<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f5ba0-06b0-7d38-bca4-b316edcae20b,g:6bfe28ea-5946-4192-9499-f255d9c5a816-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMEUNAUDITED" xlink:type="simple" xlink:href="zts-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMEUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMEUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019f5ba0-0852-7ab5-9188-b271131d2b87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-72f0-9193-0e057f009b75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019f5ba0-0852-7ab5-9188-b271131d2b87" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-72f0-9193-0e057f009b75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019f5ba0-0852-7ebf-a9ae-7f63f69d8e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019f5ba0-0852-7ab5-9188-b271131d2b87" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019f5ba0-0852-7ebf-a9ae-7f63f69d8e4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_019f5ba0-0852-7406-9edd-b4ad80522df4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_InterestExpense_019f5ba0-0852-7406-9edd-b4ad80522df4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction_019f5ba0-0852-7e72-bc8d-087797c4e461" xlink:href="zts-20260630.xsd#zts_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_zts_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction_019f5ba0-0852-7e72-bc8d-087797c4e461" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0852-7049-9cac-33cb45f25b99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0852-7049-9cac-33cb45f25b99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019f5ba0-0852-7687-a244-71824c9918fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019f5ba0-0852-7687-a244-71824c9918fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019f5ba0-0852-71a1-992a-38299cda6b6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019f5ba0-0852-71a1-992a-38299cda6b6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019f5ba0-0852-7343-8272-2e2012fec7a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019f5ba0-0852-7343-8272-2e2012fec7a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts_019f5ba0-0852-7a02-8cbc-fffc0adb26da" xlink:href="zts-20260630.xsd#zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts_019f5ba0-0852-7a02-8cbc-fffc0adb26da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019f5ba0-0852-7d62-9031-f9dbd724d7d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0852-7f0c-9345-577608da37cd" xlink:to="loc_us-gaap_Revenues_019f5ba0-0852-7d62-9031-f9dbd724d7d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f5ba0-0852-7c03-bc8e-cdd56e142a7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019f5ba0-0852-728c-86b8-59c912d44434" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f5ba0-0852-7c03-bc8e-cdd56e142a7b" xlink:to="loc_us-gaap_ProfitLoss_019f5ba0-0852-728c-86b8-59c912d44434" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019f5ba0-0852-7b70-a74d-6ee5e74ae549" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f5ba0-0852-7c03-bc8e-cdd56e142a7b" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019f5ba0-0852-7b70-a74d-6ee5e74ae549" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="simple" xlink:href="zts-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7d3e-b5c9-ac8407a2b731" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019f5ba0-0852-7f4e-8c13-e6cee744c41e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7d3e-b5c9-ac8407a2b731" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019f5ba0-0852-7f4e-8c13-e6cee744c41e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019f5ba0-0852-73d3-ab4f-62af39a13558" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7d3e-b5c9-ac8407a2b731" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019f5ba0-0852-73d3-ab4f-62af39a13558" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019f5ba0-0852-7c1c-b2f1-e2ad057a0722" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7d3e-b5c9-ac8407a2b731" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019f5ba0-0852-7c1c-b2f1-e2ad057a0722" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7ab7-8731-9788360b1f44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019f5ba0-0852-701f-a69a-0e3def7f1092" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7ab7-8731-9788360b1f44" xlink:to="loc_us-gaap_ProfitLoss_019f5ba0-0852-701f-a69a-0e3def7f1092" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7e3b-aca0-e95b03bb221f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7ab7-8731-9788360b1f44" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-7e3b-aca0-e95b03bb221f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f5ba0-0852-7762-9dbf-a042ffd7ca77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7a8c-a358-7b01280264f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f5ba0-0852-7762-9dbf-a042ffd7ca77" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7a8c-a358-7b01280264f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019f5ba0-0852-7abf-a179-f659951cda11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f5ba0-0852-7762-9dbf-a042ffd7ca77" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019f5ba0-0852-7abf-a179-f659951cda11" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="simple" xlink:href="zts-20260630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f5ba0-0852-7379-b592-68cc8c03b6ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f5ba0-0852-7379-b592-68cc8c03b6ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019f5ba0-0852-7182-90de-7da9bc80ac16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:to="loc_us-gaap_ShortTermInvestments_019f5ba0-0852-7182-90de-7da9bc80ac16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019f5ba0-0852-7e1b-acdd-945013b5cc32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019f5ba0-0852-7e1b-acdd-945013b5cc32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019f5ba0-0852-747a-aaeb-884ad560ad77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:to="loc_us-gaap_InventoryNet_019f5ba0-0852-747a-aaeb-884ad560ad77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019fb4bd-f6e0-71b6-8ebf-8d1085bf0bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f5ba0-0852-767b-a102-06b3dc4c72b2" xlink:to="loc_us-gaap_OtherAssetsCurrent_019fb4bd-f6e0-71b6-8ebf-8d1085bf0bb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f5ba0-0852-7253-b4c9-c87cac30c06f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_AssetsCurrent_019f5ba0-0852-7253-b4c9-c87cac30c06f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019f5ba0-0852-7c27-9bb6-a8e79e3bd92b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019f5ba0-0852-7c27-9bb6-a8e79e3bd92b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019f5ba0-0852-7094-a513-ecc5499b0863" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_Goodwill_019f5ba0-0852-7094-a513-ecc5499b0863" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f5ba0-0852-722d-8127-400151de7b07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f5ba0-0852-722d-8127-400151de7b07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019f5ba0-0852-74e9-a5e3-98bab4f8340c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019f5ba0-0852-74e9-a5e3-98bab4f8340c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f5ba0-0852-78a0-8a5d-2c62be6ff65c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f5ba0-0852-78a0-8a5d-2c62be6ff65c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019f5ba0-0852-7b70-ad16-66b19546cca2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f5ba0-0852-7ae0-b9a3-b0ec9cfc7016" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019f5ba0-0852-7b70-ad16-66b19546cca2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7175-a674-b84ef89fee39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7e8b-865e-d881beec9d1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7175-a674-b84ef89fee39" xlink:to="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7e8b-865e-d881beec9d1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019f5ba0-0852-7bec-9e5f-51aeac77e407" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-7175-a674-b84ef89fee39" xlink:to="loc_us-gaap_MinorityInterest_019f5ba0-0852-7bec-9e5f-51aeac77e407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019f5ba0-0852-7768-890e-b59df054d6b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019f5ba0-0852-7768-890e-b59df054d6b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019f5ba0-0852-7c63-95a1-bf26041ff17f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_TaxesPayableCurrent_019f5ba0-0852-7c63-95a1-bf26041ff17f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019f5ba0-0852-751b-b978-93587aa12571" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_AccountsPayableCurrent_019f5ba0-0852-751b-b978-93587aa12571" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019f5ba0-0852-73a1-a2c9-8640c62eb7cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019f5ba0-0852-73a1-a2c9-8640c62eb7cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrent_019f5ba0-0852-7636-83c1-4f94d057e446" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_DividendsPayableCurrent_019f5ba0-0852-7636-83c1-4f94d057e446" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019f5ba0-0852-79e8-b1e2-e777026e686f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-799a-80f6-5356b7ccbe18" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019f5ba0-0852-79e8-b1e2-e777026e686f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019f5ba0-0852-7f67-9934-6e7d1bbaac4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019f5ba0-0852-7f67-9934-6e7d1bbaac4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f5ba0-0852-70b3-9086-a6ab2aeaa441" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f5ba0-0852-70b3-9086-a6ab2aeaa441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-70fe-8c8d-4b733edc2da8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f5ba0-0852-70fe-8c8d-4b733edc2da8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019f5ba0-0852-7f0b-93c3-e54ac5b1541f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:to="loc_us-gaap_TreasuryStockValue_019f5ba0-0852-7f0b-93c3-e54ac5b1541f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019f5ba0-0852-7981-9cc0-d7aec57ea421" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f5ba0-0852-7c5b-9e4a-040e2ef034be" xlink:to="loc_us-gaap_CommonStockValue_019f5ba0-0852-7981-9cc0-d7aec57ea421" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-7ca7-871f-0683c2375983" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_LiabilitiesCurrent_019f5ba0-0852-7ca7-871f-0683c2375983" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019f5ba0-0852-7589-b64c-c008e41603f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019f5ba0-0852-7589-b64c-c008e41603f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019f5ba0-0852-7a73-9f2e-586a4fe867d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019f5ba0-0852-7a73-9f2e-586a4fe867d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019f5ba0-0852-7281-863b-905dca71e295" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019f5ba0-0852-7281-863b-905dca71e295" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019f5ba0-0852-73af-a59d-d51a63f44459" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019f5ba0-0852-73af-a59d-d51a63f44459" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019f5ba0-0852-7528-99a6-1cb5a13f21c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f5ba0-0852-73a2-9942-7fefb8a95045" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019f5ba0-0852-7528-99a6-1cb5a13f21c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f5ba0-0852-76eb-b859-937be378bd41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-78c1-a2a7-e4c30cb06555" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f5ba0-0852-76eb-b859-937be378bd41" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019f5ba0-0852-78c1-a2a7-e4c30cb06555" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f5ba0-0852-77ec-a1d7-0ef3a4e92762" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f5ba0-0852-76eb-b859-937be378bd41" xlink:to="loc_us-gaap_Liabilities_019f5ba0-0852-77ec-a1d7-0ef3a4e92762" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019f5ba0-0852-729b-84c0-a5e7a74579e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f5ba0-0852-76eb-b859-937be378bd41" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019f5ba0-0852-729b-84c0-a5e7a74579e3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="zts-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f5ba0-0852-70dc-8cd4-908c0195d9f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f5ba0-0852-70dc-8cd4-908c0195d9f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessTwoNetOfCashAcquired_019f5ba0-0852-75be-b9db-d654357e7c9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessTwoNetOfCashAcquired"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessTwoNetOfCashAcquired_019f5ba0-0852-75be-b9db-d654357e7c9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_019f5ba0-0852-7ed5-bb63-e4be88b246de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_019f5ba0-0852-7ed5-bb63-e4be88b246de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromHedgeInvestingActivities_019f5ba0-0852-7875-8f0e-281629e370fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromHedgeInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_PaymentsForProceedsFromHedgeInvestingActivities_019f5ba0-0852-7875-8f0e-281629e370fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_019f5ba0-0852-7c82-a182-a04d2eee8dcc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_019f5ba0-0852-7c82-a182-a04d2eee8dcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019fb4b6-cc34-7b36-ae93-2dd143d37e8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019fb4b6-cc34-7b36-ae93-2dd143d37e8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fb4b6-cc34-7f21-9dc5-ef5b73e588c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-7542-8bd0-1f4b35346315" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fb4b6-cc34-7f21-9dc5-ef5b73e588c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f5ba0-0852-7134-a157-27c06ffb6f1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-78e8-8fa8-45f1b1decc66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f5ba0-0852-7134-a157-27c06ffb6f1f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-78e8-8fa8-45f1b1decc66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f5ba0-0852-7df7-aa68-8eef49531a51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f5ba0-0852-7134-a157-27c06ffb6f1f" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f5ba0-0852-7df7-aa68-8eef49531a51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-790b-a2d0-ebd705096df1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f5ba0-0852-7134-a157-27c06ffb6f1f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f5ba0-0852-790b-a2d0-ebd705096df1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-747f-be1d-199c3329112d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f5ba0-0852-7134-a157-27c06ffb6f1f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-747f-be1d-199c3329112d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019f5ba0-0852-7716-9b53-53572eba6e11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_ProfitLoss_019f5ba0-0852-7716-9b53-53572eba6e11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019f5ba0-0852-7b45-812c-1a32da8e10d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019f5ba0-0852-7b45-812c-1a32da8e10d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019f5ba0-0852-7cec-987a-26b5c4460f27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_ShareBasedCompensation_019f5ba0-0852-7cec-987a-26b5c4460f27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019f5ba0-0852-7102-a17f-1baa446dcb35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_AssetImpairmentCharges_019f5ba0-0852-7102-a17f-1baa446dcb35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges_019f5ba0-0852-7aee-b1ab-ddcf504fbe11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges_019f5ba0-0852-7aee-b1ab-ddcf504fbe11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019f5ba0-0852-70f8-87eb-a01ef7c37d1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_InventoryWriteDown_019f5ba0-0852-70f8-87eb-a01ef7c37d1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019f5ba0-0852-708b-b33d-d082f2e8199c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019f5ba0-0852-708b-b33d-d082f2e8199c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019f5ba0-0852-7508-a0f6-271629ff05a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019f5ba0-0852-7508-a0f6-271629ff05a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f5ba0-0852-79de-8f99-4482186c8957" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f5ba0-0852-79de-8f99-4482186c8957" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019f5ba0-0852-7cd3-a8f5-3655f3c339d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019f5ba0-0852-7cd3-a8f5-3655f3c339d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019f5ba0-0852-7a9f-9c5b-d15ce57b0243" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019f5ba0-0852-7a9f-9c5b-d15ce57b0243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f5ba0-0852-74f1-b288-e511cee33372" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f5ba0-0852-74f1-b288-e511cee33372" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019f5ba0-0852-7afe-8c96-edbec783b25a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019f5ba0-0852-7afe-8c96-edbec783b25a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_019f5ba0-0852-71c9-b716-13fc765578ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedTaxesPayable"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_019f5ba0-0852-71c9-b716-13fc765578ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_019fb4cf-0791-731e-8402-78b936da3444" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f5ba0-0852-7d4e-a295-2f3ba4077ecb" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_019fb4cf-0791-731e-8402-78b936da3444" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-7a8d-a5b0-32d8c7aeb676" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_ShareBasedCompensationRelatedProceedsNetOfTaxesPaidOnWithholdingShares_019f5ba0-0852-710a-97c3-d7208a69bc72" xlink:href="zts-20260630.xsd#zts_ShareBasedCompensationRelatedProceedsNetOfTaxesPaidOnWithholdingShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-7a8d-a5b0-32d8c7aeb676" xlink:to="loc_zts_ShareBasedCompensationRelatedProceedsNetOfTaxesPaidOnWithholdingShares_019f5ba0-0852-710a-97c3-d7208a69bc72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019f5ba0-0852-79d6-a1b6-42bcb3b04660" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-7a8d-a5b0-32d8c7aeb676" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019f5ba0-0852-79d6-a1b6-42bcb3b04660" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfOrdinaryDividends_019f5ba0-0852-7eed-9db7-d6cdf4e4829d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfOrdinaryDividends"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-7a8d-a5b0-32d8c7aeb676" xlink:to="loc_us-gaap_PaymentsOfOrdinaryDividends_019f5ba0-0852-7eed-9db7-d6cdf4e4829d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f5ba0-0852-775a-861f-911fd1bfb396" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f5ba0-0852-7a8d-a5b0-32d8c7aeb676" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f5ba0-0852-775a-861f-911fd1bfb396" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandDivestituresDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandDivestituresDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandDivestituresDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts_019f5ba0-0910-7780-bd3d-fe69e2584a35" xlink:href="zts-20260630.xsd#zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_019f5ba0-0910-7397-aa03-05ac2d07361e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeveranceCosts1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts_019f5ba0-0910-7780-bd3d-fe69e2584a35" xlink:to="loc_us-gaap_SeveranceCosts1_019f5ba0-0910-7397-aa03-05ac2d07361e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019f5ba0-0910-7ef5-a061-80e130ea47ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_zts_RestructuringChargesAndAcquisitionAndDivestitureRelatedCosts_019f5ba0-0910-7780-bd3d-fe69e2584a35" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019f5ba0-0910-7ef5-a061-80e130ea47ed" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/OtherIncomeDeductionsNetDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#OtherIncomeDeductionsNetDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/OtherIncomeDeductionsNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f5ba0-0910-70bb-a763-b9f0e9885582" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f5ba0-0910-70bb-a763-b9f0e9885582" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019f5ba0-0910-7457-b10b-52fcf1f8a0d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019f5ba0-0910-7457-b10b-52fcf1f8a0d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges_019f5ba0-0910-7eb0-b253-5d9c82c38181" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_GainLossOnSalesOfAssetsAndAssetImpairmentCharges_019f5ba0-0910-7eb0-b253-5d9c82c38181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_019f5ba0-0910-7730-ae79-dbdfacd76b7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_019f5ba0-0910-7730-ae79-dbdfacd76b7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019fb4b5-7dfe-7425-818e-df17fdc8b176" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019fb4b5-7dfe-7425-818e-df17fdc8b176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fb4b5-7dfe-7bf6-bef7-997288b3fb41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-702c-8838-654cdf9ab15e" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fb4b5-7dfe-7bf6-bef7-997288b3fb41" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/FinancialInstrumentsLongtermDebtMaturityDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#FinancialInstrumentsLongtermDebtMaturityDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/FinancialInstrumentsLongtermDebtMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019f5ba0-0910-7037-80de-e9bfe9bdf64a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019f5ba0-0910-7037-80de-e9bfe9bdf64a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_LongTermDebtMaturityAfterYearFour_019f5ba0-0910-745f-b7fc-d8aa7f9a5483" xlink:href="zts-20260630.xsd#zts_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_zts_LongTermDebtMaturityAfterYearFour_019f5ba0-0910-745f-b7fc-d8aa7f9a5483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019f5ba0-0910-76f7-b3f9-ba0249d6214a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019f5ba0-0910-76f7-b3f9-ba0249d6214a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019f5ba0-0910-7ded-95de-2043604e76f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019f5ba0-0910-7ded-95de-2043604e76f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019f5ba0-0910-7931-82a0-0cb33598d7b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019f5ba0-0910-7931-82a0-0cb33598d7b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019f5ba0-0910-710f-bf8a-b63a695c8015" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019f5ba0-0910-7c71-994e-9b76266c7b99" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019f5ba0-0910-710f-bf8a-b63a695c8015" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/FinancialInstrumentsFairValueofDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#FinancialInstrumentsFairValueofDerivativeInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/FinancialInstrumentsFairValueofDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_019f5ba0-0910-726d-a60d-c5935ec66e19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019f5ba0-0910-7e77-a65b-6d53a7ec8510" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeNet_019f5ba0-0910-726d-a60d-c5935ec66e19" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019f5ba0-0910-7e77-a65b-6d53a7ec8510" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019f5ba0-0910-762a-bad3-59d09d23c039" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeNet_019f5ba0-0910-726d-a60d-c5935ec66e19" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019f5ba0-0910-762a-bad3-59d09d23c039" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/InventoriesDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019f5ba0-0910-7f43-9e0a-8ac9b9e43ff2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019f5ba0-0910-73c2-b375-312acaa13bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019f5ba0-0910-7f43-9e0a-8ac9b9e43ff2" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019f5ba0-0910-73c2-b375-312acaa13bdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019f5ba0-0910-744c-afe0-58525bf4a634" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019f5ba0-0910-7f43-9e0a-8ac9b9e43ff2" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019f5ba0-0910-744c-afe0-58525bf4a634" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_019f5ba0-0910-7a2b-b3ca-8e1e8f20248b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019f5ba0-0910-7f43-9e0a-8ac9b9e43ff2" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_019f5ba0-0910-7a2b-b3ca-8e1e8f20248b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/GoodwillandOtherIntangibleAssetsOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#GoodwillandOtherIntangibleAssetsOtherIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/GoodwillandOtherIntangibleAssetsOtherIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f5ba0-0910-7464-8596-ebeb246e3411" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019f5ba0-0910-7abc-8600-1fc398a5779c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f5ba0-0910-7464-8596-ebeb246e3411" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019f5ba0-0910-7abc-8600-1fc398a5779c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f5ba0-0910-7a33-b595-ef25ed1f892e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f5ba0-0910-7464-8596-ebeb246e3411" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f5ba0-0910-7a33-b595-ef25ed1f892e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f5ba0-0910-73bd-b148-eaf551447a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019f5ba0-0910-70e8-80dd-11d893dc8de3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f5ba0-0910-73bd-b148-eaf551447a3a" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019f5ba0-0910-70e8-80dd-11d893dc8de3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f5ba0-0910-7160-a72f-329f5442cfa4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f5ba0-0910-73bd-b148-eaf551447a3a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f5ba0-0910-7160-a72f-329f5442cfa4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/EarningsperShareDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#EarningsperShareDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/EarningsperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019f5ba0-0910-7fef-b10e-7040159387c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019f5ba0-0910-7c80-9ac4-302f142d8b1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019f5ba0-0910-7fef-b10e-7040159387c0" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019f5ba0-0910-7c80-9ac4-302f142d8b1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019f5ba0-0910-76b8-a302-4aad66e1a44b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019f5ba0-0910-7fef-b10e-7040159387c0" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019f5ba0-0910-76b8-a302-4aad66e1a44b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.zoetis.com/role/SegmentInformationSelectedStatementofIncomeDetails" xlink:type="simple" xlink:href="zts-20260630.xsd#SegmentInformationSelectedStatementofIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.zoetis.com/role/SegmentInformationSelectedStatementofIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019f5ba0-0910-713d-a3c6-c501f9220e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_us-gaap_OperatingExpenses_019f5ba0-0910-713d-a3c6-c501f9220e2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-7262-8a71-9841f86e6d5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019f5ba0-0910-7262-8a71-9841f86e6d5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019f5ba0-0910-7b31-ad57-395aa71a1435" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_us-gaap_GrossProfit_019f5ba0-0910-7b31-ad57-395aa71a1435" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_019f5ba0-0910-7c0a-84af-1900e4f512df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_us-gaap_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferred_019f5ba0-0910-7c0a-84af-1900e4f512df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_BusinessCombinationAcquisitionAndDivestureRelatedCosts_019f5ba0-0910-7b3a-80a8-3d4d850f53e0" xlink:href="zts-20260630.xsd#zts_BusinessCombinationAcquisitionAndDivestureRelatedCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_zts_BusinessCombinationAcquisitionAndDivestureRelatedCosts_019f5ba0-0910-7b3a-80a8-3d4d850f53e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_CertainSignificantReconcilingItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest_019f5ba0-0910-78b1-99ac-7da631fef8a4" xlink:href="zts-20260630.xsd#zts_CertainSignificantReconcilingItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_zts_CertainSignificantReconcilingItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest_019f5ba0-0910-78b1-99ac-7da631fef8a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zts_OtherUnallocatedItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest_019f5ba0-0910-708f-b9ab-bc8801e7a5fc" xlink:href="zts-20260630.xsd#zts_OtherUnallocatedItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f5ba0-0910-78d1-97f1-74804194c68a" xlink:to="loc_zts_OtherUnallocatedItemsIncludedinIncomeLossfromContinuingOperationsbeforeIncomeTaxesNoncontrollingInterest_019f5ba0-0910-708f-b9ab-bc8801e7a5fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019f5ba0-0910-7bb0-bd3c-973e582af1c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019f5ba0-0910-78ba-8675-7132a1094e35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019f5ba0-0910-7bb0-bd3c-973e582af1c4" xlink:to="loc_us-gaap_Revenues_019f5ba0-0910-78ba-8675-7132a1094e35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019f5ba0-0910-7095-9af2-cfc41746677b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019f5ba0-0910-7bb0-bd3c-973e582af1c4" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019f5ba0-0910-7095-9af2-cfc41746677b" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
