75000 - Document - Document and Entity Information
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75010 - Statement - Condensed Consolidated Balance Sheets
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75020 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Condensed Consolidated Statements of Stockholders' Equity
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75050 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Parenthetical)
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75060 - Statement - Condensed Consolidated Statements of Cash Flows
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75070 - Statement - Consolidated Statements of Cash Flows (Parenthetical)
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995455 - Disclosure - Nature of the Business and Basis of Presentation
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Marketable Securities and Fair Value of Financial Assets and Liabilities
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995485 - Disclosure - Accrued Expenses and Other Current Liabilities
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995495 - Disclosure - Preferred Stock, Series A Non-Voting Convertible Preferred Stock and Common Stock
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995505 - Disclosure - Stock-Based Compensation
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995515 - Disclosure - Commitments and Contingencies
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995525 - Disclosure - Debt
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995535 - Disclosure - Net Loss Per Share
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995545 - Disclosure - Retirement Plan
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995555 - Disclosure - Segment Information
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995565 - Disclosure - Subsequent Events
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995575 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995585 - Disclosure - Marketable Securities and Fair Value of Financial Assets and Liabilities (Tables)
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995595 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)
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995605 - Disclosure - Stock-Based Compensation (Tables)
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995615 - Disclosure - Debt (Tables)
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995625 - Disclosure - Net Loss Per Share (Tables)
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995635 - Disclosure - Segment Information (Tables)
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995645 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Detail)
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995655 - Disclosure - Marketable Securities and Fair Value of Financial Assets and Liabilities - Summary of Marketable Securities (Detail)
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995665 - Disclosure - Marketable Securities and Fair Value of Financial Assets and Liabilities - Additional Information (Detail)
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995675 - Disclosure - Marketable Securities and Fair Value of Financial Assets and Liabilities - Schedule of Financial Assets and Liabilities at Fair Value on Recurring Basis (Detail)
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995685 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail)
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995695 - Disclosure - Preferred Stock, Series A and Series B Non-Voting Convertible Preferred Stock and Common Stock - Additional Information (Detail)
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995705 - Disclosure - Stock-Based Compensation - Additional Information (Detail)
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995715 - Disclosure - Stock-Based Compensation - Schedule of Stock-based Compensation Expense by Type of Award (Detail)
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995725 - Disclosure - Stock-Based Compensation - Schedule of Stock Based Compensation Expense (Detail)
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995735 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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995745 - Disclosure - Debt - Additional Information (Detail)
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995755 - Disclosure - Debt - Schedule of Outstanding Balance of Notes (Detail)
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995765 - Disclosure - Debt - Summary of Estimated Future Principal Payments Due (Detail)
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995775 - Disclosure - Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Detail)
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995785 - Disclosure - Net Loss Per Share - Summary of Potential Dilutive Securities (Detail)
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995795 - Disclosure - Retirement Plan - Additional Information (Detail)
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995805 - Disclosure - Segment Information - Additional Information (Detail)
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995815 - Disclosure - Segment Information - Schedule of Segment Information (Detail)
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995825 - Disclosure - Subsequent Events - Additional Information (Detail)
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Segments [Domain]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Stock Issued During Period, Shares,Performance-Based Restricted Stock Units , Vested
Stock Issued During Period, Shares,Performance-Based Restricted Stock Units , Vested.
Issuance of common stock upon PSU vesting, Shares
Preferred Stock, Shares Issued
Preferred stock, shares issued
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Series B Non-Voting Convertible Preferred Stock [Member]
Series b convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Plan Name [Axis]
Plan Name
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Unrealized loss position more than 12 months
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, Shares authorized
Time based restricted stock unit.
Time Based Restricted Stock Unit [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Shell Company
Entity Shell Company
Other Accrued Liabilities, Current
Other
Convertible Debt [Member]
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Schedule of Maturities of Long-Term Debt [Table Text Block]
Summary of Estimated Future Principal Payments Due
Common Stock, Shares, Issued
Common stock, Shares issued
Common stock shares issued
Statement [Table]
Statement [Table]
Restricted cash
Restricted Cash, Noncurrent
Right-of-use assets obtained in exchange for new operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Issuance Of Common Stock From Pre funded Warrant Exercises
Issuance of common stock from pre funded warrant exercises.
Issuance of common stock from pre-funded warrant exercises
Statement [Line Items]
Statement [Line Items]
Entity Filer Category
Entity Filer Category
Liabilities and Equity
Total liabilities and stockholders’ equity
Debt Instrument [Line Items]
Payables and Accruals [Abstract]
Payments to Acquire Marketable Securities
Purchases of marketable securities
Purchases of marketable securities
Long-Term Debt, Maturity, Year Three
2027
Convertible preferred stock shares issuable Upon conversion.
Convertible Preferred Stock Shares Issuable Upon Conversion
Convertible preferred stock, common stock issuable upon conversion
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Subsequent Event [Line Items]
Other Operational Infrastructure and Advisory Support [Member]
Other operational infrastructure and advisory support.
Other Operational Infrastructure and Advisory Support [Member]
Stock Options to Purchase Common Stock [Member]
Investment Income, Interest
Interest income
Interest income
Debt Securities, Available-for-Sale, Noncurrent
Marketable Securities, Fair Value
Long-term marketable securities
Debt securities available for sale credit related impairments charges.
Debt Securities Available For Sale Credit Related Impairments Charges
Marketable debt securities, charges for credit-related impairments
Converstion of shares percentage.
Converstion of Shares Percentage
Converstion of shares percentage
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Defined contribution plan, employer matching contribution percent
Evan Kearns [Member]
Evan Kearns.
Common Stock, Capital Shares Reserved Additional for Future Issuance
Common stock, capital shares reserved additional for future issuance.
Additional Shares Reserved For Future Issuance
Additional Paid in Capital, Common Stock
Additional paid-in capital
Performance-based restricted stock units (PSUs) [Member]
Performance-based restricted stock units (PSUs) [Member]
Unvested PSUs [Member]
Debt Instrument, Interest Rate During Period
Percentation of Interest rate during period
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Number of development performance milestones
Number of development performance milestones.
Vesting [Domain]
Aggregate payments received upon satisfaction of clinical milestones.
Aggregate Payments Received Upon Satisfaction Of Clinical Milestones
Aggregate payments received upon satisfaction of clinical milestones
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Computation of Basic and Diluted Net Loss Per Share
Net loss per share attributable to common stockholders, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Net loss per share, basic
Sublease, area of square feet.
Sublease Area Of Square Feet
Square feet of office space
Retirement Benefits [Text Block]
Retirement Plan
Accrued professional and consulting services.
Accrued Professional And Consulting Services
Accrued professional and consulting services
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Payments of Debt Issuance Costs
Payment of debt issuance costs
Equity, Attributable to Parent [Abstract]
Stockholders’ equity:
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Preferred Stock [Member]
Preferred Stock [Member]
Sale of Stock, Price Per Share
Stock offering price, per share
Commitments And Contingencies Disclosure [Table]
Commitments And Contingencies Disclosure [Table]
Commitments And Contingencies Disclosure [Table]
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Guggenheim Securities, LLC.
Guggenheim Securities L L C [Member]
Guggenheim Securities, LLC [Member]
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Lease Contractual Term [Axis]
Maximum number of shares issuable under certificate of designation.
Maximum Number of Shares Issuable Under Certificate of Designation
Maximum number of shares issuable under certificate of designation
Amendment Flag
Amendment Flag
Maturities of Long-Term Debt [Abstract]
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment and Tax
Unrealized gains (losses) on marketable securities
Unrealized losses on marketable securities
Pre-funded warrants, shares
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Liabilities and Equity [Abstract]
Liabilities and Stockholders’ Equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock [Member]
Common Stock [Member]
Defined Contribution Plan, Employer Discretionary Contribution Amount
Defined contribution plan, matching amount
Long-Term Debt, Maturity, Year One
2025
U.S. Treasury Bills and Notes (Due within One Year) [Member]
US Treasury Bills and Notes Securities [Member]
US treasury bills and notes securities.
Plexxikon license agreement.
Plexxikon License Agreement [Member]
Plexxikon License Agreement [Member]
Debt Instrument, Interest Rate, Effective Percentage
Effective interest rate
Entity Address, Address Line One
Entity Address, Address Line One
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger
Debt instrument convertible threshold percentage of stock price trigger
Earnings Per Share [Abstract]
Extended Lease Term Of Contract
Extended lease term of contract.
Extended lease term of contract
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow information:
Investment Type [Axis]
Time-based Stock Options [Member]
Time Based Stock Options [Member]
Time-based stock options.
Operating lease, initial right-of-use asset
Operating Lease, Right-of-Use Asset
Operating lease, right-of-use assets
Milestone Payments Payable Upon Achievement Regulatory Milestones
Milestone payments payable upon achievement regulatory milestones.
Milestone payments payable upon achievement regulatory milestones
Document Type
Document Type
Beneficial ownership limitation percentage for conversion of common stock issued and outstanding
Beneficial ownership limitation percentage for conversion of common stock issued and outstanding.
Beneficial Ownership Limitation Percentage For Conversion Of Common Stock Issued And Outstanding
Beneficial ownership limitation percentage for conversion of common stock issued and outstanding
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Dr. Jessica Sachs [Member]
Dr. Jessica Sachs.
Summary of Marketable Securities
Debt Securities, Available-for-Sale [Table Text Block]
Per principal amount of Convertible Notes
Per Principal Amount Of Convertible Notes
Per principal amount of convertible notes.
Number Of Consecutive Trading Days
Number of consecutive trading days.
Number of consecutive trading days
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net (decrease) increase in cash, cash equivalents and restricted cash
Debt Instrument Tranche One [Member]
Debt Instrument Tranche One.
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Potential dilutive securities excluded from computation of diluted net loss per common share
Underwriting discounts and commissions expenses
Underwriting Discounts And Commissions Expenses
Underwriting discounts and commissions expenses.
Common Stock, Par or Stated Value Per Share
Common stock, Par value
Security Deposit
Security deposit amount
1-year Anniversary of Grant Date [Member]
Share-Based Payment Arrangement, Tranche One [Member]
Amortization of operating leases, right-of-use assets
Operating Lease, Right-of-Use Asset, Periodic Reduction
Increase (Decrease) in Other Operating Liabilities
Increase (Decrease) in Other Operating Liabilities, Total
Other liabilities
Marketable Securities, Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Marketable Securities, Fair Value
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Marketable Securities, Amortized Cost
Marketable Securities, Fair Value
Debt Securities, Available-for-Sale
Debt Instruments [Abstract]
Exercise of stock options additional shares of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock from exercises of stock options, Shares
Debt Disclosure [Abstract]
Waltham Lease [Member]
Waltham lease.
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Offering expenses
Offering Expenses
Offering expenses.
Document Quarterly Report
Document Quarterly Report
Entity Address, State or Province
Entity Address, State or Province
Conversion of preferred stock into common stock
Stock Issued During Period, Value, Conversion of Convertible Securities
Debt instrument convertible threshold consecutive trading days
Debt Instrument, Convertible, Threshold Consecutive Trading Days
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Marketable Securities, Gross Unrealized Gains
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for future issuance
At-the-market.
At The Market [Member]
ATM [Member]
Performance-based restricted stock units subject to vesting.
Performance-based Restricted Stock Units Subject To Vesting [Member]
Conversion of Stock, Shares Converted
Cumulative amount of shares conversion
Milestone Payable in second quarter.
Milestone Payable In Second Quarter
Clinical milestone achieved, triggering payment
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Stock Based Compensation Expense
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock from exercises of stock options
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Accrued Expenses and Other Current Liabilities
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive income (loss)
Base rent initial rate per square foot.
Base Rent Initial Rate Per Square Foot
Initial base rent per square foot per year
Maturities and sales of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Long-Term Debt, Fair Value
Estimated fair value of Notes
Subsequent Event [Member]
Subsequent Event [Member]
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
2024
Long-Term Debt, Maturity, Remainder of Fiscal Year
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Increased in authorized shares reserved for issuance
Other Assets, Noncurrent
Other assets
Unamortized debt discount and issuance costs
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total
Convertible Senior Notes Due 2031 [Member]
Convertible senior notes due 2031.
Marketable Securities, Fair Value
Marketable Securities, Fair Value
Marketable securities
Short-term marketable securities
Antidilutive Securities [Axis]
Antidilutive Securities
Percentage of vesting of award
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Interest Expense, Debt
Interest Expense, Debt, Total
Interest expense related to the Credit Facility
Interest expense
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Schedule of Stock-based Compensation Expense by Type of Award
Lease Term Of Contract
Lease term of contract.
Lease term of contract
Accumulated Other Comprehensive Income (Loss) [Member]
AOCI Attributable to Parent [Member]
Contingent value right liability current.
Contingent Value Right Liability Current
CVR liability (Note 3)
Preferred Stock, Value, Issued
Preferred stock, value
Minimum [Member]
Minimum [Member]
Financial Instrument [Axis]
Financial Instrument
Debt Discount Included In Accrued Expenses And Other Liabilities
Debt discount included in accrued expenses and other liabilities.
Debt discount included in accrued expenses and other liabilities
Assets, Current [Abstract]
Current assets:
Collaborative Arrangement, Rights and Obligations
License agreement expiration terms
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
Segment Reporting [Abstract]
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets and Liabilities at Fair Value on Recurring Basis
Liabilities, Current [Abstract]
Current liabilities:
Performance-based restricted stock units.
Performance-based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units Subject to Vesting [Member]
Shares, Outstanding
Ending Balances, Shares
Beginning Balances, Shares
Commitments and Contingencies
Commitments and contingencies (Note 7)
Arlene Morris [Member]
Arlene Morris.
Commitments And Contingencies Disclosure [Line Items]
Commitments And Contingencies Disclosure [Line Items]
Commitments And Contingencies Disclosure [Line Items]
General and Administrative Expenses [Member]
General and Administrative Expense [Member]
Two thousand eighteen stock option and incentive plan.
Two Thousand Eighteen Stock Option And Incentive Plan [Member]
2018 Stock Option and Incentive Plan [Member]
Forecast [Member]
Aggregate payments received upon satisfaction of regulatory.
Aggregate Payments Received Upon Satisfaction Of Regulatory
Aggregate payments received
Performance based Restricted Stock Unit Member
Performance-based restricted stock unit.
Performance-based Restricted Stock Units [Member]
Amount of increase (decrease) in operating lease obligations.
Increase Decrease In Operating Leases
Operating lease liability
Long-Term Debt, Maturity, Year Two
2026
Bezuclastinib Development [Member]
Bezuclastinib development.
Lease commencement date
Lease Commencement Date
Lease commencement date.
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Lease Contractual Term [Domain]
Debt Instrument, Maturity Date Range, Start
Debt instrument of maturity date start
Convertible Preferred Stock Converted to Other Securities
Conversion of Series A Preferred Stock into common shares
Long-Term Debt, Type [Domain]
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted average common stock outstanding, basic
Weighted average shares outstanding, basic
Exchange agreements.
Exchange Agreements [Member]
Exchange Agreements [Member]
Scenario [Axis]
Document Information [Line Items]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Segments [Axis]
Carrying value as of the balance sheet date of obligations incurred through that date and payable for external research and development expense. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued External Research And Development Expenses Current
Accrued external research and development expense
Proceeds from Issuance of Private Placement
Proceeds form private placement, net
Subsequent Events [Text Block]
Subsequent Events
Long-Term Debt
Long-term debt, net
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Other expense (income), net
Other Nonoperating Expense Income Net
Other nonoperating expense (income) net.
Equity, Attributable to Parent
Ending Balances
Beginning Balances
Total stockholders’ equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Statement of Stockholders' Equity [Abstract]
Series A Preferred Stock [Member]
Series A Preferred Stock [Member]
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Over-Allotment Option [Member]
Over-Allotment Option [Member]
Entity Address, Address Line Two
Entity Address, Address Line Two
Pre-funded warrants remain outstanding
Pre-funded Warrants Remain Outstanding
Pre-funded warrants remain outstanding.
Proceeds From Pre-Funded Warrant Exercises
Proceeds from pre-funded warrant exercises.
Proceeds from pre-funded warrant exercises
Research and Development Software, Facilities and Other Strategic Support [Member]
Research and development software, facilities and other strategic support.
Research and Development Software, Facilities and Other Strategic Support [Member]
Debt Instrument, Name [Domain]
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of noncash investing and financing information:
Long-Term Debt, Maturity, Year Four
2028 (7 Months)
Number of shares additionally granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Additional Grants In Period
Share based compensation arrangement by share based payment award equity instruments other than options additional grants in period.
The cash inflow during the period from the issuance or sale of common stock, preferred stock, debt securities, warrants, or a combination of these securities.
Proceeds From Issuance Or Sale Of Equity And Debt
Proceeds from issuance of equity and debt financing
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Plan Name
Increase (Decrease) in Other Operating Assets
Other assets
Increase (Decrease) in Other Operating Assets, Total
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Vesting term
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights
Entity Address, City or Town
Entity Address, City or Town
Security Exchange Name
Security Exchange Name
Exchange of common stock for series b preferred stock, shares.
Exchange Of Common Stock For Series B Preferred Stock, Shares
Exchange of common stock for Series B Preferred Stock, Shares
Principal amount
Long-Term Debt, Gross
Issuance Of Common Stock From Pre Funded Warrant Exercises Shares
Issuance of common stock from pre funded warrant exercises shares
Issuance of common stock from pre-funded warrant exercises, Shares
Counterparty Name [Axis]
Counterparty Name
Number of development performance milestones to be probable of achievement
Number of development performance milestones to be probable of achievement.
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Number Of Reportable Segments Not Disclosed [Flag]
Number of reportable segments not disclosed flag.
Total
Sum of the carrying values as of the balance sheet date of accrued expenses and other current liabilities.
Accrued Expenses And Other Liabilities Current
Accrued expenses and other current liabilities
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Total
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Pre-funded warrants, exercise price
Pre-funded warrants, purchase price per share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Assets, Current
Total current assets
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Document Period End Date
Document Period End Date
Convertible Notes Purchased Due To Exercise Of Under writer Option
Convertible notes purchased due to exercise of under writer option.
Convertible notes purchased, due to exercise of underwriter option
Title and Position [Axis]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Change in fair value of contingent value right liability.
Change In Fair Value Of Contingent Value Right Liability
Change in fair value of CVR liability
Change in fair value of CVR liability
Loss on fixed asset disposal
Gain (Loss) on Disposition of Property Plant Equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Options to purchase number of common shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Purchased for Award
Nonqualified Options [Member]
Nonqualified Options [Member]
Nonqualified options.
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted stock units [Member]
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Vesting [Axis]
Class of Stock [Axis]
Class of Stock
Series A Non-Voting Convertible Preferred Stock [Member]
Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions
Number of held securities in an unrealized loss position
Minimum percentage of originally issued shares remain issued and outstanding.
Minimum Percentage Of Originally Issued Shares Remain Issued And Outstanding
Minimum percentage of originally issued shares remain issued and outstanding
Liabilities
Total liabilities
Two thousand eighteen employee stock purchase plan.
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
2018 Employee Stock Purchase Plan [Member]
Financial Instruments [Domain]
Financial Instruments
Line Of Credit Facility Amount Available For Use
Line of credit facility amount available for use.
Term loan facility amount available for use
The percentage of the number of shares of the Company's common stock outstanding on the immediately preceding December 31 which will determine the increase in shares of common stock issued under the Plan.
Percentage Of Outstanding Shares Of Common Stock Reserved For Future Issuance
Percentage of shares of common stock available for issuance
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted average common stock outstanding, diluted
Weighted average shares outstanding, diluted
Entity File Number
Securities Act File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Net unrealized gains (losses) on marketable securities
Cover [Abstract]
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Percentage of Share Based Compensation Nonvested Awards Stock Maximum Achievement
Investments [Domain]
ATM program [Member]
At The Market Program [Member]
At the market program.
Scenario [Domain]
US Treasury Securities [Member]
U.S. Treasury Bills and Notes [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of increases in authorized shares
Number of operating segment
Number of Operating Segments
Sale of Stock
Sale of Stock [Domain]
Segment Information
Segment Reporting Disclosure [Text Block]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Series B Preferred Stock [Member]
Series B Preferred Stock [Member]
Subsequent Event [Table]
Shares issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Initial conversion price
Debt Instrument, Convertible, Conversion Price
Long Term Debt Maturities Repayments Of Principal After Year Four
Long term debt maturities repayments of principal after year four.
Thereafter
Period by which Base Rent Obligation paid after the Commencement Date
Period by which base rent obligation paid after the commencement date.
Period by which base rent obligation paid after the commencement date
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted and Issued Accounting Pronouncements
Amount of transfers of assets measured on a recurring basis between Level 1, Level 2 and Level 3.
Fair Value Assets Transfers Between Level One Two And Three
Fair value asset, transfers between Level 1, Level 2 and Level 3, amount
Debt Instrument Covenant Required Amount Outstanding
Debt instrument covenant required amount outstanding.
Outstanding notes
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Computation of Basic and Diluted Net Loss Per Share [Line items]
Conversion of preferred stock into common stock, Shares
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of preferred stock into common stock, Shares
Percentage of preferred stock issued.
Percentage Of Preferred Stock Issued
Percentage of preferred stock issued
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Former Address [Member]
Former Address [Member]
Andrew Robbins [Member]
Andrew Robbins.
Proceeds from Issuance of Long-Term Debt
Proceeds from Issuance of Long-Term Debt, Total
Proceeds from long-term debt
Unrecognized compensation cost, other than options
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Preferred stock and common stock.
Preferred Stock And Common Stock [Text Block]
Preferred Stock, Series A and Series B Non-Voting Convertible Preferred Stock and Common Stock
Common Stock, Shares, Outstanding
Common stock, Shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Operating Lease, Liability, Current
Operating lease liabilities
Document Transition Report
Document Transition Report
Research and Development Expense
Research and development
Research and Development Expense, Total
Statement of Cash Flows [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock under ATM, net of issuance costs
Assets:
Assets, Fair Value Disclosure [Abstract]
Earnings Per Share [Text Block]
Net Loss Per Share
Sale of Stock, Consideration Received Per Transaction
Sale of securities, value
Net loss
Net loss
Segment net loss and consolidated net loss
Net loss
Preferred Stock, Convertible, Shares Issuable
Number of shares convertible
Time-based restricted stock units subject to vesting.
Time-Based Restricted Stock Units Subject To Vesting [Member]
Assets [Abstract]
Assets
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Amortization of Debt Issuance Costs and Discounts
Amortization of Debt Issuance Costs and Discounts, Total
Amortization of debt discount and issuance costs
Amortization of debt discount and issuance costs
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Early Stage, Preclinical and Discovery Programs [Member]
Early stage, preclinical and discovery programs.
Early-stage, Preclinical and Discovery Programs [Member]
Interest Expense, Nonoperating
Interest Expense, Nonoperating, Total
Interest expense
Interest expense
Research and Development Expenses [Member]
Research and Development Expense [Member]
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities and Fair Value of Financial Assets and Liabilities
Karen Ferrante [Member]
Karen Ferrante.
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Defined contribution plan, employer matching contribution percentage of match
Proceeds from Stock Options Exercised
Proceeds from issuance of common stock upon stock option exercises
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common stockholders
Debt Instrument [Axis]
Share-Based Payment Arrangement [Abstract]
Employees [Member]
Employees [Member]
Employees [Member]
Total assets
Total Assets
Assets, Fair Value Disclosure
Sale of Stock
Sale of Stock [Axis]
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Excluding Option Exercised
Proceeds from issuance of common stock from Employee Stock Purchase Plan
Stock Issued During Period, Shares, Restricted Stock Award, Vested
Stock issued during period, shares, restricted stock award, vested.
Issuance of common stock upon RSU vesting
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash (used in) provided by investing activities
Private Placement [Member]
Private Placement [Member]
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Money Market Funds [Member]
Money Market Funds [Member]
Underwritten Public Offering [Member]
Underwritten Public Offering Member
Underwritten Public Offering [Member]
Latestage development [Member]
Late-stage development.
Late-stage Development [Member]
Debt instrument of maturity date end
Debt Instrument, Maturity Date Range, End
Document Information [Table]
Other Liabilities, Noncurrent
Other liabilities
Research and Development Personnel Related [Member]
Research and development personnel related.
R&D Personnel Related [Member]
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Number of research performance milestones
Number of research performance milestones.
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other current liabilities
Measurement Frequency [Domain]
Measurement Frequency
Statement of Income Location, Balance [Axis]
Income Statement Location
Trading Symbol
Trading Symbol
Stock options exercised for which cash proceeds had not yet been received
Stock Options Exercised and Cash Proceeds Not Yet Received
Stock options exercised and cash proceeds not yet received.
Underwriters Exercise Period Option
Underwriters exercise period option.
Underwriters exercise period option
Subsequent Event Type [Axis]
Credit Facility [Member]
Credit Facility.
Depreciation Expense [Member]
Depreciation expense.
Depreciation Expense [Member]
Employee-related Liabilities, Current
Accrued employee compensation and benefits
Employee-related Liabilities, Current, Total
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Fair Value, Recurring [Member]
Recurring Basis [Member]
Entity Ex Transition Period
Entity Ex Transition Period
Equity Components
Equity Components [Axis]
Long Term Debt Excluding Convertible Debt Noncurrent
Long term debt excluding convertible debt noncurrent.
Long-term debt, net
Deferred Compensation Arrangement with Individual, Allocated Share-Based Compensation Expense
Compensation expense recognized
Nonoperating Income (Expense)
Total other income, net
Equity Component
Equity Component [Domain]
Address Type [Domain]
Issuance of common stock under Employee Stock Purchase Plan, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization expense
Depreciation, Depletion and Amortization, Nonproduction, Total
Common Stock, Voting Rights
Common stock voting right
Two thousand twenty inducement plan.
Two Thousand Twenty Inducement Plan [Member]
2020 Inducement Plan [Member]
Maximum [Member]
Maximum [Member]
Entity Addresses, Address Type [Axis]
Statistical Measurement [Axis]
Statistical Measurement
Common Stock, Value, Issued
Common stock, $0.001 par value; 300,000,000 shares authorized; 171,598,409 and 160,980,024 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively
The percentage of the number of shares of the Company's common stock outstanding on the immediately preceding December 31 by which the number of shares reserved will be increased.
Annual Increase In Aggregate Number Of Shares Reserved For Future Issuance As Percentage Shares Outstanding
Percentage applied to the outstanding shares as annual increase in the number of shares authorized for issuance
Long Term Debt Maturities Repayments Of Principal Gross
Long term debt maturities repayments of principal gross.
Total
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
John Green [Member]
John Green.
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Costs and Expenses
Total operating expenses
Schedule of Debt [Table Text Block]
Schedule of Outstanding Balance of Notes
Employee Stock [Member]
Employee Stock Purchase Plan [Member]
Entity Registrant Name
Entity Registrant Name
Debt Disclosure [Text Block]
Debt
Share-Based Payment Arrangement, Accelerated Cost
Incremental stock compensation expense
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Marketable Securities, Gross Unrealized Losses
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense), net
Other expense (income), net
Other expense (income), net
Initial conversion rate for convertible notes
Initial Conversion Rate For Convertible Notes
Initial conversion rate for convertible notes.
Subsequent Events [Abstract]
Conversion of Convertible Notes [Member]
Conversion of convertible notes.
Shares Issuable Upon Conversion of Convertible Notes [Member]
Proceeds from issuance under at the market offering.
Proceeds From Issuance Under At The Market Offering
Proceeds from issuance of common stock under ATM, net of issuance costs of $1.4 million and $0.7 million, respectively
Measurement Frequency [Axis]
Measurement Frequency
Proceeds from issuance of common stock to LPC
Proceeds from Issuance of Common Stock
Proceeds from issuance of shares of common stock, net of offering costs of $10.7 million
Costs and Expenses [Abstract]
Operating expenses:
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Chief Commercial Officer [Member]
Chief Commercial Officer [Member]
Chief Commercial Officer.
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated other comprehensive income (loss)
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Number of shares grants
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of shares issued to employees under the ESPP
Assets
Total assets
Income Statement [Abstract]
Sale of Stock, Number of Shares Issued in Transaction
Stock issued (in shares)
Shares of common stock issued and sold
Stock Issued During Period, Shares, New Issues
Issuance of common stock under ATM, net of issuance costs, Shares
Milestone payable in next twelve month.
Milestone Payable In Next Twelve Month
Milestone payments payable as a result of progression of on-going clinical studies
Stock-Based Compensation Expense [Member]
Stock-based compensation expense.
Stock-Based Compensation Expense [Member]
Earnings Per Share, Diluted, Total
Net loss per share attributable to common stockholders, diluted
Earnings Per Share, Diluted
Net loss per share, diluted
Debt Issuance Costs Included in Accounts Payable and Accrued Expenses
Debt issuance costs included in accounts payable and accrued expenses.
Debt issuance costs included in accounts payable and accrued expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Segment Information
Title and Position [Domain]
City Area Code
City Area Code
Disclosure of accounting policy for unaudited interim financial information.
Unaudited Interim Financial Information Policy [Text Block]
Unaudited Interim Financial Information
Other Comprehensive Income (Loss), Net of Tax
Total other comprehensive income (loss)
Series A Non-voting convertible preferred stock.
Series A Non Voting Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock [Member]
Series A Non-Voting Convertible Preferred Stock [Member]
Debt Instrument, Face Amount
Term loan facility, principal amount
Securities purchase agreement member.
Securities Purchase Agreement [Member]
Purchase Agreement [Member]
Counterparty Name [Domain]
Counterparty Name
Carrying value as of the balance sheet date of obligations incurred through that date and payable for external manufacturing expense.
Accrued External Manufacturing Cost Current
Accrued external manufacturing costs
Convertible Debt, Noncurrent
Convertible senior notes, net
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under Employee Stock Purchase Plan
Segment Reporting Information [Line Items]
Pre-funded warrants exercised
Pre-funded Warrants Exercised
Pre-funded warrants exercised
Property, Plant and Equipment, Net
Property and equipment, net
Property, Plant and Equipment, Net, Total
Operating Income (Loss)
Loss from operations
Operating Expenses
Operating Expenses
Series b non voting convertible preferred stock member.
Series B Non Voting Convertible Preferred Stock Member
Series B Convertible Preferred Stock [Member]
Series B Non Voting Convertible Preferred Stock [Member]
Retained Earnings [Member]
Accumulated Deficit [Member]
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense, Total
Payments of Stock Issuance Costs
Issuance cost
Offering/Issuance costs
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Unrealized loss possition less than 12 months
Debt Instrument Convertible Thres Hold Percentage Of Last Reported Sale Price
Debt instrument convertible thres hold percentage of last reported sale price.
Debt instrument convertible thres hold percentage of last reported sale price
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Class of Stock [Line Items]
Class Of Stock [Line Items]
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
The aggregate offering price for issuance or sale of common stock.
Aggregate Offering Price Common Stock
Stock offering cost
Rent Annual Increase Per Square Foot.
Rent Annual Increase Per Square Foot
Rent annual increase per square foot
Investments, Fair Value Disclosure, Total
Investments, Fair Value Disclosure
Marketable Securities
Nonoperating Income (Expense) [Abstract]
Other income:
Undesignated preferred stock.
Undesignated Preferred Stock [Member]
Undesignated Preferred Stock [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Potential Dilutive Securities
Entity Interactive Data Current
Entity Interactive Data Current
Statement of Income Location, Balance [Domain]
Income Statement Location
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Convertible Preferred Stock, Shares Issued upon Conversion
Common stock issued upon conversion of preferred stock
PreFunded Warrants Remaining Exercised
Pre-funded warrants remaining exercised.
Pre-funded warrants remaining exercised
Accretion (Amortization) of Discounts and Premiums, Investments
Net amortization (accretion) of premiums (discounts) on marketable securities
Net amortization (accretion) of premiums (discounts) on marketable securities
Issuance of common stock remained unsold and available for sale
Issuance of Common Stock Remained Unsold and Available For Sale
Issuance of common stock remained unsold and available for sale.
Entity Tax Identification Number
Entity Tax Identification Number
Long-Term Debt, Type [Axis]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of the Business and Basis of Presentation
Number Of Business Days
Number of business days.
Number of business days
Local Phone Number
Local Phone Number
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation cost
Accounting Policies [Abstract]
Debt Instrument, Convertible, Threshold Trading Days
Debt instrument convertible threshold trading days
Class of Stock [Domain]
Class of Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares available for issuance
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation expenses, recognition period
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Us treasury bills and notes securities due after one through five years.
UsTreasury Bills And Notes Securities Due After One Through Five Years [Member]
U.S. Treasury Bills and Notes (Due After One Through Five Years) [Member]