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  <xsd:element name="NetCashProvidedByUsedInOperatingAndInvestingActivities" id="ctso_NetCashProvidedByUsedInOperatingAndInvestingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NetProceedsFromIssuanceRightsOffering" id="ctso_NetProceedsFromIssuanceRightsOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FiniteLivedIntangibleAssetsScheduledAmortization" id="ctso_FiniteLivedIntangibleAssetsScheduledAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockIssuedDuringPeriodValueRightsIssues" id="ctso_StockIssuedDuringPeriodValueRightsIssues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodSharesRightsIssues" id="ctso_StockIssuedDuringPeriodSharesRightsIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" id="ctso_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" id="ctso_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NumberOfFinancialInstitutions" id="ctso_NumberOfFinancialInstitutions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareholdersEquityAndShareBasedPaymentsAbstract" id="ctso_ShareholdersEquityAndShareBasedPaymentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockIssuedDuringPeriodValueWarrantsExercised" id="ctso_StockIssuedDuringPeriodValueWarrantsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodSharesWarrantsExercised" id="ctso_StockIssuedDuringPeriodSharesWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ControlBasedRsusMember" id="ctso_ControlBasedRsusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OtherRsuMember" id="ctso_OtherRsuMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="GoodsReceivedNotInvoiced" id="ctso_GoodsReceivedNotInvoiced" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentInterestOnlyPaymentsTerm" id="ctso_DebtInstrumentInterestOnlyPaymentsTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentTrailingPeriodForAchievingRevenueMilestone" id="ctso_DebtInstrumentTrailingPeriodForAchievingRevenueMilestone" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentMinimumRevenueMilestoneForExtensionOfInterestOnlyPaymentsPeriod" id="ctso_DebtInstrumentMinimumRevenueMilestoneForExtensionOfInterestOnlyPaymentsPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentExtensionOfInterestOnlyPaymentsPeriod" id="ctso_DebtInstrumentExtensionOfInterestOnlyPaymentsPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockOptionsAndWarrantsAndRestrictedStockUnitsMember" id="ctso_StockOptionsAndWarrantsAndRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantsNumberOfDaysForDeterminationOfVolumeWeightedAveragePrice" id="ctso_WarrantsNumberOfDaysForDeterminationOfVolumeWeightedAveragePrice" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsMinimumRequiredPrice" id="ctso_WarrantsMinimumRequiredPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfUnitsSubscribedToProRataAdjustment" id="ctso_NumberOfUnitsSubscribedToProRataAdjustment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentSuccessFeesThresholdStockPriceTrigger" id="ctso_DebtInstrumentSuccessFeesThresholdStockPriceTrigger" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SuccessFeesPayableSubjectToStockPriceTrigger" id="ctso_SuccessFeesPayableSubjectToStockPriceTrigger" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="WarrantsIssuedInConnectionWithDebt" id="ctso_WarrantsIssuedInConnectionWithDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromSaleOfNetOperatingLossesAndResearchAndDevelopmentTaxCredits" id="ctso_ProceedsFromSaleOfNetOperatingLossesAndResearchAndDevelopmentTaxCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AccruedExpensesAndOtherCurrentLiabilitiesOther" id="ctso_AccruedExpensesAndOtherCurrentLiabilitiesOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AdistributorMember" id="ctso_AdistributorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BdistributorMember" id="ctso_BdistributorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShippingAndHandlingCostsPolicyTextBlock" id="ctso_ShippingAndHandlingCostsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LoanAndSecurityAgreementTrancheTwoaMember" id="ctso_LoanAndSecurityAgreementTrancheTwoaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LoanAndSecurityAgreementTrancheTwoBMember" id="ctso_LoanAndSecurityAgreementTrancheTwoBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesRightOfferingMember" id="ctso_SeriesRightOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProceedsFromWarrantExercisesGross" id="ctso_ProceedsFromWarrantExercisesGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CdistributorMember" id="ctso_CdistributorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Numberofdistributors" id="ctso_Numberofdistributors" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ServiceBasedRestrictedStockUnitsRsuMember" id="ctso_ServiceBasedRestrictedStockUnitsRsuMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
