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  <xs:element id="expe_LegalReservesOccupancyTaxAndOther" abstract="false" name="LegalReservesOccupancyTaxAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_ComprehensiveIncomeLossNetofTaxAttributableToCommonStockholders" abstract="false" name="ComprehensiveIncomeLossNetofTaxAttributableToCommonStockholders" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_AccountsPayableMerchant" abstract="false" name="AccountsPayableMerchant" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_DeferredMerchantBookingsLiabilityCurrent" abstract="false" name="DeferredMerchantBookingsLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_EquityInstrumentsAndEmployeeStockPurchasePlanSharesExercisesInPeriod" abstract="false" name="EquityInstrumentsAndEmployeeStockPurchasePlanSharesExercisesInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="expe_EquityInstrumentsAndEmployeeStockPurchasePlanValueExercisesInPeriod" abstract="false" name="EquityInstrumentsAndEmployeeStockPurchasePlanValueExercisesInPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_TreasuryStockActivityRelatedToVestingOfEquityInstrumentsShares" abstract="false" name="TreasuryStockActivityRelatedToVestingOfEquityInstrumentsShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="expe_TreasuryStockActivityRelatedToVestingOfEquityInstruments" abstract="false" name="TreasuryStockActivityRelatedToVestingOfEquityInstruments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_ForeignExchangeGainLossOnCashCashEquivalentsAndShortTermInvestmentsNet" abstract="false" name="ForeignExchangeGainLossOnCashCashEquivalentsAndShortTermInvestmentsNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_IncreaseDecreaseInAccountsPayableMerchant" abstract="false" name="IncreaseDecreaseInAccountsPayableMerchant" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_IncreaseDecreaseInDeferredMerchantBookings" abstract="false" name="IncreaseDecreaseInDeferredMerchantBookings" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_AcquisitionsAndOtherNet" abstract="false" name="AcquisitionsAndOtherNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_ProceedsFromExerciseOfEquityAwardsAndEmployeeStockPurchasePlan" abstract="false" name="ProceedsFromExerciseOfEquityAwardsAndEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_SeasonalityPolicyPolicyTextBlock" abstract="false" name="SeasonalityPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="expe_DeferredMerchantBookingsMember" abstract="true" name="DeferredMerchantBookingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_DeferredLoyaltyRewardsMember" abstract="true" name="DeferredLoyaltyRewardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_OtherDeferredRevenueMember" abstract="true" name="OtherDeferredRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_PrepaidMerchantBookingsAssetCurrent" abstract="false" name="PrepaidMerchantBookingsAssetCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_DeferredMerchantBookingLiabilityDecreaseDuetoRecognitionDuringPeriod" abstract="false" name="DeferredMerchantBookingLiabilityDecreaseDuetoRecognitionDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_BankTimeDepositsAndCertificatesOfDepositMember" abstract="true" name="BankTimeDepositsAndCertificatesOfDepositMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_GlobalBusinessTravelGroupMember" abstract="true" name="GlobalBusinessTravelGroupMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_Despegar.comCorp.Member" abstract="true" name="Despegar.comCorp.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_CrossCurrencyInterestRateContract2022SwapsMember" abstract="true" name="CrossCurrencyInterestRateContract2022SwapsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_CrossCurrencyInterestRateContract2025SwapMember" abstract="true" name="CrossCurrencyInterestRateContract2025SwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_NumberOfDerivativeInstruments" abstract="false" name="NumberOfDerivativeInstruments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="expe_FivePointZeroPercentSeniorNotesDueOnTwoZeroTwoSixMember" abstract="true" name="FivePointZeroPercentSeniorNotesDueOnTwoZeroTwoSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_ConvertibleSeniorNotesDue2026Member" abstract="true" name="ConvertibleSeniorNotesDue2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_FourPointSixTwoFivePercentSeniorNotesDueTwoThousandTwentySevenMember" abstract="true" name="FourPointSixTwoFivePercentSeniorNotesDueTwoThousandTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_ThreePointEightPercentSeniorNotesDueOnTwoZeroTwoEightMember" abstract="true" name="ThreePointEightPercentSeniorNotesDueOnTwoZeroTwoEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_ThreePointTwentyFivePercentSeniorNotesDueTwoThousandThirtyMember" abstract="true" name="ThreePointTwentyFivePercentSeniorNotesDueTwoThousandThirtyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TwoPointNineFivePercentageSeniorNotesDue2031Member" abstract="true" name="TwoPointNineFivePercentageSeniorNotesDue2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_FivePointFourPercentageSeniorNotesDue2035Member" abstract="true" name="FivePointFourPercentageSeniorNotesDue2035Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_FivePointFivePercentageSeniorNotesDue2036Member" abstract="true" name="FivePointFivePercentageSeniorNotesDue2036Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_SeniorUnsecuredNotesDueApril2036Member" abstract="true" name="SeniorUnsecuredNotesDueApril2036Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_ForeignCreditFacilityMember" abstract="true" name="ForeignCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TermBenchmarkLoansIndexRateMember" abstract="true" name="TermBenchmarkLoansIndexRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_SeniorNotesIssuedPricePercentage" abstract="false" name="SeniorNotesIssuedPricePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="expe_PaymentsRelatedToConversionValueInExcessOfThePrincipalAmountOfConvertibleNotes" abstract="false" name="PaymentsRelatedToConversionValueInExcessOfThePrincipalAmountOfConvertibleNotes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_DebtInstrumentConvertibleConversionGainsLosses" abstract="false" name="DebtInstrumentConvertibleConversionGainsLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_TwoPointFivePercentSeniorNotesDueOnTwoThousandTwentyTwoMember" abstract="true" name="TwoPointFivePercentSeniorNotesDueOnTwoThousandTwentyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_CumulativeTranslationAdjustmentForNetInvestmentHedgesNetOfTax" abstract="false" name="CumulativeTranslationAdjustmentForNetInvestmentHedgesNetOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_CumulativeTranslationAdjustmentForNetInvestmentHedgeBeforeTax" abstract="false" name="CumulativeTranslationAdjustmentForNetInvestmentHedgeBeforeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_TaxYears2011To2013Member" abstract="true" name="TaxYears2011To2013Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TaxYears2014To2016Member" abstract="true" name="TaxYears2014To2016Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TaxYears2017To2018Member" abstract="true" name="TaxYears2017To2018Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_LitigationRelatingToOccupancyTaxMember" abstract="true" name="LitigationRelatingToOccupancyTaxMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_MattersRelatingToInternationalWithholdingTaxMember" abstract="true" name="MattersRelatingToInternationalWithholdingTaxMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_LossContingencyNumberOfLawsuitsCurrentlyActive" abstract="false" name="LossContingencyNumberOfLawsuitsCurrentlyActive" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="expe_ITATaxReportAmount" abstract="false" name="ITATaxReportAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_NumberOfReportableSegmentsDisclosedByDefinitionFlag" abstract="false" name="NumberOfReportableSegmentsDisclosedByDefinitionFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="expe_B2CMember" abstract="true" name="B2CMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_B2BMember" abstract="true" name="B2BMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TrivagoMember" abstract="true" name="TrivagoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_B2CAndB2BMember" abstract="true" name="B2CAndB2BMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_AdjustedEarningsBeforeIncomeTaxDepreciationAmortization" abstract="false" name="AdjustedEarningsBeforeIncomeTaxDepreciationAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_UnallocatedCorporateAndOtherIncomeExpense" abstract="false" name="UnallocatedCorporateAndOtherIncomeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_RestructuringAndRelatedReorganizationCharges" abstract="false" name="RestructuringAndRelatedReorganizationCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_OtherNonoperatingIncomeExpenseAdjusted" abstract="false" name="OtherNonoperatingIncomeExpenseAdjusted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_RealizedGainLossOnRevenueHedges" abstract="false" name="RealizedGainLossOnRevenueHedges" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="expe_MerchantCustomersMember" abstract="true" name="MerchantCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_AgencyCustomersMember" abstract="true" name="AgencyCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_AdvertisingMediaAndOtherCustomersMember" abstract="true" name="AdvertisingMediaAndOtherCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_LodgingMember" abstract="true" name="LodgingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_AirMember" abstract="true" name="AirMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_ExpediaGroupEGAdvertisingMember" abstract="true" name="ExpediaGroupEGAdvertisingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_TrivagoAdvertisingMember" abstract="true" name="TrivagoAdvertisingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="expe_OtherServicesMember" abstract="true" name="OtherServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
