<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e887c-e5a8-7165-a4ba-6d5844c9ad70,g:0b161456-a63d-4474-9cf6-8e0b0bbd363e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.steris.com/role/Cover" xlink:type="simple" xlink:href="ste-20260630.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_019e887c-e744-7a1b-b401-62b124e12543" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntitiesTable_019e887c-e744-7a1b-b401-62b124e12543" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e887c-e744-7645-a9a8-592b26d327dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_019e887c-e744-7a1b-b401-62b124e12543" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e887c-e744-7645-a9a8-592b26d327dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e887c-e744-7645-a9a8-592b26d327dc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e887c-e744-7645-a9a8-592b26d327dc" xlink:to="loc_us-gaap_ClassOfStockDomain_019e887c-e744-7645-a9a8-592b26d327dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e887c-e744-72d7-9978-852a6765c294" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e887c-e744-7645-a9a8-592b26d327dc" xlink:to="loc_us-gaap_ClassOfStockDomain_019e887c-e744-72d7-9978-852a6765c294" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_STETwo700SeniorNotesDue2031MemberMember_019e887c-e744-727b-9f23-941295302b75" xlink:href="ste-20260630.xsd#ste_STETwo700SeniorNotesDue2031MemberMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e887c-e744-72d7-9978-852a6765c294" xlink:to="loc_ste_STETwo700SeniorNotesDue2031MemberMember_019e887c-e744-727b-9f23-941295302b75" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Two700SeniorNotesDue2051MemberMember_019e887c-e744-78e6-b5cb-ee0ed9eaa459" xlink:href="ste-20260630.xsd#ste_Two700SeniorNotesDue2051MemberMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e887c-e744-72d7-9978-852a6765c294" xlink:to="loc_ste_Two700SeniorNotesDue2051MemberMember_019e887c-e744-78e6-b5cb-ee0ed9eaa459" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OrdinarySharesMember_019e887c-e744-762e-a1d1-8c730676f102" xlink:href="ste-20260630.xsd#ste_OrdinarySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e887c-e744-72d7-9978-852a6765c294" xlink:to="loc_ste_OrdinarySharesMember_019e887c-e744-762e-a1d1-8c730676f102" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e887c-e744-7d6f-a61d-d5dc38ab2111" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityRegistrantName_019e887c-e744-7d6f-a61d-d5dc38ab2111" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e887c-e744-7448-b637-447ba10400e5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityCentralIndexKey_019e887c-e744-7448-b637-447ba10400e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e887c-e744-74d0-9339-d4e31132b8d0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentType_019e887c-e744-74d0-9339-d4e31132b8d0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_019e887c-e744-744d-bb1a-9cbda6877ac0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentTransitionReport_019e887c-e744-744d-bb1a-9cbda6877ac0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e887c-e744-7109-aba6-806ba51f9ead" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentPeriodEndDate_019e887c-e744-7109-aba6-806ba51f9ead" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e887c-e744-7d9c-990c-5096361a2c8b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_AmendmentFlag_019e887c-e744-7d9c-990c-5096361a2c8b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_019e887c-e744-7ad9-9bbc-f9be61d5ec37" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentFiscalYearFocus_019e887c-e744-7ad9-9bbc-f9be61d5ec37" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_019e887c-e744-75ae-bdcd-6ecc98a784f8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentFiscalPeriodFocus_019e887c-e744-75ae-bdcd-6ecc98a784f8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_019e887c-e744-73f7-917b-526c2fa6b1a7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_CurrentFiscalYearEndDate_019e887c-e744-73f7-917b-526c2fa6b1a7" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_019e887c-e744-75ae-9d93-ebb066951798" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityCurrentReportingStatus_019e887c-e744-75ae-9d93-ebb066951798" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_019e887c-e744-7183-8827-5730da270bc4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityInteractiveDataCurrent_019e887c-e744-7183-8827-5730da270bc4" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_019e887c-e744-782f-96ff-4301cb94d85f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityFilerCategory_019e887c-e744-782f-96ff-4301cb94d85f" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_019e887c-e744-7d6b-8be6-603dad652281" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_019e887c-e744-7d6b-8be6-603dad652281" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_019e887c-e744-787c-8991-faab56bc208e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntitySmallBusiness_019e887c-e744-787c-8991-faab56bc208e" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e887c-e744-71f9-8d3c-4e6c53774e6f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e887c-e744-71f9-8d3c-4e6c53774e6f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e887c-e744-77d3-84be-73d296680a31" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityFileNumber_019e887c-e744-77d3-84be-73d296680a31" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e887c-e744-7538-8a18-a8fbdcf09011" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e887c-e744-7538-8a18-a8fbdcf09011" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e887c-e744-7529-bea6-4d03aa1931be" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e887c-e744-7529-bea6-4d03aa1931be" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e887c-e744-72b0-92ec-c18e5fe6180a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_LocalPhoneNumber_019e887c-e744-72b0-92ec-c18e5fe6180a" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e887c-e744-78f6-bb28-c9c95d85f1b7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_CityAreaCode_019e887c-e744-78f6-bb28-c9c95d85f1b7" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_019e887c-e744-7b37-8e84-2cc99f2f7472" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_DocumentQuarterlyReport_019e887c-e744-7b37-8e84-2cc99f2f7472" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e887c-e744-7a96-8225-8254a05f0535" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityAddressAddressLine1_019e887c-e744-7a96-8225-8254a05f0535" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e887c-e744-7db0-b521-d866469a2156" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityAddressCityOrTown_019e887c-e744-7db0-b521-d866469a2156" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_019e887c-e744-7d5f-acf0-8110c51df6cc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCountry"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityAddressCountry_019e887c-e744-7d5f-acf0-8110c51df6cc" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e887c-e744-74fe-8731-c68d0d876fa9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityAddressPostalZipCode_019e887c-e744-74fe-8731-c68d0d876fa9" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e887c-e744-7040-81af-6d6a6ec63907" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_Security12bTitle_019e887c-e744-7040-81af-6d6a6ec63907" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e887c-e744-724b-bc31-c4db8d529422" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_TradingSymbol_019e887c-e744-724b-bc31-c4db8d529422" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e887c-e744-7c73-927e-676f8db8f2b3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_SecurityExchangeName_019e887c-e744-7c73-927e-676f8db8f2b3" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_019e887c-e744-7b21-8a24-647b8cc5e47a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019e887c-e744-7e2d-b27f-323ce27885ce" xlink:to="loc_dei_EntityShellCompany_019e887c-e744-7b21-8a24-647b8cc5e47a" xlink:type="arc" order="28"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e887c-e743-7994-a926-e0e1e10606ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e887c-e743-7cc5-9cdd-167f5e5d7a55" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e887c-e743-7994-a926-e0e1e10606ce" xlink:to="loc_us-gaap_StatementTable_019e887c-e743-7cc5-9cdd-167f5e5d7a55" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e887c-e743-7873-b86f-9a90431c9a52" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e887c-e743-7cc5-9cdd-167f5e5d7a55" xlink:to="loc_srt_ProductOrServiceAxis_019e887c-e743-7873-b86f-9a90431c9a52" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e887c-e743-7873-b86f-9a90431c9a52_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e887c-e743-7873-b86f-9a90431c9a52" xlink:to="loc_srt_ProductsAndServicesDomain_019e887c-e743-7873-b86f-9a90431c9a52_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e887c-e743-7dd3-add9-e3ac12bfe868" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e887c-e743-7873-b86f-9a90431c9a52" xlink:to="loc_srt_ProductsAndServicesDomain_019e887c-e743-7dd3-add9-e3ac12bfe868" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_019e887c-e743-75b1-b803-1cafc226b15b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e887c-e743-7dd3-add9-e3ac12bfe868" xlink:to="loc_us-gaap_ProductMember_019e887c-e743-75b1-b803-1cafc226b15b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServiceMember_019e887c-e743-790d-a8ea-4766796f5db3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ServiceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e887c-e743-7dd3-add9-e3ac12bfe868" xlink:to="loc_us-gaap_ServiceMember_019e887c-e743-790d-a8ea-4766796f5db3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e887c-e743-7994-a926-e0e1e10606ce" xlink:to="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019e887c-e743-7815-a763-e3be4e6e2bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_RevenuesAbstract_019e887c-e743-7815-a763-e3be4e6e2bc0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e887c-e743-75ec-b268-759882f6a7da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019e887c-e743-7815-a763-e3be4e6e2bc0" xlink:to="loc_us-gaap_Revenues_019e887c-e743-75ec-b268-759882f6a7da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenueAbstract_019e887c-e743-7bfb-a683-ab0b6f22000a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_CostOfRevenueAbstract_019e887c-e743-7bfb-a683-ab0b6f22000a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e887c-e743-76b0-9711-0d951d273383" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostOfRevenueAbstract_019e887c-e743-7bfb-a683-ab0b6f22000a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e887c-e743-76b0-9711-0d951d273383" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e887c-e743-7c0a-a8b4-4c7ab4100787" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostOfRevenueAbstract_019e887c-e743-7bfb-a683-ab0b6f22000a" xlink:to="loc_us-gaap_CostOfRevenue_019e887c-e743-7c0a-a8b4-4c7ab4100787" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e887c-e743-7df5-a915-5126720348b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_GrossProfit_019e887c-e743-7df5-a915-5126720348b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e743-7c21-9f6a-246b6ff2df6b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e743-7c21-9f6a-246b6ff2df6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e743-75f8-8a71-ba5746508c13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e743-75f8-8a71-ba5746508c13" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_019e887c-e743-71b5-9a35-1e8395d4278d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:to="loc_us-gaap_RestructuringCosts_019e887c-e743-71b5-9a35-1e8395d4278d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e887c-e743-7e4b-8ebb-82a8fc0af393" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019e887c-e743-7f75-8373-06b6a7ae4148" xlink:to="loc_us-gaap_OperatingExpenses_019e887c-e743-7e4b-8ebb-82a8fc0af393" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7262-89e6-a850286bb230" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7262-89e6-a850286bb230" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e887c-e743-784c-a07a-d52525598e3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e887c-e743-784c-a07a-d52525598e3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e887c-e743-75db-a2d4-7bc1dba13d51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e887c-e743-75db-a2d4-7bc1dba13d51" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_019e887c-e743-78a0-bc20-74e25dd164d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_019e887c-e743-78a0-bc20-74e25dd164d2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e743-787f-ba59-6129b63c3dc2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_019e887c-e743-72db-a1bb-5d839f23fdfa" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e743-787f-ba59-6129b63c3dc2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-792b-b4e4-eace11f2fc92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-792b-b4e4-eace11f2fc92" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e887c-e743-7f4d-a289-1b1a193cf9fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e887c-e743-7f4d-a289-1b1a193cf9fc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7809-948d-267eaced7efe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7809-948d-267eaced7efe" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019e887c-e743-7ddd-8886-c8de96841c00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_ProfitLoss_019e887c-e743-7ddd-8886-c8de96841c00" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019e887c-e743-742e-a4d0-6db404ac9bc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019e887c-e743-742e-a4d0-6db404ac9bc5" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e887c-e743-7e8c-90c4-1b684db7e9cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_NetIncomeLoss_019e887c-e743-7e8c-90c4-1b684db7e9cc" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_019e887c-e743-7fae-adf3-f52ab7b73aa6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_EarningsPerShareAbstract_019e887c-e743-7fae-adf3-f52ab7b73aa6" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019e887c-e743-77de-8e40-dac348cb0a96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019e887c-e743-7fae-adf3-f52ab7b73aa6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019e887c-e743-77de-8e40-dac348cb0a96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019e887c-e743-72c1-87cb-42e65b1de937" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019e887c-e743-7fae-adf3-f52ab7b73aa6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019e887c-e743-72c1-87cb-42e65b1de937" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_019e887c-e743-73f2-b16f-48e92ad4bf10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract_019e887c-e743-73c6-bbf6-4f4fcf09dcbb" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_019e887c-e743-73f2-b16f-48e92ad4bf10" xlink:type="arc" order="14"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTOFSHAREHOLDERSEQUITYStatement" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDSTATEMENTOFSHAREHOLDERSEQUITYStatement"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTOFSHAREHOLDERSEQUITYStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e887c-e744-7e98-9846-7b9a4adacf9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e887c-e744-7182-a0a6-2ecd7fef2e2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e887c-e744-7e98-9846-7b9a4adacf9b" xlink:to="loc_us-gaap_StatementTable_019e887c-e744-7182-a0a6-2ecd7fef2e2e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e744-7fb5-80e3-1f767be6044f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e887c-e744-7182-a0a6-2ecd7fef2e2e" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e744-7fb5-80e3-1f767be6044f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e887c-e744-7fb5-80e3-1f767be6044f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e744-7fb5-80e3-1f767be6044f" xlink:to="loc_us-gaap_EquityComponentDomain_019e887c-e744-7fb5-80e3-1f767be6044f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e744-7fb5-80e3-1f767be6044f" xlink:to="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019e887c-e744-72fe-8729-380a48a6661e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:to="loc_us-gaap_CommonStockMember_019e887c-e744-72fe-8729-380a48a6661e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019e887c-e744-77cc-a81a-6a102a74b6b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:to="loc_us-gaap_RetainedEarningsMember_019e887c-e744-77cc-a81a-6a102a74b6b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e887c-e744-74d8-b8d0-06381cc217c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e887c-e744-74d8-b8d0-06381cc217c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_019e887c-e744-7457-bf18-408b6fabf3d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e744-78e4-9a8f-0c7690c5acb5" xlink:to="loc_us-gaap_NoncontrollingInterestMember_019e887c-e744-7457-bf18-408b6fabf3d9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e887c-e744-7e98-9846-7b9a4adacf9b" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e887c-e744-7b00-b28e-6f365cff950a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019e887c-e744-7b00-b28e-6f365cff950a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e744-705c-b0ca-7aa4c1e0175f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e744-705c-b0ca-7aa4c1e0175f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019e887c-e744-7eeb-a18c-62b8cbb25305" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_ProfitLoss_019e887c-e744-7eeb-a18c-62b8cbb25305" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7156-a2f9-725276add6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7156-a2f9-725276add6cd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_019e887c-e744-7063-b10a-04d04eb51d90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_019e887c-e744-7063-b10a-04d04eb51d90" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_019e887c-e744-7b0e-888f-f808e330f324" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_019e887c-e744-7b0e-888f-f808e330f324" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019e887c-e744-7396-8dd4-d23808b87b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019e887c-e744-7396-8dd4-d23808b87b6a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019e887c-e744-700b-b5dd-6b5340f108d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019e887c-e744-700b-b5dd-6b5340f108d3" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_019e887c-e744-77c7-8955-0cef5a4f51be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_us-gaap_DividendsCommonStockCash_019e887c-e744-77c7-8955-0cef5a4f51be" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_IncreaseDecreaseInNoncontrollingInterestsOther_019e887c-e744-7faa-8fe6-9e0e6cdb0fbb" xlink:href="ste-20260630.xsd#ste_IncreaseDecreaseInNoncontrollingInterestsOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e887c-e744-7aeb-a3b8-7caf600d54d1" xlink:to="loc_ste_IncreaseDecreaseInNoncontrollingInterestsOther_019e887c-e744-7faa-8fe6-9e0e6cdb0fbb" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e744-76c4-b540-5015639825ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e887c-e744-7e16-8ca6-0297c1a9990d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfProductInformationTable_019e887c-e744-7f47-8ddc-9ed72b165a4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfProductInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:to="loc_us-gaap_ScheduleOfProductInformationTable_019e887c-e744-7f47-8ddc-9ed72b165a4b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeAxis_019e887c-e744-7f40-8697-d4f63bf708cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueArrangementTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfProductInformationTable_019e887c-e744-7f47-8ddc-9ed72b165a4b" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeAxis_019e887c-e744-7f40-8697-d4f63bf708cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7f40-8697-d4f63bf708cd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueArrangementTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeAxis_019e887c-e744-7f40-8697-d4f63bf708cd" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7f40-8697-d4f63bf708cd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7532-8730-24c8047fc1a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueArrangementTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeAxis_019e887c-e744-7f40-8697-d4f63bf708cd" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7532-8730-24c8047fc1a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ExpectedrecognitionwithinthenextyearMember_019e887c-e744-7256-ab0a-b1a0b1789a94" xlink:href="ste-20260630.xsd#ste_ExpectedrecognitionwithinthenextyearMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7532-8730-24c8047fc1a9" xlink:to="loc_ste_ExpectedrecognitionwithinthenextyearMember_019e887c-e744-7256-ab0a-b1a0b1789a94" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ExpectedrecognitionbeyondthenextyearMemberMember_019e887c-e744-7c6f-9b70-46663fb5458c" xlink:href="ste-20260630.xsd#ste_ExpectedrecognitionbeyondthenextyearMemberMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_019e887c-e744-7532-8730-24c8047fc1a9" xlink:to="loc_ste_ExpectedrecognitionbeyondthenextyearMemberMember_019e887c-e744-7c6f-9b70-46663fb5458c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019e887c-e744-7508-9ce5-daa7d06cc991" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:to="loc_us-gaap_NumberOfReportableSegments_019e887c-e744-7508-9ce5-daa7d06cc991" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueRevenueRecognized1_019e887c-e744-7b8f-8bab-cbebb67f6b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueRevenueRecognized1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:to="loc_us-gaap_DeferredRevenueRevenueRecognized1_019e887c-e744-7b8f-8bab-cbebb67f6b7a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019e887c-e744-7d54-b230-8ab9a4046f2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019e887c-e744-7d54-b230-8ab9a4046f2a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_019e887c-e744-7697-918b-0c3852c47666" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_019e887c-e744-7c0f-92c5-54a4551e87df" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_019e887c-e744-7697-918b-0c3852c47666" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/RestructuringNarrativeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#RestructuringNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/RestructuringNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7798-8814-1dc84daaaef5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-79e0-8c32-5505bcbe22e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7798-8814-1dc84daaaef5" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-79e0-8c32-5505bcbe22e1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-725f-bb23-2dd9820b8b58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-79e0-8c32-5505bcbe22e1" xlink:to="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-725f-bb23-2dd9820b8b58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-725f-bb23-2dd9820b8b58_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-725f-bb23-2dd9820b8b58" xlink:to="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-725f-bb23-2dd9820b8b58_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-732b-89b2-50132e4378f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-725f-bb23-2dd9820b8b58" xlink:to="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-732b-89b2-50132e4378f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Fiscal20242025RestructuringPlanMember_019e887c-e744-781c-8ab6-be111406d79e" xlink:href="ste-20260630.xsd#ste_Fiscal20242025RestructuringPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-732b-89b2-50132e4378f3" xlink:to="loc_ste_Fiscal20242025RestructuringPlanMember_019e887c-e744-781c-8ab6-be111406d79e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-74df-96d3-c0335530299b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-79e0-8c32-5505bcbe22e1" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-74df-96d3-c0335530299b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-74df-96d3-c0335530299b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-74df-96d3-c0335530299b" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-74df-96d3-c0335530299b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-71cc-9c50-9be9b086ee87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-74df-96d3-c0335530299b" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-71cc-9c50-9be9b086ee87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ProductRationalizationMember_019fd3b3-e18b-77ff-b16f-a3eac4829b48" xlink:href="ste-20260630.xsd#ste_ProductRationalizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-71cc-9c50-9be9b086ee87" xlink:to="loc_ste_ProductRationalizationMember_019fd3b3-e18b-77ff-b16f-a3eac4829b48" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated_019e887c-e744-7838-a1fe-b4b42c64b494" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7798-8814-1dc84daaaef5" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated_019e887c-e744-7838-a1fe-b4b42c64b494" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019e887c-e744-78d2-8823-a634e54a00b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7798-8814-1dc84daaaef5" xlink:to="loc_us-gaap_RestructuringCharges_019e887c-e744-78d2-8823-a634e54a00b5" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/RestructuringRestructuringExpensesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#RestructuringRestructuringExpensesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/RestructuringRestructuringExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7ce0-be87-de6316910f7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-7e22-88b1-32ba6bb93537" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7ce0-be87-de6316910f7d" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-7e22-88b1-32ba6bb93537" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-7718-9620-d0dc129e2138" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-7e22-88b1-32ba6bb93537" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-7718-9620-d0dc129e2138" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-7718-9620-d0dc129e2138_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-7718-9620-d0dc129e2138" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-7718-9620-d0dc129e2138_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-715d-8282-e88a0794c952" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019e887c-e744-7718-9620-d0dc129e2138" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-715d-8282-e88a0794c952" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019e887c-e744-72d8-a3d6-b4ff029720d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-715d-8282-e88a0794c952" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019e887c-e744-72d8-a3d6-b4ff029720d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReducedDepreciationMember_019e887c-e744-7c49-9d29-f1bd6c19f82a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReducedDepreciationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-715d-8282-e88a0794c952" xlink:to="loc_us-gaap_ReducedDepreciationMember_019e887c-e744-7c49-9d29-f1bd6c19f82a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ProductRationalizationMember_019e887c-e744-705d-b0ae-ac147a1b465b" xlink:href="ste-20260630.xsd#ste_ProductRationalizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019e887c-e744-715d-8282-e88a0794c952" xlink:to="loc_ste_ProductRationalizationMember_019e887c-e744-705d-b0ae-ac147a1b465b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-7acb-98c4-2daa3b12a2d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019e887c-e744-7e22-88b1-32ba6bb93537" xlink:to="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-7acb-98c4-2daa3b12a2d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-7acb-98c4-2daa3b12a2d7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-7acb-98c4-2daa3b12a2d7" xlink:to="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-7acb-98c4-2daa3b12a2d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-7ec9-aaa2-6369abe1dd60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019e887c-e744-7acb-98c4-2daa3b12a2d7" xlink:to="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-7ec9-aaa2-6369abe1dd60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Fiscal20242025RestructuringPlanMember_019e887c-e744-7c9a-ae28-b0c43e0adfab" xlink:href="ste-20260630.xsd#ste_Fiscal20242025RestructuringPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019e887c-e744-7ec9-aaa2-6369abe1dd60" xlink:to="loc_ste_Fiscal20242025RestructuringPlanMember_019e887c-e744-7c9a-ae28-b0c43e0adfab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019e887c-e744-7933-b1a4-5c0e2abb4d7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7ce0-be87-de6316910f7d" xlink:to="loc_us-gaap_RestructuringCharges_019e887c-e744-7933-b1a4-5c0e2abb4d7d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_019e887c-e744-7fba-af50-7195217a844c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019e887c-e744-7ce0-be87-de6316910f7d" xlink:to="loc_us-gaap_RestructuringReserveRollForward_019e887c-e744-7fba-af50-7195217a844c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019e887c-e744-78f1-90d3-0b39e5a9e331" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019e887c-e744-7fba-af50-7195217a844c" xlink:to="loc_us-gaap_RestructuringReserve_019e887c-e744-78f1-90d3-0b39e5a9e331" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAccrualAdjustment1_019e887c-e744-71aa-936d-166fc27b2f9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveAccrualAdjustment1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019e887c-e744-7fba-af50-7195217a844c" xlink:to="loc_us-gaap_RestructuringReserveAccrualAdjustment1_019e887c-e744-71aa-936d-166fc27b2f9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReservePeriodIncreaseDecrease_019e887c-e744-7d90-9ef6-d42ab82a6cc3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReservePeriodIncreaseDecrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019e887c-e744-7fba-af50-7195217a844c" xlink:to="loc_us-gaap_RestructuringReservePeriodIncreaseDecrease_019e887c-e744-7d90-9ef6-d42ab82a6cc3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019e887c-e744-78bf-837d-a68f4c629f24" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessAcquisitionsandDivestituresNarrativeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessAcquisitionsandDivestituresNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessAcquisitionsandDivestituresNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019e887c-e744-74bd-b7cf-2882db817f57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019e887c-e744-7631-af7d-5d40f8084230" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019e887c-e744-74bd-b7cf-2882db817f57" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019e887c-e744-7631-af7d-5d40f8084230" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019e887c-e744-76bd-843b-0785a257c2d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019e887c-e744-7631-af7d-5d40f8084230" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019e887c-e744-76bd-843b-0785a257c2d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-76bd-843b-0785a257c2d7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019e887c-e744-76bd-843b-0785a257c2d7" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-76bd-843b-0785a257c2d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-779c-94f4-36a1894c48f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019e887c-e744-76bd-843b-0785a257c2d7" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-779c-94f4-36a1894c48f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OtherFY26AcquisitionsMember_019e887c-e744-705b-bce3-b2226567cf34" xlink:href="ste-20260630.xsd#ste_OtherFY26AcquisitionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-779c-94f4-36a1894c48f9" xlink:to="loc_ste_OtherFY26AcquisitionsMember_019e887c-e744-705b-bce3-b2226567cf34" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OtherFY25AcquisitionMember_019e887c-e744-7fc7-ba31-42b75db58c8f" xlink:href="ste-20260630.xsd#ste_OtherFY25AcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019e887c-e744-779c-94f4-36a1894c48f9" xlink:to="loc_ste_OtherFY25AcquisitionMember_019e887c-e744-7fc7-ba31-42b75db58c8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019e887c-e744-75ec-b12f-55afb8039e12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019e887c-e744-74bd-b7cf-2882db817f57" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019e887c-e744-75ec-b12f-55afb8039e12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e887c-e744-773d-8aed-83b4cc85f43a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019e887c-e744-74bd-b7cf-2882db817f57" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e887c-e744-773d-8aed-83b4cc85f43a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DebtIndebtednessDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#DebtIndebtednessDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DebtIndebtednessDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019e887c-e744-74da-a189-408a89b06cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_DebtInstrumentTable_019e887c-e744-74da-a189-408a89b06cfc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019e887c-e744-7dcd-8052-0c1bc9a2edbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019e887c-e744-74da-a189-408a89b06cfc" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019e887c-e744-7dcd-8052-0c1bc9a2edbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019e887c-e744-7dcd-8052-0c1bc9a2edbe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019e887c-e744-7dcd-8052-0c1bc9a2edbe" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019e887c-e744-7dcd-8052-0c1bc9a2edbe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019e887c-e744-7b08-b004-68549fa702c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019e887c-e744-7dcd-8052-0c1bc9a2edbe" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019e887c-e744-7b08-b004-68549fa702c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_019e887c-e744-7fdc-aa03-2fb77dd255f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019e887c-e744-7b08-b004-68549fa702c7" xlink:to="loc_us-gaap_PrivatePlacementMember_019e887c-e744-7fdc-aa03-2fb77dd255f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-738a-95f8-b28be91d8a76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019e887c-e744-74da-a189-408a89b06cfc" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-738a-95f8-b28be91d8a76" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-738a-95f8-b28be91d8a76_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-738a-95f8-b28be91d8a76" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-738a-95f8-b28be91d8a76_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7265-9f45-fc1f7f9bd407" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-738a-95f8-b28be91d8a76" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7265-9f45-fc1f7f9bd407" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_019e887c-e744-71d1-9c1a-389e2a7273a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7265-9f45-fc1f7f9bd407" xlink:to="loc_us-gaap_PrivatePlacementMember_019e887c-e744-71d1-9c1a-389e2a7273a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019e887c-e744-76b3-a288-e39ec49c3bc6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7265-9f45-fc1f7f9bd407" xlink:to="loc_us-gaap_SeniorNotesMember_019e887c-e744-76b3-a288-e39ec49c3bc6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesCurrent_019e887c-e744-7d4d-8117-be98bbe0dc49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_SeniorNotesCurrent_019e887c-e744-7d4d-8117-be98bbe0dc49" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019e887c-e744-73f8-93e8-0384e13576ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_ShortTermBorrowings_019e887c-e744-73f8-93e8-0384e13576ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorLongTermNotes_019e887c-e744-7e3b-befa-7751e40e8b09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorLongTermNotes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_SeniorLongTermNotes_019e887c-e744-7e3b-befa-7751e40e8b09" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_019e887c-e744-726c-a523-e585eeb1c999" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_LineOfCredit_019e887c-e744-726c-a523-e585eeb1c999" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019e887c-e744-7f50-8e95-cbac8facb70c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019e887c-e744-7f50-8e95-cbac8facb70c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e887c-e744-7226-b6c0-4f02c7d65bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_LongTermDebt_019e887c-e744-7226-b6c0-4f02c7d65bfb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019e887c-e744-7266-a40c-ec6a42e9e581" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-75a8-8ca4-d9aaafd7b72a" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019e887c-e744-7266-a40c-ec6a42e9e581" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DebtNarrativeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#DebtNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DebtNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-7209-9714-2c2d5f1fc7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019e887c-e744-7cc0-83b4-22c2091b2cc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-7209-9714-2c2d5f1fc7b1" xlink:to="loc_us-gaap_DebtInstrumentTable_019e887c-e744-7cc0-83b4-22c2091b2cc8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_019e887c-e744-73b5-9cdb-d0af7f4e80ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019e887c-e744-7cc0-83b4-22c2091b2cc8" xlink:to="loc_us-gaap_CreditFacilityAxis_019e887c-e744-73b5-9cdb-d0af7f4e80ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019e887c-e744-73b5-9cdb-d0af7f4e80ce_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_019e887c-e744-73b5-9cdb-d0af7f4e80ce" xlink:to="loc_us-gaap_CreditFacilityDomain_019e887c-e744-73b5-9cdb-d0af7f4e80ce_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019e887c-e744-7cd2-a015-e175f8f8d2a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_019e887c-e744-73b5-9cdb-d0af7f4e80ce" xlink:to="loc_us-gaap_CreditFacilityDomain_019e887c-e744-7cd2-a015-e175f8f8d2a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_019e887c-e744-7004-9e9c-9820b99d39a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019e887c-e744-7cd2-a015-e175f8f8d2a2" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_019e887c-e744-7004-9e9c-9820b99d39a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-7ac4-86f4-c701786a33f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019e887c-e744-7cc0-83b4-22c2091b2cc8" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-7ac4-86f4-c701786a33f3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7ac4-86f4-c701786a33f3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-7ac4-86f4-c701786a33f3" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-7ac4-86f4-c701786a33f3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-78c8-b258-21689bdb135e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019e887c-e744-7ac4-86f4-c701786a33f3" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-78c8-b258-21689bdb135e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019e887c-e744-783a-9c78-0a4d1bc5f9dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019e887c-e744-78c8-b258-21689bdb135e" xlink:to="loc_us-gaap_LineOfCreditMember_019e887c-e744-783a-9c78-0a4d1bc5f9dc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019e887c-e744-7505-9da0-a14cb307d28e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-7209-9714-2c2d5f1fc7b1" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019e887c-e744-7505-9da0-a14cb307d28e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_LineOfCreditFacilityCovenantMaximumAlternativeCurrencyAdvances_019e887c-e744-71d5-a9b6-dfbef1714ab0" xlink:href="ste-20260630.xsd#ste_LineOfCreditFacilityCovenantMaximumAlternativeCurrencyAdvances"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-7209-9714-2c2d5f1fc7b1" xlink:to="loc_ste_LineOfCreditFacilityCovenantMaximumAlternativeCurrencyAdvances_019e887c-e744-71d5-a9b6-dfbef1714ab0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_019e887c-e744-76b4-b9b3-c9b9fa574c82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019e887c-e744-7209-9714-2c2d5f1fc7b1" xlink:to="loc_us-gaap_DebtInstrumentTerm_019e887c-e744-76b4-b9b3-c9b9fa574c82" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/ContingenciesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#ContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_019f908e-798e-7464-801a-59894d0a72dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_LossContingenciesTable_019f908e-798e-7464-801a-59894d0a72dd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_019f908e-798e-7963-b254-6207a811da7c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_019f908e-798e-7464-801a-59894d0a72dd" xlink:to="loc_srt_LitigationCaseAxis_019f908e-798e-7963-b254-6207a811da7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_019f908e-798e-7963-b254-6207a811da7c_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_019f908e-798e-7963-b254-6207a811da7c" xlink:to="loc_srt_LitigationCaseTypeDomain_019f908e-798e-7963-b254-6207a811da7c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_019f908e-798e-708c-9290-00398bc4b043" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_019f908e-798e-7963-b254-6207a811da7c" xlink:to="loc_srt_LitigationCaseTypeDomain_019f908e-798e-708c-9290-00398bc4b043" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_IllinoisEOLitigationMember_019f908e-798e-7550-92f2-ce8545d684e5" xlink:href="ste-20260630.xsd#ste_IllinoisEOLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019f908e-798e-708c-9290-00398bc4b043" xlink:to="loc_ste_IllinoisEOLitigationMember_019f908e-798e-7550-92f2-ce8545d684e5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusAxis_019f908e-798e-7631-96e5-e78a7d2d06a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_019f908e-798e-7464-801a-59894d0a72dd" xlink:to="loc_us-gaap_LitigationStatusAxis_019f908e-798e-7631-96e5-e78a7d2d06a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_019f908e-798e-7631-96e5-e78a7d2d06a3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_019f908e-798e-7631-96e5-e78a7d2d06a3" xlink:to="loc_us-gaap_LitigationStatusDomain_019f908e-798e-7631-96e5-e78a7d2d06a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_019f908e-798e-70b4-89b0-d1264d922687" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_019f908e-798e-7631-96e5-e78a7d2d06a3" xlink:to="loc_us-gaap_LitigationStatusDomain_019f908e-798e-70b4-89b0-d1264d922687" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SettledLitigationMember_019f908e-798e-772a-916e-eba46432c7a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SettledLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_019f908e-798e-70b4-89b0-d1264d922687" xlink:to="loc_us-gaap_SettledLitigationMember_019f908e-798e-772a-916e-eba46432c7a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingenciesByNatureAxis_019f90b0-2ec8-7996-8373-38fe80decaca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainContingenciesByNatureAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_019f908e-798e-7464-801a-59894d0a72dd" xlink:to="loc_us-gaap_GainContingenciesByNatureAxis_019f90b0-2ec8-7996-8373-38fe80decaca" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_019f90b0-2ec8-7996-8373-38fe80decaca_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_019f90b0-2ec8-7996-8373-38fe80decaca" xlink:to="loc_us-gaap_GainContingencyNatureDomain_019f90b0-2ec8-7996-8373-38fe80decaca_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_019f90b0-2ec8-768a-a44c-28371c22d5fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_019f90b0-2ec8-7996-8373-38fe80decaca" xlink:to="loc_us-gaap_GainContingencyNatureDomain_019f90b0-2ec8-768a-a44c-28371c22d5fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_IEEPATariffRefundMember_019f90b0-77a3-7394-908b-d65155c9669a" xlink:href="ste-20260630.xsd#ste_IEEPATariffRefundMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GainContingencyNatureDomain_019f90b0-2ec8-768a-a44c-28371c22d5fb" xlink:to="loc_ste_IEEPATariffRefundMember_019f90b0-77a3-7394-908b-d65155c9669a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserve_019e887c-e744-74ee-bf80-59b26178108f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_LitigationReserve_019e887c-e744-74ee-bf80-59b26178108f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RecoveryOfDirectCosts_019f90ac-85e2-7d59-817d-c617ba256905" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RecoveryOfDirectCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_RecoveryOfDirectCosts_019f90ac-85e2-7d59-817d-c617ba256905" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f90ac-e782-7c93-8cc2-7b224a6c143a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f90ac-e782-7c93-8cc2-7b224a6c143a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_RecoveryOfDirectCostRefundsAndInterest_019f90af-b8bc-7f21-8163-4e1d3e414720" xlink:href="ste-20260630.xsd#ste_RecoveryOfDirectCostRefundsAndInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_ste_RecoveryOfDirectCostRefundsAndInterest_019f90af-b8bc-7f21-8163-4e1d3e414720" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesPaidValue_019f908e-798e-78bf-b2b6-81abf9ba04f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyDamagesPaidValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_LossContingencyDamagesPaidValue_019f908e-798e-78bf-b2b6-81abf9ba04f1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyUnrecordedAmount_019f90b2-a6f4-721e-b9b1-eab2a5d82598" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainContingencyUnrecordedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019f908e-798e-7705-986b-c5de7efeeb59" xlink:to="loc_us-gaap_GainContingencyUnrecordedAmount_019f90b2-a6f4-721e-b9b1-eab2a5d82598" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessSegmentInformationIncomeStatementDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessSegmentInformationIncomeStatementDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessSegmentInformationIncomeStatementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-75e7-843e-20f6bad580e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-75e7-843e-20f6bad580e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_019e887c-e744-7d95-8aaa-4bfdb131b9b4" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-75e7-843e-20f6bad580e2" xlink:to="loc_srt_ConsolidationItemsAxis_019e887c-e744-7d95-8aaa-4bfdb131b9b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019e887c-e744-7d95-8aaa-4bfdb131b9b4_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_019e887c-e744-7d95-8aaa-4bfdb131b9b4" xlink:to="loc_srt_ConsolidationItemsDomain_019e887c-e744-7d95-8aaa-4bfdb131b9b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019e887c-e744-74a1-8aa6-2ff9d6426b2d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_019e887c-e744-7d95-8aaa-4bfdb131b9b4" xlink:to="loc_srt_ConsolidationItemsDomain_019e887c-e744-74a1-8aa6-2ff9d6426b2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_019e887c-e744-7850-ac50-2b6a6877e7d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019e887c-e744-74a1-8aa6-2ff9d6426b2d" xlink:to="loc_us-gaap_OperatingSegmentsMember_019e887c-e744-7850-ac50-2b6a6877e7d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_019e887c-e744-7531-a21c-46fd93384568" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019e887c-e744-74a1-8aa6-2ff9d6426b2d" xlink:to="loc_us-gaap_CorporateNonSegmentMember_019e887c-e744-7531-a21c-46fd93384568" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7147-86c7-0074dc898341" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-75e7-843e-20f6bad580e2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7147-86c7-0074dc898341" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7147-86c7-0074dc898341_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7147-86c7-0074dc898341" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7147-86c7-0074dc898341_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7c32-a540-c97f2042c356" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7147-86c7-0074dc898341" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7c32-a540-c97f2042c356" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_HealthcareSegmentMember_019e887c-e744-7822-a1d6-c41e33702b1f" xlink:href="ste-20260630.xsd#ste_HealthcareSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7c32-a540-c97f2042c356" xlink:to="loc_ste_HealthcareSegmentMember_019e887c-e744-7822-a1d6-c41e33702b1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7c57-bd42-aae32fc8d82b" xlink:href="ste-20260630.xsd#ste_AppliedSterilizationTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7c32-a540-c97f2042c356" xlink:to="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7c57-bd42-aae32fc8d82b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_LifeScienceMember_019e887c-e744-759f-8c8f-3a58e7e82d99" xlink:href="ste-20260630.xsd#ste_LifeScienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7c32-a540-c97f2042c356" xlink:to="loc_ste_LifeScienceMember_019e887c-e744-759f-8c8f-3a58e7e82d99" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e887c-e744-79b1-a1e0-110c20580701" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_Revenues_019e887c-e744-79b1-a1e0-110c20580701" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e887c-e744-7154-b96e-6afb7dd0ae58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_CostOfRevenue_019e887c-e744-7154-b96e-6afb7dd0ae58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e744-7ae6-bf1b-204b01ca779b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e744-7ae6-bf1b-204b01ca779b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e744-78d6-8de3-99b5e4551eac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e744-78d6-8de3-99b5e4551eac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e887c-e744-74bf-aeb7-5e22cec4d303" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e887c-e744-74bf-aeb7-5e22cec4d303" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OperatingIncomeLossBeforeAdjustments_019e887c-e744-7201-a338-5d1dd90e1f9c" xlink:href="ste-20260630.xsd#ste_OperatingIncomeLossBeforeAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_ste_OperatingIncomeLossBeforeAdjustments_019e887c-e744-7201-a338-5d1dd90e1f9c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Amortizationandimpairmentofacquiredintangibleassets_019e887c-e744-7247-92f0-cf25fe8a81fe" xlink:href="ste-20260630.xsd#ste_Amortizationandimpairmentofacquiredintangibleassets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_ste_Amortizationandimpairmentofacquiredintangibleassets_019e887c-e744-7247-92f0-cf25fe8a81fe" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e887c-e744-77d9-8658-d8b14e7624c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e887c-e744-77d9-8658-d8b14e7624c5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Redomiciliationcosts_019e887c-e744-7d6a-bbe2-fbc41205e224" xlink:href="ste-20260630.xsd#ste_Redomiciliationcosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_ste_Redomiciliationcosts_019e887c-e744-7d6a-bbe2-fbc41205e224" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Amortizationofinventoryandpropertystepuptofairvalue_019e887c-e744-77f3-af88-378284d082b7" xlink:href="ste-20260630.xsd#ste_Amortizationofinventoryandpropertystepuptofairvalue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_ste_Amortizationofinventoryandpropertystepuptofairvalue_019e887c-e744-77f3-af88-378284d082b7" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019e887c-e744-7dbd-8e22-0a1a0b32fade" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7859-93be-13d8689093a1" xlink:to="loc_us-gaap_RestructuringCharges_019e887c-e744-7dbd-8e22-0a1a0b32fade" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessSegmentInformationAssetsDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessSegmentInformationAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessSegmentInformationAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7c01-b7f1-18cb99566157" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cd2-a566-fbbe45f77c32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7c01-b7f1-18cb99566157" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cd2-a566-fbbe45f77c32" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7209-ba4a-10db1a463562" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cd2-a566-fbbe45f77c32" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7209-ba4a-10db1a463562" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7209-ba4a-10db1a463562_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7209-ba4a-10db1a463562" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7209-ba4a-10db1a463562_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7250-8b67-a426726e5161" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-7209-ba4a-10db1a463562" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7250-8b67-a426726e5161" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_HealthcareProductsandLifeSciencesMember_019e887c-e744-7759-a1e7-15583dae0010" xlink:href="ste-20260630.xsd#ste_HealthcareProductsandLifeSciencesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7250-8b67-a426726e5161" xlink:to="loc_ste_HealthcareProductsandLifeSciencesMember_019e887c-e744-7759-a1e7-15583dae0010" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-75a8-9a06-1d5614726fc9" xlink:href="ste-20260630.xsd#ste_AppliedSterilizationTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7250-8b67-a426726e5161" xlink:to="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-75a8-9a06-1d5614726fc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7dd7-a024-c5d1f5b66235" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cd2-a566-fbbe45f77c32" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7dd7-a024-c5d1f5b66235" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7dd7-a024-c5d1f5b66235_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7dd7-a024-c5d1f5b66235" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7dd7-a024-c5d1f5b66235_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7a28-a71b-f1f9387dee7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7dd7-a024-c5d1f5b66235" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7a28-a71b-f1f9387dee7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_019e887c-e744-7600-a6de-6e13f08be391" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentContinuingOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7a28-a71b-f1f9387dee7d" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_019e887c-e744-7600-a6de-6e13f08be391" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e887c-e744-7535-90d0-ebd6e51bb9d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7c01-b7f1-18cb99566157" xlink:to="loc_us-gaap_Assets_019e887c-e744-7535-90d0-ebd6e51bb9d1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessSegmentInformationCapitalExpendituresandDepreciationDepletionandAmortizationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessSegmentInformationCapitalExpendituresandDepreciationDepletionandAmortizationDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessSegmentInformationCapitalExpendituresandDepreciationDepletionandAmortizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7557-87d6-10b719fa988c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7c9c-8de7-d9e7c9a3f441" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7557-87d6-10b719fa988c" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7c9c-8de7-d9e7c9a3f441" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-708e-8be0-9fc9c663f4e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7c9c-8de7-d9e7c9a3f441" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-708e-8be0-9fc9c663f4e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-708e-8be0-9fc9c663f4e8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-708e-8be0-9fc9c663f4e8" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-708e-8be0-9fc9c663f4e8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7c70-8e6a-d1eafe3a1c6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-708e-8be0-9fc9c663f4e8" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7c70-8e6a-d1eafe3a1c6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_HealthcareProductsandLifeSciencesMember_019e887c-e744-7f2a-84d0-d492f25883cf" xlink:href="ste-20260630.xsd#ste_HealthcareProductsandLifeSciencesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7c70-8e6a-d1eafe3a1c6c" xlink:to="loc_ste_HealthcareProductsandLifeSciencesMember_019e887c-e744-7f2a-84d0-d492f25883cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7ce6-88f2-f794ae650639" xlink:href="ste-20260630.xsd#ste_AppliedSterilizationTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7c70-8e6a-d1eafe3a1c6c" xlink:to="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7ce6-88f2-f794ae650639" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7166-b756-b602a3651e36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7c9c-8de7-d9e7c9a3f441" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7166-b756-b602a3651e36" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7166-b756-b602a3651e36_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7166-b756-b602a3651e36" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7166-b756-b602a3651e36_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7eca-948d-f8590a93364b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentOperatingActivitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_019e887c-e744-7166-b756-b602a3651e36" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7eca-948d-f8590a93364b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_019e887c-e744-786e-a973-f0aaa10f2940" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentContinuingOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_019e887c-e744-7eca-948d-f8590a93364b" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_019e887c-e744-786e-a973-f0aaa10f2940" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_019e887c-e744-72df-a4d5-9d2b11746c68" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentExpenditureAdditionToLongLivedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7557-87d6-10b719fa988c" xlink:to="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_019e887c-e744-72df-a4d5-9d2b11746c68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e887c-e744-7c37-aeb0-cc813910e724" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7557-87d6-10b719fa988c" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e887c-e744-7c37-aeb0-cc813910e724" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessSegmentInformationInformationbyGeographicalLocationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessSegmentInformationInformationbyGeographicalLocationDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessSegmentInformationInformationbyGeographicalLocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7bee-a399-eb42b54c40b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7de2-973e-cccd2f0d88d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7bee-a399-eb42b54c40b1" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7de2-973e-cccd2f0d88d3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019e887c-e744-750a-aa0a-4ebc1c7abf7d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7de2-973e-cccd2f0d88d3" xlink:to="loc_srt_StatementGeographicalAxis_019e887c-e744-750a-aa0a-4ebc1c7abf7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019e887c-e744-750a-aa0a-4ebc1c7abf7d_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019e887c-e744-750a-aa0a-4ebc1c7abf7d" xlink:to="loc_srt_SegmentGeographicalDomain_019e887c-e744-750a-aa0a-4ebc1c7abf7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019e887c-e744-7c2e-ad44-3bfa46e82832" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019e887c-e744-750a-aa0a-4ebc1c7abf7d" xlink:to="loc_srt_SegmentGeographicalDomain_019e887c-e744-7c2e-ad44-3bfa46e82832" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_IE_019e887c-e744-7fa5-bbbe-f8469079457e" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_IE"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-7c2e-ad44-3bfa46e82832" xlink:to="loc_country_IE_019e887c-e744-7fa5-bbbe-f8469079457e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019e887c-e744-76ec-b4a9-a8abe2d7c5f6" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-7c2e-ad44-3bfa46e82832" xlink:to="loc_country_US_019e887c-e744-76ec-b4a9-a8abe2d7c5f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_019e887c-e744-7345-9925-cc13a87cab24" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-7c2e-ad44-3bfa46e82832" xlink:to="loc_us-gaap_NonUsMember_019e887c-e744-7345-9925-cc13a87cab24" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e744-76bd-ac1b-885c27063e16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7bee-a399-eb42b54c40b1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e744-76bd-ac1b-885c27063e16" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessSegmentInformationRevenuesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#BusinessSegmentInformationRevenuesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/BusinessSegmentInformationRevenuesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e887c-e744-773e-bc2e-c5c22d85b6ec" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:to="loc_srt_ProductOrServiceAxis_019e887c-e744-773e-bc2e-c5c22d85b6ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e887c-e744-773e-bc2e-c5c22d85b6ec_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e887c-e744-773e-bc2e-c5c22d85b6ec" xlink:to="loc_srt_ProductsAndServicesDomain_019e887c-e744-773e-bc2e-c5c22d85b6ec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e887c-e744-7f9d-ae54-e5aec400b08d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e887c-e744-773e-bc2e-c5c22d85b6ec" xlink:to="loc_srt_ProductsAndServicesDomain_019e887c-e744-7f9d-ae54-e5aec400b08d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_CapitalequipmentrevenuesMember_019e887c-e744-7660-ae5c-f6cdbdf598c8" xlink:href="ste-20260630.xsd#ste_CapitalequipmentrevenuesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e887c-e744-7f9d-ae54-e5aec400b08d" xlink:to="loc_ste_CapitalequipmentrevenuesMember_019e887c-e744-7660-ae5c-f6cdbdf598c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ConsumablerevenuesMember_019e887c-e744-7ef8-9285-5942a435dbed" xlink:href="ste-20260630.xsd#ste_ConsumablerevenuesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e887c-e744-7f9d-ae54-e5aec400b08d" xlink:to="loc_ste_ConsumablerevenuesMember_019e887c-e744-7ef8-9285-5942a435dbed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ServicerevenuesMember_019e887c-e744-725a-bb36-1db946dc31ab" xlink:href="ste-20260630.xsd#ste_ServicerevenuesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e887c-e744-7f9d-ae54-e5aec400b08d" xlink:to="loc_ste_ServicerevenuesMember_019e887c-e744-725a-bb36-1db946dc31ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-78b5-a22a-e1d4b6afd766" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-78b5-a22a-e1d4b6afd766" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-78b5-a22a-e1d4b6afd766_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-78b5-a22a-e1d4b6afd766" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-78b5-a22a-e1d4b6afd766_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e887c-e744-7be6-9b42-be8c625613d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e887c-e744-78b5-a22a-e1d4b6afd766" xlink:to="loc_us-gaap_SegmentDomain_019e887c-e744-7be6-9b42-be8c625613d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_HealthcareSegmentMember_019e887c-e744-70bd-9f7e-fb7bfdb9fa43" xlink:href="ste-20260630.xsd#ste_HealthcareSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7be6-9b42-be8c625613d2" xlink:to="loc_ste_HealthcareSegmentMember_019e887c-e744-70bd-9f7e-fb7bfdb9fa43" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7cda-892f-fea52d6bf63c" xlink:href="ste-20260630.xsd#ste_AppliedSterilizationTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7be6-9b42-be8c625613d2" xlink:to="loc_ste_AppliedSterilizationTechnologiesMember_019e887c-e744-7cda-892f-fea52d6bf63c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_LifeScienceMember_019e887c-e744-79ea-992e-1e41e036953d" xlink:href="ste-20260630.xsd#ste_LifeScienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e887c-e744-7be6-9b42-be8c625613d2" xlink:to="loc_ste_LifeScienceMember_019e887c-e744-79ea-992e-1e41e036953d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019e887c-e744-7de3-8425-ba88a0faa9ed" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:to="loc_srt_StatementGeographicalAxis_019e887c-e744-7de3-8425-ba88a0faa9ed" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019e887c-e744-7de3-8425-ba88a0faa9ed_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019e887c-e744-7de3-8425-ba88a0faa9ed" xlink:to="loc_srt_SegmentGeographicalDomain_019e887c-e744-7de3-8425-ba88a0faa9ed_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019e887c-e744-754a-b0e1-eca5016272e4" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019e887c-e744-7de3-8425-ba88a0faa9ed" xlink:to="loc_srt_SegmentGeographicalDomain_019e887c-e744-754a-b0e1-eca5016272e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_IE_019e887c-e744-787b-bba7-2e570b31dd1a" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_IE"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-754a-b0e1-eca5016272e4" xlink:to="loc_country_IE_019e887c-e744-787b-bba7-2e570b31dd1a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019e887c-e744-721c-b118-d32f18ad9249" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-754a-b0e1-eca5016272e4" xlink:to="loc_country_US_019e887c-e744-721c-b118-d32f18ad9249" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_019e887c-e744-7a37-96b4-80f2afc17347" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019e887c-e744-754a-b0e1-eca5016272e4" xlink:to="loc_us-gaap_NonUsMember_019e887c-e744-7a37-96b4-80f2afc17347" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_019e887c-e744-7cd9-98fc-102990d8f0f9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019e887c-e744-7cf9-828c-69053f175ab8" xlink:to="loc_srt_ConsolidationItemsAxis_019e887c-e744-7cd9-98fc-102990d8f0f9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019e887c-e744-7cd9-98fc-102990d8f0f9_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_019e887c-e744-7cd9-98fc-102990d8f0f9" xlink:to="loc_srt_ConsolidationItemsDomain_019e887c-e744-7cd9-98fc-102990d8f0f9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019e887c-e744-758f-a781-6771c50001f9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_019e887c-e744-7cd9-98fc-102990d8f0f9" xlink:to="loc_srt_ConsolidationItemsDomain_019e887c-e744-758f-a781-6771c50001f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_019e887c-e744-732a-b29e-a9f460c07cb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019e887c-e744-758f-a781-6771c50001f9" xlink:to="loc_us-gaap_OperatingSegmentsMember_019e887c-e744-732a-b29e-a9f460c07cb1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_019e887c-e744-7f11-90bc-05ff2f72c74a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019e887c-e744-758f-a781-6771c50001f9" xlink:to="loc_us-gaap_CorporateNonSegmentMember_019e887c-e744-7f11-90bc-05ff2f72c74a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e887c-e744-77f7-8a78-1992ba6bc0e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:to="loc_us-gaap_Revenues_019e887c-e744-77f7-8a78-1992ba6bc0e7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e887c-e744-7e75-a159-2c607999f5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:to="loc_us-gaap_CostOfRevenue_019e887c-e744-7e75-a159-2c607999f5b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e744-7bf8-af8a-8243a99ace39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e744-7bf8-af8a-8243a99ace39" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e744-7606-8a30-d24bee282a1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019e887c-e744-7a3f-aa74-d161fe083706" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e744-7606-8a30-d24bee282a1a" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/SharesandPreferredSharesOrdinarySharesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#SharesandPreferredSharesOrdinarySharesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/SharesandPreferredSharesOrdinarySharesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e887c-e812-7d43-9e06-896764932bfd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e887c-e812-7d43-9e06-896764932bfd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CurrencyAxis_019e887c-e812-747e-a698-87be788d26a1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CurrencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e887c-e812-7d43-9e06-896764932bfd" xlink:to="loc_srt_CurrencyAxis_019e887c-e812-747e-a698-87be788d26a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-747e-a698-87be788d26a1_default" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-747e-a698-87be788d26a1" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-747e-a698-87be788d26a1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-7abb-8e60-37684d27c953" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-747e-a698-87be788d26a1" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-7abb-8e60-37684d27c953" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_EUR_019e887c-e812-7e2e-a0ff-07b76bdd8aa4" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_EUR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7abb-8e60-37684d27c953" xlink:to="loc_currency_EUR_019e887c-e812-7e2e-a0ff-07b76bdd8aa4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e887c-e812-7200-b0f4-30de3b533a1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e887c-e812-7d43-9e06-896764932bfd" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e887c-e812-7200-b0f4-30de3b533a1f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e887c-e812-7200-b0f4-30de3b533a1f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e887c-e812-7200-b0f4-30de3b533a1f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e887c-e812-7200-b0f4-30de3b533a1f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e887c-e812-785c-bef3-67166b030c8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e887c-e812-7200-b0f4-30de3b533a1f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e887c-e812-785c-bef3-67166b030c8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e887c-e812-7013-b2cd-3605bfb84e84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e887c-e812-785c-bef3-67166b030c8a" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e887c-e812-7013-b2cd-3605bfb84e84" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019e887c-e812-7a85-b4bf-8a6ba41d6eea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019e887c-e812-7a85-b4bf-8a6ba41d6eea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019e887c-e812-7025-af02-7edf0af05d60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019e887c-e812-7025-af02-7edf0af05d60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e887c-e812-7887-8904-7393531f875a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e887c-e812-7887-8904-7393531f875a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e887c-e812-7850-83cc-7a1a407226ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019e887c-e812-7850-83cc-7a1a407226ac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_DeferredOrdinaryShares_019e887c-e812-7205-9d49-e74efec83fef" xlink:href="ste-20260630.xsd#ste_DeferredOrdinaryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_ste_DeferredOrdinaryShares_019e887c-e812-7205-9d49-e74efec83fef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ParValueEurosofDeferredOrdinaryShares_019e887c-e812-78fb-8e51-3dcdf5233671" xlink:href="ste-20260630.xsd#ste_ParValueEurosofDeferredOrdinaryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e887c-e812-73cd-9d7a-bcdb463afd5e" xlink:to="loc_ste_ParValueEurosofDeferredOrdinaryShares_019e887c-e812-78fb-8e51-3dcdf5233671" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/RepurchasesofSharesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#RepurchasesofSharesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/RepurchasesofSharesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramTable_019f9098-7370-73fc-9882-6930d89b4409" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_srt_ShareRepurchaseProgramTable_019f9098-7370-73fc-9882-6930d89b4409" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramAxis_019f9098-7370-7357-918a-0aa2892b762d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ShareRepurchaseProgramTable_019f9098-7370-73fc-9882-6930d89b4409" xlink:to="loc_srt_ShareRepurchaseProgramAxis_019f9098-7370-7357-918a-0aa2892b762d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramDomain_019f9098-7370-7357-918a-0aa2892b762d_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ShareRepurchaseProgramAxis_019f9098-7370-7357-918a-0aa2892b762d" xlink:to="loc_srt_ShareRepurchaseProgramDomain_019f9098-7370-7357-918a-0aa2892b762d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramDomain_019f9098-7370-7bf8-bcef-821a221a77ca" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ShareRepurchaseProgramAxis_019f9098-7370-7357-918a-0aa2892b762d" xlink:to="loc_srt_ShareRepurchaseProgramDomain_019f9098-7370-7bf8-bcef-821a221a77ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_NewRepurchaseProgramMember_019f9098-7370-71b0-8e90-52a23a93b0fd" xlink:href="ste-20260630.xsd#ste_NewRepurchaseProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramDomain_019f9098-7370-7bf8-bcef-821a221a77ca" xlink:to="loc_ste_NewRepurchaseProgramMember_019f9098-7370-71b0-8e90-52a23a93b0fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019f9098-7370-732a-9644-cbfbc8df9240" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ShareRepurchaseProgramTable_019f9098-7370-73fc-9882-6930d89b4409" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019f9098-7370-732a-9644-cbfbc8df9240" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019f9098-7370-732a-9644-cbfbc8df9240_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019f9098-7370-732a-9644-cbfbc8df9240" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019f9098-7370-732a-9644-cbfbc8df9240_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019f9098-7370-7959-aef0-217126c4bb75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019f9098-7370-732a-9644-cbfbc8df9240" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019f9098-7370-7959-aef0-217126c4bb75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019f9098-7370-7470-ad71-750a8e9670cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019f9098-7370-7959-aef0-217126c4bb75" xlink:to="loc_us-gaap_SubsequentEventMember_019f9098-7370-7470-ad71-750a8e9670cc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StockRepurchaseProgramAuthorizedAmount1_019e887c-e812-78ba-bbb5-c80d61ccd33c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_srt_StockRepurchaseProgramAuthorizedAmount1_019e887c-e812-78ba-bbb5-c80d61ccd33c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_019e887c-e812-7ac8-8ba3-97ee916ffec1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_019e887c-e812-7ac8-8ba3-97ee916ffec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_019e887c-e812-7306-818b-80aa4b6a1c58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_019e887c-e812-7306-818b-80aa4b6a1c58" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OrdinaryStockRepurchasesNotIncludingSharesWithheldForTaxes_019e887c-e812-72bc-9e94-3a7915a68e6b" xlink:href="ste-20260630.xsd#ste_OrdinaryStockRepurchasesNotIncludingSharesWithheldForTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_ste_OrdinaryStockRepurchasesNotIncludingSharesWithheldForTaxes_019e887c-e812-72bc-9e94-3a7915a68e6b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_019e887c-e812-7436-b89c-c7a1d392271e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_019e887c-e812-7436-b89c-c7a1d392271e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e887c-e812-7552-9cff-3d9177d8c492" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramLineItems_019f9098-7370-7c69-b61f-1185d255d836" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e887c-e812-7552-9cff-3d9177d8c492" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/ShareBasedCompensationShareBasedCompensationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#ShareBasedCompensationShareBasedCompensationDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/ShareBasedCompensationShareBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e887c-e812-7dce-82e0-7926e5c0f3a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e887c-e812-7dce-82e0-7926e5c0f3a3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e887c-e812-7a72-a1e1-bd5b557f27ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e887c-e812-7dce-82e0-7926e5c0f3a3" xlink:to="loc_us-gaap_AwardTypeAxis_019e887c-e812-7a72-a1e1-bd5b557f27ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-7a72-a1e1-bd5b557f27ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e887c-e812-7a72-a1e1-bd5b557f27ab" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-7a72-a1e1-bd5b557f27ab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-72a7-b9bd-d46dfb37d6e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e887c-e812-7a72-a1e1-bd5b557f27ab" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-72a7-b9bd-d46dfb37d6e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_019e887c-e812-73d5-b9f1-bce374fadc92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-72a7-b9bd-d46dfb37d6e7" xlink:to="loc_us-gaap_RestrictedStockMember_019e887c-e812-73d5-b9f1-bce374fadc92" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019e887c-e812-791c-8236-a1a6a2b5757a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e887c-e812-72a7-b9bd-d46dfb37d6e7" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019e887c-e812-791c-8236-a1a6a2b5757a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019e887c-e812-713c-909c-8492b95dde06" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019e887c-e812-713c-909c-8492b95dde06" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019e887c-e812-72a5-a298-3b7ed9bef916" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019e887c-e812-72a5-a298-3b7ed9bef916" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019e887c-e812-7dd5-bbcf-408a2b1adb9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019e887c-e812-7dd5-bbcf-408a2b1adb9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019e887c-e812-7cf4-ae35-ba02d9680b48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019e887c-e812-7cf4-ae35-ba02d9680b48" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate_019e887c-e812-73b9-b231-9afee52978a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate_019e887c-e812-73b9-b231-9afee52978a7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate_019e887c-e812-7eed-9b67-5ef78cb12ef2" xlink:href="ste-20260630.xsd#ste_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_019e887c-e812-73e8-aad1-2658210b49e3" xlink:to="loc_ste_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate_019e887c-e812-7eed-9b67-5ef78cb12ef2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e887c-e812-7bc3-9d8c-ffdc74b3e0a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e887c-e812-7bc3-9d8c-ffdc74b3e0a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_019e887c-e812-79d3-9d6f-dfcaee7a13cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_019e887c-e812-79d3-9d6f-dfcaee7a13cf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019e887c-e812-7dcc-9f05-06617f9ab4f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019e887c-e812-7dcc-9f05-06617f9ab4f8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019e887c-e812-7f6c-b9d7-b52aec85def8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019e887c-e812-7593-ab5a-eb8a7400fb32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019e887c-e812-7593-ab5a-eb8a7400fb32" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e887c-e812-7aa3-84a4-3a5665aa0b86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e887c-e812-7aa3-84a4-3a5665aa0b86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019e887c-e812-7c15-be5c-81cd36b854b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019e887c-e812-7c15-be5c-81cd36b854b4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019e887c-e812-7b75-bf38-0385ee1cd54a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019e887c-e812-7b75-bf38-0385ee1cd54a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019e887c-e812-7534-b61e-97f4018546ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019e887c-e812-7a4a-9605-a248801dcf9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019e887c-e812-76b9-8092-4dd572844783" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019e887c-e812-7a4a-9605-a248801dcf9c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_019e887c-e812-7efc-a66a-42b931fd2693" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_019e887c-e812-7efc-a66a-42b931fd2693" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_019e887c-e812-75a8-a996-4271ef61855e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_019e887c-e812-75a8-a996-4271ef61855e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_019e887c-e812-7237-9dfb-ae56c551f1c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_019e887c-e812-7237-9dfb-ae56c551f1c2" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_019e887c-e812-7dac-85d9-3e939fbe8aac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019e887c-e812-76b1-ae82-213cd854666f" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_019e887c-e812-7dac-85d9-3e939fbe8aac" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_019e887c-e812-7df7-8ae9-e1fe2ee86f65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_019e887c-e812-7df7-8ae9-e1fe2ee86f65" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_CommonStockFairMarketValuePerShare_019e887c-e812-707b-8ae9-a77e88a65233" xlink:href="ste-20260630.xsd#ste_CommonStockFairMarketValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_ste_CommonStockFairMarketValuePerShare_019e887c-e812-707b-8ae9-a77e88a65233" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_019e887c-e812-79ad-9c7d-d7fe32c42e6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_019e887c-e812-79ad-9c7d-d7fe32c42e6a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019e887c-e812-7eb0-97c6-2ca56f3a02cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019e887c-e812-7eb0-97c6-2ca56f3a02cd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-79e8-a56c-1be528673181" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-79e8-a56c-1be528673181" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019e887c-e812-7fb4-a9b9-943022b4080f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019e887c-e812-7fb4-a9b9-943022b4080f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e887c-e812-78ce-8707-a1673cd788b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e887c-e812-78ce-8707-a1673cd788b6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019e887c-e812-7ab6-9063-f00ccc8c3535" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019e887c-e812-7ab6-9063-f00ccc8c3535" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-729e-8a92-6d68edabc56e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-729e-8a92-6d68edabc56e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019e887c-e812-7494-98e6-f2880a019e19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019e887c-e812-7494-98e6-f2880a019e19" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-702e-b671-255d34a08009" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019e887c-e812-702e-b671-255d34a08009" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019e887c-e812-7f6d-bf8d-ecb1579cec12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019e887c-e812-7f6d-bf8d-ecb1579cec12" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019e887c-e812-7991-9df5-62185f5054b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_019e887c-e812-7cf4-bffe-9433fd971255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019e887c-e812-7991-9df5-62185f5054b0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019e887c-e812-783b-8ff2-caa977fe73bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019e887c-e812-7734-ac6b-bee8724c413f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019e887c-e812-7e00-bb09-af9ad64faeed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019e887c-e812-7e00-bb09-af9ad64faeed" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_019e887c-e812-72be-bb93-6587d2e4fea7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_019e887c-e812-72be-bb93-6587d2e4fea7" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019e887c-e812-7835-bf45-102b5cc3d6e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019e887c-e812-7835-bf45-102b5cc3d6e9" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019e887c-e812-7652-9a11-252885d6c3b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019e887c-e812-7652-9a11-252885d6c3b3" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019e887c-e812-7797-9d30-fbb4b1a587b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019e887c-e812-7797-9d30-fbb4b1a587b8" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019e887c-e812-789a-be71-c42c6b6a1b75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019e887c-e812-789a-be71-c42c6b6a1b75" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019e887c-e812-7cb8-8e3c-6008e66af94c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e887c-e812-790e-8d02-1886e105d49b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019e887c-e812-7cb8-8e3c-6008e66af94c" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyLiabilityLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyLiabilityTable_019e887c-e812-781e-9420-199baa5c517b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyLiabilityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyLiabilityTable_019e887c-e812-781e-9420-199baa5c517b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-730e-922a-708545094652" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ProductWarrantyLiabilityTable_019e887c-e812-781e-9420-199baa5c517b" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-730e-922a-708545094652" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-74db-b36e-84791f5cd42b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-74db-b36e-84791f5cd42b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrualWarrantiesIssued_019e887c-e812-72e7-8012-7545078051ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrualWarrantiesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyAccrualWarrantiesIssued_019e887c-e812-72e7-8012-7545078051ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StandardProductWarrantyAccrualPayments_019e887c-e812-7c6d-b413-0211df63f1ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StandardProductWarrantyAccrualPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_StandardProductWarrantyAccrualPayments_019e887c-e812-7c6d-b413-0211df63f1ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-778e-b463-50c4d8dc9951" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrual"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails_1" xlink:type="simple" xlink:href="ste-20260630.xsd#FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails_1"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/FinancialandOtherGuaranteesFinancialandOtherGuaranteesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyLiabilityLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyLiabilityTable_019e887c-e812-781e-9420-199baa5c517b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyLiabilityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyLiabilityTable_019e887c-e812-781e-9420-199baa5c517b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-74db-b36e-84791f5cd42b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-74db-b36e-84791f5cd42b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrualWarrantiesIssued_019e887c-e812-72e7-8012-7545078051ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrualWarrantiesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_ProductWarrantyAccrualWarrantiesIssued_019e887c-e812-72e7-8012-7545078051ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StandardProductWarrantyAccrualPayments_019e887c-e812-7c6d-b413-0211df63f1ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StandardProductWarrantyAccrualPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductWarrantyLiabilityLineItems_019e887c-e812-7405-8b75-b8e5a591809a" xlink:to="loc_us-gaap_StandardProductWarrantyAccrualPayments_019e887c-e812-7c6d-b413-0211df63f1ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_019e887c-e812-778e-b463-50c4d8dc9951" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrual"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CurrencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AUD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_EUR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_NZD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_MXN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-70bb-9b93-ec7e2ed5ab85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-70bb-9b93-ec7e2ed5ab85" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-727c-8cb9-e30a7ee3d061" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-727c-8cb9-e30a7ee3d061" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNonmonetaryNotionalAmountMass"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_1" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_1"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CurrencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AUD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_EUR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_NZD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_MXN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNonmonetaryNotionalAmountMass"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_2" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_2"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_2" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CurrencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AUD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_EUR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_NZD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_MXN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-70bb-9b93-ec7e2ed5ab85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019e887c-e812-70bb-9b93-ec7e2ed5ab85" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNonmonetaryNotionalAmountMass"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_3" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_3"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingFairValueofDerivativesBalanceSheetLocationDetails_3" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CurrencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-74bd-ac81-d0d354397f61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AllCurrenciesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CurrencyAxis_019e887c-e812-74bd-ac81-d0d354397f61" xlink:to="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_AUD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_AUD_019e887c-e812-7cc8-9138-562bb7d74f5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_EUR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_EUR_019e887c-e812-7bab-9fba-545899c08754" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_NZD"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_NZD_019e887c-e812-78c9-88a9-633469cb4db2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:href="https://xbrl.sec.gov/currency/2026/currency-2026.xsd#currency_MXN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_currency_AllCurrenciesDomain_019e887c-e812-7d3f-93c2-b093d84952b9" xlink:to="loc_currency_MXN_019f9071-d28e-7338-9a38-70a4ef71af55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7d67-a9fb-683f141e2a0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7d67-a9fb-683f141e2a0b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-72d6-b126-e23db96be65d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-745a-aee4-4f125169ec3f" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7d8c-9ce4-95b739e2ddab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-727c-8cb9-e30a7ee3d061" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019e887c-e812-7f4e-9cba-00b2001f76e2" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-727c-8cb9-e30a7ee3d061" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNonmonetaryNotionalAmountMass"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeNonmonetaryNotionalAmountMass_019e887c-e812-7178-ae94-f55970e346c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssets_019e887c-e812-7ac9-8bea-5c5a9b62d7f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilities_019e887c-e812-703c-b404-84698d438ab8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_019e887c-e812-70f0-aa29-a52ba61a32e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fb88a-5bd7-79c1-a319-f0493881ffb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fb88c-672f-7961-aa04-6057ec71f09c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_019fb96e-9f88-7368-9bf8-194e5f3caa0b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019e887c-e812-70ca-88ec-72d7b72c22e1" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_019fb96f-81d5-7543-ab5e-d15025dfc7af" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7792-b2e3-38830b4aa608_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7792-b2e3-38830b4aa608_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-7c05-950a-0d128c199fac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-7c05-950a-0d128c199fac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7cd6-98f9-91d063e15d44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7cd6-98f9-91d063e15d44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-7196-b2b7-647676835934" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019e887c-e812-7196-b2b7-647676835934" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fd3b7-5366-7a96-b1fc-d69a3d4f62da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fd3b7-5366-7a96-b1fc-d69a3d4f62da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fd3b7-5366-792e-b5bc-ca43840896e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fd3b7-5366-792e-b5bc-ca43840896e0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails_1" xlink:type="simple" xlink:href="ste-20260630.xsd#DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails_1"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/DerivativesandHedgingGainLossonDerivativesIncomeStatementLocationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019e887c-e812-7fdb-8cd9-d3dfc68b66d2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7792-b2e3-38830b4aa608_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-7792-b2e3-38830b4aa608_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019e887c-e812-7792-b2e3-38830b4aa608" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-7c05-950a-0d128c199fac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019e887c-e812-7c05-950a-0d128c199fac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_019e887c-e812-7cd6-98f9-91d063e15d44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019e887c-e812-73e7-bb44-9400b3fa1d50" xlink:to="loc_us-gaap_CommodityContractMember_019e887c-e812-7cd6-98f9-91d063e15d44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fd3b7-5366-7a96-b1fc-d69a3d4f62da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativesRecordedInEarningsNet_019fd3b7-5366-7a96-b1fc-d69a3d4f62da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fd3b7-5366-792e-b5bc-ca43840896e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfCommodityContracts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019e887c-e812-74d6-89f8-76b4bbc68914" xlink:to="loc_us-gaap_GainLossOnSaleOfCommodityContracts_019fd3b7-5366-792e-b5bc-ca43840896e0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/FairValueMeasurementsFairValueHierarchyDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#FairValueMeasurementsFairValueHierarchyDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/FairValueMeasurementsFairValueHierarchyDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e812-750a-9a80-c5452f99ebaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-7af1-8403-298ebcafc125" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e812-750a-9a80-c5452f99ebaa" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-7af1-8403-298ebcafc125" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_019e887c-e812-7130-b294-4975d1d0a12b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-7af1-8403-298ebcafc125" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_019e887c-e812-7130-b294-4975d1d0a12b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e887c-e812-7130-b294-4975d1d0a12b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019e887c-e812-7130-b294-4975d1d0a12b" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e887c-e812-7130-b294-4975d1d0a12b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019e887c-e812-72c1-af7c-dbfb9687af4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019e887c-e812-7130-b294-4975d1d0a12b" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019e887c-e812-72c1-af7c-dbfb9687af4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e887c-e812-73d0-bf9b-7b78ee8163fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019e887c-e812-72c1-af7c-dbfb9687af4c" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e887c-e812-73d0-bf9b-7b78ee8163fa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_019e887c-e812-79ee-97f4-77a06db9c763" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019e887c-e812-73d0-bf9b-7b78ee8163fa" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_019e887c-e812-79ee-97f4-77a06db9c763" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e812-79fe-b8be-f9e90d754299" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-7af1-8403-298ebcafc125" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e812-79fe-b8be-f9e90d754299" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-79fe-b8be-f9e90d754299_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e812-79fe-b8be-f9e90d754299" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-79fe-b8be-f9e90d754299_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-7385-97d9-cc55be29a328" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e812-79fe-b8be-f9e90d754299" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-7385-97d9-cc55be29a328" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019e887c-e812-7b0c-8ada-3861cc4c2d86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-7385-97d9-cc55be29a328" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019e887c-e812-7b0c-8ada-3861cc4c2d86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019e887c-e812-7821-b9f7-0c7b58181e49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-7385-97d9-cc55be29a328" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019e887c-e812-7821-b9f7-0c7b58181e49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019e887c-e812-7c11-a569-c08ca852be40" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e812-7385-97d9-cc55be29a328" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019e887c-e812-7c11-a569-c08ca852be40" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019e887c-e812-7904-9419-d62f658da0f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e812-750a-9a80-c5452f99ebaa" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019e887c-e812-7904-9419-d62f658da0f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e812-750a-9a80-c5452f99ebaa" xlink:to="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e887c-e812-7b67-bd53-8eae04a2c01d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e887c-e812-7b67-bd53-8eae04a2c01d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_019e887c-e812-7f2e-952e-0ba3227f2582" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyContractAssetFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:to="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_019e887c-e812-7f2e-952e-0ba3227f2582" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019e887c-e812-72be-8ef9-dfc47a29397d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019e887c-e812-72be-8ef9-dfc47a29397d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_019e887c-e812-7f99-9bd3-5b99fe8f0ac4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_019e887c-e812-77fc-a2e1-83db527bf418" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_019e887c-e812-7f99-9bd3-5b99fe8f0ac4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e812-750a-9a80-c5452f99ebaa" xlink:to="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_019e887c-e812-7783-a398-d985a0f74680" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:to="loc_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_019e887c-e812-7783-a398-d985a0f74680" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent_019e887c-e812-77f4-9ca3-5bd057dfbf78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:to="loc_us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent_019e887c-e812-77f4-9ca3-5bd057dfbf78" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_019e887c-e812-72db-90e9-e45a5ef60f16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:to="loc_us-gaap_LongTermDebtFairValue_019e887c-e812-72db-90e9-e45a5ef60f16" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019e887c-e812-7ff2-bbb0-c4cb9b626412" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_019e887c-e812-79df-b0fb-553fc015fcd1" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019e887c-e812-7ff2-bbb0-c4cb9b626412" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e813-7144-9df3-ab7a3ec1f2ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-728c-b9de-82473ff80d79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e813-7144-9df3-ab7a3ec1f2ca" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-728c-b9de-82473ff80d79" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e813-7615-91cf-08ab4c8d9155" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019e887c-e812-728c-b9de-82473ff80d79" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e813-7615-91cf-08ab4c8d9155" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e813-7615-91cf-08ab4c8d9155_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e813-7615-91cf-08ab4c8d9155" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e813-7615-91cf-08ab4c8d9155_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e813-7e45-b2ab-f4362306f64f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e887c-e813-7615-91cf-08ab4c8d9155" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e813-7e45-b2ab-f4362306f64f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019e887c-e813-7d86-a79e-17c5910f77f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e887c-e813-7e45-b2ab-f4362306f64f" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019e887c-e813-7d86-a79e-17c5910f77f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019e887c-e813-71d9-81cd-37d8faaf7929" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019e887c-e813-7144-9df3-ab7a3ec1f2ca" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019e887c-e813-71d9-81cd-37d8faaf7929" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_019e887c-e813-797f-bc44-44a708616e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_019e887c-e813-7c85-951a-2d28136b0b5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_019e887c-e813-797f-bc44-44a708616e0e" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_019e887c-e813-7c85-951a-2d28136b0b5c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e813-7549-a987-bdfe49ae6595" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_019e887c-e813-7c85-951a-2d28136b0b5c" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e813-7549-a987-bdfe49ae6595" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e887c-e813-7549-a987-bdfe49ae6595_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e813-7549-a987-bdfe49ae6595" xlink:to="loc_us-gaap_EquityComponentDomain_019e887c-e813-7549-a987-bdfe49ae6595_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e887c-e813-797f-901d-14da3ff65f13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e887c-e813-7549-a987-bdfe49ae6595" xlink:to="loc_us-gaap_EquityComponentDomain_019e887c-e813-797f-901d-14da3ff65f13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019e887c-e813-729b-be70-f4248a5f6492" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e813-797f-901d-14da3ff65f13" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019e887c-e813-729b-be70-f4248a5f6492" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019e887c-e813-75ca-a6b7-f5f816dcc570" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e813-797f-901d-14da3ff65f13" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019e887c-e813-75ca-a6b7-f5f816dcc570" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e887c-e813-708b-9f7b-eef0fc41e761" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e887c-e813-797f-901d-14da3ff65f13" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019e887c-e813-708b-9f7b-eef0fc41e761" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_019e887c-e813-797f-bc44-44a708616e0e" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e813-7593-a662-09a99eee1fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e813-7593-a662-09a99eee1fd6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019e887c-e813-798e-95fe-6856f48e6184" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019e887c-e813-798e-95fe-6856f48e6184" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019e887c-e813-755c-afdc-0f299f151ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019e887c-e813-755c-afdc-0f299f151ad6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e887c-e813-74bd-bf4c-b92e3ed3d8fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_019e887c-e813-757c-a395-0be3abdaf020" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e887c-e813-74bd-bf4c-b92e3ed3d8fa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e813-7ba7-b160-c9bd8fe1253f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.steris.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://www.steris.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_019e887c-e813-7325-8b3b-e447392ce795" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_019e887c-e813-73ae-abf6-7d6c3cef0488" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_019e887c-e813-7325-8b3b-e447392ce795" xlink:to="loc_us-gaap_SubsequentEventTable_019e887c-e813-73ae-abf6-7d6c3cef0488" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019fd3c3-d5d0-7f54-924d-e1c287f40b7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019e887c-e813-73ae-abf6-7d6c3cef0488" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019fd3c3-d5d0-7f54-924d-e1c287f40b7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019fd3c3-d5d0-7f54-924d-e1c287f40b7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019fd3c3-d5d0-7f54-924d-e1c287f40b7d" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019fd3c3-d5d0-7f54-924d-e1c287f40b7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019fd3c3-d5d0-7435-b0e8-9c5404d924cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019fd3c3-d5d0-7f54-924d-e1c287f40b7d" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019fd3c3-d5d0-7435-b0e8-9c5404d924cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019fd3c4-14e1-76fa-8163-a72b70bab990" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019fd3c3-d5d0-7435-b0e8-9c5404d924cf" xlink:to="loc_us-gaap_SubsequentEventMember_019fd3c4-14e1-76fa-8163-a72b70bab990" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019fd3c7-4141-7812-9ec8-5ba2c615d047" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019e887c-e813-73ae-abf6-7d6c3cef0488" xlink:to="loc_srt_RangeAxis_019fd3c7-4141-7812-9ec8-5ba2c615d047" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fd3c7-4141-7812-9ec8-5ba2c615d047_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019fd3c7-4141-7812-9ec8-5ba2c615d047" xlink:to="loc_srt_RangeMember_019fd3c7-4141-7812-9ec8-5ba2c615d047_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fd3c7-4141-7722-a0e4-79391c7b49fb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019fd3c7-4141-7812-9ec8-5ba2c615d047" xlink:to="loc_srt_RangeMember_019fd3c7-4141-7722-a0e4-79391c7b49fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019fd3c7-561b-7644-8544-30c12e747aa5" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fd3c7-4141-7722-a0e4-79391c7b49fb" xlink:to="loc_srt_MinimumMember_019fd3c7-561b-7644-8544-30c12e747aa5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019fd3c7-8403-7149-a2ea-8096af00a397" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fd3c7-4141-7722-a0e4-79391c7b49fb" xlink:to="loc_srt_MaximumMember_019fd3c7-8403-7149-a2ea-8096af00a397" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019fd3c0-e38d-79ba-963c-df329d8d7ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostExpectedCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019e887c-e813-7325-8b3b-e447392ce795" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019fd3c0-e38d-79ba-963c-df329d8d7ae6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_RestructuringAndRelatedCostExpectedCostCashExpenditures_019fd3c2-b67a-7132-ae13-f5a3072088d1" xlink:href="ste-20260630.xsd#ste_RestructuringAndRelatedCostExpectedCostCashExpenditures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019e887c-e813-7325-8b3b-e447392ce795" xlink:to="loc_ste_RestructuringAndRelatedCostExpectedCostCashExpenditures_019fd3c2-b67a-7132-ae13-f5a3072088d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_RestructuringAndRelatedCostExpectedCostNonCashCharges_019fd3c3-22dc-72d0-a94f-507e7487779f" xlink:href="ste-20260630.xsd#ste_RestructuringAndRelatedCostExpectedCostNonCashCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019e887c-e813-7325-8b3b-e447392ce795" xlink:to="loc_ste_RestructuringAndRelatedCostExpectedCostNonCashCharges_019fd3c3-22dc-72d0-a94f-507e7487779f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-roles-2026.xsd#eedm1"/>
  <link:definitionLink xlink:role="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent" xlink:type="arc" order="101"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:type="arc" order="102"/>
  </link:definitionLink>
</link:linkbase>
