<?xml version="1.0" encoding="ASCII"?>
<!-- XBRL document created with Praxa -->
<!-- Copyright (c) 2026 Praxa LLC. All Rights Reserved.-->
<!-- Creation Date: 2026-08-10T21:19:16.2199+00:00 -->
<xs:schema targetNamespace="http://oramed.com/20260630" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ormp="http://oramed.com/20260630" xmlns:us-gaap="http://fasb.org/us-gaap/2026" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:srt="http://fasb.org/srt/2026" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:ecd="http://xbrl.sec.gov/ecd/2026" xmlns:dei="http://xbrl.sec.gov/dei/2026" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2026">
  <xs:import namespace="http://fasb.org/us-gaap/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd" />
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xs:import namespace="http://fasb.org/srt/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd" />
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/ecd/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd" />
  <xs:import namespace="http://xbrl.org/2020/extensible-enumerations-2.0" schemaLocation="https://www.xbrl.org/2020/extensible-enumerations-2.0.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-sub-2026.xsd" />
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ormp-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ormp-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ormp-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ormp-20260630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:title="Calculation link" xlink:type="simple" />
      <link:roleType roleURI="http://oramed.com/20260630/role/DocumentandEntityInformation" id="DocumentandEntityInformation">
        <link:definition>995300 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedBalanceSheetsUnaudited" id="InterimCondensedConsolidatedBalanceSheetsUnaudited">
        <link:definition>995301 - Statement - Interim Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedBalanceSheetsUnauditedParentheticals" id="InterimCondensedConsolidatedBalanceSheetsUnauditedParentheticals">
        <link:definition>995302 - Statement - Interim Condensed Consolidated Balance Sheets (Unaudited) (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" id="InterimCondensedConsolidatedStatementsofComprehensiveIncomeUnaudited">
        <link:definition>995303 - Statement - Interim Condensed Consolidated Statements of Comprehensive Income (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" id="InterimCondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited">
        <link:definition>995304 - Statement - Interim Condensed Consolidated Statements of Changes in Stockholders&#8217; Equity (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InterimCondensedConsolidatedStatementsofCashFlowsUnaudited" id="InterimCondensedConsolidatedStatementsofCashFlowsUnaudited">
        <link:definition>995305 - Statement - Interim Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/General" id="General">
        <link:definition>995306 - Disclosure - General</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SignificantAccountingPolicies" id="SignificantAccountingPolicies">
        <link:definition>995307 - Disclosure - Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/MarketableSecurities" id="MarketableSecurities">
        <link:definition>995308 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValue" id="InvestmentsatFairValue">
        <link:definition>995309 - Disclosure - Investments, at Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentInRealEstate" id="InvestmentInRealEstate">
        <link:definition>995310 - Disclosure - Investment In Real Estate</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/LoantoanEquityMethodInvestee" id="LoantoanEquityMethodInvestee">
        <link:definition>995311 - Disclosure - Loan to an Equity Method Investee</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/LoanAgreementMeasuredinFairValue" id="LoanAgreementMeasuredinFairValue">
        <link:definition>995312 - Disclosure - Loan Agreement Measured in Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValue" id="InvestmentinAssociateatFairValue">
        <link:definition>995313 - Disclosure - Investment in Associate at Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/Commitments" id="Commitments">
        <link:definition>995314 - Disclosure - Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/AccountsPayableandAccruedExpenses" id="AccountsPayableandAccruedExpenses">
        <link:definition>995315 - Disclosure - Accounts Payable and Accrued Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/StockholdersEquity" id="StockholdersEquity">
        <link:definition>995316 - Disclosure - Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/IncomePerShareofCommonStock" id="IncomePerShareofCommonStock">
        <link:definition>995317 - Disclosure - Income Per Share of Common Stock</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/OtherIncomeNet" id="OtherIncomeNet">
        <link:definition>995318 - Disclosure - Other Income, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/FinancialIncomeNet" id="FinancialIncomeNet">
        <link:definition>995319 - Disclosure - Financial Income, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/TaxesonIncome" id="TaxesonIncome">
        <link:definition>995320 - Disclosure - Taxes on Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SegmentReporting" id="SegmentReporting">
        <link:definition>995321 - Disclosure - Segment Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/RelatedPartyTransactions" id="RelatedPartyTransactions">
        <link:definition>995322 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SubsequentEvents" id="SubsequentEvents">
        <link:definition>995323 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InsiderTradingArrangements" id="InsiderTradingArrangements">
        <link:definition>995324 - Disclosure - Insider Trading Arrangements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/AccountingPoliciesbyPolicyPolicies" id="AccountingPoliciesbyPolicyPolicies">
        <link:definition>996325 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SignificantAccountingPoliciesTables" id="SignificantAccountingPoliciesTables">
        <link:definition>996326 - Disclosure - Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/MarketableSecuritiesTables" id="MarketableSecuritiesTables">
        <link:definition>996327 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueTables" id="InvestmentsatFairValueTables">
        <link:definition>996328 - Disclosure - Investments, at Fair Value (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueTables" id="InvestmentinAssociateatFairValueTables">
        <link:definition>996329 - Disclosure - Investment in Associate at Fair Value (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/CommitmentsTables" id="CommitmentsTables">
        <link:definition>996330 - Disclosure - Commitments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/AccountsPayableandAccruedExpensesTables" id="AccountsPayableandAccruedExpensesTables">
        <link:definition>996331 - Disclosure - Accounts Payable and Accrued Expenses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/StockholdersEquityTables" id="StockholdersEquityTables">
        <link:definition>996332 - Disclosure - Stockholders' Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/IncomePerShareofCommonStockTables" id="IncomePerShareofCommonStockTables">
        <link:definition>996333 - Disclosure - Income Per Share of Common Stock (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/OtherIncomeNetTables" id="OtherIncomeNetTables">
        <link:definition>996334 - Disclosure - Other Income, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/FinancialIncomeNetTables" id="FinancialIncomeNetTables">
        <link:definition>996335 - Disclosure - Financial Income, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/TaxesonIncomeTables" id="TaxesonIncomeTables">
        <link:definition>996336 - Disclosure - Taxes on Income (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/GeneralDetails" id="GeneralDetails">
        <link:definition>996337 - Disclosure - General (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SignificantAccountingPoliciesDetails" id="SignificantAccountingPoliciesDetails">
        <link:definition>996338 - Disclosure - Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SignificantAccountingPoliciesScheduleofFairValueMeasurementsonaRecurringBasisDetails" id="SignificantAccountingPoliciesScheduleofFairValueMeasurementsonaRecurringBasisDetails">
        <link:definition>996339 - Disclosure - Significant Accounting Policies - Schedule of Fair Value Measurements on a Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/MarketableSecuritiesDetails" id="MarketableSecuritiesDetails">
        <link:definition>996340 - Disclosure - Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/MarketableSecuritiesScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesDetails" id="MarketableSecuritiesScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesDetails">
        <link:definition>996341 - Disclosure - Marketable Securities - Schedule of Marketable Securities Include Investments in Equity Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueDetails" id="InvestmentsatFairValueDetails">
        <link:definition>996342 - Disclosure - Investments, at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofAssumptionsandEstimatesValueDetails" id="InvestmentsatFairValueScheduleofAssumptionsandEstimatesValueDetails">
        <link:definition>996343 - Disclosure - Investments, at Fair Value - Schedule of Assumptions and Estimates Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueCompositionDetails" id="InvestmentsatFairValueScheduleofFairValueCompositionDetails">
        <link:definition>996344 - Disclosure - Investments, at Fair Value - Schedule of Fair Value Composition (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofRefinancingTransactionDetails" id="InvestmentsatFairValueScheduleofRefinancingTransactionDetails">
        <link:definition>996345 - Disclosure - Investments, at Fair Value - Schedule of Refinancing Transaction (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentsatFairValueScheduleofFairValueBreakdownDetails" id="InvestmentsatFairValueScheduleofFairValueBreakdownDetails">
        <link:definition>996346 - Disclosure - Investments, at Fair Value - Schedule of Fair Value Breakdown (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentInRealEstateDetails" id="InvestmentInRealEstateDetails">
        <link:definition>996347 - Disclosure - Investment In Real Estate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/LoantoanEquityMethodInvesteeDetails" id="LoantoanEquityMethodInvesteeDetails">
        <link:definition>996348 - Disclosure - Loan to an Equity Method Investee (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/LoanAgreementMeasuredinFairValueDetails" id="LoanAgreementMeasuredinFairValueDetails">
        <link:definition>996349 - Disclosure - Loan Agreement Measured in Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueDetails" id="InvestmentinAssociateatFairValueDetails">
        <link:definition>996350 - Disclosure - Investment in Associate at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofFinancialInformationDetails" id="InvestmentinAssociateatFairValueScheduleofFinancialInformationDetails">
        <link:definition>996351 - Disclosure - Investment in Associate at Fair Value- Schedule of Financial Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/InvestmentinAssociateatFairValueScheduleofValuationoftheWarrantsDetails" id="InvestmentinAssociateatFairValueScheduleofValuationoftheWarrantsDetails">
        <link:definition>996352 - Disclosure - Investment in Associate at Fair Value - Schedule of Valuation of the Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/CommitmentsDetails" id="CommitmentsDetails">
        <link:definition>996353 - Disclosure - Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/CommitmentsScheduleofOperatingRightofUseAssetsandOperatingLeaseLiabilitiesDetails" id="CommitmentsScheduleofOperatingRightofUseAssetsandOperatingLeaseLiabilitiesDetails">
        <link:definition>996354 - Disclosure - Commitments - Schedule of Operating Right-of-Use Assets and Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/CommitmentsScheduleofRightofUseAssetsOvertheRemainingLeaseDetails" id="CommitmentsScheduleofRightofUseAssetsOvertheRemainingLeaseDetails">
        <link:definition>996355 - Disclosure - Commitments - Schedule of Right-of-Use Assets Over the Remaining Lease (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetails" id="AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetails">
        <link:definition>996356 - Disclosure - Accounts Payable and Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/StockholdersEquityDetails" id="StockholdersEquityDetails">
        <link:definition>996357 - Disclosure - Stockholders' Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/StockholdersEquityScheduleofRSUGrantedtoEmployeesDetails" id="StockholdersEquityScheduleofRSUGrantedtoEmployeesDetails">
        <link:definition>996358 - Disclosure - Stockholders' Equity - Schedule of RSU Granted to Employees (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/IncomePerShareofCommonStockDetails" id="IncomePerShareofCommonStockDetails">
        <link:definition>996359 - Disclosure - Income Per Share of Common Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/IncomePerShareofCommonStockScheduleofEarningsPerShareDetails" id="IncomePerShareofCommonStockScheduleofEarningsPerShareDetails">
        <link:definition>996360 - Disclosure - Income Per Share of Common Stock - Schedule of Earnings Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/OtherIncomeNetScheduleofOtherIncomeNetDetails" id="OtherIncomeNetScheduleofOtherIncomeNetDetails">
        <link:definition>996361 - Disclosure - Other Income, Net - Schedule of Other Income, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/FinancialIncomeNetScheduleofFinancialIncomeNetDetails" id="FinancialIncomeNetScheduleofFinancialIncomeNetDetails">
        <link:definition>996362 - Disclosure - Financial Income, Net - Schedule of Financial Income, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/TaxesonIncomeScheduleofTaxesonIncomeDetails" id="TaxesonIncomeScheduleofTaxesonIncomeDetails">
        <link:definition>996363 - Disclosure - Taxes on Income - Schedule of Taxes on Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SegmentReportingDetails" id="SegmentReportingDetails">
        <link:definition>996364 - Disclosure - Segment Reporting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/RelatedPartyTransactionsDetails" id="RelatedPartyTransactionsDetails">
        <link:definition>996365 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/20260630/role/SubsequentEventsDetails" id="SubsequentEventsDetails">
        <link:definition>996366 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="ormp_AlphaTauWarrantMember" name="AlphaTauWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_CapitalGainFromSaleOfIPMember" name="CapitalGainFromSaleOfIPMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ClinicalTrialManagementAgreementMember" name="ClinicalTrialManagementAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MedicoxLicenseAgreementsMember" name="MedicoxLicenseAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfOtherIncomeNetLineItems" name="ScheduleOfOtherIncomeNetLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_OtherIncomeNetTable" name="OtherIncomeNetTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ConvertibleNoteCurrent" name="ConvertibleNoteCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_EmployeeRightsUponRetirementNoncurrent" name="EmployeeRightsUponRetirementNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_InterestReceived" name="InterestReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_InvestmentInEquityMethod" name="InvestmentInEquityMethod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_ForfeitedDividends" name="ForfeitedDividends" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_LoanToAnEquityMethodInvesteeAbstract" name="LoanToAnEquityMethodInvesteeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInInvestmentInAssociateAtFairValueLifeward" name="InvestmentInInvestmentInAssociateAtFairValueLifeward" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_PurchaseOfNonMarketableSecurities" name="PurchaseOfNonMarketableSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_NonCashInvestmentInSharesAndOtherInstrumentsOfInvestee" name="NonCashInvestmentInSharesAndOtherInstrumentsOfInvestee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_WarrantsReceivedFromAlphaTau" name="WarrantsReceivedFromAlphaTau" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_AlphaTauMember" name="AlphaTauMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MedicoxLicenseAgreementMember" name="MedicoxLicenseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_StraightlineIncomeRecognition" name="StraightlineIncomeRecognition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_NonRefundableConsideration" name="NonRefundableConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_ClinicalTrialManagementAgreementWithOratechLtdMember" name="ClinicalTrialManagementAgreementWithOratechLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_OraTechLtdMember" name="OraTechLtdMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ExcessCost" name="ExcessCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_EightyThreeWytheLoanMember" name="EightyThreeWytheLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ServiceExpenses" name="ServiceExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_PercentageOfRevenueSharingPayments" name="PercentageOfRevenueSharingPayments" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_LifewardRevenueShareTerm" name="LifewardRevenueShareTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_GeneralDetailsTable" name="GeneralDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_SeniorSecuredConvertibleNotesMember" name="SeniorSecuredConvertibleNotesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_Rule10b51ArrangementModifiedFlag" name="Rule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_NonRule10b51ArrangementModifiedFlag" name="NonRule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_DNAMember" name="DNAMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ConvertibleNoteMember" name="ConvertibleNoteMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfRefinancingTransactionTableTextBlock" name="ScheduleOfRefinancingTransactionTableTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_InvestmentinAssociateatFairValueDetailsTable" name="InvestmentinAssociateatFairValueDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MeasurementInputYieldMember" name="MeasurementInputYieldMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RoyaltyPurchaseAgreementMember" name="RoyaltyPurchaseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheAMember" name="TrancheAMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheBMember" name="TrancheBMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AccruedInterest" name="AccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_RefundedAmount" name="RefundedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_PercentageOfWeightedAverageCashflowsOfLoanDiscounted" name="PercentageOfWeightedAverageCashflowsOfLoanDiscounted" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="ormp_ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract" name="ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TwoThousandTwentyThreeScilexTransactionMember" name="TwoThousandTwentyThreeScilexTransactionMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheANoteMember" name="TrancheANoteMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInSharesAndOtherInstruments" name="InvestmentInSharesAndOtherInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_LoanNetLoss" name="LoanNetLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_PaymentDue" name="PaymentDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_CommitmentsDetailsTable" name="CommitmentsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_EnteraMember" name="EnteraMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FinancialIncomeRecognized" name="FinancialIncomeRecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_PercentageOfDiscountRate" name="PercentageOfDiscountRate" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_PercentageOfOrdinaryShares" name="PercentageOfOrdinaryShares" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_NonRefundableFee" name="NonRefundableFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_PelthosMember" name="PelthosMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NanoMember" name="NanoMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PercentageOfBeneficialOwnership" name="PercentageOfBeneficialOwnership" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_PercentageOfProjectProfits" name="PercentageOfProjectProfits" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_RoyaltyVestMember" name="RoyaltyVestMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PercentageOfIssuedAndOutstandingCapitalStock" name="PercentageOfIssuedAndOutstandingCapitalStock" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember" name="NanosPutOptionsAndWrittenCallOptionsNetMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RubyCapitalMember" name="RubyCapitalMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInAlphaTausSharesMember" name="InvestmentInAlphaTausSharesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LoanToAnEquityMethodInvesteeMember" name="LoanToAnEquityMethodInvesteeMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MeasurementInputCurveRateMember" name="MeasurementInputCurveRateMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheBWarrantsMember" name="TrancheBWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ShortTermAbstract" name="ShortTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LongTermAbstract" name="LongTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfAssumptionsAndEstimatesValuationAbstract" name="ScheduleOfAssumptionsAndEstimatesValuationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable" name="InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfFinancialInformationAbstract" name="ScheduleOfFinancialInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PromissoryNote" name="PromissoryNote" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_AdditionalPrincipalAmount" name="AdditionalPrincipalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_AnnumAndSecuredInterestPercentage" name="AnnumAndSecuredInterestPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_AdditionalCashPayment" name="AdditionalCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_MarketableSecuritiesDetailsTable" name="MarketableSecuritiesDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ChiefScientificOfficerMember" name="ChiefScientificOfficerMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ChiefExecutiveOfficersMember" name="ChiefExecutiveOfficersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AdditionalLoanAmount" name="AdditionalLoanAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_NanoTransactionsMember" name="NanoTransactionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ProfitSharingLoanAgreementMember" name="ProfitSharingLoanAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NetProceeds" name="NetProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_AnnualPreferredReturn" name="AnnualPreferredReturn" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="ormp_InvestmentAllocatedToFirstProject" name="InvestmentAllocatedToFirstProject" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_ScheduleOfEarningsPerShareAbstract" name="ScheduleOfEarningsPerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems" name="FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FinancialIncomeLossNet" name="FinancialIncomeLossNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_RevaluationOfRealEstateLoansMember" name="RevaluationOfRealEstateLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RelatedPartyTransactionsDetailsTable" name="RelatedPartyTransactionsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_KNRYMember" name="KNRYMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ConsultingFee" name="ConsultingFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_SubsequentEventsDetailsTable" name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PurchaseOfAdditionalOrdinaryShares" name="PurchaseOfAdditionalOrdinaryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_AggregatePurchasePrice" name="AggregatePurchasePrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_AccumulatedDeficitForfeitedDividend" name="AccumulatedDeficitForfeitedDividend" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_StockIssuedDuringPeriodValueStockBasedCompensationOfSubsidiary" name="StockIssuedDuringPeriodValueStockBasedCompensationOfSubsidiary" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_StockIssuedDuringPeriodSharesStockBasedCompensationOfSubsidiary" name="StockIssuedDuringPeriodSharesStockBasedCompensationOfSubsidiary" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_GainOnAmountsFundedInRespectOfEmployeeRightsUponRetirement" name="GainOnAmountsFundedInRespectOfEmployeeRightsUponRetirement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_IncreaseDecreaseinDeferredIncome" name="IncreaseDecreaseinDeferredIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_PaymentFromInvestmentAtFairValue" name="PaymentFromInvestmentAtFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_InvestmentInEquityMethodInvestee" name="InvestmentInEquityMethodInvestee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_ConsecutiveTradingDays" name="ConsecutiveTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_SignificantAccountingPoliciesDetailsTable" name="SignificantAccountingPoliciesDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AdditionalSecuritiesPurchaseAgreementMember" name="AdditionalSecuritiesPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_OtherIncomePolicyPolicyTextBlock" name="OtherIncomePolicyPolicyTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_InvestmentInAlphaTauPolicyTextBlock" name="InvestmentInAlphaTauPolicyTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_InvestmentInLifewardPolicyTextBlock" name="InvestmentInLifewardPolicyTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" name="RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ScheduleOfAssumptionsAndEstimatesValuationTableTextBlock" name="ScheduleOfAssumptionsAndEstimatesValuationTableTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_PercentageOfPreFundedWarrants" name="PercentageOfPreFundedWarrants" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod" name="ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_WarrantsExpirationTerm" name="WarrantsExpirationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_IncreaseInWarrantPercentage" name="IncreaseInWarrantPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_LifewardOrdinarySharesMember" name="LifewardOrdinarySharesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_SharePurchaseAgreementMember" name="SharePurchaseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LifewardNotesPurchaseAgreementMember" name="LifewardNotesPurchaseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PrefundedWarrantsMember" name="PrefundedWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_SharePurchaseWarrantsMember" name="SharePurchaseWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NoteWarrantsMember" name="NoteWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities" name="FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_OutstandingPercentage" name="OutstandingPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_StockholdersEquityDetailsTable" name="StockholdersEquityDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PerformanceRestrictedStockUnitsMember" name="PerformanceRestrictedStockUnitsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ExecutiveOfficersMember" name="ExecutiveOfficersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract" name="InvestmentInSharesAndOtherInstrumentsOfInvesteesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInSharesMember" name="InvestmentInSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInARPreFundedWarrantsMember" name="InvestmentInARPreFundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInARWarrantsMember" name="InvestmentInARWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInARNoteAndNoteWarrantsMember" name="InvestmentInARNoteAndNoteWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TotalFairValue" name="TotalFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_AdditionalTaxPayment" name="AdditionalTaxPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_ExtensionAgreementMember" name="ExtensionAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FundedAmount" name="FundedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_LoantoanEquityMethodInvesteeDetailsTable" name="LoantoanEquityMethodInvesteeDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LoanAgreementMeasuredinFairValueDetailsTable" name="LoanAgreementMeasuredinFairValueDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TovaChochmaImNachalaLtdMember" name="TovaChochmaImNachalaLtdMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InformationByCategoryOfDebtSecurityDomainDomain" name="InformationByCategoryOfDebtSecurityDomainDomain" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheBNoteMember" name="TrancheBNoteMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_WarrantsNoteBMember" name="WarrantsNoteBMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInAlphaTausWarrantsMember" name="InvestmentInAlphaTausWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LoanAgreementMeasuredInFairValueMember" name="LoanAgreementMeasuredInFairValueMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract" name="ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_WarrenAtBayLoanMember" name="WarrenAtBayLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PercentageOfNetSales" name="PercentageOfNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_PeriodOfProducts" name="PeriodOfProducts" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_AmortizationPayment" name="AmortizationPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="ormp_ExtensionObligationMember" name="ExtensionObligationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_JuniorParticipationInterestIn83WytheLoanMember" name="JuniorParticipationInterestIn83WytheLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PercentageOfAnnualReturn" name="PercentageOfAnnualReturn" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ParticipationInterestWarrenAtBayLoanMember" name="ParticipationInterestWarrenAtBayLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TrancheNoteBMember" name="TrancheNoteBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PenaltyPayment" name="PenaltyPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_ShareholdersMember" name="ShareholdersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RestrictedStockHoldersMember" name="RestrictedStockHoldersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_WarrantHoldersMember" name="WarrantHoldersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ALPHATauWarrantsMember" name="ALPHATauWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScilexMember" name="ScilexMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AdditionalLoanAgreementMember" name="AdditionalLoanAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RubySapphireIIMember" name="RubySapphireIIMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LifewardMember" name="LifewardMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AmendedAndRestatedWarrantMember" name="AmendedAndRestatedWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InitialNotesMember" name="InitialNotesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_OrdinarySharesClosingPercentage" name="OrdinarySharesClosingPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_InvestmentInSharesAndOtherInstrumentsOfInvesteeMember" name="InvestmentInSharesAndOtherInstrumentsOfInvesteeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NasdaqCapitalMarketMember" name="NasdaqCapitalMarketMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_AmendedAndRestatedPreFundWarrantMember" name="AmendedAndRestatedPreFundWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LifewardRevenue" name="LifewardRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_PercentageOfBearingInterestPerAnnum" name="PercentageOfBearingInterestPerAnnum" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_LoanAgreementMember" name="LoanAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_LoanExtensionMember" name="LoanExtensionMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NewTalpiotLtdMember" name="NewTalpiotLtdMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MaturityDaysOfLoan" name="MaturityDaysOfLoan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ScheduleOfValuationOfTheWarrantsAbstract" name="ScheduleOfValuationOfTheWarrantsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_MeasurementInputFloorRateMember" name="MeasurementInputFloorRateMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems" name="InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfFairValueCompositionAbstract" name="ScheduleOfFairValueCompositionAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable" name="InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_ScheduleOfRefinancingTransactionAbstract" name="ScheduleOfRefinancingTransactionAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable" name="InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_IncomeFromTheRoyaltyAgreement" name="IncomeFromTheRoyaltyAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_PrincipalPayments" name="PrincipalPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_ProceedsFromTheSaleOfSubsequentPennyWarrants" name="ProceedsFromTheSaleOfSubsequentPennyWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="ormp_InterestPayments" name="InterestPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_ScheduleOfFairValueBreakdownAbstract" name="ScheduleOfFairValueBreakdownAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_NotesMember" name="NotesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RoyaltyPurchaseAgreementPaymentMember" name="RoyaltyPurchaseAgreementPaymentMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentsatFairValueDetailsTable" name="InvestmentsatFairValueDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_PercentageOfVotingInterest" name="PercentageOfVotingInterest" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_SecuredPromissoryNoteMember" name="SecuredPromissoryNoteMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable" name="FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfScilexNetMember" name="RevaluationOfScilexNetMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfHapisgaNetMember" name="RevaluationOfHapisgaNetMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfAlphaTauNetMember" name="RevaluationOfAlphaTauNetMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_InvestmentInMAROramedJVLLCMember" name="InvestmentInMAROramedJVLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_TotalInvestment" name="TotalInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_GeneralPartnerDistributionsPercentage" name="GeneralPartnerDistributionsPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="ormp_FirstProjectPayment" name="FirstProjectPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="ormp_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodVestingPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodVestingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ProjectProfitsInterestRate" name="ProjectProfitsInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="ormp_ScheduleOfFinancialIncomeLossNetAbstract" name="ScheduleOfFinancialIncomeLossNetAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfRoyaltyVestLoanNetMember" name="RevaluationOfRoyaltyVestLoanNetMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfProfitSharingLoanAgreementMember" name="RevaluationOfProfitSharingLoanAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfRubyCapitalMember" name="RevaluationOfRubyCapitalMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_RevaluationOfLifewardMember" name="RevaluationOfLifewardMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="ormp_IncomeLossPerShareofCommonStockDetailsTable" name="IncomeLossPerShareofCommonStockDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
</xs:schema>
