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  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationPositiveNegativeSellingPrice" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationPositiveNegativeSellingPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationCarryingBasis" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationCarryingBasis" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationPeriodOfClosing" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationPeriodOfClosing" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_StockCompensationExpenseMember" abstract="true" name="StockCompensationExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_ArgonautMember" abstract="true" name="ArgonautMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_GlobalCoolingMember" abstract="true" name="GlobalCoolingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationPeriodOfRecordingServices" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationPeriodOfRecordingServices" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_CompetitionCovenantPeriod" abstract="false" name="CompetitionCovenantPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_DiscontinuedOperationsOutstandingMinimumLeasePaymentsForTheLeaseTerminations" abstract="false" name="DiscontinuedOperationsOutstandingMinimumLeasePaymentsForTheLeaseTerminations" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationGrossProfit" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationGrossProfit" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpense" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationDepreciation" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationDepreciation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationAmortization" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationStockBasedCompensation" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationStockBasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DisposalGroupIncludingDiscontinuedOperationCapitalExpendituresCost" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationCapitalExpendituresCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_ConvertiblePromissoryNoteMember" abstract="true" name="ConvertiblePromissoryNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_DebtSecuritiesAvailableforsaleUnrealizedGainCurrent" abstract="false" name="DebtSecuritiesAvailableforsaleUnrealizedGainCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtSecuritiesAvailableForSaleUnrealizedLossCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedLossCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtSecuritiesAvailableforsaleUnrealizedGainNoncurrent" abstract="false" name="DebtSecuritiesAvailableforsaleUnrealizedGainNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtSecuritiesAvailableForSaleUnrealizedLossNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedLossNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_RealEstateLeaseMember" abstract="true" name="RealEstateLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_OperatingLeaseCostsAndShortTermLeaseCosts" abstract="false" name="OperatingLeaseCostsAndShortTermLeaseCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_FurnitureAndComputerEquipmentMember" abstract="true" name="FurnitureAndComputerEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_AmortizationOfIntangibleAssetsDefiniteLived" abstract="false" name="AmortizationOfIntangibleAssetsDefiniteLived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_AccruedLeaseIncentiveCurrent" abstract="false" name="AccruedLeaseIncentiveCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_The2023TermLoanMember" abstract="true" name="The2023TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_SecondAmendmentTermLoanMember" abstract="true" name="SecondAmendmentTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_VariableRateComponentAxis" abstract="true" name="VariableRateComponentAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="blfs_VariableRateComponentDomain" abstract="true" name="VariableRateComponentDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_VariableRateComponentTwoMember" abstract="true" name="VariableRateComponentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_DebtInstrumentMaximumBorrowingCapacity" abstract="false" name="DebtInstrumentMaximumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtInstrumentMaximumBorrowingCapacityAtClosing" abstract="false" name="DebtInstrumentMaximumBorrowingCapacityAtClosing" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtInstrumentAdditionalMaximumAmountWithinNineMonthsAfterClosing" abstract="false" name="DebtInstrumentAdditionalMaximumAmountWithinNineMonthsAfterClosing" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtInstrumentAdditionalMaximumAmountUponCertainMilestoneAchievements" abstract="false" name="DebtInstrumentAdditionalMaximumAmountUponCertainMilestoneAchievements" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtInstrumentAdditionalMaximumAtDiscretionOfLender" abstract="false" name="DebtInstrumentAdditionalMaximumAtDiscretionOfLender" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_DebtInstrumentInterestRateMaximumStatedPercentageForEachTrancheBorrowed" abstract="false" name="DebtInstrumentInterestRateMaximumStatedPercentageForEachTrancheBorrowed" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="blfs_DebtInstrumentNonRefundableTerminationFeeAmount" abstract="false" name="DebtInstrumentNonRefundableTerminationFeeAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_TotalDebtMember" abstract="true" name="TotalDebtMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_PerformanceBasedRestrictedStockMember" abstract="true" name="PerformanceBasedRestrictedStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_MarketbasedRestrictedStockMember" abstract="true" name="MarketbasedRestrictedStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAwards" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAwards" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="blfs_ShareBasedPaymentArrangementSharesGrantedPercentage" abstract="false" name="ShareBasedPaymentArrangementSharesGrantedPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="blfs_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRatePeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRatePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsTargetShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsTargetShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="blfs_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="blfs_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAttainmentRate" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAttainmentRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="blfs_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRateDiscreteItemsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRateDiscreteItemsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="blfs_WeightedAverageNumberOfSharesIssuedDiluted" abstract="false" name="WeightedAverageNumberOfSharesIssuedDiluted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="blfs_SupplierOneMember" abstract="true" name="SupplierOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_SupplierTwoMember" abstract="true" name="SupplierTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_SupplierThreeMember" abstract="true" name="SupplierThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CustomerAMember" abstract="true" name="CustomerAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CustomerBMember" abstract="true" name="CustomerBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CustomerCMember" abstract="true" name="CustomerCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CustomerDMember" abstract="true" name="CustomerDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CustomerEMember" abstract="true" name="CustomerEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_CryoStorProductsMember" abstract="true" name="CryoStorProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_GeographicOtherMember" abstract="true" name="GeographicOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="blfs_MergerAgreementTerminationExtensionPeriodAntitrustOrRestraintCondition" abstract="false" name="MergerAgreementTerminationExtensionPeriodAntitrustOrRestraintCondition" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_MergerAgreementTerminationExtensionPeriodSECEffectiveCondition" abstract="false" name="MergerAgreementTerminationExtensionPeriodSECEffectiveCondition" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_MergerAgreementNumberOfDaysToWithdrawTransactionProposal" abstract="false" name="MergerAgreementNumberOfDaysToWithdrawTransactionProposal" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_MergerAgreementProposalOfTerminationPeriod" abstract="false" name="MergerAgreementProposalOfTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="blfs_BusinessCombinationTerminationFee" abstract="false" name="BusinessCombinationTerminationFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
