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Ltd.</inf:issuerName><inf:cusip>Y95308105</inf:cusip><inf:isin>SG9999014716</inf:isin><inf:meetingDate>08/05/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis only, the frequency of holding future shareholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>900000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>900000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>UroGen Pharma Ltd.</inf:issuerName><inf:cusip>M96088105</inf:cusip><inf:isin>IL0011407140</inf:isin><inf:meetingDate>08/26/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the Company's proxy statement for the Annual Meeting.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>UroGen Pharma Ltd.</inf:issuerName><inf:cusip>M96088105</inf:cusip><inf:isin>IL0011407140</inf:isin><inf:meetingDate>08/26/2025</inf:meetingDate><inf:voteDescription>To indicate, on an advisory basis, the preferred frequency of shareholder advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Replimune Group, Inc.</inf:issuerName><inf:cusip>76029N106</inf:cusip><inf:isin>US76029N1063</inf:isin><inf:meetingDate>09/03/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of Replimune Group, Inc.'s named executive officers for the fiscal year ended March 31, 2025.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2065010.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2065010.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Akero Therapeutics, Inc.</inf:issuerName><inf:cusip>00973Y108</inf:cusip><inf:isin>US00973Y1082</inf:isin><inf:meetingDate>12/02/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory, non-binding basis, the payment of certain compensation that may be paid or become payable by Akero to its named executive officers in connection with the Merger.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>208000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>208000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Berkshire Hathaway Inc.</inf:issuerName><inf:cusip>084670702</inf:cusip><inf:isin>US0846707026</inf:isin><inf:meetingDate>05/02/2026</inf:meetingDate><inf:voteDescription>Non-binding resolution to approve the compensation of the Company's Named Executive Officers, as described in the 2026 Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3065298.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3065298.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Fulgent Genetics, Inc.</inf:issuerName><inf:cusip>359664109</inf:cusip><inf:isin>US3596641098</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, compensation awarded to the Company's named executive officers (Say-on-Pay).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1289000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1289000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Repligen Corporation</inf:issuerName><inf:cusip>759916109</inf:cusip><inf:isin>US7599161095</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve the compensation paid to Repligen Corporation's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1206000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1206000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ultragenyx Pharmaceutical Inc.</inf:issuerName><inf:cusip>90400D108</inf:cusip><inf:isin>US90400D1081</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>Advisory (non-binding) vote to approve the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1500000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>1500000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Alkermes plc</inf:issuerName><inf:cusip>G01767105</inf:cusip><inf:isin>IE00B56GVS15</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, in a non-binding, advisory vote, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1672356.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1672356.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Rocket Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>77313F106</inf:cusip><inf:isin>US77313F1066</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>A non-binding, advisory vote on the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>16734217.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>16734217.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Dianthus Therapeutics, Inc.</inf:issuerName><inf:cusip>252828108</inf:cusip><inf:isin>US2528281080</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>248063.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>248063.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Verastem, Inc.</inf:issuerName><inf:cusip>92337C203</inf:cusip><inf:isin>US92337C2035</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve an advisory vote on the compensation of the named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>6576306.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>6576306.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Establishment Labs Holdings Inc.</inf:issuerName><inf:cusip>G31249108</inf:cusip><inf:isin>VGG312491084</inf:isin><inf:meetingDate>05/22/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2042232.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2042232.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Compass Pathways Plc</inf:issuerName><inf:cusip>20451W101</inf:cusip><inf:isin>US20451W1018</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers for the year ended 31 December 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4869798.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4869798.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>iRhythm Holdings, Inc.</inf:issuerName><inf:cusip>450056106</inf:cusip><inf:isin>US4500561067</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2758335.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2758335.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Acadia Pharmaceuticals Inc.</inf:issuerName><inf:cusip>004225108</inf:cusip><inf:isin>US0042251084</inf:isin><inf:meetingDate>05/29/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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YEAR</inf:howVoted><inf:sharesVoted>250000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CG Oncology, Inc.</inf:issuerName><inf:cusip>156944100</inf:cusip><inf:isin>US1569441009</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>7010964.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>7010964.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CG Oncology, Inc.</inf:issuerName><inf:cusip>156944100</inf:cusip><inf:isin>US1569441009</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To indicate, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>7010964.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>7010964.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Savara Inc.</inf:issuerName><inf:cusip>805111101</inf:cusip><inf:isin>US8051111016</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executives.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>5952380.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>5952380.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Tango Therapeutics, Inc.</inf:issuerName><inf:cusip>87583X109</inf:cusip><inf:isin>US87583X1090</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4186599.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>4186599.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Milestone Pharmaceuticals Inc.</inf:issuerName><inf:cusip>59935V107</inf:cusip><inf:isin>CA59935V1076</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Say-on-Pay - A non-binding advisory vote on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2586356.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2586356.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>uniQure N.V.</inf:issuerName><inf:cusip>N90064101</inf:cusip><inf:isin>NL0010696654</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the frequency of advisory votes on the compensation of the named  executive officers of the Company.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2586356.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2586356.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Medline Inc.</inf:issuerName><inf:cusip>58507V107</inf:cusip><inf:isin>US58507V1070</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>Advisory Vote to Approve Our Executive Compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>70000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>70000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Medline Inc.</inf:issuerName><inf:cusip>58507V107</inf:cusip><inf:isin>US58507V1070</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>Advisory Vote on the Frequency of Votes on Our Executive Compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>70000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>70000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ocugen, Inc.</inf:issuerName><inf:cusip>67577C105</inf:cusip><inf:isin>US67577C1053</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of Ocugen, Inc.'s named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>50.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>50.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ocugen, Inc.</inf:issuerName><inf:cusip>67577C105</inf:cusip><inf:isin>US67577C1053</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation of Ocugen, Inc.'s named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>666790.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>666790.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Allogene Therapeutics, Inc.</inf:issuerName><inf:cusip>019770106</inf:cusip><inf:isin>US0197701065</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4543895.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Axogen, Inc.</inf:issuerName><inf:cusip>05463X106</inf:cusip><inf:isin>US05463X1063</inf:isin><inf:meetingDate>06/23/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers as disclosed in the Company's Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>653655.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>653655.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Orchestra Biomed Holdings, Inc.</inf:issuerName><inf:cusip>68572M106</inf:cusip><inf:isin>US68572M1062</inf:isin><inf:meetingDate>06/23/2026</inf:meetingDate><inf:voteDescription>Adoption of an advisory (non-binding) resolution approving the compensation of our "named executive officers".</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1099900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>1099900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kymera Therapeutics, Inc.</inf:issuerName><inf:cusip>501575104</inf:cusip><inf:isin>US5015751044</inf:isin><inf:meetingDate>06/24/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>240000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>240000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Tarsus Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>87650L103</inf:cusip><inf:isin>US87650L1035</inf:isin><inf:meetingDate>06/25/2026</inf:meetingDate><inf:voteDescription>To hold an advisory vote to approve, on a non-binding basis, our named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3346025.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3346025.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Mark Pruzanski, Chairman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Frederic Cren, CEO until September 30, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Andrew Obenshain, CEO from October 1, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Pierre Broqua, Vice-CEO until June 30, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1248092.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable></inf:proxyVoteTable>
