v3.26.1
Shareholders' Equity - Changes in Shareholders' Deficit (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Mar. 31, 2026
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2026
Jun. 30, 2025
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance   $ 52,072     $ 52,072  
Net loss $ (137,311)   $ (198,147)   (267,843) $ (419,824)
Ending balance $ 12,222       $ 12,222  
Common Shares            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance (in shares) 150,506,490 132,775,113 102,104,024 101,221,989 132,775,113 101,221,989
Beginning balance $ 2,132,908 $ 1,934,276 $ 1,689,346 $ 1,656,702 $ 1,934,276 $ 1,656,702
Issuance of common shares, net of offering costs (in shares)   17,164,940        
Issuance of common shares, net of offering costs   $ 178,884        
Issuance of common shares as payment under license and other agreements (in shares)   76,383 3,588,688 354,819    
Issuance of common shares as payment under license and other agreements   $ 858 $ 51,426 $ 13,398    
Issuance of common shares under 2022 Equity Incentive Plan (in shares) 511,041 490,054   527,216    
Issuance of common shares under 2022 Equity Incentive Plan $ 5,953 $ 18,890   $ 19,246    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan (in shares)     89,735      
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan     $ 2,337      
Ending balance (in shares) 151,017,531 150,506,490 105,782,447 102,104,024 151,017,531 105,782,447
Ending balance $ 2,138,861 $ 2,132,908 $ 1,743,109 $ 1,689,346 $ 2,138,861 $ 1,743,109
Additional Paid-in Capital            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance 203,358 193,984 137,467 112,369 193,984 112,369
Issuance of common shares as payment under license and other agreements       (8,554)    
Issuance of common shares under 2022 Equity Incentive Plan (2,157) (18,912)   (19,410)    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan     (1,260)      
Non-cash share-based compensation expense 19,164 28,286 20,812 53,062    
Ending balance 220,365 203,358 157,019 137,467 220,365 157,019
Accumulated Deficit            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance (2,215,068) (2,084,536) (1,567,391) (1,345,714) (2,084,536) (1,345,714)
Net loss (137,311) (130,532) (198,147) (221,677)    
Ending balance (2,352,379) (2,215,068) (1,765,538) (1,567,391) (2,352,379) (1,765,538)
Accumulated Other Comprehensive Income (Loss)            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance 8,302 8,348 73 79 8,348 79
Other comprehensive loss (2,927) (46) (76) (6) (2,973) (82)
Ending balance 5,375 8,302 (3) 73 5,375 (3)
Total Shareholders' Equity (Deficit)            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance 129,500 52,072 259,495 423,436 52,072 423,436
Net loss (137,311) (130,532) (198,147) (221,677)    
Issuance of common shares, net of offering costs   178,884        
Issuance of common shares as payment under license and other agreements   858 51,426 4,844    
Issuance of common shares under 2022 Equity Incentive Plan 3,796 (22)   (164)    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan     1,077      
Non-cash share-based compensation expense 19,164 28,286 20,812 53,062    
Other comprehensive loss (2,927) (46) (76) (6)    
Ending balance $ 12,222 $ 129,500 $ 134,587 $ 259,495 $ 12,222 $ 134,587