<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fae3b-9ee4-7620-8c15-02bf7c190367,g:0d3b0179-536a-4514-9913-05b481846c55-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="zts-20260806.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019fae3b-9ee4-7994-bcf4-1080b00f6943" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_DocumentType_019fae3b-9ee4-7994-bcf4-1080b00f6943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fae3b-9ee4-741d-9b67-030f8840078e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_DocumentPeriodEndDate_019fae3b-9ee4-741d-9b67-030f8840078e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019fae3b-9ee4-7763-ba24-ab971b884ac2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityRegistrantName_019fae3b-9ee4-7763-ba24-ab971b884ac2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019fae3b-9ee4-7732-ad47-1550f97cda62" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityCentralIndexKey_019fae3b-9ee4-7732-ad47-1550f97cda62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019fae3b-9ee4-7d4e-b657-dea4ef265df6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_AmendmentFlag_019fae3b-9ee4-7d4e-b657-dea4ef265df6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019fae3b-9ee4-767e-9478-1e7418edd449" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019fae3b-9ee4-767e-9478-1e7418edd449" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019fae3b-9ee4-7e4c-bcff-33f6afdec9cd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityFileNumber_019fae3b-9ee4-7e4c-bcff-33f6afdec9cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019fae3b-9ee4-7ba2-9aac-40dda6f54b7f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityTaxIdentificationNumber_019fae3b-9ee4-7ba2-9aac-40dda6f54b7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019fae3b-9ee4-763e-bf26-3d2080fedefa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityAddressAddressLine1_019fae3b-9ee4-763e-bf26-3d2080fedefa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019fae3b-9ee4-791d-ab4c-a902e29beda4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityAddressCityOrTown_019fae3b-9ee4-791d-ab4c-a902e29beda4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019fae3b-9ee4-7e30-8fdb-db7379ce50d4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityAddressStateOrProvince_019fae3b-9ee4-7e30-8fdb-db7379ce50d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019fae3b-9ee4-7219-8f56-e26c1da6e7b6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityAddressPostalZipCode_019fae3b-9ee4-7219-8f56-e26c1da6e7b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019fae3b-9ee4-7ebb-b98c-c9c0f274e757" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_CityAreaCode_019fae3b-9ee4-7ebb-b98c-c9c0f274e757" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019fae3b-9ee4-72d8-b4f2-f58a1bd6027c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_LocalPhoneNumber_019fae3b-9ee4-72d8-b4f2-f58a1bd6027c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019fae3b-9ee4-7c25-b432-0df50e9f26d2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_WrittenCommunications_019fae3b-9ee4-7c25-b432-0df50e9f26d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019fae3b-9ee4-7e6f-9698-b4693d073cac" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_SolicitingMaterial_019fae3b-9ee4-7e6f-9698-b4693d073cac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019fae3b-9ee4-7537-9127-0cfd4b6ebe50" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_PreCommencementTenderOffer_019fae3b-9ee4-7537-9127-0cfd4b6ebe50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019fae3b-9ee4-7732-aedb-3a5b79fc12d7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019fae3b-9ee4-7732-aedb-3a5b79fc12d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019fae3b-9ee4-7695-9eec-225a1a2f9a9c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_Security12bTitle_019fae3b-9ee4-7695-9eec-225a1a2f9a9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019fae3b-9ee4-7ae0-8ccd-832b6648d74b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_TradingSymbol_019fae3b-9ee4-7ae0-8ccd-832b6648d74b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019fae3b-9ee4-7e4a-be9e-505c3914bdb0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_SecurityExchangeName_019fae3b-9ee4-7e4a-be9e-505c3914bdb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019fae3b-9ee4-73fc-8653-341ba92449b8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_EntityEmergingGrowthCompany_019fae3b-9ee4-73fc-8653-341ba92449b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019fae3b-9ee4-739c-8215-d1739d43a78f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fae3b-9ee4-7e80-861c-0a3fa0f4e0cb" xlink:to="loc_dei_DocumentInformationTable_019fae3b-9ee4-739c-8215-d1739d43a78f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019fae3b-9ee4-7925-aac9-24818ed93ad3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019fae3b-9ee4-739c-8215-d1739d43a78f" xlink:to="loc_dei_DocumentInformationLineItems_019fae3b-9ee4-7925-aac9-24818ed93ad3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fae3b-9ee4-742d-b481-8f8a5953c06c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019fae3b-9ee4-7925-aac9-24818ed93ad3" xlink:to="loc_dei_DocumentPeriodEndDate_019fae3b-9ee4-742d-b481-8f8a5953c06c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
