000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Unaudited) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited) link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 1 - Organization and Nature of Business link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 3 - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 4 - Balance Sheet Components link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 5 - Revenue link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 7 - Leases link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 8 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 9 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 10 - Equity Incentive Plans link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 11 - Net Loss Per Share Attributable to Common Stockholders link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 12 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 13 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 995466 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995467 - Disclosure - Note 3 - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 995468 - Disclosure - Note 4 - Balance Sheet Components (Tables) link:calculationLink link:definitionLink link:presentationLink 995469 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Tables) link:calculationLink link:definitionLink link:presentationLink 995470 - Disclosure - Note 7 - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 995471 - Disclosure - Note 9 - Stockholders' Equity (Tables) link:calculationLink link:definitionLink link:presentationLink 995472 - Disclosure - Note 10 - Equity Incentive Plans (Tables) link:calculationLink link:definitionLink link:presentationLink 995473 - Disclosure - Note 11 - Net Loss Per Share Attributable to Common Stockholders (Tables) link:calculationLink link:definitionLink link:presentationLink 995474 - Disclosure - Note 12 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 995475 - Disclosure - Note 1 - Organization and Nature of Business (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995476 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995477 - Disclosure - Note 3 - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995478 - Disclosure - Note 3 - Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 995479 - Disclosure - Note 4 - Balance Sheet Components (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995480 - Disclosure - Note 4 - Balance Sheet Components - Cash and Cash Equivalents and Investments (Details) link:calculationLink link:definitionLink link:presentationLink 995481 - Disclosure - Note 4 - Balance Sheet Components - Prepaid Expenses and Other Current Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995482 - Disclosure - Note 4 - Balance Sheet Components - Property and Equipment, Net (Details) link:calculationLink link:definitionLink link:presentationLink 995483 - Disclosure - Note 4 - Balance Sheet Components - Intangible Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995484 - Disclosure - Note 4 - Balance Sheet Components - Estimated Future Amortization Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995485 - Disclosure - Note 4 - Balance Sheet Components - Deferred Revenue, by Arrangement, Disclosure (Details) link:calculationLink link:definitionLink link:presentationLink 995486 - Disclosure - Note 4 - Balance Sheet Components - Accrued Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995487 - Disclosure - Note 5 - Revenue (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995488 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995489 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties - Deferred Revenue Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995490 - Disclosure - Note 7 - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995491 - Disclosure - Note 7 - Leases - Lease Liabilities Payment Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 995492 - Disclosure - Note 7 - Leases - Operating Lease Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 995493 - Disclosure - Note 8 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995494 - Disclosure - Note 9 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995495 - Disclosure - Note 9 - Stockholders' Equity - Shares of Common Stock Reserved for Issuance (Details) link:calculationLink link:definitionLink link:presentationLink 995496 - Disclosure - Note 9 - Stockholders' Equity - Summary of Warrants Outstanding (Details) link:calculationLink link:definitionLink link:presentationLink 995497 - Disclosure - Note 10 - Equity Incentive Plans (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995498 - Disclosure - Note 10 - Equity Incentive Plans - Summary of Stock Option Transactions (Details) link:calculationLink link:definitionLink link:presentationLink 995499 - Disclosure - Note 10 - Equity Incentive Plans - Assumptions of Options (Details) link:calculationLink link:definitionLink link:presentationLink 995500 - Disclosure - Note 10 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options (Details) link:calculationLink link:definitionLink link:presentationLink 995501 - Disclosure - Note 10 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options 2 (Details) link:calculationLink link:definitionLink link:presentationLink 995502 - Disclosure - Note 11 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net (Loss) Income Per Share (Details) link:calculationLink link:definitionLink link:presentationLink 995503 - Disclosure - Note 11 - Net Loss Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995504 - Disclosure - Note 12 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995505 - Disclosure - Note 12 - Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details) link:calculationLink link:definitionLink link:presentationLink 995506 - Disclosure - Note 13 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink