Non-Cash Share-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2026

Share-Based Payment Arrangement [Abstract]

Schedule of non-cash share-based compensation expense

Non-cash share-based compensation expense, consisting of expense for share options, restricted share units ("RSUs"), performance share options, and the Employee Share Purchase Plan, was classified in the condensed consolidated statements of operations and comprehensive loss as follows:


	Three Months Ended June 30,				Six Months Ended June 30,
	2026		2025		2026		2025
Research and development expenses	$	11,983	$	13,110	$	30,458	$	48,344
General and administrative expenses	7,181		7,702		16,992		25,530
Total non-cash share-based compensation expense	$	19,164	$	20,812	$	47,450	$	73,874

Schedule of stock option activity

The following table is a summary of the Company's share option activity for the six months ended June 30, 2026:


	Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term	Aggregate Intrinsic Value
				(in years)
Outstanding as of December 31, 2025	15,649,514	$	21.06
Granted	5,213,525	$	11.34
Exercised	(306,185)	$	7.04
Forfeited	(181,320)	$	27.75
Outstanding as of June 30, 2026	20,375,534	$	18.72	7.66	$	75,673
Options exercisable as of June 30, 2026	13,947,512	$	17.79	7.00	$	61,344
Vested and expected to vest as of June 30, 2026	20,375,534	$	18.72	7.66	$	75,673

Schedule of RSU activity

The following table is a summary of the RSU activity for the six months ended June 30, 2026:


	Number of shares	Weighted Average Grant Date Fair Value
Unvested as of December 31, 2025	1,402,696	$	38.48
Granted	15,850	$	11.02
Vested	(482,437)	$	39.01
Forfeited	(36,530)	$	38.97
Unvested as of June 30, 2026	899,579	$	37.70