<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e887c-e5a8-7165-a4ba-6d5844c9ad70,g:0b161456-a63d-4474-9cf6-8e0b0bbd363e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e887c-e743-7795-8a9d-e4d5692c0fae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e887c-e743-77b8-bdc6-90d982f953a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e887c-e743-7795-8a9d-e4d5692c0fae" xlink:to="loc_us-gaap_CommonStockValue_019e887c-e743-77b8-bdc6-90d982f953a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e887c-e743-7fb6-a612-f9e91d3955b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e887c-e743-7795-8a9d-e4d5692c0fae" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e887c-e743-7fb6-a612-f9e91d3955b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e887c-e743-77b3-a795-27d9f48b1d30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e887c-e743-7795-8a9d-e4d5692c0fae" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e887c-e743-77b3-a795-27d9f48b1d30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OperatingAndFinanceLeaseObligationNoncurrent_019e887c-e743-758e-aaf1-384b00593cb0" xlink:href="ste-20260630.xsd#ste_OperatingAndFinanceLeaseObligationNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:to="loc_ste_OperatingAndFinanceLeaseObligationNoncurrent_019e887c-e743-758e-aaf1-384b00593cb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_019e887c-e743-7e1d-80c1-a0262b042433" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_019e887c-e743-7e1d-80c1-a0262b042433" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e887c-e743-7de9-b0c0-21a95c5c68d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e887c-e743-7de9-b0c0-21a95c5c68d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7d5c-b227-30be080d56e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7d5c-b227-30be080d56e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e743-7756-ba14-e7aa4d20de1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e887c-e743-7756-a8c1-6c6bdc7ceec0" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e743-7756-ba14-e7aa4d20de1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e887c-e743-7392-aca7-5153106a790b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_AssetsCurrent_019e887c-e743-7392-aca7-5153106a790b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e743-750f-998a-df9ea37db0de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e743-750f-998a-df9ea37db0de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e887c-e743-7236-8c92-9876b96e3c94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e887c-e743-7236-8c92-9876b96e3c94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e887c-e743-74ff-8ad5-934aefb967a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e887c-e743-74ff-8ad5-934aefb967a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e887c-e743-7a9d-9885-78e4214f784f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_Goodwill_019e887c-e743-7a9d-9885-78e4214f784f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e887c-e743-7d34-a02d-a7e36fbfadd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e887c-e743-782e-ac9e-867297a1bba8" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e887c-e743-7d34-a02d-a7e36fbfadd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e887c-e743-78f9-9b74-2bcdfcf0571e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e887c-e743-78f9-9b74-2bcdfcf0571e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e743-76ad-96bc-844ee9d8cbfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e743-76ad-96bc-844ee9d8cbfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019e887c-e743-75d3-bb70-11a4045495cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_ShortTermBorrowings_019e887c-e743-75d3-bb70-11a4045495cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e743-7bd0-ae10-62274cc2c319" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e743-7bd0-ae10-62274cc2c319" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019e887c-e743-7049-b13e-4b4822f52e0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019e887c-e743-7049-b13e-4b4822f52e0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e887c-e743-7a87-ab48-dc2d6f2d8b4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e887c-e743-7a13-abb4-1eb1d0a5d02c" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e887c-e743-7a87-ab48-dc2d6f2d8b4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e887c-e743-707d-abf8-4a93182021f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e887c-e743-7599-93a2-68b6ec94343f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e887c-e743-707d-abf8-4a93182021f0" xlink:to="loc_us-gaap_Liabilities_019e887c-e743-7599-93a2-68b6ec94343f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-79be-a2a3-dc594e6b9f3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e887c-e743-707d-abf8-4a93182021f0" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-79be-a2a3-dc594e6b9f3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e887c-e743-704f-9878-947d325fbd85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e887c-e743-707d-abf8-4a93182021f0" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e887c-e743-704f-9878-947d325fbd85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7f27-b9cd-e75f259122aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e887c-e743-76c5-8e70-cf3d667cf8ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7f27-b9cd-e75f259122aa" xlink:to="loc_us-gaap_StockholdersEquity_019e887c-e743-76c5-8e70-cf3d667cf8ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019e887c-e743-7a95-9ecf-e363903aa609" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7f27-b9cd-e75f259122aa" xlink:to="loc_us-gaap_MinorityInterest_019e887c-e743-7a95-9ecf-e363903aa609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e887c-e743-7eac-83f9-b214f0ace019" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e887c-e743-7233-ab63-e7515cc19dd0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e887c-e743-7eac-83f9-b214f0ace019" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e887c-e743-7233-ab63-e7515cc19dd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e887c-e743-7336-b104-6bb2d8540791" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e887c-e743-7eac-83f9-b214f0ace019" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e887c-e743-7336-b104-6bb2d8540791" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e887c-e743-7bd6-b0c4-219dbe7b49ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e887c-e743-7eac-83f9-b214f0ace019" xlink:to="loc_us-gaap_InventoryNet_019e887c-e743-7bd6-b0c4-219dbe7b49ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent_019e887c-e743-7f92-9324-10fd6a3df384" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e887c-e743-7eac-83f9-b214f0ace019" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent_019e887c-e743-7f92-9324-10fd6a3df384" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e887c-e744-70bf-9fa4-429dac6f3f02" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e887c-e744-7945-8225-18f8d471f671" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfRevenue_019e887c-e744-70bf-9fa4-429dac6f3f02" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e887c-e744-7945-8225-18f8d471f671" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7a07-a945-849277b56179" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-7a70-b66c-2ef3e7596dfa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7a07-a945-849277b56179" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-7a70-b66c-2ef3e7596dfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e887c-e743-7d0e-81b7-aec5225ca51b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7a07-a945-849277b56179" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e887c-e743-7d0e-81b7-aec5225ca51b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e887c-e743-7aea-bc90-8cebaeb975d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e743-750e-8584-a98f2613e89d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e887c-e743-7aea-bc90-8cebaeb975d7" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e887c-e743-750e-8584-a98f2613e89d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e743-7740-a73b-b2fb461563c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e887c-e743-7aea-bc90-8cebaeb975d7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e887c-e743-7740-a73b-b2fb461563c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_019e887c-e743-7885-8fc8-372685a21e8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e887c-e743-7aea-bc90-8cebaeb975d7" xlink:to="loc_us-gaap_RestructuringCosts_019e887c-e743-7885-8fc8-372685a21e8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e744-7dd5-8ff3-53baef3acf42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e887c-e744-7882-b367-6ff23882de1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e744-7dd5-8ff3-53baef3acf42" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e887c-e744-7882-b367-6ff23882de1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e887c-e744-7819-9335-f344929d44c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e744-7dd5-8ff3-53baef3acf42" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e887c-e744-7819-9335-f344929d44c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_019e887c-e744-7d06-af88-5865d25cf3ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e744-7dd5-8ff3-53baef3acf42" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_019e887c-e744-7d06-af88-5865d25cf3ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-7601-9244-031ce10a9577" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e743-7335-8121-610135c699c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-7601-9244-031ce10a9577" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e887c-e743-7335-8121-610135c699c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7046-8082-1faded001bf0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e887c-e743-7601-9244-031ce10a9577" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7046-8082-1faded001bf0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7513-9061-b5748dd36ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e887c-e743-7779-97ca-74eb5b109299" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7513-9061-b5748dd36ffd" xlink:to="loc_us-gaap_OperatingExpenses_019e887c-e743-7779-97ca-74eb5b109299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e887c-e743-7797-a1c1-8ca380ca52e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e887c-e743-7513-9061-b5748dd36ffd" xlink:to="loc_us-gaap_GrossProfit_019e887c-e743-7797-a1c1-8ca380ca52e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e887c-e743-7c44-b35f-d4b3f26643c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7227-bf05-138e567e1841" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e887c-e743-7c44-b35f-d4b3f26643c0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019e887c-e743-7227-bf05-138e567e1841" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019e887c-e744-783a-be8c-6930b7bbf578" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e887c-e743-7c44-b35f-d4b3f26643c0" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019e887c-e744-783a-be8c-6930b7bbf578" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e887c-e744-7ca1-a425-09a9bc97ebf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e887c-e744-7908-a6c8-c84e82ed6481" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e887c-e744-7ca1-a425-09a9bc97ebf1" xlink:to="loc_us-gaap_Revenues_019e887c-e744-7908-a6c8-c84e82ed6481" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e887c-e744-7e1a-a0cf-7ee11e4f9dab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e887c-e744-7ca1-a425-09a9bc97ebf1" xlink:to="loc_us-gaap_CostOfRevenue_019e887c-e744-7e1a-a0cf-7ee11e4f9dab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e887c-e744-7e69-afe5-0df250fa5126" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e887c-e744-7c5b-a048-e5f2852bc01d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e887c-e744-7e69-afe5-0df250fa5126" xlink:to="loc_us-gaap_NetIncomeLoss_019e887c-e744-7c5b-a048-e5f2852bc01d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7768-825f-249cc675f6cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e887c-e744-7e69-afe5-0df250fa5126" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7768-825f-249cc675f6cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7a65-aed3-b9df584adbcf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019e887c-e744-72d0-b398-0ff34ef52555" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e887c-e744-7a65-aed3-b9df584adbcf" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019e887c-e744-72d0-b398-0ff34ef52555" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited" xlink:type="simple" xlink:href="ste-20260630.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-79b4-af9d-e0fba7ba727a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e887c-e744-706b-bbd6-24239f315746" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-79b4-af9d-e0fba7ba727a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e887c-e744-706b-bbd6-24239f315746" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019e887c-e744-71d2-89da-0dad42096e69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-79b4-af9d-e0fba7ba727a" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019e887c-e744-71d2-89da-0dad42096e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_019e887c-e744-7373-817d-9c5f8f11153c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-79b4-af9d-e0fba7ba727a" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_019e887c-e744-7373-817d-9c5f8f11153c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019e887c-e744-7fa7-9d10-95a6bd62c398" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-79b4-af9d-e0fba7ba727a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019e887c-e744-7fa7-9d10-95a6bd62c398" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019e887c-e744-7014-8c97-89c2b6d4944d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_ProfitLoss_019e887c-e744-7014-8c97-89c2b6d4944d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e887c-e744-7c78-9249-2b2309f09428" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e887c-e744-7c78-9249-2b2309f09428" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e887c-e744-7a5f-9140-78cebf0ee20f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e887c-e744-7a5f-9140-78cebf0ee20f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e887c-e744-79b9-80ed-c302828c02f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_ShareBasedCompensation_019e887c-e744-79b9-80ed-c302828c02f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019e887c-e744-795c-885b-5a49de4bb57f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019e887c-e744-795c-885b-5a49de4bb57f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e887c-e744-7895-b613-b9c443954746" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e887c-e744-7895-b613-b9c443954746" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e887c-e744-755c-af97-7d0b0a46eaff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e887c-e744-755c-af97-7d0b0a46eaff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e887c-e744-708b-8c9e-63d114929500" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e887c-e744-708b-8c9e-63d114929500" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e887c-e744-70bf-ae19-37621566be44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e887c-e744-70bf-ae19-37621566be44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e887c-e744-7b3e-ba3f-24332bbc672a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-7fe7-8927-1355e0decbd8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e887c-e744-7b3e-ba3f-24332bbc672a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e887c-e744-7df7-ac1b-810809485e00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-739b-bc4f-65278f8fd111" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e887c-e744-7df7-ac1b-810809485e00" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-739b-bc4f-65278f8fd111" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-7da6-ae44-635e475e3ea7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e887c-e744-7df7-ac1b-810809485e00" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e887c-e744-7da6-ae44-635e475e3ea7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-712d-b493-2f00d26fe607" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e887c-e744-7df7-ac1b-810809485e00" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e887c-e744-712d-b493-2f00d26fe607" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e887c-e744-778c-91b8-6e4d953b4025" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e887c-e744-7df7-ac1b-810809485e00" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e887c-e744-778c-91b8-6e4d953b4025" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_019e887c-e744-7cf1-a3e2-54b54b3aa493" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_019e887c-e744-7cf1-a3e2-54b54b3aa493" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_019e887c-e744-743f-9690-816998ea3e41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentsOfLinesOfCredit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_019e887c-e744-743f-9690-816998ea3e41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_019e887c-e744-783e-be36-fb339cbe5663" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_019e887c-e744-783e-be36-fb339cbe5663" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e887c-e744-79b1-9a88-fb5293dd436b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e887c-e744-79b1-9a88-fb5293dd436b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_019e887c-e744-7400-8dae-aef206c7e324" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_019e887c-e744-7400-8dae-aef206c7e324" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019e887c-e744-7ee1-af14-f55657868091" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e887c-e744-7e0f-be55-a87f3cdef8a2" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019e887c-e744-7ee1-af14-f55657868091" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/InventoriesNetInventoriesNetDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#InventoriesNetInventoriesNetDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/InventoriesNetInventoriesNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e887c-e744-7203-862d-ca371eb3285e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_019e887c-e744-7760-965a-b2efbe60fd62" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e887c-e744-7203-862d-ca371eb3285e" xlink:to="loc_us-gaap_InventoryRawMaterials_019e887c-e744-7760-965a-b2efbe60fd62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_019e887c-e744-71dc-bc28-f3c7c38ad0b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e887c-e744-7203-862d-ca371eb3285e" xlink:to="loc_us-gaap_InventoryWorkInProcess_019e887c-e744-71dc-bc28-f3c7c38ad0b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_019e887c-e744-7999-8447-7501e78ec5ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e887c-e744-7203-862d-ca371eb3285e" xlink:to="loc_us-gaap_InventoryFinishedGoods_019e887c-e744-7999-8447-7501e78ec5ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_019e887c-e744-7c81-aa47-fac751ed3a93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryValuationReserves"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e887c-e744-7203-862d-ca371eb3285e" xlink:to="loc_us-gaap_InventoryValuationReserves_019e887c-e744-7c81-aa47-fac751ed3a93" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/PropertyPlantandEquipmentPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#PropertyPlantandEquipmentPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/PropertyPlantandEquipmentPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e744-7c3e-8be7-8dec923fc94b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7df5-86b3-465766f88504" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e744-7c3e-8be7-8dec923fc94b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7df5-86b3-465766f88504" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e887c-e744-7ccd-a9ec-e51ac7a89be7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e887c-e744-7c3e-8be7-8dec923fc94b" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e887c-e744-7ccd-a9ec-e51ac7a89be7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Land_019e887c-e744-7c23-83fa-02e16fa7e16c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Land"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_us-gaap_Land_019e887c-e744-7c23-83fa-02e16fa7e16c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_019e887c-e744-7c34-92c1-dd6e602411ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BuildingsAndImprovementsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_019e887c-e744-7c34-92c1-dd6e602411ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_019e887c-e744-7f99-9588-da89174af04e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MachineryAndEquipmentGross"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_019e887c-e744-7f99-9588-da89174af04e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_CapitalizedComputerHardwareSoftwareGross_019e887c-e744-77a6-aa8e-6b9f23de9ba7" xlink:href="ste-20260630.xsd#ste_CapitalizedComputerHardwareSoftwareGross"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_ste_CapitalizedComputerHardwareSoftwareGross_019e887c-e744-77a6-aa8e-6b9f23de9ba7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialsSuppliesAndOther_019e887c-e744-79c3-827b-624f3cd6cc86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MaterialsSuppliesAndOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_us-gaap_MaterialsSuppliesAndOther_019e887c-e744-79c3-827b-624f3cd6cc86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_019e887c-e744-73aa-bc4c-a13aff6ae56b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019e887c-e744-7f77-b1e8-809d9153b0bd" xlink:to="loc_us-gaap_ConstructionInProgressGross_019e887c-e744-73aa-bc4c-a13aff6ae56b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/DebtIndebtednessDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#DebtIndebtednessDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/DebtIndebtednessDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019e887c-e744-75b3-ab07-7898c74a3536" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesCurrent_019e887c-e744-7697-ba29-c68decdc9fb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_019e887c-e744-75b3-ab07-7898c74a3536" xlink:to="loc_us-gaap_SeniorNotesCurrent_019e887c-e744-7697-ba29-c68decdc9fb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019e887c-e744-731a-8cc7-cd0d2e496250" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019e887c-e744-772b-8918-049c6ea5579b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019e887c-e744-731a-8cc7-cd0d2e496250" xlink:to="loc_us-gaap_ShortTermBorrowings_019e887c-e744-772b-8918-049c6ea5579b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e887c-e744-7b71-bec9-e03b0ea8bb4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019e887c-e744-731a-8cc7-cd0d2e496250" xlink:to="loc_us-gaap_LongTermDebt_019e887c-e744-7b71-bec9-e03b0ea8bb4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e887c-e744-7df1-9eed-04592f19c22e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorLongTermNotes_019e887c-e744-7a64-96a6-0f96010cb443" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorLongTermNotes"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e887c-e744-7df1-9eed-04592f19c22e" xlink:to="loc_us-gaap_SeniorLongTermNotes_019e887c-e744-7a64-96a6-0f96010cb443" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_019e887c-e744-744e-ab42-98a926abb262" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCredit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e887c-e744-7df1-9eed-04592f19c22e" xlink:to="loc_us-gaap_LineOfCredit_019e887c-e744-744e-ab42-98a926abb262" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019e887c-e744-799e-90e6-dd254b98be26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e887c-e744-7df1-9eed-04592f19c22e" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019e887c-e744-799e-90e6-dd254b98be26" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/AdditionalConsolidatedBalanceSheetsInformationAdditionalConsolidatedBalanceSheetsInformationDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#AdditionalConsolidatedBalanceSheetsInformationAdditionalConsolidatedBalanceSheetsInformationDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/AdditionalConsolidatedBalanceSheetsInformationAdditionalConsolidatedBalanceSheetsInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent_019e887c-e744-7fdf-8d06-42a7afc65d09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent_019e887c-e744-7fdf-8d06-42a7afc65d09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedVacationCurrent_019e887c-e744-745a-958e-30b4b5f9bc43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedVacationCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_AccruedVacationCurrent_019e887c-e744-745a-958e-30b4b5f9bc43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrentAndNoncurrent_019e887c-e744-7313-89e4-56e06ec04edb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedBonusesCurrentAndNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_AccruedBonusesCurrentAndNoncurrent_019e887c-e744-7313-89e4-56e06ec04edb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesForCommissionsExpenseAndTaxes_019e887c-e744-7e28-b31f-06319543cdba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesForCommissionsExpenseAndTaxes"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_AccruedLiabilitiesForCommissionsExpenseAndTaxes_019e887c-e744-7e28-b31f-06319543cdba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitsPayableCurrentAndNoncurrent_019e887c-e744-72d7-affa-59ae35901df8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPostretirementBenefitsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_OtherPostretirementBenefitsPayableCurrentAndNoncurrent_019e887c-e744-72d7-affa-59ae35901df8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrentAndNoncurrent_019e887c-e744-7fc7-9e32-b8e506183531" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e887c-e744-71d4-b030-6a9c8307443f" xlink:to="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrentAndNoncurrent_019e887c-e744-7fc7-9e32-b8e506183531" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SelfInsuranceReserveNoncurrent_019e887c-e744-7d42-a120-42de566851f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SelfInsuranceReserveNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_SelfInsuranceReserveNoncurrent_019e887c-e744-7d42-a120-42de566851f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitsPayableNoncurrent_019e887c-e744-7a86-8a19-e2e768861fee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPostretirementBenefitsPayableNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_OtherPostretirementBenefitsPayableNoncurrent_019e887c-e744-7a86-8a19-e2e768861fee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_019e887c-e744-7d2f-8a80-cc1e9790435f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_019e887c-e744-7d2f-8a80-cc1e9790435f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_019e887c-e744-70d5-858c-77f97160313e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesNoncurrent_019e887c-e744-70d5-858c-77f97160313e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e887c-e744-7b70-a804-590cf4a1f443" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e887c-e744-7b70-a804-590cf4a1f443" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationsNoncurrent_019e887c-e744-72b9-883b-4f196498c01b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetRetirementObligationsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_us-gaap_AssetRetirementObligationsNoncurrent_019e887c-e744-72b9-883b-4f196498c01b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Longtermliabilitiesother_019e887c-e744-7e43-8414-109dd1f9b387" xlink:href="ste-20260630.xsd#ste_Longtermliabilitiesother"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e887c-e744-7000-a28f-de4d1149e3bb" xlink:to="loc_ste_Longtermliabilitiesother_019e887c-e744-7e43-8414-109dd1f9b387" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenue_019e887c-e744-7f55-b3c7-4c6048ca5669" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_DeferredRevenue_019e887c-e744-7f55-b3c7-4c6048ca5669" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_Serviceliabilities_019e887c-e744-790c-9464-3baaf9fb1616" xlink:href="ste-20260630.xsd#ste_Serviceliabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_ste_Serviceliabilities_019e887c-e744-790c-9464-3baaf9fb1616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SelfInsuranceReserveCurrent_019e887c-e744-7a2c-ad8a-54b1615baed1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SelfInsuranceReserveCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_SelfInsuranceReserveCurrent_019e887c-e744-7a2c-ad8a-54b1615baed1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_019e887c-e744-7ab7-875a-cf235b549fa2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedSalesCommissionCurrentAndNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_019e887c-e744-7ab7-875a-cf235b549fa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_019e887c-e744-7c4d-b1b2-d3fb729f634c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductWarrantyAccrual"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_ProductWarrantyAccrual_019e887c-e744-7c4d-b1b2-d3fb729f634c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationCurrent_019e887c-e744-750a-8b20-f80c04d93b75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetRetirementObligationCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_AssetRetirementObligationCurrent_019e887c-e744-750a-8b20-f80c04d93b75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AccruedInterest_019e887c-e744-741f-b17e-2e644846efbf" xlink:href="ste-20260630.xsd#ste_AccruedInterest"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_ste_AccruedInterest_019e887c-e744-741f-b17e-2e644846efbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_019e887c-e744-7606-8254-ec6239f94cfd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_019e887c-e744-7606-8254-ec6239f94cfd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserve_019e887c-e744-7f79-a21d-26e1f46fc8c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserve"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e887c-e744-765e-b0b8-ca8eb91a4843" xlink:to="loc_us-gaap_LitigationReserve_019e887c-e744-7f79-a21d-26e1f46fc8c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="ste-20260630.xsd#ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/ReclassificationsoutofAccumulatedOtherComprehensiveIncomeReclassificationoutofAccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e887c-e813-7723-9b7d-25231c7d45ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019e887c-e813-7217-8681-3cdddcf724d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e887c-e813-7723-9b7d-25231c7d45ba" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019e887c-e813-7217-8681-3cdddcf724d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019e887c-e813-739b-8825-43ade8d9be03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e887c-e813-7723-9b7d-25231c7d45ba" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019e887c-e813-739b-8825-43ade8d9be03" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
