0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Condensed Consolidated Statements of Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Organization link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Composition of Certain Balance Sheet Items link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Net Income (Loss) Per Ordinary Share link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Commitment and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Significant Agreements link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Share-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Composition of Certain Balance Sheet Items (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Net Income (Loss) Per Ordinary Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Share-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Restructuring (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Organization - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Summary of Significant Accounting Policies - Concentration of Risks and Other Risks and Uncertainties (Details) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Summary of Significant Accounting Policies - Segment (Details) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Composition of Certain Balance Sheet Items - Schedule of Property and Equipment (Detail) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Composition of Certain Balance Sheet Items - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Composition of Certain Balance Sheet Items - Schedule of Other Current Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Composition of Certain Balance Sheet Items - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Net Income (Loss) Per Ordinary Share - Calculation of Basic and Diluted Net Income (Loss) Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Net Income (Loss) Per Ordinary Share - Ordinary Shares Equivalent Not Included in Diluted Net Income (Loss) Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Commitment and Contingencies - Lease Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Commitment and Contingencies - New Brisbane Facility (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Commitment and Contingencies - Schedule of Lease Liability Maturity Analysis- (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Commitment and Contingencies - Schedule of Lease Liability Maturity Analysis- (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Commitment and Contingencies - Commitment Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Commitment and Contingencies - Commitment Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Commitment and Contingencies - Contractual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Commitment and Contingencies - Contractual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Significant Agreements - Roche License Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Significant Agreements - Bristol Myers Squibb Collaboration Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Significant Agreements - Global License Agreement for PRX019 (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Significant Agreements - Novo Nordisk Share Purchase Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Shareholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Shareholders' Equity - December 2022 Public Offering - (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Shareholders' Equity - At-the-Market Offering (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Shareholders' Equity - Share Repurchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Share-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Share-Based Compensation - Summary of Share-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Share-Based Compensation - Summary of Share-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Share-Based Compensation - Fair Value of Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Share-based Compensation - Share-based Compensation Plan - Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Share-Based Compensation - Summary of RSU Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Restructuring - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Restructuring - Schedule of Restructuring Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink