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<edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns="http://www.sec.gov/edgar/npx">
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    <submissionType>N-PX</submissionType>
    <filerInfo>
      <registrantType>IM</registrantType>
      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <issuerCredentials>
          <cik>0002013341</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>
      <periodOfReport>06/30/2026</periodOfReport>
    </filerInfo>
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    <coverPage>
      <yearOrQuarter>YEAR</yearOrQuarter>
      <reportCalendarYear>2026</reportCalendarYear>
      <reportingPerson>
        <name>Foresite Capital Management VI LLC</name>
        <phoneNumber>310 981 3630</phoneNumber>
        <address>
          <com:street1>9200 Sunset Boulevard</com:street1>
          <com:street2>Suite PH1</com:street2>
          <com:city>West Hollywood</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90069</com:zipCode>
        </address>
      </reportingPerson>
      <agentForService>
        <address>
          <com:street1>9200 Sunset Boulevard</com:street1>
          <com:street2>Suite PH1</com:street2>
          <com:city>West Hollywood</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90069</com:zipCode>
        </address>
      </agentForService>
      <reportInfo>
        <reportType>INSTITUTIONAL MANAGER VOTING REPORT</reportType>
        <confidentialTreatment>N</confidentialTreatment>
      </reportInfo>
      <fileNumber>028-25267</fileNumber>
      <explanatoryInformation>
        <explanatoryChoice>N</explanatoryChoice>
      </explanatoryInformation>
    </coverPage>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
    </summaryPage>
    <signaturePage>
      <reportingPerson>Foresite Capital Management VI LLC</reportingPerson>
      <txSignature>Amelia Stoj</txSignature>
      <txPrintedSignature>Amelia Stoj</txPrintedSignature>
      <txTitle>CCO and Assistant GC</txTitle>
      <txAsOfDate>08/07/2026</txAsOfDate>
    </signaturePage>
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