<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ed234-36c2-795c-ac1e-167ac4868021,g:1ac29ea4-d010-4c1f-b47b-079f08cc5171-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="simple" xlink:href="ttwo-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019ed234-379b-728a-a0ef-d3bd1fbcd686" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_StatementTable_019ed234-379b-728a-a0ef-d3bd1fbcd686" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019ed234-379b-770c-944b-16f066300a19" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019ed234-379b-728a-a0ef-d3bd1fbcd686" xlink:to="loc_srt_ProductOrServiceAxis_019ed234-379b-770c-944b-16f066300a19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019ed234-379b-770c-944b-16f066300a19_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019ed234-379b-770c-944b-16f066300a19" xlink:to="loc_srt_ProductsAndServicesDomain_019ed234-379b-770c-944b-16f066300a19_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019ed234-379b-79ab-aecd-75dac423f803" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019ed234-379b-770c-944b-16f066300a19" xlink:to="loc_srt_ProductsAndServicesDomain_019ed234-379b-79ab-aecd-75dac423f803" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_GameMember_019ed234-379b-74f5-833e-62c01b919bf2" xlink:href="ttwo-20260630.xsd#ttwo_GameMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-79ab-aecd-75dac423f803" xlink:to="loc_ttwo_GameMember_019ed234-379b-74f5-833e-62c01b919bf2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingMember_019ed234-379b-7c9b-8635-187b0fc4f05e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdvertisingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-79ab-aecd-75dac423f803" xlink:to="loc_us-gaap_AdvertisingMember_019ed234-379b-7c9b-8635-187b0fc4f05e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-379b-76a5-bea6-3e132842a764" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-379b-76a5-bea6-3e132842a764" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019ed234-379b-780d-ac7f-d8062c22424f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_CostOfRevenue_019ed234-379b-780d-ac7f-d8062c22424f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019ed234-379b-7891-a248-4be5dfa5c744" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_GrossProfit_019ed234-379b-7891-a248-4be5dfa5c744" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_019ed234-379b-7124-938e-cd276cc4b15e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_SellingAndMarketingExpense_019ed234-379b-7124-938e-cd276cc4b15e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_019ed234-379b-7c53-ba99-112ff2df0f04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_019ed234-379b-7c53-ba99-112ff2df0f04" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019ed234-379b-737d-907a-ed890e1b9186" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019ed234-379b-737d-907a-ed890e1b9186" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019ed234-379b-7588-8c1e-fe5c0d30dab7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019ed234-379b-7588-8c1e-fe5c0d30dab7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019ed234-379b-7525-b26e-43e047667904" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_OperatingExpenses_019ed234-379b-7525-b26e-43e047667904" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ed234-379b-7015-8e3b-19bb7a03221b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_OperatingIncomeLoss_019ed234-379b-7015-8e3b-19bb7a03221b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_InterestIncomeNonoperating_019f7f35-3f0f-7f27-ab0a-daf71f0d5011" xlink:href="ttwo-20260630.xsd#ttwo_InterestIncomeNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_ttwo_InterestIncomeNonoperating_019f7f35-3f0f-7f27-ab0a-daf71f0d5011" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019f7f33-d3b6-7995-a1db-d59951f5bd0e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019f7f33-d3b6-7995-a1db-d59951f5bd0e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fa808-f4bb-75c4-8188-d99ab9523946" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fa808-f4bb-75c4-8188-d99ab9523946" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ed234-379b-750d-b062-91596bb19e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019ed234-379b-750d-b062-91596bb19e9e" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ed234-379b-7240-95fc-8bd6f0ee6b07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ed234-379b-7240-95fc-8bd6f0ee6b07" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019ed234-379b-7ba1-b9c7-bc562bb68c60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019ed234-379b-7ba1-b9c7-bc562bb68c60" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ed234-379b-7933-a440-3bc756bc556a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_NetIncomeLoss_019ed234-379b-7933-a440-3bc756bc556a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_019ed234-379b-7cd7-8b13-7f9afa8deced" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-744b-accb-d42a9c4f6681" xlink:to="loc_us-gaap_EarningsPerShareAbstract_019ed234-379b-7cd7-8b13-7f9afa8deced" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019ed234-379b-78f3-8130-6bfd7b09d677" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019ed234-379b-7cd7-8b13-7f9afa8deced" xlink:to="loc_us-gaap_EarningsPerShareBasic_019ed234-379b-78f3-8130-6bfd7b09d677" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019ed234-379b-726e-bb70-472368fda131" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019ed234-379b-7cd7-8b13-7f9afa8deced" xlink:to="loc_us-gaap_EarningsPerShareDiluted_019ed234-379b-726e-bb70-472368fda131" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited" xlink:type="simple" xlink:href="ttwo-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019ed234-379b-7d91-9420-c5e52dcd3018" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StatementTable_019ed234-379b-7d91-9420-c5e52dcd3018" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019ed234-379b-70e9-a936-b9b66be1a119" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019ed234-379b-7d91-9420-c5e52dcd3018" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019ed234-379b-70e9-a936-b9b66be1a119" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019ed234-379b-70e9-a936-b9b66be1a119_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019ed234-379b-70e9-a936-b9b66be1a119" xlink:to="loc_us-gaap_EquityComponentDomain_019ed234-379b-70e9-a936-b9b66be1a119_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019ed234-379b-70e9-a936-b9b66be1a119" xlink:to="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019ed234-379b-7f62-8fd2-6446f9257ec9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:to="loc_us-gaap_CommonStockMember_019ed234-379b-7f62-8fd2-6446f9257ec9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019ed234-379b-7c94-924a-851ac5e7fe64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019ed234-379b-7c94-924a-851ac5e7fe64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_019ed234-379b-717f-83d3-a037bd1a9d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:to="loc_us-gaap_TreasuryStockCommonMember_019ed234-379b-717f-83d3-a037bd1a9d4c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019ed234-379b-7a4e-aeb1-2ecee7891348" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:to="loc_us-gaap_RetainedEarningsMember_019ed234-379b-7a4e-aeb1-2ecee7891348" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019ed234-379b-788a-959c-81a98a320099" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019ed234-379b-7621-a1c1-653c649f2727" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019ed234-379b-788a-959c-81a98a320099" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019f4c88-d273-7568-b928-43beecd8f1bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019f4c88-d273-7568-b928-43beecd8f1bf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f4c88-d273-7d76-9340-ae3c9bfc9f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f4c88-d273-7d76-9340-ae3c9bfc9f6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019f4c88-d273-7aaa-a76e-9d6d4239e295" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_TreasuryStockCommonShares_019f4c88-d273-7aaa-a76e-9d6d4239e295" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f4c88-d273-7fcd-bc6a-d76d3234b538" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_NetIncomeLoss_019f4c88-d273-7fcd-bc6a-d76d3234b538" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019f4c88-d273-7d43-b7fc-7da1558548e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019f4c88-d273-7d43-b7fc-7da1558548e0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019f4c88-d273-7d1d-a3bd-7830c68d8df1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019f4c88-d273-7d1d-a3bd-7830c68d8df1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_019f4c88-d273-755d-80a7-55ff7af5b07a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_019f4c88-d273-755d-80a7-55ff7af5b07a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_StockIssuedDuringPeriodValueRestrictedStockAwardSettlement_019f4c88-d273-7933-af8e-d17004bd4b59" xlink:href="ttwo-20260630.xsd#ttwo_StockIssuedDuringPeriodValueRestrictedStockAwardSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_ttwo_StockIssuedDuringPeriodValueRestrictedStockAwardSettlement_019f4c88-d273-7933-af8e-d17004bd4b59" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares_019f4c88-d273-7825-8a24-30e63dd318bc" xlink:href="ttwo-20260630.xsd#ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares_019f4c88-d273-7825-8a24-30e63dd318bc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlan_019f4c88-d273-7d19-bd96-1e6860dd4c90" xlink:href="ttwo-20260630.xsd#ttwo_SettlementRelatedToEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlan_019f4c88-d273-7d19-bd96-1e6860dd4c90" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019ed234-379b-7677-ad64-3300ee262e92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019ed234-379b-7677-ad64-3300ee262e92" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019f4c88-d273-794b-84ea-4d766af0da44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019f4c88-d273-794b-84ea-4d766af0da44" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_019f4c88-d273-7ce9-bd04-8f46c4b0e7fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019ed234-379b-7dd7-836c-e225571d14b8" xlink:to="loc_us-gaap_StockholdersEquityOther_019f4c88-d273-7ce9-bd04-8f46c4b0e7fb" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019f4c88-d273-7f8d-95b2-07398fa35bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f4c88-d273-73e1-9c0f-91cf154ab7db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019f4c88-d273-7d5b-8e81-3b6e187ec708" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019ed234-379b-7590-b9f9-63930a1a6581" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019ed234-379b-71af-9d56-13c7b485f845" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019ed234-379b-7590-b9f9-63930a1a6581" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019ed234-379b-71af-9d56-13c7b485f845" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019ed234-379b-72fc-ad87-dbdd347c2577" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019ed234-379b-71af-9d56-13c7b485f845" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019ed234-379b-72fc-ad87-dbdd347c2577" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-72fc-ad87-dbdd347c2577_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019ed234-379b-72fc-ad87-dbdd347c2577" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-72fc-ad87-dbdd347c2577_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-7d6d-834a-d626c469baf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019ed234-379b-72fc-ad87-dbdd347c2577" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-7d6d-834a-d626c469baf9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember_019ed234-379b-7132-a83f-d1c8e97a9e8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransferredOverTimeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-7d6d-834a-d626c469baf9" xlink:to="loc_us-gaap_TransferredOverTimeMember_019ed234-379b-7132-a83f-d1c8e97a9e8b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredAtPointInTimeMember_019ed234-379b-79f7-9d97-5ada809317eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransferredAtPointInTimeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019ed234-379b-7d6d-834a-d626c469baf9" xlink:to="loc_us-gaap_TransferredAtPointInTimeMember_019ed234-379b-79f7-9d97-5ada809317eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019ed234-379b-7e2b-933f-8677a4377e09" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019ed234-379b-71af-9d56-13c7b485f845" xlink:to="loc_srt_ProductOrServiceAxis_019ed234-379b-7e2b-933f-8677a4377e09" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019ed234-379b-7e2b-933f-8677a4377e09_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019ed234-379b-7e2b-933f-8677a4377e09" xlink:to="loc_srt_ProductsAndServicesDomain_019ed234-379b-7e2b-933f-8677a4377e09_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019ed234-379b-7e2b-933f-8677a4377e09" xlink:to="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RecurrentCustomerSpendingMember_019ed234-379b-7f9d-9a24-4bc15dc78f42" xlink:href="ttwo-20260630.xsd#ttwo_RecurrentCustomerSpendingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_RecurrentCustomerSpendingMember_019ed234-379b-7f9d-9a24-4bc15dc78f42" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_FullGameAndOtherMember_019ed234-379b-7108-8325-76c1ff314a13" xlink:href="ttwo-20260630.xsd#ttwo_FullGameAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_FullGameAndOtherMember_019ed234-379b-7108-8325-76c1ff314a13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MobileMember_019ed234-379b-7eb4-b2ef-56a13cec002d" xlink:href="ttwo-20260630.xsd#ttwo_MobileMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_MobileMember_019ed234-379b-7eb4-b2ef-56a13cec002d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConsoleMember_019ed234-379b-7d51-a263-9b31559bf8df" xlink:href="ttwo-20260630.xsd#ttwo_ConsoleMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_ConsoleMember_019ed234-379b-7d51-a263-9b31559bf8df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PCAndOtherProductsMember_019ed234-379b-7de5-a5cc-15b55a5eb4c8" xlink:href="ttwo-20260630.xsd#ttwo_PCAndOtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_PCAndOtherProductsMember_019ed234-379b-7de5-a5cc-15b55a5eb4c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DigitalOnlineMember_019ed234-379b-7c44-8f01-1bf90065a378" xlink:href="ttwo-20260630.xsd#ttwo_DigitalOnlineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_DigitalOnlineMember_019ed234-379b-7c44-8f01-1bf90065a378" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PhysicalRetailAndOtherMember_019ed234-379b-7af4-af3a-eb3d27e14da3" xlink:href="ttwo-20260630.xsd#ttwo_PhysicalRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019ed234-379b-732a-96d4-396b830d244d" xlink:to="loc_ttwo_PhysicalRetailAndOtherMember_019ed234-379b-7af4-af3a-eb3d27e14da3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-379b-7a95-b9dc-18ded16e437b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019ed234-379b-7590-b9f9-63930a1a6581" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-379b-7a95-b9dc-18ded16e437b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019ed234-379b-7790-96cb-3cd7786f35dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019ed234-379b-7790-96cb-3cd7786f35dc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_019ed234-379b-726f-b0c9-783cd1432d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019ed234-379b-7790-96cb-3cd7786f35dc" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_019ed234-379b-726f-b0c9-783cd1432d2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019ed234-379b-7813-9001-65e8a31c63d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019ed234-379b-7813-9001-65e8a31c63d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019ed234-379b-7647-9ae0-7f3bbcb1f0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019ed234-379b-7647-9ae0-7f3bbcb1f0b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019ed234-379b-7ab1-8929-2e073179fe6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019ed234-379b-7ab1-8929-2e073179fe6d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019ed234-379b-70f2-bd81-31531cc1f50e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019ed234-379b-70f2-bd81-31531cc1f50e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019ed234-379b-7ef3-baba-44498fb72314" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019ed234-379b-7ef3-baba-44498fb72314" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019ed234-379b-72c0-a78d-bba848a3a6cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TradeReceivablesHeldForSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019ed234-379b-72c0-a78d-bba848a3a6cb" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="simple" xlink:href="ttwo-20260630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019ed234-379b-7790-96cb-3cd7786f35dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019ed234-379b-7790-96cb-3cd7786f35dc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019ed234-379b-7813-9001-65e8a31c63d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019ed234-379b-7813-9001-65e8a31c63d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019ed234-379b-7647-9ae0-7f3bbcb1f0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019ed234-379b-7647-9ae0-7f3bbcb1f0b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019ed234-379b-7ab1-8929-2e073179fe6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019ed234-379b-7ab1-8929-2e073179fe6d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019ed234-379b-70f2-bd81-31531cc1f50e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019ed234-379b-70f2-bd81-31531cc1f50e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019ed234-379b-7ef3-baba-44498fb72314" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019ed234-379b-7ef3-baba-44498fb72314" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019ed234-379b-72c0-a78d-bba848a3a6cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TradeReceivablesHeldForSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019ed234-379b-7939-b8e1-a24b9ee1ab1d" xlink:to="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019ed234-379b-72c0-a78d-bba848a3a6cb" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#MANAGEMENTAGREEMENTNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7680-9b95-9386c65e0536" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7680-9b95-9386c65e0536" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7680-9b95-9386c65e0536_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7680-9b95-9386c65e0536" xlink:to="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7680-9b95-9386c65e0536_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7749-94ac-4ba56a6d7264" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7680-9b95-9386c65e0536" xlink:to="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7749-94ac-4ba56a6d7264" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZelnickMediaCorporationMember_019ed234-3871-76a1-9125-0c73e16fd997" xlink:href="ttwo-20260630.xsd#ttwo_ZelnickMediaCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7749-94ac-4ba56a6d7264" xlink:to="loc_ttwo_ZelnickMediaCorporationMember_019ed234-3871-76a1-9125-0c73e16fd997" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019ed234-3871-7668-9b11-87adab6bb8ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019ed234-3871-7668-9b11-87adab6bb8ff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019ed234-3871-7668-9b11-87adab6bb8ff_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019ed234-3871-7668-9b11-87adab6bb8ff" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019ed234-3871-7668-9b11-87adab6bb8ff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019ed234-3871-7718-aeef-38d6ce11fd5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019ed234-3871-7668-9b11-87adab6bb8ff" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019ed234-3871-7718-aeef-38d6ce11fd5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ManagementAgreement2022Member_019ed234-3871-7556-8463-0e5025c33df0" xlink:href="ttwo-20260630.xsd#ttwo_ManagementAgreement2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019ed234-3871-7718-aeef-38d6ce11fd5f" xlink:to="loc_ttwo_ManagementAgreement2022Member_019ed234-3871-7556-8463-0e5025c33df0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019ed234-3871-7417-888c-57c68e3e78cc" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:to="loc_srt_RangeAxis_019ed234-3871-7417-888c-57c68e3e78cc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019ed234-3871-7417-888c-57c68e3e78cc_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019ed234-3871-7417-888c-57c68e3e78cc" xlink:to="loc_srt_RangeMember_019ed234-3871-7417-888c-57c68e3e78cc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019ed234-3871-7578-a48e-593ca845faea" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019ed234-3871-7417-888c-57c68e3e78cc" xlink:to="loc_srt_RangeMember_019ed234-3871-7578-a48e-593ca845faea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019ed234-3871-7729-a0da-93718014d727" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019ed234-3871-7578-a48e-593ca845faea" xlink:to="loc_srt_MaximumMember_019ed234-3871-7729-a0da-93718014d727" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019ed234-3871-7421-b9cf-429e48ed34f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-737c-a84d-70511c36f8aa" xlink:to="loc_us-gaap_AwardTypeAxis_019ed234-3871-7421-b9cf-429e48ed34f4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7421-b9cf-429e48ed34f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3871-7421-b9cf-429e48ed34f4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7421-b9cf-429e48ed34f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-795b-b758-dacaffe8a2c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3871-7421-b9cf-429e48ed34f4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-795b-b758-dacaffe8a2c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019ed234-3871-7b2c-940a-4957438a0828" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-795b-b758-dacaffe8a2c9" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019ed234-3871-7b2c-940a-4957438a0828" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019ed234-3871-79e3-9ccb-65d0f1ff86f2" xlink:href="ttwo-20260630.xsd#ttwo_PerformanceBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-795b-b758-dacaffe8a2c9" xlink:to="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019ed234-3871-79e3-9ccb-65d0f1ff86f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MarketBasedRestrictedStockMember_019ed234-3871-74b8-b473-7e4134be7be4" xlink:href="ttwo-20260630.xsd#ttwo_MarketBasedRestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-795b-b758-dacaffe8a2c9" xlink:to="loc_ttwo_MarketBasedRestrictedStockMember_019ed234-3871-74b8-b473-7e4134be7be4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionAnnualManagementFee_019ed234-3871-79fe-8734-583af7227575" xlink:href="ttwo-20260630.xsd#ttwo_RelatedPartyTransactionAnnualManagementFee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_ttwo_RelatedPartyTransactionAnnualManagementFee_019ed234-3871-79fe-8734-583af7227575" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionBonusPerFiscalYear_019ed234-3871-75e2-9067-0bc85a225c3a" xlink:href="ttwo-20260630.xsd#ttwo_RelatedPartyTransactionBonusPerFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_ttwo_RelatedPartyTransactionBonusPerFiscalYear_019ed234-3871-75e2-9067-0bc85a225c3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionConsultingExpenseBenefit_019ed234-3871-7058-bbc1-052fc4d424cc" xlink:href="ttwo-20260630.xsd#ttwo_RelatedPartyTransactionConsultingExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_ttwo_RelatedPartyTransactionConsultingExpenseBenefit_019ed234-3871-7058-bbc1-052fc4d424cc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_019ed234-3871-7882-ba05-de1dc662cfa9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_019ed234-3871-7882-ba05-de1dc662cfa9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod_019ed234-3871-7fbc-aa9d-eaec2185d220" xlink:href="ttwo-20260630.xsd#ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod_019ed234-3871-7fbc-aa9d-eaec2185d220" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement_019ed234-3871-7d8e-8ecd-396fb46611d7" xlink:href="ttwo-20260630.xsd#ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement_019ed234-3871-7d8e-8ecd-396fb46611d7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019ed234-3871-75c0-b958-92e9fbceaca1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019ed234-3871-75c0-b958-92e9fbceaca1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019ed234-3871-7cc3-8424-9681fe75594b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019ed234-3871-7cc3-8424-9681fe75594b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019ed234-3871-761b-aa49-90d3a8838e0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019ed234-3871-761b-aa49-90d3a8838e0f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019ed234-3871-71f0-a0f4-5e5fc60cfa79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-783a-b306-503d7063a456" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019ed234-3871-71f0-a0f4-5e5fc60cfa79" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-78d1-b82a-83e99cac75ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-7cd9-bee1-d73dcd0d0ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-78d1-b82a-83e99cac75ef" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-7cd9-bee1-d73dcd0d0ffc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019ed234-3871-7fbd-9133-e363559aef0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-7cd9-bee1-d73dcd0d0ffc" xlink:to="loc_us-gaap_AwardTypeAxis_019ed234-3871-7fbd-9133-e363559aef0d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7fbd-9133-e363559aef0d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3871-7fbd-9133-e363559aef0d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7fbd-9133-e363559aef0d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3871-7fbd-9133-e363559aef0d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_TimeBasedRestrictedUnitsMember_019ed234-3871-712a-9f1e-ea7bcf5c52d1" xlink:href="ttwo-20260630.xsd#ttwo_TimeBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:to="loc_ttwo_TimeBasedRestrictedUnitsMember_019ed234-3871-712a-9f1e-ea7bcf5c52d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MarketBasedRestrictedUnitsMember_019ed234-3871-7115-9de8-68f0dd6a25cc" xlink:href="ttwo-20260630.xsd#ttwo_MarketBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:to="loc_ttwo_MarketBasedRestrictedUnitsMember_019ed234-3871-7115-9de8-68f0dd6a25cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019ed234-3871-778e-af46-ee45ef54742a" xlink:href="ttwo-20260630.xsd#ttwo_PerformanceBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:to="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019ed234-3871-778e-af46-ee45ef54742a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019ed234-3871-7bbd-92b7-3fbae34c38cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3871-7746-979d-5dc8908cef5e" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019ed234-3871-7bbd-92b7-3fbae34c38cd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7081-b5df-df835de7ebf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019ed234-3871-7cd9-bee1-d73dcd0d0ffc" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7081-b5df-df835de7ebf8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7081-b5df-df835de7ebf8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7081-b5df-df835de7ebf8" xlink:to="loc_us-gaap_RelatedPartyDomain_019ed234-3871-7081-b5df-df835de7ebf8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019ed234-3871-703a-9114-1e43bc3c7929" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019ed234-3871-7081-b5df-df835de7ebf8" xlink:to="loc_us-gaap_RelatedPartyDomain_019ed234-3871-703a-9114-1e43bc3c7929" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZelnickMediaCorporationMember_019ed234-3871-7c8c-9eb9-32ded4aa21bb" xlink:href="ttwo-20260630.xsd#ttwo_ZelnickMediaCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019ed234-3871-703a-9114-1e43bc3c7929" xlink:to="loc_ttwo_ZelnickMediaCorporationMember_019ed234-3871-7c8c-9eb9-32ded4aa21bb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019ed234-3871-77dc-8acf-23f34cce4299" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019ed234-3871-78d1-b82a-83e99cac75ef" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019ed234-3871-77dc-8acf-23f34cce4299" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019ed234-3871-7105-9bc3-ea94a5313399" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019ed234-3871-7f3d-acf6-713c2798303e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019ed234-3871-7105-9bc3-ea94a5313399" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019ed234-3871-7f3d-acf6-713c2798303e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3871-749f-b9dc-613e5434c68f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019ed234-3871-7f3d-acf6-713c2798303e" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3871-749f-b9dc-613e5434c68f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-749f-b9dc-613e5434c68f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3871-749f-b9dc-613e5434c68f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-749f-b9dc-613e5434c68f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-789a-927c-62e79099d2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3871-749f-b9dc-613e5434c68f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-789a-927c-62e79099d2f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019ed234-3871-7840-9e1c-93735b100954" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-789a-927c-62e79099d2f0" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019ed234-3871-7840-9e1c-93735b100954" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3871-7a64-b359-d8b336aa1dfa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-789a-927c-62e79099d2f0" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3871-7a64-b359-d8b336aa1dfa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019ed234-3871-7db7-8ba8-cec4f8b55e0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3871-789a-927c-62e79099d2f0" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019ed234-3871-7db7-8ba8-cec4f8b55e0d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019ed234-3871-7c4c-bbf3-f84562088337" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019ed234-3871-7f3d-acf6-713c2798303e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019ed234-3871-7c4c-bbf3-f84562088337" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-7c4c-bbf3-f84562088337_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019ed234-3871-7c4c-bbf3-f84562088337" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-7c4c-bbf3-f84562088337_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-755d-a444-d9bb50881e22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019ed234-3871-7c4c-bbf3-f84562088337" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-755d-a444-d9bb50881e22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019ed234-3871-7a9e-82e2-8abb4dc93f22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-755d-a444-d9bb50881e22" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019ed234-3871-7a9e-82e2-8abb4dc93f22" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-731d-ba94-8e8c2cca3d1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ed234-3871-755d-a444-d9bb50881e22" xlink:to="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-731d-ba94-8e8c2cca3d1b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-75dd-82fc-c084f88a1c55" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019ed234-3871-7f3d-acf6-713c2798303e" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-75dd-82fc-c084f88a1c55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-75dd-82fc-c084f88a1c55_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-75dd-82fc-c084f88a1c55" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-75dd-82fc-c084f88a1c55_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-75dd-82fc-c084f88a1c55" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-7c1f-b64f-9eeb9276b015" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:to="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-7c1f-b64f-9eeb9276b015" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivateEquityFundsMember_019ed234-3871-70ac-b010-dd2f447febfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrivateEquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:to="loc_us-gaap_PrivateEquityFundsMember_019ed234-3871-70ac-b010-dd2f447febfc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019ed234-3871-7f2c-8d45-ef93af7d3db1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019ed234-3871-7f2c-8d45-ef93af7d3db1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityFundsMember_019ed234-3871-704f-98e0-09018f51a57b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7cb4-85af-1cc51cc79824" xlink:to="loc_us-gaap_EquityFundsMember_019ed234-3871-704f-98e0-09018f51a57b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019ed234-3871-7105-9bc3-ea94a5313399" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ed234-3871-7201-b40d-c352782f31ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ed234-3871-7201-b40d-c352782f31ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019ed234-3871-71e8-95e7-a4f771492bab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_us-gaap_ShortTermInvestments_019ed234-3871-71e8-95e7-a4f771492bab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashAtFairValue_019ed234-3871-7a7b-a324-cb559b922661" xlink:href="ttwo-20260630.xsd#ttwo_RestrictedCashAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_ttwo_RestrictedCashAtFairValue_019ed234-3871-7a7b-a324-cb559b922661" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019f7f45-91bf-759d-89a5-6f157725a218" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_us-gaap_DerivativeAssets_019f7f45-91bf-759d-89a5-6f157725a218" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_019ed234-3871-7993-bc28-7f7dce61e1f0" xlink:href="ttwo-20260630.xsd#ttwo_RestrictedCashNoncurrentFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_019ed234-3871-7993-bc28-7f7dce61e1f0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019ed234-3871-748a-89d1-070f89e7c815" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019ed234-3871-748a-89d1-070f89e7c815" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019ed234-3871-7c50-9841-1dd5903f56f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019ed234-3871-7787-bf8e-169d5eee3ac9" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019ed234-3871-7c50-9841-1dd5903f56f2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019ed234-3871-726e-a451-254246d67e04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019ed234-3871-7105-9bc3-ea94a5313399" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019ed234-3871-726e-a451-254246d67e04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019f7f43-155d-7f34-acb5-5f028dd4ab28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019ed234-3871-726e-a451-254246d67e04" xlink:to="loc_us-gaap_DerivativeLiabilities_019f7f43-155d-7f34-acb5-5f028dd4ab28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_019f4cae-a950-7507-87f1-6dfa7bf9ccb9" xlink:href="ttwo-20260630.xsd#ttwo_ConvertibleDebtCurrentFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019ed234-3871-726e-a451-254246d67e04" xlink:to="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_019f4cae-a950-7507-87f1-6dfa7bf9ccb9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_019ed234-3871-7ad6-bbea-b0552d193990" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019ed234-3871-726e-a451-254246d67e04" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_019ed234-3871-7ad6-bbea-b0552d193990" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#SHORTTERMINVESTMENTSShorttermInvestmentsDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019ed234-3871-79d9-b992-0ed029c58e8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019ed234-3871-79d9-b992-0ed029c58e8b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-76c3-b49a-953280d1c6de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019ed234-3871-79d9-b992-0ed029c58e8b" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-76c3-b49a-953280d1c6de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-76c3-b49a-953280d1c6de_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-76c3-b49a-953280d1c6de" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-76c3-b49a-953280d1c6de_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7fa9-a863-eda24d15063d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019ed234-3871-76c3-b49a-953280d1c6de" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7fa9-a863-eda24d15063d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-7b9f-9251-2ef4844b198c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019ed234-3871-7fa9-a863-eda24d15063d" xlink:to="loc_us-gaap_BankTimeDepositsMember_019ed234-3871-7b9f-9251-2ef4844b198c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019ed234-3871-7b7c-b752-d5e846169cee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:to="loc_us-gaap_ShortTermInvestments_019ed234-3871-7b7c-b752-d5e846169cee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax_019ed234-3871-7ece-a41c-d558479d4f87" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:to="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax_019ed234-3871-7ece-a41c-d558479d4f87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax_019ed234-3871-78e9-9b85-c7908be39163" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:to="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax_019ed234-3871-78e9-9b85-c7908be39163" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsFairValueDisclosure_019ed234-3871-7ae1-9b07-4837f0c14159" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermInvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019ed234-3871-76e8-8c3e-32ceec59a4d1" xlink:to="loc_ttwo_ShortTermInvestmentsFairValueDisclosure_019ed234-3871-7ae1-9b07-4837f0c14159" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019ed234-3871-714b-9995-0983964800f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019ed234-3871-74a0-96be-e499a9803cf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019ed234-3871-714b-9995-0983964800f5" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019ed234-3871-74a0-96be-e499a9803cf9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019ed234-3871-7add-b328-decd063f8aef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019ed234-3871-74a0-96be-e499a9803cf9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019ed234-3871-7add-b328-decd063f8aef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-7add-b328-decd063f8aef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019ed234-3871-7add-b328-decd063f8aef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-7add-b328-decd063f8aef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-795b-b107-3c3f373e03db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019ed234-3871-7add-b328-decd063f8aef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-795b-b107-3c3f373e03db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareInternalDevelopmentMember_019ed234-3871-78d6-b7df-2d1dccf7a76e" xlink:href="ttwo-20260630.xsd#ttwo_SoftwareInternalDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-795b-b107-3c3f373e03db" xlink:to="loc_ttwo_SoftwareInternalDevelopmentMember_019ed234-3871-78d6-b7df-2d1dccf7a76e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareExternalDevelopmentMember_019ed234-3871-7e66-ac17-b0e361daed50" xlink:href="ttwo-20260630.xsd#ttwo_SoftwareExternalDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-795b-b107-3c3f373e03db" xlink:to="loc_ttwo_SoftwareExternalDevelopmentMember_019ed234-3871-7e66-ac17-b0e361daed50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareLicensesMember_019ed234-3871-7585-9035-0dfc9fcb2198" xlink:href="ttwo-20260630.xsd#ttwo_SoftwareLicensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019ed234-3871-795b-b107-3c3f373e03db" xlink:to="loc_ttwo_SoftwareLicensesMember_019ed234-3871-7585-9035-0dfc9fcb2198" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_019ed234-3871-758a-8387-bbf915101935" xlink:href="ttwo-20260630.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019ed234-3871-714b-9995-0983964800f5" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_019ed234-3871-758a-8387-bbf915101935" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_019ed234-3871-78d4-ac62-07c2878b1066" xlink:href="ttwo-20260630.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019ed234-3871-714b-9995-0983964800f5" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_019ed234-3871-78d4-ac62-07c2878b1066" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareImpairments1_019ed234-3872-7a2a-8326-913f8951c8b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CapitalizedComputerSoftwareImpairments1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019ed234-3871-714b-9995-0983964800f5" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareImpairments1_019ed234-3872-7a2a-8326-913f8951c8b4" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTLongtermDebtNetDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7977-9900-8019c5a7a735" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7977-9900-8019c5a7a735" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-732a-adbe-629837ef315c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7977-9900-8019c5a7a735" xlink:to="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-732a-adbe-629837ef315c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-732a-adbe-629837ef315c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-732a-adbe-629837ef315c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-732a-adbe-629837ef315c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-732a-adbe-629837ef315c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019ed234-3872-7e29-846b-6cf695ecb3e7" xlink:href="ttwo-20260630.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:to="loc_ttwo_A2027NotesMember_019ed234-3872-7e29-846b-6cf695ecb3e7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2028NotesMember_019ed234-3872-7b17-9d7b-7aab9b6b7c46" xlink:href="ttwo-20260630.xsd#ttwo_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:to="loc_ttwo_A2028NotesMember_019ed234-3872-7b17-9d7b-7aab9b6b7c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029NotesMember_019ed234-3872-7618-a468-07a0ca31303f" xlink:href="ttwo-20260630.xsd#ttwo_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:to="loc_ttwo_A2029NotesMember_019ed234-3872-7618-a468-07a0ca31303f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2032NotesMember_019ed234-3872-7a78-8898-fd0548430da3" xlink:href="ttwo-20260630.xsd#ttwo_A2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:to="loc_ttwo_A2032NotesMember_019ed234-3872-7a78-8898-fd0548430da3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2034NotesMember_019ed234-3872-74d0-a03c-3d98f8c325d8" xlink:href="ttwo-20260630.xsd#ttwo_A2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e9b-bda1-e8965f416c46" xlink:to="loc_ttwo_A2034NotesMember_019ed234-3872-74d0-a03c-3d98f8c325d8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-73de-b229-a38138986a67" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7977-9900-8019c5a7a735" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-73de-b229-a38138986a67" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-73de-b229-a38138986a67_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-73de-b229-a38138986a67" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-73de-b229-a38138986a67_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-77fe-af92-c0673e4fb9a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-73de-b229-a38138986a67" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-77fe-af92-c0673e4fb9a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3872-78ab-8343-bc943b82e967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-77fe-af92-c0673e4fb9a1" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3872-78ab-8343-bc943b82e967" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019ed234-3872-7d00-97af-c7a07a486516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019ed234-3872-7d00-97af-c7a07a486516" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019ed234-3872-79db-9beb-5f60de69aa0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019ed234-3872-79db-9beb-5f60de69aa0b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019ed234-3872-79ac-8c42-b3b02009eb4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019ed234-3872-79ac-8c42-b3b02009eb4e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019ed234-3872-78e1-a285-f17dc02c275b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7604-beac-b56c323fbb30" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019ed234-3872-78e1-a285-f17dc02c275b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTShorttermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_019ed234-3872-76fc-bf8e-d05aa97336e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShortTermDebtTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_019ed234-3872-76fc-bf8e-d05aa97336e7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7d02-9e76-3e04ae20dee4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_019ed234-3872-76fc-bf8e-d05aa97336e7" xlink:to="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7d02-9e76-3e04ae20dee4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7d02-9e76-3e04ae20dee4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7d02-9e76-3e04ae20dee4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7d02-9e76-3e04ae20dee4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e50-8f8e-7d761517ccd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7d02-9e76-3e04ae20dee4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e50-8f8e-7d761517ccd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019f4cc6-7353-7544-9996-d990294ce61f" xlink:href="ttwo-20260630.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e50-8f8e-7d761517ccd3" xlink:to="loc_ttwo_A2027NotesMember_019f4cc6-7353-7544-9996-d990294ce61f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026ConvertibleNotesMember_019ed234-3872-7541-bf23-0302c4fc3eda" xlink:href="ttwo-20260630.xsd#ttwo_A2026ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7e50-8f8e-7d761517ccd3" xlink:to="loc_ttwo_A2026ConvertibleNotesMember_019ed234-3872-7541-bf23-0302c4fc3eda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-7793-ae59-1a5b8b0dfa71" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_019ed234-3872-76fc-bf8e-d05aa97336e7" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-7793-ae59-1a5b8b0dfa71" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-7793-ae59-1a5b8b0dfa71_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-7793-ae59-1a5b8b0dfa71" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-7793-ae59-1a5b8b0dfa71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-7ee1-acb9-f15a4c02ff54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019ed234-3872-7793-ae59-1a5b8b0dfa71" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-7ee1-acb9-f15a4c02ff54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3872-777f-96a9-43f501e8fc22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019ed234-3872-7ee1-acb9-f15a4c02ff54" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019ed234-3872-777f-96a9-43f501e8fc22" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019ed234-3872-734f-a224-9ab07a564e4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019ed234-3872-734f-a224-9ab07a564e4f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtGross_019ed234-3872-76af-bb7c-044f845a7ab5" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermDebtGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:to="loc_ttwo_ShortTermDebtGross_019ed234-3872-76af-bb7c-044f845a7ab5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019ed234-3872-7143-82bc-b81f67c57a1d" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:to="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019ed234-3872-7143-82bc-b81f67c57a1d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019ed234-3872-7c8b-b08b-544d9dec16e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7574-916f-8a6986bed248" xlink:to="loc_us-gaap_ShortTermBorrowings_019ed234-3872-7c8b-b08b-544d9dec16e3" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTInterestandOtherNetDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTInterestandOtherNetDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTInterestandOtherNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7cde-b065-7a78bab69583" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-779b-87cf-30affae7b61b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7cde-b065-7a78bab69583" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-779b-87cf-30affae7b61b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7ff3-b2b0-379780c85448" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-779b-87cf-30affae7b61b" xlink:to="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7ff3-b2b0-379780c85448" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7ff3-b2b0-379780c85448_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7ff3-b2b0-379780c85448" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-7ff3-b2b0-379780c85448_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019ed234-3872-7ff3-b2b0-379780c85448" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2025NotesMember_019ed234-3872-754e-8995-0ceddfb29731" xlink:href="ttwo-20260630.xsd#ttwo_A2025NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2025NotesMember_019ed234-3872-754e-8995-0ceddfb29731" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026NotesMember_019ed234-3872-7e8f-b256-bb62d4378f7c" xlink:href="ttwo-20260630.xsd#ttwo_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2026NotesMember_019ed234-3872-7e8f-b256-bb62d4378f7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019ed234-3872-75f4-bcb7-7dac065351da" xlink:href="ttwo-20260630.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2027NotesMember_019ed234-3872-75f4-bcb7-7dac065351da" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2028NotesMember_019ed234-3872-766c-a853-f8e949e4232c" xlink:href="ttwo-20260630.xsd#ttwo_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2028NotesMember_019ed234-3872-766c-a853-f8e949e4232c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029NotesMember_019ed234-3872-7957-bbc3-b5fd8ff7042e" xlink:href="ttwo-20260630.xsd#ttwo_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2029NotesMember_019ed234-3872-7957-bbc3-b5fd8ff7042e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2032NotesMember_019ed234-3872-7cc5-b539-623b659b1de0" xlink:href="ttwo-20260630.xsd#ttwo_A2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2032NotesMember_019ed234-3872-7cc5-b539-623b659b1de0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2034NotesMember_019ed234-3872-7ee6-8d71-44d3c2d4b871" xlink:href="ttwo-20260630.xsd#ttwo_A2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019ed234-3872-76fa-a970-8ea694dc57d6" xlink:to="loc_ttwo_A2034NotesMember_019ed234-3872-7ee6-8d71-44d3c2d4b871" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_019ed234-3872-72d8-92c5-d8ab54b4a4b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7cde-b065-7a78bab69583" xlink:to="loc_us-gaap_InterestExpenseDebt_019ed234-3872-72d8-92c5-d8ab54b4a4b7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTSeniorNotesDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTSeniorNotesDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTSeniorNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-773b-bb3f-1bc88eb2b67f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-773b-bb3f-1bc88eb2b67f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019fa83c-4b1d-736b-bc77-95f98a62676a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-773b-bb3f-1bc88eb2b67f" xlink:to="loc_us-gaap_DebtInstrumentAxis_019fa83c-4b1d-736b-bc77-95f98a62676a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-736b-bc77-95f98a62676a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83c-4b1d-736b-bc77-95f98a62676a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-736b-bc77-95f98a62676a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-701c-9136-2a2539575b05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83c-4b1d-736b-bc77-95f98a62676a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-701c-9136-2a2539575b05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A20252027And2032NotesMember_019fa83c-4b1d-7936-ae86-e7ae007cc1d0" xlink:href="ttwo-20260630.xsd#ttwo_A20252027And2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-701c-9136-2a2539575b05" xlink:to="loc_ttwo_A20252027And2032NotesMember_019fa83c-4b1d-7936-ae86-e7ae007cc1d0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026NotesMember_019fa83c-4b1d-7d5b-a4cb-c7b7a215a699" xlink:href="ttwo-20260630.xsd#ttwo_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-701c-9136-2a2539575b05" xlink:to="loc_ttwo_A2026NotesMember_019fa83c-4b1d-7d5b-a4cb-c7b7a215a699" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2025NotesMember_019fa83c-4b1d-7823-8147-7848271889f5" xlink:href="ttwo-20260630.xsd#ttwo_A2025NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-4b1d-701c-9136-2a2539575b05" xlink:to="loc_ttwo_A2025NotesMember_019fa83c-4b1d-7823-8147-7848271889f5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-4b1d-78d2-ae28-8e7b407126d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-773b-bb3f-1bc88eb2b67f" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-4b1d-78d2-ae28-8e7b407126d5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-4b1d-78d2-ae28-8e7b407126d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-4b1d-78d2-ae28-8e7b407126d5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-4b1d-78d2-ae28-8e7b407126d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-4b1d-7b3a-827c-4a96daed4ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-4b1d-78d2-ae28-8e7b407126d5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-4b1d-7b3a-827c-4a96daed4ec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019fa83c-4b1d-727d-bfb0-eaf80d4107ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-4b1d-7b3a-827c-4a96daed4ec1" xlink:to="loc_us-gaap_SeniorNotesMember_019fa83c-4b1d-727d-bfb0-eaf80d4107ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019fa83c-4b1d-7c21-bbc9-3872c10c2d69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-773b-bb3f-1bc88eb2b67f" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019fa83c-4b1d-7c21-bbc9-3872c10c2d69" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019fa83c-4b1d-7c21-bbc9-3872c10c2d69_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019fa83c-4b1d-7c21-bbc9-3872c10c2d69" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019fa83c-4b1d-7c21-bbc9-3872c10c2d69_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019fa83c-4b1d-701f-a294-333a1afed228" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019fa83c-4b1d-7c21-bbc9-3872c10c2d69" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019fa83c-4b1d-701f-a294-333a1afed228" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019fa83c-4b1d-7ac9-924f-20092adedeaf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019fa83c-4b1d-701f-a294-333a1afed228" xlink:to="loc_us-gaap_SeniorNotesMember_019fa83c-4b1d-7ac9-924f-20092adedeaf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentPeriodicPaymentInterest_019fa83c-4b1d-7b78-aef3-95a904807a5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentPeriodicPaymentInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:to="loc_us-gaap_DebtInstrumentPeriodicPaymentInterest_019fa83c-4b1d-7b78-aef3-95a904807a5d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019fa83c-4b1d-73fe-bb95-083766f5ba06" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019fa83c-4b1d-73fe-bb95-083766f5ba06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_019fa83c-4b1d-73a3-964d-1ad2b36b95f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_019fa83c-4b1d-73a3-964d-1ad2b36b95f8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019fa83c-4b1d-72ba-bda9-21ad03c4dd9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7073-9f7f-561ab337edd1" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019fa83c-4b1d-72ba-bda9-21ad03c4dd9c" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTCreditAgreementDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTCreditAgreementDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_019fa83c-efdf-7259-8fd4-e7ff3c470b85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:to="loc_us-gaap_CreditFacilityAxis_019fa83c-efdf-7259-8fd4-e7ff3c470b85" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019fa83c-efdf-7259-8fd4-e7ff3c470b85_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_019fa83c-efdf-7259-8fd4-e7ff3c470b85" xlink:to="loc_us-gaap_CreditFacilityDomain_019fa83c-efdf-7259-8fd4-e7ff3c470b85_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019fa83c-efdf-748b-b6c4-cb6d47a79cfe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_019fa83c-efdf-7259-8fd4-e7ff3c470b85" xlink:to="loc_us-gaap_CreditFacilityDomain_019fa83c-efdf-748b-b6c4-cb6d47a79cfe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_019fa83c-efdf-715e-99a5-d9278ed51fe5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019fa83c-efdf-748b-b6c4-cb6d47a79cfe" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_019fa83c-efdf-715e-99a5-d9278ed51fe5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-efdf-7256-8f2a-0eb9b9061d53" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-efdf-7256-8f2a-0eb9b9061d53" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-efdf-7256-8f2a-0eb9b9061d53_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-efdf-7256-8f2a-0eb9b9061d53" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-efdf-7256-8f2a-0eb9b9061d53_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-efdf-75d4-80ec-41dbb8b7a654" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83c-efdf-7256-8f2a-0eb9b9061d53" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-efdf-75d4-80ec-41dbb8b7a654" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019fa83c-efdf-785e-b78b-c98651ca53d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019fa83c-efdf-75d4-80ec-41dbb8b7a654" xlink:to="loc_us-gaap_LineOfCreditMember_019fa83c-efdf-785e-b78b-c98651ca53d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019fa83c-efdf-78f0-8f36-627772fe567b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:to="loc_srt_RangeAxis_019fa83c-efdf-78f0-8f36-627772fe567b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fa83c-efdf-78f0-8f36-627772fe567b_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019fa83c-efdf-78f0-8f36-627772fe567b" xlink:to="loc_srt_RangeMember_019fa83c-efdf-78f0-8f36-627772fe567b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fa83c-efdf-7ac3-9643-3f03779ce846" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019fa83c-efdf-78f0-8f36-627772fe567b" xlink:to="loc_srt_RangeMember_019fa83c-efdf-7ac3-9643-3f03779ce846" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019fa83c-efdf-76df-a440-99988a7afd9c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fa83c-efdf-7ac3-9643-3f03779ce846" xlink:to="loc_srt_MinimumMember_019fa83c-efdf-76df-a440-99988a7afd9c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019fa83c-efdf-70ce-b40d-283f6612b317" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fa83c-efdf-7ac3-9643-3f03779ce846" xlink:to="loc_srt_MaximumMember_019fa83c-efdf-70ce-b40d-283f6612b317" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_019fa83c-efdf-722c-bb29-5da29ac5dc79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:to="loc_us-gaap_VariableRateAxis_019fa83c-efdf-722c-bb29-5da29ac5dc79" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_019fa83c-efdf-722c-bb29-5da29ac5dc79_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_019fa83c-efdf-722c-bb29-5da29ac5dc79" xlink:to="loc_us-gaap_VariableRateDomain_019fa83c-efdf-722c-bb29-5da29ac5dc79_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_019fa83c-efdf-782b-afea-4be74d172a13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_019fa83c-efdf-722c-bb29-5da29ac5dc79" xlink:to="loc_us-gaap_VariableRateDomain_019fa83c-efdf-782b-afea-4be74d172a13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_019fa83c-efdf-7ad0-b8fd-6141bb70304c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BaseRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_019fa83c-efdf-782b-afea-4be74d172a13" xlink:to="loc_us-gaap_BaseRateMember_019fa83c-efdf-7ad0-b8fd-6141bb70304c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_019fa83c-efdf-74f0-9554-14d395deb790" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SecuredOvernightFinancingRateSofrMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_019fa83c-efdf-782b-afea-4be74d172a13" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_019fa83c-efdf-74f0-9554-14d395deb790" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019fa83c-efdf-73cc-b75b-b441929e1bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-770d-ae01-da35d3f8574d" xlink:to="loc_us-gaap_DebtInstrumentAxis_019fa83c-efdf-73cc-b75b-b441929e1bf8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-efdf-73cc-b75b-b441929e1bf8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83c-efdf-73cc-b75b-b441929e1bf8" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-efdf-73cc-b75b-b441929e1bf8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-efdf-7bbe-aac2-2818d645d90d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83c-efdf-73cc-b75b-b441929e1bf8" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-efdf-7bbe-aac2-2818d645d90d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2022CreditAgreementMember_019fa83c-efdf-722c-adca-89ab9d2b99a7" xlink:href="ttwo-20260630.xsd#ttwo_A2022CreditAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83c-efdf-7bbe-aac2-2818d645d90d" xlink:to="loc_ttwo_A2022CreditAgreementMember_019fa83c-efdf-722c-adca-89ab9d2b99a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019fa83c-efdf-7b8a-874b-56fc97a087a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019fa83c-efdf-7b8a-874b-56fc97a087a6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_019fa83c-efdf-7a03-bf2e-47f704fe7ce9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_DebtInstrumentTerm_019fa83c-efdf-7a03-bf2e-47f704fe7ce9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019fa83c-efdf-7d96-a75a-c3d064085c21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019fa83c-efdf-7d96-a75a-c3d064085c21" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019fa83c-efdf-71c2-8036-1304dbc03217" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019fa83c-efdf-71c2-8036-1304dbc03217" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fa83c-efdf-7126-be6d-aae01dcd95da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fa83c-efdf-7126-be6d-aae01dcd95da" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019fa83c-efdf-74f0-a8f7-6a59b1ab75f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7871-89b7-4264da2d500a" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019fa83c-efdf-74f0-a8f7-6a59b1ab75f7" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7226-a91b-333e534a2681" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7777-851a-c53b142c1d07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7226-a91b-333e534a2681" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7777-851a-c53b142c1d07" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019ed234-3872-7199-8a34-459a70386b78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-7777-851a-c53b142c1d07" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019ed234-3872-7199-8a34-459a70386b78" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019ed234-3872-7199-8a34-459a70386b78_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019ed234-3872-7199-8a34-459a70386b78" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019ed234-3872-7199-8a34-459a70386b78_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019ed234-3872-7a77-8a06-84bab6d126cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019ed234-3872-7199-8a34-459a70386b78" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019ed234-3872-7a77-8a06-84bab6d126cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019ed234-3872-7cf3-bd0e-8015e612d867" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019ed234-3872-7a77-8a06-84bab6d126cc" xlink:to="loc_us-gaap_LineOfCreditMember_019ed234-3872-7cf3-bd0e-8015e612d867" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019ed234-3872-7fbb-91f6-b75f9697b958" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7226-a91b-333e534a2681" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019ed234-3872-7fbb-91f6-b75f9697b958" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_019ed234-3872-79bc-aef0-8be1dcf24b5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7226-a91b-333e534a2681" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_019ed234-3872-79bc-aef0-8be1dcf24b5f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTConvertibleNotesDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#DEBTConvertibleNotesDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTConvertibleNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019ed234-3872-76ca-9412-1ec5d07759e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:to="loc_us-gaap_DebtInstrumentTable_019ed234-3872-76ca-9412-1ec5d07759e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019fa83d-e107-7948-9a98-44a22f712064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-76ca-9412-1ec5d07759e4" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019fa83d-e107-7948-9a98-44a22f712064" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fa83d-e107-7948-9a98-44a22f712064_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019fa83d-e107-7948-9a98-44a22f712064" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fa83d-e107-7948-9a98-44a22f712064_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fa83d-e107-7a4e-8f68-7e356c9388eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019fa83d-e107-7948-9a98-44a22f712064" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fa83d-e107-7a4e-8f68-7e356c9388eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZyngaIncMember_019fa83d-e107-76a9-94be-8088f48d03fb" xlink:href="ttwo-20260630.xsd#ttwo_ZyngaIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fa83d-e107-7a4e-8f68-7e356c9388eb" xlink:to="loc_ttwo_ZyngaIncMember_019fa83d-e107-76a9-94be-8088f48d03fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019fa83d-e107-75df-98a1-4d8aa0a1dafc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-76ca-9412-1ec5d07759e4" xlink:to="loc_us-gaap_DebtInstrumentAxis_019fa83d-e107-75df-98a1-4d8aa0a1dafc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-75df-98a1-4d8aa0a1dafc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83d-e107-75df-98a1-4d8aa0a1dafc" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-75df-98a1-4d8aa0a1dafc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-749f-9e38-ca326a9539f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fa83d-e107-75df-98a1-4d8aa0a1dafc" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-749f-9e38-ca326a9539f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A025ConvertibleSeniorNotesDue2024Member_019fa83d-e107-79d6-995c-0bc32873d971" xlink:href="ttwo-20260630.xsd#ttwo_A025ConvertibleSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-749f-9e38-ca326a9539f2" xlink:to="loc_ttwo_A025ConvertibleSeniorNotesDue2024Member_019fa83d-e107-79d6-995c-0bc32873d971" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A0ConvertibleSeniorNotesDue2026Member_019fa83d-e107-7a4b-b928-279c00a32712" xlink:href="ttwo-20260630.xsd#ttwo_A0ConvertibleSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-749f-9e38-ca326a9539f2" xlink:to="loc_ttwo_A0ConvertibleSeniorNotesDue2026Member_019fa83d-e107-7a4b-b928-279c00a32712" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026ConvertibleNotesMember_019fa83d-e107-7385-8935-196e399f8556" xlink:href="ttwo-20260630.xsd#ttwo_A2026ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fa83d-e107-749f-9e38-ca326a9539f2" xlink:to="loc_ttwo_A2026ConvertibleNotesMember_019fa83d-e107-7385-8935-196e399f8556" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019fa83d-e107-7f71-bf9b-9901e2ae2494" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019ed234-3872-76ca-9412-1ec5d07759e4" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019fa83d-e107-7f71-bf9b-9901e2ae2494" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83d-e107-7f71-bf9b-9901e2ae2494_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83d-e107-7f71-bf9b-9901e2ae2494" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83d-e107-7f71-bf9b-9901e2ae2494_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fa83d-e107-7dc3-a37c-ef4ff1802df2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fa83d-e107-7f71-bf9b-9901e2ae2494" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fa83d-e107-7dc3-a37c-ef4ff1802df2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_019fa83d-e107-78a3-8e52-80beec525fa5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019fa83d-e107-7dc3-a37c-ef4ff1802df2" xlink:to="loc_us-gaap_ConvertibleDebtMember_019fa83d-e107-78a3-8e52-80beec525fa5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fa83d-e107-7a17-b05a-cf728315377d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fa83d-e107-7a17-b05a-cf728315377d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019fa83d-e107-7fdd-addc-f9e98089e1b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:to="loc_us-gaap_LongTermDebt_019fa83d-e107-7fdd-addc-f9e98089e1b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtGross_019fa83d-e107-71c0-b8ab-640d37dceb53" xlink:href="ttwo-20260630.xsd#ttwo_ShortTermDebtGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:to="loc_ttwo_ShortTermDebtGross_019fa83d-e107-71c0-b8ab-640d37dceb53" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019fa83d-e107-717b-bb12-5d7d0d21caf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019ed234-3872-7194-9eba-623a7cf48f3a" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019fa83d-e107-717b-bb12-5d7d0d21caf8" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/LOSSPERSHARENarrativeDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#LOSSPERSHARENarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/LOSSPERSHARENarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019ed234-3872-7a23-9766-afcf2125834e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019ed234-3872-7a23-9766-afcf2125834e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019ed234-3872-77df-a859-1bf4f05cfd05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019ed234-3872-7a23-9766-afcf2125834e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019ed234-3872-77df-a859-1bf4f05cfd05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-77df-a859-1bf4f05cfd05_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019ed234-3872-77df-a859-1bf4f05cfd05" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-77df-a859-1bf4f05cfd05_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-7d59-8b60-c6df4ee94229" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019ed234-3872-77df-a859-1bf4f05cfd05" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-7d59-8b60-c6df4ee94229" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockCompensationPlanMember_019ed234-3872-747b-b60d-d1bc33dd9990" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockCompensationPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-7d59-8b60-c6df4ee94229" xlink:to="loc_us-gaap_StockCompensationPlanMember_019ed234-3872-747b-b60d-d1bc33dd9990" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_019ed234-3872-730b-b9bd-d67b263861db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019ed234-3872-7d59-8b60-c6df4ee94229" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_019ed234-3872-730b-b9bd-d67b263861db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019ed234-3872-7dfe-be1d-2e5b5d2e1d12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019ed234-3872-7a23-9766-afcf2125834e" xlink:to="loc_us-gaap_AwardTypeAxis_019ed234-3872-7dfe-be1d-2e5b5d2e1d12" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3872-7dfe-be1d-2e5b5d2e1d12_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3872-7dfe-be1d-2e5b5d2e1d12" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3872-7dfe-be1d-2e5b5d2e1d12_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3872-77ae-88e8-9892a614e2a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019ed234-3872-7dfe-be1d-2e5b5d2e1d12" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3872-77ae-88e8-9892a614e2a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_019ed234-3872-7e0f-b365-856b1dfc3be7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019ed234-3872-77ae-88e8-9892a614e2a4" xlink:to="loc_us-gaap_RestrictedStockMember_019ed234-3872-7e0f-b365-856b1dfc3be7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019ed234-3872-7004-a75a-d786a213d961" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019ed234-3872-7004-a75a-d786a213d961" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019ed234-3872-7086-b97c-c4544899bc28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019ed234-3872-7086-b97c-c4544899bc28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019ed234-3872-7573-8b47-79784f819b1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019ed234-3872-7573-8b47-79784f819b1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_019ed234-3872-791a-8392-87a07980ad50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019ed234-3872-7968-9704-a1d5a270ee75" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_019ed234-3872-791a-8392-87a07980ad50" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONScheduleofNetRevenuebyGeographicRegionsDetails" xlink:type="simple" xlink:href="ttwo-20260630.xsd#SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONScheduleofNetRevenuebyGeographicRegionsDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONScheduleofNetRevenuebyGeographicRegionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019ed234-3872-7770-83b6-5033b68503ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019ed234-3872-74f0-b720-c9deea4b5096" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019ed234-3872-7770-83b6-5033b68503ab" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019ed234-3872-74f0-b720-c9deea4b5096" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019ed234-3872-7e8a-a1af-8c6d1a0f9141" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019ed234-3872-74f0-b720-c9deea4b5096" xlink:to="loc_srt_StatementGeographicalAxis_019ed234-3872-7e8a-a1af-8c6d1a0f9141" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019ed234-3872-7e8a-a1af-8c6d1a0f9141_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019ed234-3872-7e8a-a1af-8c6d1a0f9141" xlink:to="loc_srt_SegmentGeographicalDomain_019ed234-3872-7e8a-a1af-8c6d1a0f9141_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019ed234-3872-706e-957d-6b7c20cf38b5" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019ed234-3872-7e8a-a1af-8c6d1a0f9141" xlink:to="loc_srt_SegmentGeographicalDomain_019ed234-3872-706e-957d-6b7c20cf38b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019ed234-3872-7922-80f9-66b6438672b2" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019ed234-3872-706e-957d-6b7c20cf38b5" xlink:to="loc_country_US_019ed234-3872-7922-80f9-66b6438672b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_019ed234-3872-705c-8d36-7624014feeb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019ed234-3872-706e-957d-6b7c20cf38b5" xlink:to="loc_us-gaap_NonUsMember_019ed234-3872-705c-8d36-7624014feeb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-3872-7ec3-b426-59b660ecde2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019ed234-3872-7770-83b6-5033b68503ab" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ed234-3872-7ec3-b426-59b660ecde2d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_LainieGoldsteinMember_019ed234-36c3-7e68-a087-22d3300c5998" xlink:href="ttwo-20260630.xsd#ttwo_LainieGoldsteinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_LainieGoldsteinMember_019ed234-36c3-7e68-a087-22d3300c5998" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_WilliamBingGordonMember_019fc916-a4be-7363-86b0-b4e47fa32966" xlink:href="ttwo-20260630.xsd#ttwo_WilliamBingGordonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_WilliamBingGordonMember_019fc916-a4be-7363-86b0-b4e47fa32966" xlink:type="arc" order="3"/>
  </link:definitionLink>
</link:linkbase>
