0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Business, Presentation and Recent Accounting Pronouncements link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Balance Sheet Information link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair Value Disclosures link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Capital Stock link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Warrants link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Net Loss per Share - Basic and Diluted link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Prepaid Collaboration Expenses link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Roll-forward of TOI Activity link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Business, Presentation and Recent Accounting Pronouncements (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Balance Sheet Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair Value Disclosures (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Warrants (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Net Loss per Share - Basic and Diluted (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Prepaid Collaboration Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Roll-forward of TOI Activity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Business, Presentation and Recent Accounting Pronouncements (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Balance Sheet Information - Schedule of of Cash and Cash Equivalents and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Balance Sheet Information - Schedule of Short term Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Balance Sheet Information - Schedule of Maturities of Short-term Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Balance Sheet Information - Schedule of Available-for-Sale Investments Gross Unrealized Losses and Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Balance Sheet Information - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Balance Sheet Information - Schedule of Tax and Other Receivables (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Balance Sheet Information - Schedule of Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Fair Value Disclosures - Schedule of Assets Measured on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Fair Value Disclosures - Schedule of Liabilities Measured on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Fair Value Disclosures - Schedule of Unobservable Level 3 Inputs (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Fair Value Disclosures - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Fair Value Disclosures - Schedule of Estimate to Measure Contingent Consideration Unobservable Level 3 In-process R&D (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Capital Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Net Loss per Share - Basic and Diluted (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Stock-Based Compensation - Schedule of Weighted Average Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Collaboration Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Commitments and Contingencies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Commitments and Contingencies - Schedule of Supplemental Balance Sheet Information Related to the Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Commitments and Contingencies - Schedule of Future Annual Minimum Lease Payments under Non-cancellable Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Commitments and Contingencies - Schedule of Maximum Obligation Payments per Respective Agreements and Estimated Fair Value of Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Segment Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Segment Information - Schedule of Revenue, Significant Expenses, and Net (Loss) Income (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Prepaid Collaboration Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Roll-forward of TOI Activity (Details) link:presentationLink link:calculationLink link:definitionLink