v3.26.1
Segment Reporting - Schedule of Sales from Products (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Segment Reporting [Line Items]        
Sales $ 16,607 $ 15,806 $ 32,893 $ 31,335
Increase in hedge revenue     (153) 16
Revenue related to the sale of the marketing rights 132 100    
U.S.        
Segment Reporting [Line Items]        
Sales 9,367 8,836 18,532 17,359
Non-US        
Segment Reporting [Line Items]        
Sales 7,240 6,969 14,361 13,977
Operating Segments        
Segment Reporting [Line Items]        
Sales 16,535 15,696 32,675 30,922
Operating Segments | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 14,760 14,050 29,109 27,688
Operating Segments | Animal Health        
Segment Reporting [Line Items]        
Sales 1,775 1,646 3,566 3,234
Operating Segments | U.S.        
Segment Reporting [Line Items]        
Sales 9,362 8,827 18,392 17,255
Operating Segments | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 8,827 8,328 17,338 16,254
Operating Segments | U.S. | Animal Health        
Segment Reporting [Line Items]        
Sales 535 499 1,054 1,001
Operating Segments | Non-US        
Segment Reporting [Line Items]        
Sales 7,173 6,869 14,283 13,667
Operating Segments | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 5,933 5,722 11,771 11,434
Operating Segments | Non-US | Animal Health        
Segment Reporting [Line Items]        
Sales 1,240 1,147 2,512 2,233
Operating Segments | Keytruda | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 7,904 7,956 15,810 15,161
Operating Segments | Keytruda | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 4,611 4,749 9,210 9,057
Operating Segments | Keytruda | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 3,293 3,207 6,600 6,104
Operating Segments | Keytruda Qlex | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 463 0 590 0
Operating Segments | Keytruda Qlex | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 395 0 501 0
Operating Segments | Keytruda Qlex | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 68 0 89 0
Operating Segments | Alliance revenue - Lynparza | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 365 370 706 682
Operating Segments | Alliance revenue - Lynparza | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 167 174 315 319
Operating Segments | Alliance revenue - Lynparza | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 198 195 391 363
Operating Segments | Alliance revenue - Lenvima | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 283 265 539 523
Operating Segments | Alliance revenue - Lenvima | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 194 183 369 368
Operating Segments | Alliance revenue - Lenvima | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 90 83 170 155
Operating Segments | Welireg | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 271 162 470 300
Operating Segments | Welireg | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 214 138 366 261
Operating Segments | Welireg | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 57 24 103 39
Operating Segments | Alliance Revenue - Reblozyl | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 122 107 270 226
Operating Segments | Alliance Revenue - Reblozyl | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 98 88 226 189
Operating Segments | Alliance Revenue - Reblozyl | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 25 19 45 37
Operating Segments | Gardasil/Gardasil 9 | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 1,169 1,126 2,238 2,453
Operating Segments | Gardasil/Gardasil 9 | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 542 545 1,027 1,082
Operating Segments | Gardasil/Gardasil 9 | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 626 581 1,211 1,371
Operating Segments | ProQuad/M-M-R II/Varivax | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 592 609 1,130 1,148
Operating Segments | ProQuad/M-M-R II/Varivax | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 438 481 847 903
Operating Segments | ProQuad/M-M-R II/Varivax | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 154 128 283 245
Operating Segments | Vaxneuvance | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 148 229 350 459
Operating Segments | Vaxneuvance | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 69 136 192 275
Operating Segments | Vaxneuvance | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 80 93 158 184
Operating Segments | RotaTeq | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 134 121 340 349
Operating Segments | RotaTeq | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 84 60 249 225
Operating Segments | RotaTeq | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 50 61 91 125
Operating Segments | Capvaxive | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 184 129 325 236
Operating Segments | Capvaxive | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 138 129 256 235
Operating Segments | Capvaxive | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 45 0 69 1
Operating Segments | Winrevair | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 588 336 1,114 615
Operating Segments | Winrevair | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 522 323 999 591
Operating Segments | Winrevair | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 66 12 114 24
Operating Segments | Ohtuvayre | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 204 0 335 0
Operating Segments | Ohtuvayre | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 204 0 335 0
Operating Segments | Ohtuvayre | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 0 0 0 0
Operating Segments | Alliance revenue - Adempas/Verquvo | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 126 123 235 229
Operating Segments | Alliance revenue - Adempas/Verquvo | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 112 108 221 205
Operating Segments | Alliance revenue - Adempas/Verquvo | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 14 15 14 23
Operating Segments | Adempas | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 78 80 156 147
Operating Segments | Adempas | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 0 0 0 0
Operating Segments | Adempas | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 78 80 156 147
Operating Segments | Bridion | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 497 461 969 902
Operating Segments | Bridion | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 460 411 887 789
Operating Segments | Bridion | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 37 50 82 113
Operating Segments | Prevymis | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 295 228 568 436
Operating Segments | Prevymis | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 147 115 282 217
Operating Segments | Prevymis | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 148 113 285 219
Operating Segments | Delstrigo | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 101 83 176 150
Operating Segments | Delstrigo | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 13 14 23 29
Operating Segments | Delstrigo | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 88 70 153 121
Operating Segments | Zerbaxa | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 77 74 159 145
Operating Segments | Zerbaxa | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 44 45 95 87
Operating Segments | Zerbaxa | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 34 29 64 57
Operating Segments | Isentress/Isentress HD | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 60 86 119 176
Operating Segments | Isentress/Isentress HD | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 36 48 71 99
Operating Segments | Isentress/Isentress HD | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 24 38 49 77
Operating Segments | Dificid | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 22 96 56 179
Operating Segments | Dificid | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 11 83 35 155
Operating Segments | Dificid | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 12 13 21 24
Operating Segments | Lagevrio | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 5 83 32 185
Operating Segments | Lagevrio | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 1 30 18 66
Operating Segments | Lagevrio | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 3 52 15 119
Operating Segments | Januvia | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 258 372 625 921
Operating Segments | Januvia | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 149 216 401 561
Operating Segments | Januvia | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 109 155 224 360
Operating Segments | Janumet | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 171 251 378 498
Operating Segments | Janumet | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 28 68 96 133
Operating Segments | Janumet | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 143 184 283 366
Operating Segments | Other pharmaceutical | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 643 703 1,419 1,568
Operating Segments | Other pharmaceutical | U.S. | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 150 184 317 408
Operating Segments | Other pharmaceutical | Non-US | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 491 520 1,101 1,160
Operating Segments | Livestock | Animal Health        
Segment Reporting [Line Items]        
Sales 1,041 961 2,105 1,885
Operating Segments | Livestock | U.S. | Animal Health        
Segment Reporting [Line Items]        
Sales 202 190 414 384
Operating Segments | Livestock | Non-US | Animal Health        
Segment Reporting [Line Items]        
Sales 838 771 1,691 1,501
Operating Segments | Companion Animal | Animal Health        
Segment Reporting [Line Items]        
Sales 734 685 1,461 1,349
Operating Segments | Companion Animal | U.S. | Animal Health        
Segment Reporting [Line Items]        
Sales 333 309 640 617
Operating Segments | Companion Animal | Non-US | Animal Health        
Segment Reporting [Line Items]        
Sales 402 376 821 732
Operating Segments | Alliance revenue - Koselugo | Pharmaceutical        
Segment Reporting [Line Items]        
Sales 10 43 171 87
Corporate, Non-Segment        
Segment Reporting [Line Items]        
Sales 72 110 218 413
Corporate, Non-Segment | U.S.        
Segment Reporting [Line Items]        
Sales 5 9 140 104
Corporate, Non-Segment | Non-US        
Segment Reporting [Line Items]        
Sales $ 67 $ 100 $ 78 $ 310