0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED STATEMENT OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED STATEMENT OF COMPREHENSIVE (LOSS) INCOME link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED BALANCE SHEET link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED BALANCE SHEET (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Acquisitions, Research Collaborations and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Collaborative Arrangements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Financial Instruments link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Loans Payable and Long-Term Debt link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Contingencies link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Equity link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Pension and Other Postretirement Benefit Plans link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Other (Income) Expense, Net link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - (Loss) Earnings Per Share link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Other Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Basis of Presentation (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Collaborative Arrangements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Restructuring (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Pension and Other Postretirement Benefit Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Other (Income) Expense, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - (Loss) Earnings Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Other Comprehensive Income (Loss) (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Acquisitions, Research Collaborations and Licensing Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Collaborative Arrangements - AstraZeneca PLC - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Collaborative Arrangements - AstraZeneca PLC (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Collaborative Arrangements - Eisai Co., Ltd. - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Collaborative Arrangements - Eisai Co., Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Collaborative Arrangements - Bayer AG - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Collaborative Arrangements - Bayer AG (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Collaborative Arrangements - Ridgeback Biotherapeutics LP (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Collaborative Arrangements - Daiicho Sankyo - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaborative Arrangements - Schedule of Daiicho Sankyo (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Collaborative Arrangements - Moderna, Inc. - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Collaborative Arrangements - Moderna, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Collaborative Arrangements - Bristol Meyers Squibb Company - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Restructuring - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Restructuring - Schedule of Charges Activities by Type of Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Restructuring - Schedule of Charges Activities by Type of Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Restructuring - Schedule of Activities by Program (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Financial Instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Financial Instruments - Schedule of Effect of Net Investment Hedges (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Financial Instruments - Schedule of Effect of Net Investment Hedges (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Financial Instruments - Schedule of Interest Rate Swaps Held (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Financial Instruments - Schedule of Amounts Recorded on Balance Sheet Related to Fair Value Hedges (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Financial Instruments - Schedule of Fair Value of Derivatives Segregated between those Derivatives that are Designated as Hedging Instruments and those that are Not Designated as Hedging Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Financial Instruments - Schedule of Fair Value of Derivatives Segregated between those Derivatives that are Designated as Hedging Instruments and those that are Not Designated as Hedging Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Financial Instruments - Schedule of Information on Derivative Positions Subject to Master Netting Arrangements as if they were Presented on a Net Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Financial Instruments - Schedule of Location and Amount of Pretax (Gains) Losses of Derivatives (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Financial Instruments - Schedule of Location and Amount of Pretax (Gains) Losses of Derivatives (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Financial Instruments - Schedule of Income Statement Effects on Derivatives Not Designated as Hedging Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Financial Instruments - Schedule of Income Statement Effects on Derivatives Not Designated as Hedging Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Financial Instruments - Schedule of Information on Available-for-sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Financial Instruments - Schedule of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Inventories - Schedule of Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Inventories - Schedule of Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Inventories - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Loans Payable and Long-Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Pension and Other Postretirement Benefit Plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Other (Income) Expense, Net - Schedule of Other (Income) Expense, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Other (Income) Expense, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - (Loss) Earnings Per Share - Calculations of (Loss) Earnings Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - (Loss) Earnings Per Share - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Other Comprehensive Income (Loss) (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Segment Reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Segment Reporting - Schedule of Sales from Products (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Segment Reporting - Schedule of Consolidated Sales by Geographic Area (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Segment Reporting - Schedule of Reconciliation of Segment Profits to Income before Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Segment Reporting - Schedule of Equity Income from Affiliates and Depreciation Included in Segment Profits (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Segment Reporting - Schedule of Property, Plant and Equipment, Net by Geographic Area (Details) link:presentationLink link:calculationLink link:definitionLink