2288" xlink:to="us-gaap_VestingDomain_2289_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueCompositionDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1334" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember_1336" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RoyaltyPurchaseAgreementMember" xlink:label="ormp_RoyaltyPurchaseAgreementMember_1337" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBMember" xlink:label="ormp_TrancheBMember_2304" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheNoteBMember" xlink:label="ormp_TrancheNoteBMember_2284" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis_1333" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingAxis" xlink:label="us-gaap_VestingAxis_2302" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2303" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfFairValueCompositionAbstract" xlink:label="ormp_ScheduleOfFairValueCompositionAbstract_1331" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable" xlink:label="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable_1332" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="us-gaap_ClassOfWarrantOrRightLineItems_1340" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShorttermDebtFairValue" xlink:label="us-gaap_ShorttermDebtFairValue_1341" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtFairValue" xlink:label="us-gaap_LongTermDebtFairValue_1342" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentOwnedAtFairValue" xlink:label="us-gaap_InvestmentOwnedAtFairValue_1343" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1334_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2303_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InvestmentTypeAxis_1333" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1334" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1334" xlink:to="us-gaap_WarrantMember_1336" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1334" xlink:to="ormp_RoyaltyPurchaseAgreementMember_1337" />
    <link:definitionArc xlink:type="arc" order="201.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_2303" xlink:to="ormp_TrancheBMember_2304" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1334" xlink:to="ormp_TrancheNoteBMember_2284" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable_1332" xlink:to="us-gaap_InvestmentTypeAxis_1333" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable_1332" xlink:to="us-gaap_VestingAxis_2302" />
    <link:definitionArc xlink:type="arc" order="200.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VestingAxis_2302" xlink:to="us-gaap_VestingDomain_2303" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ClassOfWarrantOrRightLineItems_1340" xlink:to="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable_1332" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightLineItems_1340" xlink:to="us-gaap_ShorttermDebtFairValue_1341" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightLineItems_1340" xlink:to="us-gaap_LongTermDebtFairValue_1342" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightLineItems_1340" xlink:to="us-gaap_InvestmentOwnedAtFairValue_1343" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InvestmentTypeAxis_1333" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1334_default" />
    <link:definitionArc xlink:type="arc" order="200.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VestingAxis_2302" xlink:to="us-gaap_VestingDomain_2303_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofRefinancingTransactionDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheAMember" xlink:label="ormp_TrancheAMember_1349" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBMember" xlink:label="ormp_TrancheBMember_1350" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingAxis" xlink:label="us-gaap_VestingAxis_1347" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_1348" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Investments" xlink:label="us-gaap_Investments_1352" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PenaltyPayment" xlink:label="ormp_PenaltyPayment_2285" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfRefinancingTransactionAbstract" xlink:label="ormp_ScheduleOfRefinancingTransactionAbstract_1345" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable" xlink:label="ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable_1346" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_IncomeFromTheRoyaltyAgreement" xlink:label="ormp_IncomeFromTheRoyaltyAgreement_1354" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PrincipalPayments" xlink:label="ormp_PrincipalPayments_1355" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ProceedsFromTheSaleOfSubsequentPennyWarrants" xlink:label="ormp_ProceedsFromTheSaleOfSubsequentPennyWarrants_1356" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InterestPayments" xlink:label="ormp_InterestPayments_1357" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:label="us-gaap_FairValueOptionChangesInFairValueGainLoss1_1358" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_1348_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_1348" xlink:to="ormp_TrancheAMember_1349" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_1348" xlink:to="ormp_TrancheBMember_1350" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable_1346" xlink:to="us-gaap_VestingAxis_1347" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VestingAxis_1347" xlink:to="us-gaap_VestingDomain_1348" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="us-gaap_Investments_1352" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_PenaltyPayment_2285" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable_1346" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_IncomeFromTheRoyaltyAgreement_1354" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_PrincipalPayments_1355" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_ProceedsFromTheSaleOfSubsequentPennyWarrants_1356" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="ormp_InterestPayments_1357" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1351" xlink:to="us-gaap_FairValueOptionChangesInFairValueGainLoss1_1358" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VestingAxis_1347" xlink:to="us-gaap_VestingDomain_1348_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentsatFairValueDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TwoThousandTwentyThreeScilexTransactionMember" xlink:label="ormp_TwoThousandTwentyThreeScilexTransactionMember_1622" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheANoteMember" xlink:label="ormp_TrancheANoteMember_1636" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBMember" xlink:label="ormp_TrancheBMember_1637" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExpectedTermMember" xlink:label="us-gaap_MeasurementInputExpectedTermMember_1611" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MeasurementInputCurveRateMember" xlink:label="ormp_MeasurementInputCurveRateMember_1612" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="us-gaap_MeasurementInputRiskFreeInterestRateMember_1613" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBWarrantsMember" xlink:label="ormp_TrancheBWarrantsMember_1629" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1590" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1591" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1592" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ExtensionAgreementMember" xlink:label="ormp_ExtensionAgreementMember_1595" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ProfitSharingLoanAgreementMember" xlink:label="ormp_ProfitSharingLoanAgreementMember_1596" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember" xlink:label="us-gaap_SubsequentEventMember_2266" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioForecastMember" xlink:label="srt_ScenarioForecastMember_2269" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ExtensionObligationMember" xlink:label="ormp_ExtensionObligationMember_2273" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_JuniorParticipationInterestIn83WytheLoanMember" xlink:label="ormp_JuniorParticipationInterestIn83WytheLoanMember_2276" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ParticipationInterestWarrenAtBayLoanMember" xlink:label="ormp_ParticipationInterestWarrenAtBayLoanMember_2278" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScilexMember" xlink:label="ormp_ScilexMember_1604" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalLoanAgreementMember" xlink:label="ormp_AdditionalLoanAgreementMember_1607" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RubySapphireIIMember" xlink:label="ormp_RubySapphireIIMember_1608" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis_1620" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1621" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems" xlink:label="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentIssuedPrincipal" xlink:label="us-gaap_DebtInstrumentIssuedPrincipal_1639" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="us-gaap_DebtInstrumentMaturityDate_1640" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentRepaidPrincipal" xlink:label="us-gaap_DebtInstrumentRepaidPrincipal_1650" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PaymentDue" xlink:label="ormp_PaymentDue_2328" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfDiscountRate" xlink:label="ormp_PercentageOfDiscountRate_1659" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionAggregateDifferencesLongTermDebtInstruments" xlink:label="us-gaap_FairValueOptionAggregateDifferencesLongTermDebtInstruments_1660" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_1662" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfBeneficialOwnership" xlink:label="ormp_PercentageOfBeneficialOwnership_1663" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrincipalAmountOutstandingOfLoansHeldInPortfolio" xlink:label="us-gaap_PrincipalAmountOutstandingOfLoansHeldInPortfolio_1664" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod_1665" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfProjectProfits" xlink:label="ormp_PercentageOfProjectProfits_1666" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLoansPayable" xlink:label="us-gaap_OtherLoansPayable_1667" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentMeasurementInput" xlink:label="us-gaap_DebtInstrumentMeasurementInput_1668" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1669" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="us-gaap_MeasurementInputTypeAxis_1609" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_1610" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_1627" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1628" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_1641" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="us-gaap_DebtInstrumentFaceAmount_1644" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentIncreaseAccruedInterest" xlink:label="us-gaap_DebtInstrumentIncreaseAccruedInterest_1645" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1647" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsAbstract" xlink:label="us-gaap_InvestmentsAbstract_1587" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1593" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FundedAmount" xlink:label="ormp_FundedAmount_1670" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentOwnedAtFairValue" xlink:label="us-gaap_InvestmentOwnedAtFairValue_1671" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessExitCosts1" xlink:label="us-gaap_BusinessExitCosts1_2248" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_2251" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleNotesPayable" xlink:label="us-gaap_ConvertibleNotesPayable_2254" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentPeriodicPaymentInterest" xlink:label="us-gaap_DebtInstrumentPeriodicPaymentInterest_2257" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfNetSales" xlink:label="ormp_PercentageOfNetSales_2258" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PeriodOfProducts" xlink:label="ormp_PeriodOfProducts_2259" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Cash" xlink:label="us-gaap_Cash_2260" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherExpenses" xlink:label="us-gaap_OtherExpenses_2261" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligation" xlink:label="us-gaap_ContractualObligation_2262" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivables" xlink:label="us-gaap_OtherReceivables_2263" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis_2264" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain_2265" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis" xlink:label="srt_StatementScenarioAxis_2267" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain_2268" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_2270" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AmortizationPayment" xlink:label="ormp_AmortizationPayment_2272" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2274" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="us-gaap_InvestmentIncomeInterest_2275" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PercentageOfAnnualReturn" xlink:label="ormp_PercentageOfAnnualReturn_2277" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="us-gaap_DebtInstrumentInterestRateEffectivePercentage_2279" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingAxis" xlink:label="us-gaap_VestingAxis_2286" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2287" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1654" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1602" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1603" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentsatFairValueDetailsTable" xlink:label="ormp_InvestmentsatFairValueDetailsTable_1588" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1589" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1590_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain_1621_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_1610_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1628_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain_2265_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain_2268_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_2287_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain_1603_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1621" xlink:to="ormp_TwoThousandTwentyThreeScilexTransactionMember_1622" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_2287" xlink:to="ormp_TrancheANoteMember_1636" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_2287" xlink:to="ormp_TrancheBMember_1637" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_1610" xlink:to="us-gaap_MeasurementInputExpectedTermMember_1611" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_1610" xlink:to="ormp_MeasurementInputCurveRateMember_1612" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_1610" xlink:to="us-gaap_MeasurementInputRiskFreeInterestRateMember_1613" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1628" xlink:to="ormp_TrancheBWarrantsMember_1629" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1589" xlink:to="srt_RangeMember_1590" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1590" xlink:to="srt_MinimumMember_1591" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1590" xlink:to="srt_MaximumMember_1592" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1593" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594" xlink:to="ormp_ExtensionAgreementMember_1595" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594" xlink:to="ormp_ProfitSharingLoanAgreementMember_1596" />
    <link:definitionArc xlink:type="arc" order="169.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventTypeDomain_2265" xlink:to="us-gaap_SubsequentEventMember_2266" />
    <link:definitionArc xlink:type="arc" order="172.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ScenarioUnspecifiedDomain_2268" xlink:to="srt_ScenarioForecastMember_2269" />
    <link:definitionArc xlink:type="arc" order="176.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1621" xlink:to="ormp_ExtensionObligationMember_2273" />
    <link:definitionArc xlink:type="arc" order="179.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1621" xlink:to="ormp_JuniorParticipationInterestIn83WytheLoanMember_2276" />
    <link:definitionArc xlink:type="arc" order="181.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DebtInstrumentNameDomain_1621" xlink:to="ormp_ParticipationInterestWarrenAtBayLoanMember_2278" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1603" xlink:to="ormp_ScilexMember_1604" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1603" xlink:to="ormp_AdditionalLoanAgreementMember_1607" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain_1603" xlink:to="ormp_RubySapphireIIMember_1608" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_DebtInstrumentAxis_1620" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DebtInstrumentAxis_1620" xlink:to="us-gaap_DebtInstrumentNameDomain_1621" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentIssuedPrincipal_1639" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentMaturityDate_1640" />
    <link:definitionArc xlink:type="arc" order="21.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentRepaidPrincipal_1650" />
    <link:definitionArc xlink:type="arc" order="222.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PaymentDue_2328" />
    <link:definitionArc xlink:type="arc" order="30.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PercentageOfDiscountRate_1659" />
    <link:definitionArc xlink:type="arc" order="31.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_FairValueOptionAggregateDifferencesLongTermDebtInstruments_1660" />
    <link:definitionArc xlink:type="arc" order="33.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_OtherNonoperatingIncomeExpense_1662" />
    <link:definitionArc xlink:type="arc" order="34.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PercentageOfBeneficialOwnership_1663" />
    <link:definitionArc xlink:type="arc" order="35.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_PrincipalAmountOutstandingOfLoansHeldInPortfolio_1664" />
    <link:definitionArc xlink:type="arc" order="36.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentInterestRateDuringPeriod_1665" />
    <link:definitionArc xlink:type="arc" order="37.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PercentageOfProjectProfits_1666" />
    <link:definitionArc xlink:type="arc" order="38.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_OtherLoansPayable_1667" />
    <link:definitionArc xlink:type="arc" order="39.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentMeasurementInput_1668" />
    <link:definitionArc xlink:type="arc" order="40.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1669" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_MeasurementInputTypeAxis_1609" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_MeasurementInputTypeAxis_1609" xlink:to="us-gaap_MeasurementInputTypeDomain_1610" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_1627" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1627" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1628" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentInterestRateStatedPercentage_1641" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentFaceAmount_1644" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentIncreaseAccruedInterest_1645" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1647" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_TypeOfArrangementAxis_1593" />
    <link:definitionArc xlink:type="arc" order="41.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_FundedAmount_1670" />
    <link:definitionArc xlink:type="arc" order="42.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_InvestmentOwnedAtFairValue_1671" />
    <link:definitionArc xlink:type="arc" order="153.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_BusinessExitCosts1_2248" />
    <link:definitionArc xlink:type="arc" order="154.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_2251" />
    <link:definitionArc xlink:type="arc" order="157.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_ConvertibleNotesPayable_2254" />
    <link:definitionArc xlink:type="arc" order="160.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentPeriodicPaymentInterest_2257" />
    <link:definitionArc xlink:type="arc" order="161.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PercentageOfNetSales_2258" />
    <link:definitionArc xlink:type="arc" order="162.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PeriodOfProducts_2259" />
    <link:definitionArc xlink:type="arc" order="163.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_Cash_2260" />
    <link:definitionArc xlink:type="arc" order="164.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_OtherExpenses_2261" />
    <link:definitionArc xlink:type="arc" order="165.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_ContractualObligation_2262" />
    <link:definitionArc xlink:type="arc" order="166.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_OtherReceivables_2263" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_SubsequentEventTypeAxis_2264" />
    <link:definitionArc xlink:type="arc" order="168.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_SubsequentEventTypeAxis_2264" xlink:to="us-gaap_SubsequentEventTypeDomain_2265" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="srt_StatementScenarioAxis_2267" />
    <link:definitionArc xlink:type="arc" order="171.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_StatementScenarioAxis_2267" xlink:to="srt_ScenarioUnspecifiedDomain_2268" />
    <link:definitionArc xlink:type="arc" order="173.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_CommonStockParOrStatedValuePerShare_2270" />
    <link:definitionArc xlink:type="arc" order="175.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_AmortizationPayment_2272" />
    <link:definitionArc xlink:type="arc" order="177.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2274" />
    <link:definitionArc xlink:type="arc" order="178.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_InvestmentIncomeInterest_2275" />
    <link:definitionArc xlink:type="arc" order="180.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_PercentageOfAnnualReturn_2277" />
    <link:definitionArc xlink:type="arc" order="182.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_DebtInstrumentInterestRateEffectivePercentage_2279" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_VestingAxis_2286" />
    <link:definitionArc xlink:type="arc" order="185.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VestingAxis_2286" xlink:to="us-gaap_VestingDomain_2287" />
    <link:definitionArc xlink:type="arc" order="25.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1654" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1602" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1602" xlink:to="us-gaap_RelatedPartyDomain_1603" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ScheduleOfFairValueOfSeparateAccountsByMajorCategoryOfInvestmentLineItems_1638" xlink:to="ormp_InvestmentsatFairValueDetailsTable_1588" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_InvestmentsatFairValueDetailsTable_1588" xlink:to="srt_RangeAxis_1589" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1589" xlink:to="srt_RangeMember_1590_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1593" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1594_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_DebtInstrumentAxis_1620" xlink:to="us-gaap_DebtInstrumentNameDomain_1621_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_MeasurementInputTypeAxis_1609" xlink:to="us-gaap_MeasurementInputTypeDomain_1610_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1627" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1628_default" />
    <link:definitionArc xlink:type="arc" order="168.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_SubsequentEventTypeAxis_2264" xlink:to="us-gaap_SubsequentEventTypeDomain_2265_default" />
    <link:definitionArc xlink:type="arc" order="171.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_StatementScenarioAxis_2267" xlink:to="srt_ScenarioUnspecifiedDomain_2268_default" />
    <link:definitionArc xlink:type="arc" order="185.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VestingAxis_2286" xlink:to="us-gaap_VestingDomain_2287_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1602" xlink:to="us-gaap_RelatedPartyDomain_1603_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/MarketableSecuritiesDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_EnteraMember" xlink:label="ormp_EnteraMember_2217" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember_1571" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PelthosMember" xlink:label="ormp_PelthosMember_1575" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanoMember" xlink:label="ormp_NanoMember_1577" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember_1564" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CallOptionMember" xlink:label="us-gaap_CallOptionMember_1567" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PutOptionMember" xlink:label="us-gaap_PutOptionMember_1568" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesAbstract" xlink:label="us-gaap_MarketableSecuritiesAbstract_1560" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="us-gaap_StatementEquityComponentsAxis_1569" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1570" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="us-gaap_RelatedPartyTransactionAxis_1572" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1573" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesLineItems" xlink:label="us-gaap_MarketableSecuritiesLineItems_1578" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1579" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_1580" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionContractIndexedToEquitySettlementShareFairValue" xlink:label="us-gaap_OptionContractIndexedToEquitySettlementShareFairValue_1582" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesOther" xlink:label="us-gaap_StockIssuedDuringPeriodSharesOther_1583" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueOther" xlink:label="us-gaap_StockIssuedDuringPeriodValueOther_1584" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_MarketableSecuritiesDetailsTable" xlink:label="ormp_MarketableSecuritiesDetailsTable_1561" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis_1562" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain_1563" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="us-gaap_OptionIndexedToIssuersEquityTypeAxis_1565" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="us-gaap_OptionIndexedToIssuersEquityTypeDomain_1566" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesUnrealizedGainLoss" xlink:label="us-gaap_MarketableSecuritiesUnrealizedGainLoss_1585" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1570_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1573_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain_1563_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="us-gaap_OptionIndexedToIssuersEquityTypeDomain_1566_default" />
    <link:definitionArc xlink:type="arc" order="123.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1573" xlink:to="ormp_EnteraMember_2217" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1570" xlink:to="us-gaap_CommonStockMember_1571" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1573" xlink:to="ormp_PelthosMember_1575" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1573" xlink:to="ormp_NanoMember_1577" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain_1563" xlink:to="us-gaap_CommonStockMember_1564" />
    <link:definitionArc xlink:type="arc" order="124.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1573" xlink:to="us-gaap_CallOptionMember_1567" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OptionIndexedToIssuersEquityTypeDomain_1566" xlink:to="us-gaap_PutOptionMember_1568" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_MarketableSecuritiesDetailsTable_1561" xlink:to="us-gaap_StatementEquityComponentsAxis_1569" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementEquityComponentsAxis_1569" xlink:to="us-gaap_EquityComponentDomain_1570" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_MarketableSecuritiesDetailsTable_1561" xlink:to="us-gaap_RelatedPartyTransactionAxis_1572" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionAxis_1572" xlink:to="us-gaap_RelatedPartyTransactionDomain_1573" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_StockIssuedDuringPeriodSharesNewIssues_1579" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_StockIssuedDuringPeriodValueNewIssues_1580" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_OptionContractIndexedToEquitySettlementShareFairValue_1582" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_StockIssuedDuringPeriodSharesOther_1583" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_StockIssuedDuringPeriodValueOther_1584" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="ormp_MarketableSecuritiesDetailsTable_1561" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_MarketableSecuritiesDetailsTable_1561" xlink:to="us-gaap_StatementClassOfStockAxis_1562" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis_1562" xlink:to="us-gaap_ClassOfStockDomain_1563" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_MarketableSecuritiesDetailsTable_1561" xlink:to="us-gaap_OptionIndexedToIssuersEquityTypeAxis_1565" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_OptionIndexedToIssuersEquityTypeAxis_1565" xlink:to="us-gaap_OptionIndexedToIssuersEquityTypeDomain_1566" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1578" xlink:to="us-gaap_MarketableSecuritiesUnrealizedGainLoss_1585" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementEquityComponentsAxis_1569" xlink:to="us-gaap_EquityComponentDomain_1570_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionAxis_1572" xlink:to="us-gaap_RelatedPartyTransactionDomain_1573_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis_1562" xlink:to="us-gaap_ClassOfStockDomain_1563_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_OptionIndexedToIssuersEquityTypeAxis_1565" xlink:to="us-gaap_OptionIndexedToIssuersEquityTypeDomain_1566_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofValuationoftheWarrantsDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputPriceVolatilityMember" xlink:label="us-gaap_MeasurementInputPriceVolatilityMember_1393" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="us-gaap_MeasurementInputRiskFreeInterestRateMember_1394" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExpectedDividendRateMember" xlink:label="us-gaap_MeasurementInputExpectedDividendRateMember_1395" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputSharePriceMember" xlink:label="us-gaap_MeasurementInputSharePriceMember_1390" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AmendedAndRestatedWarrantMember" xlink:label="ormp_AmendedAndRestatedWarrantMember_2371" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InitialNotesMember" xlink:label="ormp_InitialNotesMember_2372" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1386" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember_1387" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember_1388" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember_1397" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExercisePriceMember" xlink:label="us-gaap_MeasurementInputExercisePriceMember_1391" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputExpectedTermMember" xlink:label="us-gaap_MeasurementInputExpectedTermMember_1392" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_1396" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_2187" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfValuationOfTheWarrantsAbstract" xlink:label="ormp_ScheduleOfValuationOfTheWarrantsAbstract_1383" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_1384" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1385" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="us-gaap_MeasurementInputTypeAxis_1389" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_1398" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_1399" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_2186" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1386_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_2187_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="us-gaap_MeasurementInputTypeDomain_2186_default" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputPriceVolatilityMember_1393" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputRiskFreeInterestRateMember_1394" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputExpectedDividendRateMember_1395" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputSharePriceMember_1390" />
    <link:definitionArc xlink:type="arc" order="251.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_2187" xlink:to="ormp_AmendedAndRestatedWarrantMember_2371" />
    <link:definitionArc xlink:type="arc" order="252.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_2187" xlink:to="ormp_InitialNotesMember_2372" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_RangeAxis_1385" xlink:to="srt_RangeMember_1386" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1386" xlink:to="srt_MinimumMember_1387" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_RangeMember_1386" xlink:to="srt_MaximumMember_1388" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_2187" xlink:to="us-gaap_WarrantMember_1397" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputExercisePriceMember_1391" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MeasurementInputTypeDomain_2186" xlink:to="us-gaap_MeasurementInputExpectedTermMember_1392" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_1384" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_1396" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1396" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_2187" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_1398" xlink:to="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_1384" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_1384" xlink:to="srt_RangeAxis_1385" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_1384" xlink:to="us-gaap_MeasurementInputTypeAxis_1389" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_1398" xlink:to="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_1399" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_MeasurementInputTypeAxis_1389" xlink:to="us-gaap_MeasurementInputTypeDomain_2186" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_RangeAxis_1385" xlink:to="srt_RangeMember_1386_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1396" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_2187_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_MeasurementInputTypeAxis_1389" xlink:to="us-gaap_MeasurementInputTypeDomain_2186_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/MarketableSecuritiesScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_DNAMember" xlink:label="ormp_DNAMember_1298" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_EnteraMember" xlink:label="ormp_EnteraMember_1299" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PelthosMember" xlink:label="ormp_PelthosMember_1300" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanosPutOptionsAndWrittenCallOptionsNetMember" xlink:label="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember_1301" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanoMember" xlink:label="ormp_NanoMember_1302" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InformationByCategoryOfDebtSecurityAxis" xlink:label="us-gaap_InformationByCategoryOfDebtSecurityAxis_1296" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ShortTermAbstract" xlink:label="ormp_ShortTermAbstract_1304" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="us-gaap_MarketableSecuritiesCurrent_1305" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LongTermAbstract" xlink:label="ormp_LongTermAbstract_1306" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesNoncurrent" xlink:label="us-gaap_MarketableSecuritiesNoncurrent_1307" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract" xlink:label="ormp_ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract_1294" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesTable" xlink:label="us-gaap_MarketableSecuritiesTable_1295" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InformationByCategoryOfDebtSecurityDomainDomain" xlink:label="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesLineItems" xlink:label="us-gaap_MarketableSecuritiesLineItems_1303" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InformationByCategoryOfDebtSecurityDomainDomain" xlink:label="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" xlink:to="ormp_DNAMember_1298" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" xlink:to="ormp_EnteraMember_1299" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" xlink:to="ormp_PelthosMember_1300" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" xlink:to="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember_1301" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" xlink:to="ormp_NanoMember_1302" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_MarketableSecuritiesTable_1295" xlink:to="us-gaap_InformationByCategoryOfDebtSecurityAxis_1296" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1303" xlink:to="ormp_ShortTermAbstract_1304" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_ShortTermAbstract_1304" xlink:to="us-gaap_MarketableSecuritiesCurrent_1305" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MarketableSecuritiesLineItems_1303" xlink:to="ormp_LongTermAbstract_1306" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_LongTermAbstract_1306" xlink:to="us-gaap_MarketableSecuritiesNoncurrent_1307" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_MarketableSecuritiesLineItems_1303" xlink:to="us-gaap_MarketableSecuritiesTable_1295" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InformationByCategoryOfDebtSecurityAxis_1296" xlink:to="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InformationByCategoryOfDebtSecurityAxis_1296" xlink:to="ormp_InformationByCategoryOfDebtSecurityDomainDomain_1297_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofFinancialInformationDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AlphaTauMember" xlink:label="ormp_AlphaTauMember_1379" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_LifewardMember" xlink:label="ormp_LifewardMember_2370" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfFinancialInformationAbstract" xlink:label="ormp_ScheduleOfFinancialInformationAbstract_1376" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScheduleOfCondensedFinancialStatementsTable" xlink:label="srt_ScheduleOfCondensedFinancialStatementsTable_1377" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="srt_ConsolidatedEntitiesAxis_1378" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CondensedFinancialStatementsCaptionsLineItems" xlink:label="srt_CondensedFinancialStatementsCaptionsLineItems_1380" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_1381" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="srt_ConsolidatedEntitiesDomain_2185" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="srt_ConsolidatedEntitiesDomain_2185_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ConsolidatedEntitiesDomain_2185" xlink:to="ormp_AlphaTauMember_1379" />
    <link:definitionArc xlink:type="arc" order="250.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_ConsolidatedEntitiesDomain_2185" xlink:to="ormp_LifewardMember_2370" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="srt_CondensedFinancialStatementsCaptionsLineItems_1380" xlink:to="srt_ScheduleOfCondensedFinancialStatementsTable_1377" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="srt_ScheduleOfCondensedFinancialStatementsTable_1377" xlink:to="srt_ConsolidatedEntitiesAxis_1378" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_CondensedFinancialStatementsCaptionsLineItems_1380" xlink:to="us-gaap_NetIncomeLoss_1381" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_ConsolidatedEntitiesAxis_1378" xlink:to="srt_ConsolidatedEntitiesDomain_2185" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_ConsolidatedEntitiesAxis_1378" xlink:to="srt_ConsolidatedEntitiesDomain_2185_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/StockholdersEquityDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember_1822" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_1826" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember_1816" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PerformanceRestrictedStockUnitsMember" xlink:label="ormp_PerformanceRestrictedStockUnitsMember_1825" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ExecutiveOfficersMember" xlink:label="ormp_ExecutiveOfficersMember_1829" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ShareholdersMember" xlink:label="ormp_ShareholdersMember_1830" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RestrictedStockHoldersMember" xlink:label="ormp_RestrictedStockHoldersMember_1831" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_WarrantHoldersMember" xlink:label="ormp_WarrantHoldersMember_1832" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_DirectorMember" xlink:label="srt_DirectorMember_1833" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="us-gaap_StockholdersEquityNoteAbstract_1812" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="us-gaap_SharesIssuedPricePerShare_1838" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_1840" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited" xlink:label="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited_1841" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_1842" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="us-gaap_StatementEquityComponentsAxis_1814" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1815" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_StockholdersEquityDetailsTable" xlink:label="ormp_StockholdersEquityDetailsTable_1813" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis" xlink:label="us-gaap_AwardTypeAxis_1823" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualAxis" xlink:label="srt_TitleOfIndividualAxis_1827" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TotalFairValue" xlink:label="ormp_TotalFairValue_2292" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense_2295" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalTaxPayment" xlink:label="ormp_AdditionalTaxPayment_2296" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_1820" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1821" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockLineItems" xlink:label="us-gaap_ClassOfStockLineItems_1835" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1836" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_1843" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid_1844" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStock" xlink:label="us-gaap_DividendsCommonStock_1845" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="us-gaap_DividendsPayableCurrentAndNoncurrent_1846" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain_1815_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_1821_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfWarrantOrRightDomain_1821" xlink:to="us-gaap_WarrantMember_1822" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824" xlink:to="us-gaap_RestrictedStockUnitsRSUMember_1826" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityComponentDomain_1815" xlink:to="us-gaap_CommonStockMember_1816" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824" xlink:to="ormp_PerformanceRestrictedStockUnitsMember_1825" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" xlink:to="ormp_ExecutiveOfficersMember_1829" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" xlink:to="ormp_ShareholdersMember_1830" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" xlink:to="ormp_RestrictedStockHoldersMember_1831" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" xlink:to="ormp_WarrantHoldersMember_1832" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" xlink:to="srt_DirectorMember_1833" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_AwardTypeAxis_1823" xlink:to="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_SharesIssuedPricePerShare_1838" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_1840" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited_1841" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_1842" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_StockholdersEquityDetailsTable_1813" xlink:to="us-gaap_StatementEquityComponentsAxis_1814" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementEquityComponentsAxis_1814" xlink:to="us-gaap_EquityComponentDomain_1815" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="ormp_StockholdersEquityDetailsTable_1813" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_StockholdersEquityDetailsTable_1813" xlink:to="us-gaap_AwardTypeAxis_1823" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_StockholdersEquityDetailsTable_1813" xlink:to="srt_TitleOfIndividualAxis_1827" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_TitleOfIndividualAxis_1827" xlink:to="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828" />
    <link:definitionArc xlink:type="arc" order="190.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="ormp_TotalFairValue_2292" />
    <link:definitionArc xlink:type="arc" order="193.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_AllocatedShareBasedCompensationExpense_2295" />
    <link:definitionArc xlink:type="arc" order="194.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="ormp_AdditionalTaxPayment_2296" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_StockholdersEquityDetailsTable_1813" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_1820" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1820" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1821" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_1836" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_1843" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_CommonStockDividendsPerShareCashPaid_1844" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_DividendsCommonStock_1845" />
    <link:definitionArc xlink:type="arc" order="20.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockLineItems_1835" xlink:to="us-gaap_DividendsPayableCurrentAndNoncurrent_1846" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_AwardTypeAxis_1823" xlink:to="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1824_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementEquityComponentsAxis_1814" xlink:to="us-gaap_EquityComponentDomain_1815_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_TitleOfIndividualAxis_1827" xlink:to="srt_TitleOfIndividualWithRelationshipToEntityDomain_1828_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ClassOfWarrantOrRightAxis_1820" xlink:to="us-gaap_ClassOfWarrantOrRightDomain_1821_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/SubsequentEventsDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember" xlink:label="us-gaap_SubsequentEventMember_1898" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NanoTransactionsMember" xlink:label="ormp_NanoTransactionsMember_2229" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ProfitSharingLoanAgreementMember" xlink:label="ormp_ProfitSharingLoanAgreementMember_2230" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentInMAROramedJVLLCMember" xlink:label="ormp_InvestmentInMAROramedJVLLCMember_2235" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityOtherShares" xlink:label="us-gaap_StockholdersEquityOtherShares_1915" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod_1916" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="us-gaap_TypeOfArrangementAxis_1885" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventLineItems" xlink:label="us-gaap_SubsequentEventLineItems_1906" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AdditionalLoanAmount" xlink:label="ormp_AdditionalLoanAmount_2228" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NetProceeds" xlink:label="ormp_NetProceeds_2231" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AnnualPreferredReturn" xlink:label="ormp_AnnualPreferredReturn_2232" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_InvestmentAllocatedToFirstProject" xlink:label="ormp_InvestmentAllocatedToFirstProject_2234" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="us-gaap_SubsequentEventsAbstract_1875" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_SubsequentEventsDetailsTable" xlink:label="ormp_SubsequentEventsDetailsTable_1876" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis_1896" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain_1897" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_PurchaseOfAdditionalOrdinaryShares" xlink:label="ormp_PurchaseOfAdditionalOrdinaryShares_1912" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AggregatePurchasePrice" xlink:label="ormp_AggregatePurchasePrice_1913" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TotalInvestment" xlink:label="ormp_TotalInvestment_2236" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_GeneralPartnerDistributionsPercentage" xlink:label="ormp_GeneralPartnerDistributionsPercentage_2238" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FirstProjectPayment" xlink:label="ormp_FirstProjectPayment_2243" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentIncreaseDecreaseForPeriodNet" xlink:label="us-gaap_DebtInstrumentIncreaseDecreaseForPeriodNet_2225" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ProjectProfitsInterestRate" xlink:label="ormp_ProjectProfitsInterestRate_2227" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain_1897_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis_1885" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventTypeDomain_1897" xlink:to="us-gaap_SubsequentEventMember_1898" />
    <link:definitionArc xlink:type="arc" order="135.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886" xlink:to="ormp_NanoTransactionsMember_2229" />
    <link:definitionArc xlink:type="arc" order="136.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886" xlink:to="ormp_ProfitSharingLoanAgreementMember_2230" />
    <link:definitionArc xlink:type="arc" order="141.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886" xlink:to="ormp_InvestmentInMAROramedJVLLCMember_2235" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="us-gaap_StockholdersEquityOtherShares_1915" />
    <link:definitionArc xlink:type="arc" order="19.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="us-gaap_DebtInstrumentInterestRateDuringPeriod_1916" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SubsequentEventsDetailsTable_1876" xlink:to="us-gaap_TypeOfArrangementAxis_1885" />
    <link:definitionArc xlink:type="arc" order="134.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_AdditionalLoanAmount_2228" />
    <link:definitionArc xlink:type="arc" order="137.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_NetProceeds_2231" />
    <link:definitionArc xlink:type="arc" order="138.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_AnnualPreferredReturn_2232" />
    <link:definitionArc xlink:type="arc" order="140.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_InvestmentAllocatedToFirstProject_2234" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_SubsequentEventsDetailsTable_1876" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_SubsequentEventsDetailsTable_1876" xlink:to="us-gaap_SubsequentEventTypeAxis_1896" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_SubsequentEventTypeAxis_1896" xlink:to="us-gaap_SubsequentEventTypeDomain_1897" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_PurchaseOfAdditionalOrdinaryShares_1912" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_AggregatePurchasePrice_1913" />
    <link:definitionArc xlink:type="arc" order="142.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_TotalInvestment_2236" />
    <link:definitionArc xlink:type="arc" order="143.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_GeneralPartnerDistributionsPercentage_2238" />
    <link:definitionArc xlink:type="arc" order="148.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_FirstProjectPayment_2243" />
    <link:definitionArc xlink:type="arc" order="131.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="us-gaap_DebtInstrumentIncreaseDecreaseForPeriodNet_2225" />
    <link:definitionArc xlink:type="arc" order="133.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SubsequentEventLineItems_1906" xlink:to="ormp_ProjectProfitsInterestRate_2227" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_TypeOfArrangementAxis_1885" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember_1886_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_SubsequentEventTypeAxis_1896" xlink:to="us-gaap_SubsequentEventTypeDomain_1897_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/RelatedPartyTransactionsDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ChiefScientificOfficerMember" xlink:label="ormp_ChiefScientificOfficerMember_1867" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_PresidentMember" xlink:label="srt_PresidentMember_1868" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ChiefExecutiveOfficersMember" xlink:label="ormp_ChiefExecutiveOfficersMember_1869" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_KNRYMember" xlink:label="ormp_KNRYMember_1864" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualAxis" xlink:label="srt_TitleOfIndividualAxis_1865" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="us-gaap_RelatedPartyTransactionLineItems_1870" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfessionalFees" xlink:label="us-gaap_ProfessionalFees_1871" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OfficersCompensation" xlink:label="us-gaap_OfficersCompensation_1872" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="us-gaap_RelatedPartyTransactionsAbstract_1860" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RelatedPartyTransactionsDetailsTable" xlink:label="ormp_RelatedPartyTransactionsDetailsTable_1861" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="us-gaap_RelatedPartyTransactionAxis_1862" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1863" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ConsultingFee" xlink:label="ormp_ConsultingFee_1873" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain_1863_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866" xlink:to="ormp_ChiefScientificOfficerMember_1867" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866" xlink:to="srt_PresidentMember_1868" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866" xlink:to="ormp_ChiefExecutiveOfficersMember_1869" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionDomain_1863" xlink:to="ormp_KNRYMember_1864" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_RelatedPartyTransactionsDetailsTable_1861" xlink:to="srt_TitleOfIndividualAxis_1865" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="srt_TitleOfIndividualAxis_1865" xlink:to="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems_1870" xlink:to="us-gaap_ProfessionalFees_1871" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems_1870" xlink:to="us-gaap_OfficersCompensation_1872" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_RelatedPartyTransactionLineItems_1870" xlink:to="ormp_RelatedPartyTransactionsDetailsTable_1861" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_RelatedPartyTransactionsDetailsTable_1861" xlink:to="us-gaap_RelatedPartyTransactionAxis_1862" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionAxis_1862" xlink:to="us-gaap_RelatedPartyTransactionDomain_1863" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems_1870" xlink:to="ormp_ConsultingFee_1873" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="srt_TitleOfIndividualAxis_1865" xlink:to="srt_TitleOfIndividualWithRelationshipToEntityDomain_1866_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionAxis_1862" xlink:to="us-gaap_RelatedPartyTransactionDomain_1863_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/FinancialIncomeNetScheduleofFinancialIncomeNetDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfRealEstateLoansMember" xlink:label="ormp_RevaluationOfRealEstateLoansMember_2329" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1465" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfScilexNetMember" xlink:label="ormp_RevaluationOfScilexNetMember_1466" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfHapisgaNetMember" xlink:label="ormp_RevaluationOfHapisgaNetMember_1467" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfAlphaTauNetMember" xlink:label="ormp_RevaluationOfAlphaTauNetMember_1468" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfRoyaltyVestLoanNetMember" xlink:label="ormp_RevaluationOfRoyaltyVestLoanNetMember_1469" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfProfitSharingLoanAgreementMember" xlink:label="ormp_RevaluationOfProfitSharingLoanAgreementMember_1470" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfRubyCapitalMember" xlink:label="ormp_RevaluationOfRubyCapitalMember_1473" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RevaluationOfLifewardMember" xlink:label="ormp_RevaluationOfLifewardMember_1474" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIncomeAndExpensesAbstract" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract_2298" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems" xlink:label="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FinancialIncomeLossNet" xlink:label="ormp_FinancialIncomeLossNet_1477" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesGainLossExcludingOtherThanTemporaryImpairments" xlink:label="us-gaap_MarketableSecuritiesGainLossExcludingOtherThanTemporaryImpairments_1478" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeOther" xlink:label="us-gaap_InterestIncomeOther_1479" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_1480" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_1481" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="us-gaap_NonoperatingIncomeExpense_1482" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable" xlink:label="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable_1463" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis_1464" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfFinancialIncomeLossNetAbstract" xlink:label="ormp_ScheduleOfFinancialIncomeLossNetAbstract_1462" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1465_default" />
    <link:definitionArc xlink:type="arc" order="223.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfRealEstateLoansMember_2329" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InvestmentTypeAxis_1464" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1465" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfScilexNetMember_1466" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfHapisgaNetMember_1467" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfAlphaTauNetMember_1468" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfRoyaltyVestLoanNetMember_1469" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfProfitSharingLoanAgreementMember_1470" />
    <link:definitionArc xlink:type="arc" order="17.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfRubyCapitalMember_1473" />
    <link:definitionArc xlink:type="arc" order="18.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1465" xlink:to="ormp_RevaluationOfLifewardMember_1474" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_OtherIncomeAndExpensesAbstract_2298" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherIncomeAndExpensesAbstract_2298" xlink:to="ormp_FinancialIncomeLossNet_1477" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_MarketableSecuritiesGainLossExcludingOtherThanTemporaryImpairments_1478" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_InterestIncomeOther_1479" />
    <link:definitionArc xlink:type="arc" order="14.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_1480" />
    <link:definitionArc xlink:type="arc" order="15.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_OtherNonoperatingIncomeExpense_1481" />
    <link:definitionArc xlink:type="arc" order="16.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="us-gaap_NonoperatingIncomeExpense_1482" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems_1475" xlink:to="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable_1463" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable_1463" xlink:to="us-gaap_InvestmentTypeAxis_1464" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InvestmentTypeAxis_1464" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1465_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueBreakdownDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheANoteMember" xlink:label="ormp_TrancheANoteMember_1369" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_TrancheBNoteMember" xlink:label="ormp_TrancheBNoteMember_1370" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1363" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_NotesMember" xlink:label="ormp_NotesMember_1364" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember_1365" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_RoyaltyPurchaseAgreementPaymentMember" xlink:label="ormp_RoyaltyPurchaseAgreementPaymentMember_1366" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_1368" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1371" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentOwnedAtCost" xlink:label="us-gaap_InvestmentOwnedAtCost_1372" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_AccruedInterest" xlink:label="ormp_AccruedInterest_1373" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosure" xlink:label="us-gaap_InvestmentsFairValueDisclosure_1374" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_ScheduleOfFairValueBreakdownAbstract" xlink:label="ormp_ScheduleOfFairValueBreakdownAbstract_1360" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1361" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis_1362" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingAxis" xlink:label="us-gaap_VestingAxis_1367" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1363_default" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VestingDomain" xlink:label="us-gaap_VestingDomain_1368_default" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_1368" xlink:to="ormp_TrancheANoteMember_1369" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VestingDomain_1368" xlink:to="ormp_TrancheBNoteMember_1370" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_InvestmentTypeAxis_1362" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1363" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1363" xlink:to="ormp_NotesMember_1364" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1363" xlink:to="us-gaap_WarrantMember_1365" />
    <link:definitionArc xlink:type="arc" order="13.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_InvestmentTypeCategorizationMember_1363" xlink:to="ormp_RoyaltyPurchaseAgreementPaymentMember_1366" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VestingAxis_1367" xlink:to="us-gaap_VestingDomain_1368" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1371" xlink:to="us-gaap_InvestmentOwnedAtCost_1372" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1371" xlink:to="ormp_AccruedInterest_1373" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1371" xlink:to="us-gaap_InvestmentsFairValueDisclosure_1374" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_1371" xlink:to="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1361" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1361" xlink:to="us-gaap_InvestmentTypeAxis_1362" />
    <link:definitionArc xlink:type="arc" order="12.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1361" xlink:to="us-gaap_VestingAxis_1367" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_InvestmentTypeAxis_1362" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1363_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VestingAxis_1367" xlink:to="us-gaap_VestingDomain_1368_default" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://oramed.com/20260630/role/IncomePerShareofCommonStockDetails" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember_1851" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="us-gaap_AntidilutiveSecuritiesNameDomain_2191" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1850" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1852" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_1853" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="us-gaap_EarningsPerShareAbstract_1848" />
    <link:loc xlink:type="locator" xlink:href="ormp-20260630.xsd#ormp_IncomeLossPerShareofCommonStockDetailsTable" xlink:label="ormp_IncomeLossPerShareofCommonStockDetailsTable_1849" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="us-gaap_AntidilutiveSecuritiesNameDomain_2191_default" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AntidilutiveSecuritiesNameDomain_2191" xlink:to="us-gaap_WarrantMember_1851" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1850" xlink:to="us-gaap_AntidilutiveSecuritiesNameDomain_2191" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ormp_IncomeLossPerShareofCommonStockDetailsTable_1849" xlink:to="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1850" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="false" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1852" xlink:to="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_1853" />
    <link:definitionArc xlink:type="arc" order="11.00000" priority="1" xbrldt:closed="true" use="optional" xbrldt:contextElement="segment" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1852" xlink:to="ormp_IncomeLossPerShareofCommonStockDetailsTable_1849" />
    <link:definitionArc xlink:type="arc" order="10.00000" priority="1" xbrldt:closed="true" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1850" xlink:to="us-gaap_AntidilutiveSecuritiesNameDomain_2191_default" />
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-roles-2026.xsd#eedm1" xlink:type="simple" />
  <link:definitionLink xlink:role="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="extended" xlink:title="definitionLink">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ChiefExecutiveOfficerMember" xlink:label="srt_ChiefExecutiveOfficerMember" />
    <link:definitionArc xlink:type="arc" order="0" priority="1" xbrldt:closed="true" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="srt_TitleOfIndividualWithRelationshipToEntityDomain" xlink:to="srt_ChiefExecutiveOfficerMember" />
  </link:definitionLink>
</link:linkbase>
