v3.26.1
Cover - shares
 6 Months Ended
Jun. 30, 2026
Jul. 31, 2026
Cover [Abstract]    
Document Type 10-Q  
Document Quarterly Report true  
Document Period End Date Jun. 30, 2026  
Current Fiscal Year End Date --12-31  
Document Transition Report false  
Entity File Number 001-40880  
Entity Registrant Name XERIS BIOPHARMA HOLDINGS, INC.  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 87-1082097  
Entity Address, Address Line One 1375 West Fulton Street  
Entity Address, Address Line Two Suite 1300  
Entity Address, City or Town Chicago  
Entity Address, State or Province IL  
Entity Address, Postal Zip Code 60607  
City Area Code 844  
Local Phone Number 445-5704  
Title of 12(b) Security Common Stock, $0.0001 par value per share  
Trading Symbol XERS  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Large Accelerated Filer  
Entity Small Business false  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   182,320,306
Entity Central Index Key 0001867096  
Document Fiscal Year Focus 2026  
Document Fiscal Period Focus Q2  
Amendment Flag false