99900 - Disclosure - Standard And Custom Axis Domain Defaults link:presentationLink link:calculationLink link:definitionLink 995200100 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 995200200 - Statement - Condensed Consolidated Statements of Income (Loss) link:presentationLink link:calculationLink link:definitionLink 995200300 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 995200500 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 99940301 - Disclosure - Net Income (Loss) Per Share - Computation (Details) link:presentationLink link:calculationLink link:definitionLink 99940411 - Disclosure - Collaboration, License, and Other Agreements - Litigation (Details) link:presentationLink link:calculationLink link:definitionLink 99940502 - Disclosure - Fair Value of Financial Instruments - Measured on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 99940602 - Disclosure - Leases - Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 99940605 - Disclosure - Leases - Future Minimum Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 99940606 - Disclosure - Leases - Operating Lease Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 99940701 - Disclosure - Accrued Expenses and Other Current Liabilities - Tabular Disclosure (Details) link:presentationLink link:calculationLink link:definitionLink 99940802 - Disclosure - Debt - Balances (Details) link:presentationLink link:calculationLink link:definitionLink 99940803 - Disclosure - Debt - Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 99940901 - Disclosure - Employee Stock Benefit Plans (Details) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - Employee Stock Benefit Plans Default (Details) link:presentationLink link:calculationLink link:definitionLink 995200400 - Statement - Condensed Consolidated Statements of Stockholders' Deficit link:presentationLink link:calculationLink link:definitionLink 995210101 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 995210201 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 995210301 - Disclosure - Net Income (Loss) Per Share link:presentationLink link:calculationLink link:definitionLink 995210401 - Disclosure - Collaboration, License, and Other Agreements link:presentationLink link:calculationLink link:definitionLink 995210501 - Disclosure - Fair Value of Financial Instruments link:presentationLink link:calculationLink link:definitionLink 995210701 - Disclosure - Accrued Expenses and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 995210801 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 995210901 - Disclosure - Employee Stock Benefit Plans link:presentationLink link:calculationLink link:definitionLink 995211001 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 99930303 - Disclosure - Net Income (Loss) Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 99930403 - Disclosure - Collaboration, License, and Other Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 99930703 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 99930803 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 99930903 - Disclosure - Employee Stock Benefit Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 99940201 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 99940302 - Disclosure - Net Income (Loss) Per Share - Anti-dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 99940401 - Disclosure - Collaboration, License, and Other Agreements - Summary (Details) link:presentationLink link:calculationLink link:definitionLink 99940402 - Disclosure - Collaboration, License, and Other Agreements - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 99940403 - Disclosure - Collaboration, License, and Other Agreements - North America - General Information (Details) link:presentationLink link:calculationLink link:definitionLink 99940404 - Disclosure - Collaboration, License, and Other Agreements - North America - Collaborative Arrangements Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 99940405 - Disclosure - Collaboration, License, and Other Agreements - North America - Commercial Efforts (Details) link:presentationLink link:calculationLink link:definitionLink 99940406 - Disclosure - Collaboration, License, and Other Agreements - North America - Royalty Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 99940407 - Disclosure - Collaboration, License, and Other Agreements - European and Other Territories (Details) link:presentationLink link:calculationLink link:definitionLink 99940408 - Disclosure - Collaboration, License, and Other Agreements - Japan (Details) link:presentationLink link:calculationLink link:definitionLink 99940409 - Disclosure - Collaboration, License, and Other Agreements - China, Hong Kong and Macau (Details) link:presentationLink link:calculationLink link:definitionLink 99940410 - Disclosure - Collaboration, License, and Other Agreements - Apraglutide Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 99940412 - Disclosure - Collaboration, License, and Other Agreements - Other Collaboration and License Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 99940503 - Disclosure - Fair Value of Financial Instruments - Convertible Senior Notes (Details) link:presentationLink link:calculationLink link:definitionLink 99940601 - Disclosure - Leases - Letters of Credit (Details) link:presentationLink link:calculationLink link:definitionLink 99940604 - Disclosure - Leases - Summer Street Lease (Details) link:presentationLink link:calculationLink link:definitionLink 99940801 - Disclosure - Debt - General Information (Details) link:presentationLink link:calculationLink link:definitionLink 99940804 - Disclosure - Debt - Capped Calls (Details) link:presentationLink link:calculationLink link:definitionLink 99941101 - Disclosure - Workforce Reduction and Restructuring (Details) link:presentationLink link:calculationLink link:definitionLink 995200090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 995200105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 995210601 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 995211101 - Disclosure - Workforce Reduction and Restructuring link:presentationLink link:calculationLink link:definitionLink 995211201 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 99920202 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 99930503 - Disclosure - Fair Value of Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 99930603 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 99940501 - Disclosure - Fair Value of Financial Instruments - General Information (Details) link:presentationLink link:calculationLink link:definitionLink 99940603 - Disclosure - Leases - Supplemental Information (Details) link:presentationLink link:calculationLink link:definitionLink 99940702 - Disclosure - Accrued Expenses and Other Current Liabilities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 99941001 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 99941201 - Disclosure - Segment Reporting (Details) link:presentationLink link:calculationLink link:definitionLink