<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019effb3-c9bd-73ca-93bc-13586024f61f,g:e8c72144-6383-4d1a-b397-e310affc71c0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.kenvue.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="kvue-20260628.xsd#CondensedConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019effb3-cb2e-74f5-861d-98711fe6b998" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019effb3-cb2e-7139-a91f-9039adfe5475" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019effb3-cb2e-74f5-861d-98711fe6b998" xlink:to="loc_us-gaap_StatementTable_019effb3-cb2e-7139-a91f-9039adfe5475" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019effb3-cb2e-7139-a91f-9039adfe5475" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cb2e-7fa0-8ffd-f804ab2c5eb0" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019effb3-cb2e-7d21-a39d-32c5c8024cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:to="loc_us-gaap_CommonStockMember_019effb3-cb2e-7d21-a39d-32c5c8024cf2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019effb3-cb2e-7b83-ae0d-523194f7c086" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019effb3-cb2e-7b83-ae0d-523194f7c086" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_019effb3-cb2e-7478-80f4-f3b50b803d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:to="loc_us-gaap_TreasuryStockCommonMember_019effb3-cb2e-7478-80f4-f3b50b803d0c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019effb3-cb2e-7eda-a921-626f24292067" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:to="loc_us-gaap_RetainedEarningsMember_019effb3-cb2e-7eda-a921-626f24292067" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cb2e-7f8b-99c7-185c90269ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cb2e-75f0-84ba-e6471880a68c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cb2e-7f8b-99c7-185c90269ed6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019effb3-cb2e-74f5-861d-98711fe6b998" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019effb3-cb2e-749b-9928-fc38b7baad9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019effb3-cb2e-749b-9928-fc38b7baad9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019effb3-cb2e-7c68-907d-092064869512" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_StockholdersEquity_019effb3-cb2e-7c68-907d-092064869512" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019effb3-cb2e-7f38-80f1-30619b883822" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_TreasuryStockCommonShares_019effb3-cb2e-7f38-80f1-30619b883822" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019effb3-cb2e-742b-9fd0-a6ddc45d990b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_NetIncomeLoss_019effb3-cb2e-742b-9fd0-a6ddc45d990b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019effb3-cb2e-72b8-8bf1-ea40cd281ceb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019effb3-cb2e-72b8-8bf1-ea40cd281ceb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_019effb3-cb2e-79d2-9655-2c31a26d40b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_DividendsCommonStockCash_019effb3-cb2e-79d2-9655-2c31a26d40b9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019effb3-cb2e-7a5e-9da8-1ed737e25826" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019effb3-cb2e-7a5e-9da8-1ed737e25826" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019effb3-cb2e-7585-9ee9-f8755423b26b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019effb3-cb2e-7585-9ee9-f8755423b26b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019effb3-cb2e-7d67-89c8-6f1c30199718" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019effb3-cb2e-7d67-89c8-6f1c30199718" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_019effb3-cb2e-7ecb-8399-20ca15fa04de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_019effb3-cb2e-7ecb-8399-20ca15fa04de" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019effb3-cb2e-79bd-92a4-fab567d37f43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019effb3-cb2e-7e9d-a2ff-de59c67a53c6" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019effb3-cb2e-79bd-92a4-fab567d37f43" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019effb3-cb2e-7b38-a8b5-9bbbdf72effc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019effb3-cb2e-7195-825a-1cac9ce15a21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019effb3-cb2e-72c9-a856-8523f028187e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_019effb3-cb2e-7527-b593-4edca4f2da3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_019effb3-cb2e-7527-b593-4edca4f2da3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019effb3-cb2e-7527-b593-4edca4f2da3d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019effb3-cb2e-7527-b593-4edca4f2da3d" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019effb3-cb2e-7527-b593-4edca4f2da3d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019effb3-cb2e-7104-a6bf-8a6dac126a6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019effb3-cb2e-7527-b593-4edca4f2da3d" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019effb3-cb2e-7104-a6bf-8a6dac126a6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_NetEconomicBenefitArrangementsMember_019effb3-cb2e-7a78-8270-dea64604c3df" xlink:href="kvue-20260628.xsd#kvue_NetEconomicBenefitArrangementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019effb3-cb2e-7104-a6bf-8a6dac126a6f" xlink:to="loc_kvue_NetEconomicBenefitArrangementsMember_019effb3-cb2e-7a78-8270-dea64604c3df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019effb3-cb2e-762c-9477-d3a72ebfdc33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019effb3-cb2e-762c-9477-d3a72ebfdc33" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019effb3-cb2e-762c-9477-d3a72ebfdc33_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019effb3-cb2e-762c-9477-d3a72ebfdc33" xlink:to="loc_us-gaap_RelatedPartyDomain_019effb3-cb2e-762c-9477-d3a72ebfdc33_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019effb3-cb2e-75d7-a21b-4e2364572148" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019effb3-cb2e-762c-9477-d3a72ebfdc33" xlink:to="loc_us-gaap_RelatedPartyDomain_019effb3-cb2e-75d7-a21b-4e2364572148" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_019effb3-cb2e-7bfe-95e7-abe3b1666851" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019effb3-cb2e-75d7-a21b-4e2364572148" xlink:to="loc_us-gaap_ParentMember_019effb3-cb2e-7bfe-95e7-abe3b1666851" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019effb3-cb2e-7f58-84d5-dc3fa4a4a874" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019effb3-cb2e-7f58-84d5-dc3fa4a4a874" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019effb3-cb2e-7f58-84d5-dc3fa4a4a874_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019effb3-cb2e-7f58-84d5-dc3fa4a4a874" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019effb3-cb2e-7f58-84d5-dc3fa4a4a874_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019effb3-cb2e-78f2-b380-81f51a0d7167" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019effb3-cb2e-7f58-84d5-dc3fa4a4a874" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019effb3-cb2e-78f2-b380-81f51a0d7167" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_KenvueInc.Member_019effb3-cb2e-7d86-8d59-3989e3ac5f1b" xlink:href="kvue-20260628.xsd#kvue_KenvueInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019effb3-cb2e-78f2-b380-81f51a0d7167" xlink:to="loc_kvue_KenvueInc.Member_019effb3-cb2e-7d86-8d59-3989e3ac5f1b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_019effb3-cb2e-7669-bf60-bfc2cd55bd71" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019effb3-cb2e-7445-9407-149c5e795a7b" xlink:to="loc_dei_LegalEntityAxis_019effb3-cb2e-7669-bf60-bfc2cd55bd71" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019effb3-cb2e-7669-bf60-bfc2cd55bd71_default" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_019effb3-cb2e-7669-bf60-bfc2cd55bd71" xlink:to="loc_dei_EntityDomain_019effb3-cb2e-7669-bf60-bfc2cd55bd71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019effb3-cb2e-7831-ad69-3f743b21ee12" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_019effb3-cb2e-7669-bf60-bfc2cd55bd71" xlink:to="loc_dei_EntityDomain_019effb3-cb2e-7831-ad69-3f743b21ee12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_KimberlyClarkCorporationMember_019effb3-cb2e-7d25-9cca-fb404049e74d" xlink:href="kvue-20260628.xsd#kvue_KimberlyClarkCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_019effb3-cb2e-7831-ad69-3f743b21ee12" xlink:to="loc_kvue_KimberlyClarkCorporationMember_019effb3-cb2e-7d25-9cca-fb404049e74d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019effb3-cb2e-7a51-a76e-d51abbffb609" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_NumberOfReportableSegments_019effb3-cb2e-7a51-a76e-d51abbffb609" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019effb3-cb2e-74b5-96f9-9768a14befc2" xlink:href="kvue-20260628.xsd#kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019effb3-cb2e-74b5-96f9-9768a14befc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019effb3-cb2e-7ebf-bd2b-55543251bf0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019effb3-cb2e-7ebf-bd2b-55543251bf0d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_019effb3-cb2e-7f13-a997-fecfdc39f808" xlink:href="kvue-20260628.xsd#kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_019effb3-cb2e-7f13-a997-fecfdc39f808" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected_019effb3-cb2e-7302-a029-94f2ba7a2d3a" xlink:href="kvue-20260628.xsd#kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected_019effb3-cb2e-7302-a029-94f2ba7a2d3a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected_019effb3-cb2e-7423-bbfd-2ab84949dcd4" xlink:href="kvue-20260628.xsd#kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected_019effb3-cb2e-7423-bbfd-2ab84949dcd4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019effb3-cb2e-7004-9992-62720e5e6dc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019effb3-cb2e-7004-9992-62720e5e6dc7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplierFinanceProgramObligationCurrent_019effb3-cb2e-7d38-b9ee-14335a7b8596" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SupplierFinanceProgramObligationCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_SupplierFinanceProgramObligationCurrent_019effb3-cb2e-7d38-b9ee-14335a7b8596" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019effb3-cb2e-7dc0-ae88-c78553804bc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_AccountsPayableCurrent_019effb3-cb2e-7dc0-ae88-c78553804bc1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019effb3-cb2e-730e-be3c-2ec1ac935d26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019effb3-cb2e-7c71-9339-4c88780a7d58" xlink:to="loc_us-gaap_NetIncomeLoss_019effb3-cb2e-730e-be3c-2ec1ac935d26" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cb2e-7a01-9f35-d982d7420499" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cb2e-7c14-9fc1-be6134c76b3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cb2e-7a01-9f35-d982d7420499" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cb2e-7c14-9fc1-be6134c76b3d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfExpenseAxis_019effb3-cb2e-70f1-890a-1617d3bb697f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NatureOfExpenseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cb2e-7c14-9fc1-be6134c76b3d" xlink:to="loc_us-gaap_NatureOfExpenseAxis_019effb3-cb2e-70f1-890a-1617d3bb697f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-70f1-890a-1617d3bb697f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019effb3-cb2e-70f1-890a-1617d3bb697f" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-70f1-890a-1617d3bb697f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-7ca2-b216-42bffd63ca9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019effb3-cb2e-70f1-890a-1617d3bb697f" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-7ca2-b216-42bffd63ca9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndOtherMember_019effb3-cb2e-75aa-96e5-3ded01480996" xlink:href="kvue-20260628.xsd#kvue_InformationTechnologyAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-7ca2-b216-42bffd63ca9a" xlink:to="loc_kvue_InformationTechnologyAndOtherMember_019effb3-cb2e-75aa-96e5-3ded01480996" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LegalEntityNameChangeMember_019effb3-cb2e-720f-8b85-5ffc32b82451" xlink:href="kvue-20260628.xsd#kvue_LegalEntityNameChangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019effb3-cb2e-7ca2-b216-42bffd63ca9a" xlink:to="loc_kvue_LegalEntityNameChangeMember_019effb3-cb2e-720f-8b85-5ffc32b82451" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SeparationRelatedCosts_019effb3-cb2e-7270-bb50-93f4b5ead0a0" xlink:href="kvue-20260628.xsd#kvue_SeparationRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cb2e-7a01-9f35-d982d7420499" xlink:to="loc_kvue_SeparationRelatedCosts_019effb3-cb2e-7270-bb50-93f4b5ead0a0" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillIntangibleAssetsDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#IntangibleAssetsandGoodwillIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-7fa6-b3c5-d78a3b829b9e" xlink:href="kvue-20260628.xsd#kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019effb3-cb2e-711f-a826-313efde20143" xlink:href="kvue-20260628.xsd#kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-7fa6-b3c5-d78a3b829b9e" xlink:to="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019effb3-cb2e-711f-a826-313efde20143" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-77a2-a086-04e0aec8adab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019effb3-cb2e-711f-a826-313efde20143" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-77a2-a086-04e0aec8adab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-77a2-a086-04e0aec8adab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-77a2-a086-04e0aec8adab" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-77a2-a086-04e0aec8adab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7bc2-a648-fd139f247262" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-77a2-a086-04e0aec8adab" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7bc2-a648-fd139f247262" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PatentsAndTrademarksMember_019effb3-cb2e-7127-8a95-a844fd975f37" xlink:href="kvue-20260628.xsd#kvue_PatentsAndTrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7bc2-a648-fd139f247262" xlink:to="loc_kvue_PatentsAndTrademarksMember_019effb3-cb2e-7127-8a95-a844fd975f37" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_019effb3-cb2e-7c20-bea2-d762a66b69c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7bc2-a648-fd139f247262" xlink:to="loc_us-gaap_CustomerRelationshipsMember_019effb3-cb2e-7c20-bea2-d762a66b69c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_019effb3-cb2e-7667-b301-d6c66228fdfe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7bc2-a648-fd139f247262" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_019effb3-cb2e-7667-b301-d6c66228fdfe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-7a8d-af03-baa168259145" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019effb3-cb2e-711f-a826-313efde20143" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-7a8d-af03-baa168259145" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7a8d-af03-baa168259145_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-7a8d-af03-baa168259145" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7a8d-af03-baa168259145_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7471-a7ff-d9afd08c8956" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019effb3-cb2e-7a8d-af03-baa168259145" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7471-a7ff-d9afd08c8956" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_019effb3-cb2e-7b61-8ed3-cba8695753b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7471-a7ff-d9afd08c8956" xlink:to="loc_us-gaap_TrademarksMember_019effb3-cb2e-7b61-8ed3-cba8695753b6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_019effb3-cb2e-785b-b654-dbf4ab2d7aa7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019effb3-cb2e-7471-a7ff-d9afd08c8956" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_019effb3-cb2e-785b-b654-dbf4ab2d7aa7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019effb3-cb2e-715c-9087-aca649052aeb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-7fa6-b3c5-d78a3b829b9e" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019effb3-cb2e-715c-9087-aca649052aeb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019effb3-cb2e-7042-9e6a-fdb8441cac62" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019effb3-cb2e-715c-9087-aca649052aeb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019effb3-cb2e-7042-9e6a-fdb8441cac62" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019effb3-cb2e-76d1-947a-8f7744f9a26f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019effb3-cb2e-7042-9e6a-fdb8441cac62" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019effb3-cb2e-76d1-947a-8f7744f9a26f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019effb3-cb2e-7fed-8682-53d75654f51f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019effb3-cb2e-7042-9e6a-fdb8441cac62" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019effb3-cb2e-7fed-8682-53d75654f51f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019effb3-cb2e-79e3-bf68-c97c59277a96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019effb3-cb2e-7042-9e6a-fdb8441cac62" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019effb3-cb2e-79e3-bf68-c97c59277a96" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019effb3-cb2e-78a7-9736-1a5f0344098b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019effb3-cb2e-715c-9087-aca649052aeb" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019effb3-cb2e-78a7-9736-1a5f0344098b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019effb3-cb2e-748b-a86e-f73a615e6665" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019effb3-cb2e-78a7-9736-1a5f0344098b" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019effb3-cb2e-748b-a86e-f73a615e6665" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019effb3-cb2e-7f3d-ab0f-edefc3ba41b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019effb3-cb2e-78a7-9736-1a5f0344098b" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019effb3-cb2e-7f3d-ab0f-edefc3ba41b2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019effb3-cb2e-7ced-bdf6-47bb72e1d5b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019effb3-cb2e-715c-9087-aca649052aeb" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019effb3-cb2e-7ced-bdf6-47bb72e1d5b5" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#IntangibleAssetsandGoodwillNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019effb3-cb2e-7f48-888b-ba188c81bfe0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019effb3-cb2e-7f48-888b-ba188c81bfe0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_019effb3-cb2e-7d0d-9970-9905765980db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019effb3-cb2e-7f48-888b-ba188c81bfe0" xlink:to="loc_us-gaap_ReportingUnitAxis_019effb3-cb2e-7d0d-9970-9905765980db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_019effb3-cb2e-7d0d-9970-9905765980db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReportingUnitAxis_019effb3-cb2e-7d0d-9970-9905765980db" xlink:to="loc_us-gaap_ReportingUnitDomain_019effb3-cb2e-7d0d-9970-9905765980db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_019effb3-cb2e-761f-afdd-af4f37a826ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReportingUnitAxis_019effb3-cb2e-7d0d-9970-9905765980db" xlink:to="loc_us-gaap_ReportingUnitDomain_019effb3-cb2e-761f-afdd-af4f37a826ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019effb3-cb2e-770a-83d3-ad29d05b01d3" xlink:href="kvue-20260628.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReportingUnitDomain_019effb3-cb2e-761f-afdd-af4f37a826ce" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019effb3-cb2e-770a-83d3-ad29d05b01d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019effb3-cb2e-7998-a093-dd01773cc2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019effb3-cb2e-7998-a093-dd01773cc2f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019effb3-cb2e-74eb-9e5a-57c7601e82a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019effb3-cb2e-74eb-9e5a-57c7601e82a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_019effb3-cb2e-781d-bdc7-09329f4a2993" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:to="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_019effb3-cb2e-781d-bdc7-09329f4a2993" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment_019effb3-cb2e-77b1-8583-25c0cc974028" xlink:href="kvue-20260628.xsd#kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019effb3-cb2e-74b0-a8b4-11e12bdf850e" xlink:to="loc_kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment_019effb3-cb2e-77b1-8583-25c0cc974028" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillGoodwillBySegmentDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#IntangibleAssetsandGoodwillGoodwillBySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillGoodwillBySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_019effb3-cb2e-767b-b859-e0d270c9671f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_019effb3-cb2e-79ad-a47a-2cf6cc386581" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_019effb3-cb2e-767b-b859-e0d270c9671f" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_019effb3-cb2e-79ad-a47a-2cf6cc386581" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cb2e-70c8-b019-7ca72b0e25ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_019effb3-cb2e-79ad-a47a-2cf6cc386581" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cb2e-70c8-b019-7ca72b0e25ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cb2e-70c8-b019-7ca72b0e25ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cb2e-70c8-b019-7ca72b0e25ef" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cb2e-70c8-b019-7ca72b0e25ef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cb2e-7686-ad54-28798064a50d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cb2e-70c8-b019-7ca72b0e25ef" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cb2e-7686-ad54-28798064a50d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019effb3-cb2e-7749-9de0-3d6b2ed6daa3" xlink:href="kvue-20260628.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cb2e-7686-ad54-28798064a50d" xlink:to="loc_kvue_SelfCareMember_019effb3-cb2e-7749-9de0-3d6b2ed6daa3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019effb3-cb2e-7f16-8c97-764a77c701bc" xlink:href="kvue-20260628.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cb2e-7686-ad54-28798064a50d" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019effb3-cb2e-7f16-8c97-764a77c701bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019effb3-cb2e-7ddd-b8a1-33bfe4e29f15" xlink:href="kvue-20260628.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cb2e-7686-ad54-28798064a50d" xlink:to="loc_kvue_EssentialHealthMember_019effb3-cb2e-7ddd-b8a1-33bfe4e29f15" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_019effb3-cb2e-7f86-8ff4-364637821c5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019effb3-cb2e-767b-b859-e0d270c9671f" xlink:to="loc_us-gaap_GoodwillRollForward_019effb3-cb2e-7f86-8ff4-364637821c5d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019effb3-cb2e-78a9-bbe9-e168cdcaccc2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_019effb3-cb2e-7f86-8ff4-364637821c5d" xlink:to="loc_us-gaap_Goodwill_019effb3-cb2e-78a9-bbe9-e168cdcaccc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_019effb3-cb2e-7492-9c2c-a04f36f6d0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_019effb3-cb2e-7f86-8ff4-364637821c5d" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_019effb3-cb2e-7492-9c2c-a04f36f6d0ef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019effb3-cb2e-794f-8bb2-c4157cd3149e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/BorrowingsLongTermDebtDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#BorrowingsLongTermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/BorrowingsLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019effb3-cb2e-7fea-b618-4a2825dbe17f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtInstrumentTable_019effb3-cb2e-7fea-b618-4a2825dbe17f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019effb3-cb2e-7edd-94df-88ccb4a936ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019effb3-cb2e-7fea-b618-4a2825dbe17f" xlink:to="loc_us-gaap_DebtInstrumentAxis_019effb3-cb2e-7edd-94df-88ccb4a936ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7edd-94df-88ccb4a936ff_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019effb3-cb2e-7edd-94df-88ccb4a936ff" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7edd-94df-88ccb4a936ff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019effb3-cb2e-7edd-94df-88ccb4a936ff" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A535NotesDue2026Member_019effb3-cb2e-7867-96da-b6c246ef6b07" xlink:href="kvue-20260628.xsd#kvue_A535NotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A535NotesDue2026Member_019effb3-cb2e-7867-96da-b6c246ef6b07" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A505NotesDue2028Member_019effb3-cb2e-7475-9487-a53b9207b00f" xlink:href="kvue-20260628.xsd#kvue_A505NotesDue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A505NotesDue2028Member_019effb3-cb2e-7475-9487-a53b9207b00f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A500NotesDue2030Member_019effb3-cb2e-700b-88de-ccf6a68ce592" xlink:href="kvue-20260628.xsd#kvue_A500NotesDue2030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A500NotesDue2030Member_019effb3-cb2e-700b-88de-ccf6a68ce592" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A4.85NotesDue2032Member_019effb3-cb2e-7d0a-83cf-3ca4e5739343" xlink:href="kvue-20260628.xsd#kvue_A4.85NotesDue2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A4.85NotesDue2032Member_019effb3-cb2e-7d0a-83cf-3ca4e5739343" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A490NotesDue2033Member_019effb3-cbdb-7953-91c2-064525f0ddef" xlink:href="kvue-20260628.xsd#kvue_A490NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A490NotesDue2033Member_019effb3-cbdb-7953-91c2-064525f0ddef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A510NotesDue2043Member_019effb3-cbdb-74e4-ae20-471319618016" xlink:href="kvue-20260628.xsd#kvue_A510NotesDue2043Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A510NotesDue2043Member_019effb3-cbdb-74e4-ae20-471319618016" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A505NotesDue2053Member_019effb3-cbdb-74d3-8b53-8797902536ba" xlink:href="kvue-20260628.xsd#kvue_A505NotesDue2053Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A505NotesDue2053Member_019effb3-cbdb-74d3-8b53-8797902536ba" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A520NotesDue2063Member_019effb3-cbdb-7df2-ab18-80c119478394" xlink:href="kvue-20260628.xsd#kvue_A520NotesDue2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019effb3-cb2e-7fc1-a676-e661176056c1" xlink:to="loc_kvue_A520NotesDue2063Member_019effb3-cbdb-7df2-ab18-80c119478394" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019effb3-cbdb-7e45-b401-e197826a352f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019effb3-cb2e-7fea-b618-4a2825dbe17f" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019effb3-cbdb-7e45-b401-e197826a352f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e45-b401-e197826a352f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019effb3-cbdb-7e45-b401-e197826a352f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e45-b401-e197826a352f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e3a-b543-52fc7c8f0df6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019effb3-cbdb-7e45-b401-e197826a352f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e3a-b543-52fc7c8f0df6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_019effb3-cbdb-79af-8707-1cf79c973512" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e3a-b543-52fc7c8f0df6" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_019effb3-cbdb-79af-8707-1cf79c973512" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019effb3-cbdb-77d1-9ecc-8f897b421945" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019effb3-cbdb-7e3a-b543-52fc7c8f0df6" xlink:to="loc_us-gaap_SeniorNotesMember_019effb3-cbdb-77d1-9ecc-8f897b421945" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019effb3-cbdb-7a2d-b6d8-51df229145de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019effb3-cbdb-7a2d-b6d8-51df229145de" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LongTermDebtGrossIncludingLeaseObligation_019effb3-cbdb-7714-883c-7a4955ebebe7" xlink:href="kvue-20260628.xsd#kvue_LongTermDebtGrossIncludingLeaseObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_kvue_LongTermDebtGrossIncludingLeaseObligation_019effb3-cbdb-7714-883c-7a4955ebebe7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019effb3-cbdb-7784-aa0a-d1073e8aa2bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019effb3-cbdb-7784-aa0a-d1073e8aa2bf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_019effb3-cbdb-7a87-b208-448990687e58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_019effb3-cbdb-7a87-b208-448990687e58" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019effb3-cbdb-77b9-aaeb-e9397e85a5a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_LongTermDebtCurrent_019effb3-cbdb-77b9-aaeb-e9397e85a5a1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities_019effb3-cbdb-7b9d-bf09-99c23e9229af" xlink:href="kvue-20260628.xsd#kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities_019effb3-cbdb-7b9d-bf09-99c23e9229af" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesCurrent_019effb3-cbdb-7634-9c3d-3690b5b26317" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_SeniorNotesCurrent_019effb3-cbdb-7634-9c3d-3690b5b26317" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaper_019effb3-cbdb-765b-896b-c975aa3c7e91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaper"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_CommercialPaper_019effb3-cbdb-765b-896b-c975aa3c7e91" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent_019effb3-cbdb-7fd1-b66c-cf07fc64562c" xlink:href="kvue-20260628.xsd#kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent_019effb3-cbdb-7fd1-b66c-cf07fc64562c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermBorrowings_019effb3-cbdb-7e1d-b610-8084e8f9c634" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_OtherShortTermBorrowings_019effb3-cbdb-7e1d-b610-8084e8f9c634" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_019effb3-cbdb-78f3-8e0c-414c1cbe3217" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtCurrent_019effb3-cbdb-78f3-8e0c-414c1cbe3217" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019effb3-cbdb-79ed-8ed8-0733c9ed0a2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019effb3-cbdb-79ed-8ed8-0733c9ed0a2c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019effb3-cbdb-74f5-a82e-1c34b1a09a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019effb3-cbdb-74f5-a82e-1c34b1a09a0b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019effb3-cbdb-7681-ac3d-532e705f6a70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019effb3-cbdb-7ddc-ae2c-faedc241da86" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019effb3-cbdb-7681-ac3d-532e705f6a70" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossComponentsofAOCIDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#AccumulatedOtherComprehensiveLossComponentsofAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossComponentsofAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-73ac-aa8f-fd01c86a1eca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-76a0-85cb-8997c96a0497" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-73ac-aa8f-fd01c86a1eca" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-76a0-85cb-8997c96a0497" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-7ab6-998f-ec014adedf57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-76a0-85cb-8997c96a0497" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-7ab6-998f-ec014adedf57" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-7ab6-998f-ec014adedf57_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-7ab6-998f-ec014adedf57" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-7ab6-998f-ec014adedf57_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-723a-bfba-3111aa4d4ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-7ab6-998f-ec014adedf57" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-723a-bfba-3111aa4d4ba6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cbdb-74a9-8c9f-cbbc78b28325" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-723a-bfba-3111aa4d4ba6" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cbdb-74a9-8c9f-cbbc78b28325" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019effb3-cbdb-73ae-bf09-a07e859445b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cbdb-74a9-8c9f-cbbc78b28325" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019effb3-cbdb-73ae-bf09-a07e859445b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019effb3-cbdb-7cb3-86d7-dea26464021f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cbdb-74a9-8c9f-cbbc78b28325" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019effb3-cbdb-7cb3-86d7-dea26464021f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019effb3-cbdb-7151-a1e8-254fc0606aee" xlink:href="kvue-20260628.xsd#kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019effb3-cbdb-74a9-8c9f-cbbc78b28325" xlink:to="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019effb3-cbdb-7151-a1e8-254fc0606aee" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-73ac-aa8f-fd01c86a1eca" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019effb3-cbdb-76c6-9d3a-d05c8f22efc9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:to="loc_us-gaap_StockholdersEquity_019effb3-cbdb-76c6-9d3a-d05c8f22efc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019effb3-cbdb-7d0f-98ab-cd663a4e46f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019effb3-cbdb-7d0f-98ab-cd663a4e46f6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019effb3-cbdb-789f-a73f-0209199b2af4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019effb3-cbdb-789f-a73f-0209199b2af4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019effb3-cbdb-7038-9be8-68c258a63b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019effb3-cbdb-73d9-8314-816a7bc5f438" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019effb3-cbdb-7038-9be8-68c258a63b0c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019effb3-cbdb-78dc-8eec-05255407337c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-7e17-befc-d3a538625110" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-7b70-b949-8518b76ae5eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-7e17-befc-d3a538625110" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-7b70-b949-8518b76ae5eb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-793b-bb0a-45f6fe1b9011" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019effb3-cbdb-7b70-b949-8518b76ae5eb" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-793b-bb0a-45f6fe1b9011" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-793b-bb0a-45f6fe1b9011_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-793b-bb0a-45f6fe1b9011" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-793b-bb0a-45f6fe1b9011_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-717c-b00b-db58d80032e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019effb3-cbdb-793b-bb0a-45f6fe1b9011" xlink:to="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-717c-b00b-db58d80032e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019effb3-cbdb-778a-a241-041817fae0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-717c-b00b-db58d80032e7" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019effb3-cbdb-778a-a241-041817fae0fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019effed-1351-75c0-9a16-370e7546406c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-717c-b00b-db58d80032e7" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019effed-1351-75c0-9a16-370e7546406c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019effb3-cbdb-77c0-a3b9-5dec0a4e4ee3" xlink:href="kvue-20260628.xsd#kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019effb3-cbdb-717c-b00b-db58d80032e7" xlink:to="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019effb3-cbdb-77c0-a3b9-5dec0a4e4ee3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_019effb3-cbdb-7fc6-93ac-80b38a040455" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019effb3-cbdb-7e17-befc-d3a538625110" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_019effb3-cbdb-7fc6-93ac-80b38a040455" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#StockBasedCompensationStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019effb3-cbdb-7909-a224-9b77d126b4ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019effb3-cbdb-7909-a224-9b77d126b4ba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7d7b-b7ea-72aa1057b247" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019effb3-cbdb-7909-a224-9b77d126b4ba" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7d7b-b7ea-72aa1057b247" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019effb3-cbdb-7ce6-903a-f91cb91fd8e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019effb3-cbdb-7ce6-903a-f91cb91fd8e3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails_1" xlink:type="simple" xlink:href="kvue-20260628.xsd#StockBasedCompensationStockBasedCompensationExpenseDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019effb3-cbdb-7909-a224-9b77d126b4ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019effb3-cbdb-7909-a224-9b77d126b4ba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019effb3-cbdb-7ce6-903a-f91cb91fd8e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019effb3-cbdb-71aa-b8bf-da5caf230773" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019effb3-cbdb-7ce6-903a-f91cb91fd8e3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7289-8f73-6a7e85b3f3d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7289-8f73-6a7e85b3f3d6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019effb3-cbdb-71ed-82aa-80fe8c329d71" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7289-8f73-6a7e85b3f3d6" xlink:to="loc_srt_CounterpartyNameAxis_019effb3-cbdb-71ed-82aa-80fe8c329d71" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-71ed-82aa-80fe8c329d71_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019effb3-cbdb-71ed-82aa-80fe8c329d71" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-71ed-82aa-80fe8c329d71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-70e5-9171-a2b392f39fb9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019effb3-cbdb-71ed-82aa-80fe8c329d71" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-70e5-9171-a2b392f39fb9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_JohnsonJohnsonMember_019effb3-cbdb-782e-973e-d0cbd6328f80" xlink:href="kvue-20260628.xsd#kvue_JohnsonJohnsonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-70e5-9171-a2b392f39fb9" xlink:to="loc_kvue_JohnsonJohnsonMember_019effb3-cbdb-782e-973e-d0cbd6328f80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019effb3-cbdb-71f2-ac7f-68db75b70693" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:to="loc_us-gaap_Liabilities_019effb3-cbdb-71f2-ac7f-68db75b70693" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019effb3-cbdb-7321-acda-ccdf8e795c21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:to="loc_us-gaap_Assets_019effb3-cbdb-7321-acda-ccdf8e795c21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019effb3-cbdb-794c-9ef2-5ab89e13a8c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019effb3-cbdb-794c-9ef2-5ab89e13a8c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements_019effb3-cbdb-73f3-bfe1-bc35da39f2af" xlink:href="kvue-20260628.xsd#kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7b8f-a82b-a184f5b13ca8" xlink:to="loc_kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements_019effb3-cbdb-73f3-bfe1-bc35da39f2af" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RelationshipwithJJNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RelationshipwithJJNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RelationshipwithJJNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7690-af96-4739edbb05ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7c22-9e81-b2ac8671182a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7690-af96-4739edbb05ae" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7c22-9e81-b2ac8671182a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019effb3-cbdb-7282-bcd4-81b2342c7247" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019effb3-cbdb-7c22-9e81-b2ac8671182a" xlink:to="loc_srt_CounterpartyNameAxis_019effb3-cbdb-7282-bcd4-81b2342c7247" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-7282-bcd4-81b2342c7247_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019effb3-cbdb-7282-bcd4-81b2342c7247" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-7282-bcd4-81b2342c7247_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-7a8a-9215-979c322ee9ba" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019effb3-cbdb-7282-bcd4-81b2342c7247" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-7a8a-9215-979c322ee9ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_JohnsonJohnsonMember_019effb3-cbdb-7230-8fe7-ea7a248d4e12" xlink:href="kvue-20260628.xsd#kvue_JohnsonJohnsonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019effb3-cbdb-7a8a-9215-979c322ee9ba" xlink:to="loc_kvue_JohnsonJohnsonMember_019effb3-cbdb-7230-8fe7-ea7a248d4e12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_TransitionServicesAgreementServicesExited_019effb3-cbdb-7007-8c8d-44bac287ea6d" xlink:href="kvue-20260628.xsd#kvue_TransitionServicesAgreementServicesExited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019effb3-cbdb-7690-af96-4739edbb05ae" xlink:to="loc_kvue_TransitionServicesAgreementServicesExited_019effb3-cbdb-7007-8c8d-44bac287ea6d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-784d-a88f-561f68ccc434" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-784d-a88f-561f68ccc434" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-751e-990b-9c94c0d2837e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-751e-990b-9c94c0d2837e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-729b-8e85-129448c5a8e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-729b-8e85-129448c5a8e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019effb3-cbdb-71c1-b8b7-1ecc71340c0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019effb3-cbdb-71c1-b8b7-1ecc71340c0a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019effb3-cbdb-73ba-86d3-36c58175fc51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019effb3-cbdb-73ba-86d3-36c58175fc51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019effb3-cbdb-7024-8deb-1e6770badff0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019effb3-cbdb-7024-8deb-1e6770badff0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019effb3-cbdb-7909-be26-99176595cbd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019effb3-cbdb-7909-be26-99176595cbd1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentDetailAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:to="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019effb3-cbdb-7d3b-92db-6a16a5710012" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019effb3-cbdb-7d3b-92db-6a16a5710012" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019effb3-cbdb-731b-9bff-0e97dd4347a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019effb3-cbdb-731b-9bff-0e97dd4347a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7518-8ebc-b8be91ba223b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7518-8ebc-b8be91ba223b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7e52-a5ad-14fefa0bbaf1" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-784d-a88f-561f68ccc434" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-784d-a88f-561f68ccc434" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-751e-990b-9c94c0d2837e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7c95-9b76-e3d459394d17" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-751e-990b-9c94c0d2837e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019effb3-cbdb-71ff-a405-6df115944d2d" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-729b-8e85-129448c5a8e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-729b-8e85-129448c5a8e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019effb3-cbdb-729b-8e85-129448c5a8e2" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019effb3-cbdb-71c1-b8b7-1ecc71340c0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019effb3-cbdb-71c1-b8b7-1ecc71340c0a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019effb3-cbdb-73ba-86d3-36c58175fc51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019effb3-cbdb-73ba-86d3-36c58175fc51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019effb3-cbdb-7024-8deb-1e6770badff0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019effb3-cbdb-7d0d-8639-920b1879d784" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019effb3-cbdb-7024-8deb-1e6770badff0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentDetailAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019effb3-cbdb-754f-b956-a7ecebcc9ad0" xlink:to="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019effb3-cbdb-7d3b-92db-6a16a5710012" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019effb3-cbdb-7d3b-92db-6a16a5710012" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019effb3-cbdb-731b-9bff-0e97dd4347a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019effb3-cbdb-731b-9bff-0e97dd4347a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7518-8ebc-b8be91ba223b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019effb3-cbdb-7fa1-9e18-8bfa4c66ae4e" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7518-8ebc-b8be91ba223b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-724b-82cf-91dd96a531a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-724b-82cf-91dd96a531a4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-71f0-a442-77bb82e52099" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-724b-82cf-91dd96a531a4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-71f0-a442-77bb82e52099" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-71f0-a442-77bb82e52099_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-71f0-a442-77bb82e52099" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-71f0-a442-77bb82e52099_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7dde-bb99-bbab1e022976" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-71f0-a442-77bb82e52099" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7dde-bb99-bbab1e022976" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-7f5f-b20d-fc018498cb8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7dde-bb99-bbab1e022976" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-7f5f-b20d-fc018498cb8d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019effb3-cbdb-727a-9269-d145aae78423" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-724b-82cf-91dd96a531a4" xlink:to="loc_srt_RangeAxis_019effb3-cbdb-727a-9269-d145aae78423" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019effb3-cbdb-727a-9269-d145aae78423_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019effb3-cbdb-727a-9269-d145aae78423" xlink:to="loc_srt_RangeMember_019effb3-cbdb-727a-9269-d145aae78423_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019effb3-cbdb-7291-9bb5-f33ef11c12b1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019effb3-cbdb-727a-9269-d145aae78423" xlink:to="loc_srt_RangeMember_019effb3-cbdb-7291-9bb5-f33ef11c12b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019effb3-cbdb-7c5f-bf98-a4b0116dc1fd" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019effb3-cbdb-7291-9bb5-f33ef11c12b1" xlink:to="loc_srt_MinimumMember_019effb3-cbdb-7c5f-bf98-a4b0116dc1fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019effb3-cbdb-71f3-a20a-3f1a07e8efcf" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019effb3-cbdb-7291-9bb5-f33ef11c12b1" xlink:to="loc_srt_MaximumMember_019effb3-cbdb-71f3-a20a-3f1a07e8efcf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-7eec-85d9-1abd1b3d8d54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-724b-82cf-91dd96a531a4" xlink:to="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-7eec-85d9-1abd1b3d8d54" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7eec-85d9-1abd1b3d8d54_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-7eec-85d9-1abd1b3d8d54" xlink:to="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7eec-85d9-1abd1b3d8d54_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7b85-b843-a12f552ee2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-7eec-85d9-1abd1b3d8d54" xlink:to="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7b85-b843-a12f552ee2b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_019effb3-cbdb-7c32-9e7a-8bfb429fffd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7b85-b843-a12f552ee2b5" xlink:to="loc_us-gaap_NondesignatedMember_019effb3-cbdb-7c32-9e7a-8bfb429fffd3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019effb3-cbdb-77eb-a92c-b909c5867a00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_019effb3-cbdb-77eb-a92c-b909c5867a00" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019effb3-cbdb-7a86-a73a-87ba27d05a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019effb3-cbdb-7a86-a73a-87ba27d05a8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_019effb3-cbdb-77aa-aa95-abeea08cedc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:to="loc_us-gaap_DerivativeTermOfContract_019effb3-cbdb-77aa-aa95-abeea08cedc4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7c88-a6be-41d68a82f783" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-78e9-9f0c-0fb64fa43486" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019effb3-cbdb-7c88-a6be-41d68a82f783" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsNotionalAmountDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsNotionalAmountDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsNotionalAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-776b-ba98-c0ebf587a571" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-7591-9403-d8886d4ecacf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-776b-ba98-c0ebf587a571" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-7591-9403-d8886d4ecacf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-775c-9b0b-20984d73433c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-7591-9403-d8886d4ecacf" xlink:to="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-775c-9b0b-20984d73433c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-775c-9b0b-20984d73433c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-775c-9b0b-20984d73433c" xlink:to="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-775c-9b0b-20984d73433c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7ddf-a1b1-867671107f09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_019effb3-cbdb-775c-9b0b-20984d73433c" xlink:to="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7ddf-a1b1-867671107f09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019effb3-cbdb-7ad3-88d1-96d14ab37c84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7ddf-a1b1-867671107f09" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019effb3-cbdb-7ad3-88d1-96d14ab37c84" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_019effb3-cbdb-7966-8af7-0b0083d3e3cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019effb3-cbdb-7ddf-a1b1-867671107f09" xlink:to="loc_us-gaap_NondesignatedMember_019effb3-cbdb-7966-8af7-0b0083d3e3cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-7591-9403-d8886d4ecacf" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-75af-8318-0de5f23f0c59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019effb3-cbdb-7ed2-a4c6-d2d2c03ca493" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-75af-8318-0de5f23f0c59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_019effb3-cbdb-7532-a561-8496e54a6075" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-75af-8318-0de5f23f0c59" xlink:to="loc_us-gaap_CashFlowHedgingMember_019effb3-cbdb-7532-a561-8496e54a6075" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_019effb3-cbdb-7c92-80b9-1529be911fb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-75af-8318-0de5f23f0c59" xlink:to="loc_us-gaap_FairValueHedgingMember_019effb3-cbdb-7c92-80b9-1529be911fb3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_019effb3-cbdb-7dd1-adca-f9930f3f78a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019effb3-cbdb-75af-8318-0de5f23f0c59" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_019effb3-cbdb-7dd1-adca-f9930f3f78a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7644-8fb8-55d7662dce2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-7591-9403-d8886d4ecacf" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7644-8fb8-55d7662dce2e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7644-8fb8-55d7662dce2e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7644-8fb8-55d7662dce2e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7644-8fb8-55d7662dce2e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-75a8-87c8-6ec475f9a939" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7644-8fb8-55d7662dce2e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-75a8-87c8-6ec475f9a939" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-7a7a-b6e8-3f7d09130324" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-75a8-87c8-6ec475f9a939" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019effb3-cbdb-7a7a-b6e8-3f7d09130324" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-7ade-a93b-960b0929c67b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-75a8-87c8-6ec475f9a939" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019effb3-cbdb-7ade-a93b-960b0929c67b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_019effb3-cbdb-73b5-ad22-9305d8f46b5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-776b-ba98-c0ebf587a571" xlink:to="loc_us-gaap_DerivativeNotionalAmount_019effb3-cbdb-73b5-ad22-9305d8f46b5e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7e33-8128-156ff2432f6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7e33-8128-156ff2432f6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7df7-9bbd-a76a02207cd3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7df7-9bbd-a76a02207cd3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019effb3-cbdb-7e9b-8f26-21e5bb4669d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019effb3-cbdb-7e9b-8f26-21e5bb4669d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7bbb-8d39-e31f27566a31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7bbb-8d39-e31f27566a31" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019effb3-cbdb-74d8-901f-c7e8068dfed7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019effb3-cbdb-74d8-901f-c7e8068dfed7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-708d-a6c9-150422567cef" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7df7-9bbd-a76a02207cd3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7df7-9bbd-a76a02207cd3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7df7-9bbd-a76a02207cd3" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019effb3-cbdb-7e9b-8f26-21e5bb4669d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7168-a087-eaf35ce4b895" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019effb3-cbdb-7e9b-8f26-21e5bb4669d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7bbb-8d39-e31f27566a31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7bbb-8d39-e31f27566a31" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019effb3-cbdb-74d8-901f-c7e8068dfed7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-76e4-854f-e8ed4f450a30" xlink:to="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019effb3-cbdb-74d8-901f-c7e8068dfed7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019effb3-cbdb-721a-98ae-56f3e701f762" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019effb3-cbdb-7ed1-a241-615acb15bfee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019effb3-cbdb-721a-98ae-56f3e701f762" xlink:to="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019effb3-cbdb-7ed1-a241-615acb15bfee" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7fe5-91c3-5e92a5431116" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019effb3-cbdb-7ed1-a241-615acb15bfee" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7fe5-91c3-5e92a5431116" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7fe5-91c3-5e92a5431116_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7fe5-91c3-5e92a5431116" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7fe5-91c3-5e92a5431116_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7cbf-b3f9-dfb6fcba95c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019effb3-cbdb-7fe5-91c3-5e92a5431116" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7cbf-b3f9-dfb6fcba95c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrencySwapMember_019effb3-cbdb-734c-80e6-50606b584959" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CurrencySwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019effb3-cbdb-7cbf-b3f9-dfb6fcba95c1" xlink:to="loc_us-gaap_CurrencySwapMember_019effb3-cbdb-734c-80e6-50606b584959" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7f5b-9bd3-033acf85331b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019effb3-cbdb-721a-98ae-56f3e701f762" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019effb3-cbdb-7f5b-9bd3-033acf85331b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsActivityDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-7d94-81e0-d62fac90e967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-7d94-81e0-d62fac90e967" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7424-9141-6c6b733ffd72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019effb3-cbdb-7d94-81e0-d62fac90e967" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019effb3-cbdb-7424-9141-6c6b733ffd72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019effb3-cbdb-7bd3-b4a1-17c753e512a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019effb3-cbdb-7bd3-b4a1-17c753e512a7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails_1" xlink:type="simple" xlink:href="kvue-20260628.xsd#FairValueMeasurementsActivityDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019effb3-cbdb-7d94-81e0-d62fac90e967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:to="loc_us-gaap_DerivativeTable_019effb3-cbdb-7d94-81e0-d62fac90e967" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019effb3-cbdb-7bd3-b4a1-17c753e512a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019effb3-cbdb-75e4-987d-f2c5bfa9bad9" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019effb3-cbdb-7bd3-b4a1-17c753e512a7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7a83-9bfd-5718f1220ce1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7a83-9bfd-5718f1220ce1" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_019effb3-cbdb-7b68-b261-ebfa5a6da92c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_019effb3-cbdb-7b68-b261-ebfa5a6da92c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019effb3-cbdb-7b68-b261-ebfa5a6da92c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019effb3-cbdb-7b68-b261-ebfa5a6da92c" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019effb3-cbdb-7b68-b261-ebfa5a6da92c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019effb3-cbdb-7d9b-8dcd-d395efdeafaf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019effb3-cbdb-7b68-b261-ebfa5a6da92c" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019effb3-cbdb-7d9b-8dcd-d395efdeafaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductConcentrationRiskMember_019effb3-cbdb-7596-a83c-a3b53c78563a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_019effb3-cbdb-7d9b-8dcd-d395efdeafaf" xlink:to="loc_us-gaap_ProductConcentrationRiskMember_019effb3-cbdb-7596-a83c-a3b53c78563a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019effb3-cbdb-7c28-ba8f-25779c1cb3d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019effb3-cbdb-7c28-ba8f-25779c1cb3d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019effb3-cbdb-7c28-ba8f-25779c1cb3d8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019effb3-cbdb-7c28-ba8f-25779c1cb3d8" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019effb3-cbdb-7c28-ba8f-25779c1cb3d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019effb3-cbdb-7982-b3b2-a834fd125e98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019effb3-cbdb-7c28-ba8f-25779c1cb3d8" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019effb3-cbdb-7982-b3b2-a834fd125e98" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_019effb3-cbdb-769c-817b-582f20fab599" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019effb3-cbdb-7982-b3b2-a834fd125e98" xlink:to="loc_us-gaap_SalesRevenueNetMember_019effb3-cbdb-769c-817b-582f20fab599" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019effb3-cbdb-7649-9261-995d2cc4e0df" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:to="loc_srt_ProductOrServiceAxis_019effb3-cbdb-7649-9261-995d2cc4e0df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7649-9261-995d2cc4e0df_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019effb3-cbdb-7649-9261-995d2cc4e0df" xlink:to="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7649-9261-995d2cc4e0df_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019effb3-cbdb-7649-9261-995d2cc4e0df" xlink:to="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_CoughColdAndAllergyMember_019effb3-cbdb-77a2-9747-013728939e99" xlink:href="kvue-20260628.xsd#kvue_CoughColdAndAllergyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_CoughColdAndAllergyMember_019effb3-cbdb-77a2-9747-013728939e99" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PainCareMember_019effb3-cbdb-71ec-8dfa-c67522ac5da3" xlink:href="kvue-20260628.xsd#kvue_PainCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_PainCareMember_019effb3-cbdb-71ec-8dfa-c67522ac5da3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OtherSelfCareMember_019effb3-cbdb-756f-b1a5-d8e91018f865" xlink:href="kvue-20260628.xsd#kvue_OtherSelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_OtherSelfCareMember_019effb3-cbdb-756f-b1a5-d8e91018f865" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FaceAndBodyCareMember_019effb3-cbdb-77c2-8e7f-2532e943b8c1" xlink:href="kvue-20260628.xsd#kvue_FaceAndBodyCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_FaceAndBodyCareMember_019effb3-cbdb-77c2-8e7f-2532e943b8c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_HairSunAndOtherMember_019effb3-cbdb-7fde-8079-b9c4d9847ae2" xlink:href="kvue-20260628.xsd#kvue_HairSunAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_HairSunAndOtherMember_019effb3-cbdb-7fde-8079-b9c4d9847ae2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OralCareMember_019effb3-cbdb-79d1-959b-b092f6aad202" xlink:href="kvue-20260628.xsd#kvue_OralCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_OralCareMember_019effb3-cbdb-79d1-959b-b092f6aad202" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BabyCareMember_019effb3-cbdb-7eff-bfa0-82451dc06e33" xlink:href="kvue-20260628.xsd#kvue_BabyCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_BabyCareMember_019effb3-cbdb-7eff-bfa0-82451dc06e33" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OtherEssentialHealthMember_019effb3-cbdb-71dc-a7ee-05ccab42155a" xlink:href="kvue-20260628.xsd#kvue_OtherEssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019effb3-cbdb-7208-a81b-91a8e2c22959" xlink:to="loc_kvue_OtherEssentialHealthMember_019effb3-cbdb-71dc-a7ee-05ccab42155a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-73b7-91de-3def543d7aad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-775f-9719-cb07d443266f" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-73b7-91de-3def543d7aad" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-73b7-91de-3def543d7aad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-73b7-91de-3def543d7aad" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-73b7-91de-3def543d7aad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-7c18-8b77-27dfb3e96af4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-73b7-91de-3def543d7aad" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-7c18-8b77-27dfb3e96af4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019effb3-cbdb-7c83-9e45-17dee5bf31af" xlink:href="kvue-20260628.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7c18-8b77-27dfb3e96af4" xlink:to="loc_kvue_SelfCareMember_019effb3-cbdb-7c83-9e45-17dee5bf31af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-708e-b9d9-0d3a4b6585ef" xlink:href="kvue-20260628.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7c18-8b77-27dfb3e96af4" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-708e-b9d9-0d3a4b6585ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019effb3-cbdb-78ba-9cbb-41b90ce650d2" xlink:href="kvue-20260628.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7c18-8b77-27dfb3e96af4" xlink:to="loc_kvue_EssentialHealthMember_019effb3-cbdb-78ba-9cbb-41b90ce650d2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_019effb3-cbdb-7531-989e-2b1af770f386" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7a83-9bfd-5718f1220ce1" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_019effb3-cbdb-7531-989e-2b1af770f386" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessSegmentNetSalesDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#SegmentsofBusinessSegmentNetSalesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessSegmentNetSalesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7e4a-80ad-9dee2490d82b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-76fc-a2b3-a3b2183955dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7e4a-80ad-9dee2490d82b" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-76fc-a2b3-a3b2183955dd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-70ad-9bb4-bda20b7bba25" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-76fc-a2b3-a3b2183955dd" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-70ad-9bb4-bda20b7bba25" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-70ad-9bb4-bda20b7bba25_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-70ad-9bb4-bda20b7bba25" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-70ad-9bb4-bda20b7bba25_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-77a8-97e4-dd0186dbedff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-70ad-9bb4-bda20b7bba25" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-77a8-97e4-dd0186dbedff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019effb3-cbdb-7cb5-9d6f-f6f523dba280" xlink:href="kvue-20260628.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-77a8-97e4-dd0186dbedff" xlink:to="loc_kvue_SelfCareMember_019effb3-cbdb-7cb5-9d6f-f6f523dba280" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-73cd-bdd5-5a5471da8d45" xlink:href="kvue-20260628.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-77a8-97e4-dd0186dbedff" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-73cd-bdd5-5a5471da8d45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019effb3-cbdb-79ee-b5ed-fcae88f8e5d8" xlink:href="kvue-20260628.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-77a8-97e4-dd0186dbedff" xlink:to="loc_kvue_EssentialHealthMember_019effb3-cbdb-79ee-b5ed-fcae88f8e5d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_019effb3-cbdb-73b2-93f3-108b9d47ef09" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-76fc-a2b3-a3b2183955dd" xlink:to="loc_srt_ConsolidationItemsAxis_019effb3-cbdb-73b2-93f3-108b9d47ef09" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019effb3-cbdb-73b2-93f3-108b9d47ef09_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_019effb3-cbdb-73b2-93f3-108b9d47ef09" xlink:to="loc_srt_ConsolidationItemsDomain_019effb3-cbdb-73b2-93f3-108b9d47ef09_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019effb3-cbdb-7a72-ba92-ea1cfb553f1f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_019effb3-cbdb-73b2-93f3-108b9d47ef09" xlink:to="loc_srt_ConsolidationItemsDomain_019effb3-cbdb-7a72-ba92-ea1cfb553f1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_019effb3-cbdb-757a-bff8-431e2e76b165" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019effb3-cbdb-7a72-ba92-ea1cfb553f1f" xlink:to="loc_us-gaap_OperatingSegmentsMember_019effb3-cbdb-757a-bff8-431e2e76b165" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationRevenueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7e4a-80ad-9dee2490d82b" xlink:to="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019effb3-cbdb-72d8-a397-cfaa504a9a7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019effb3-cbdb-72d8-a397-cfaa504a9a7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_CostOfGoodsAndServicesSoldAdjusted_019effb3-cbdb-78b7-b815-3f63f422d439" xlink:href="kvue-20260628.xsd#kvue_CostOfGoodsAndServicesSoldAdjusted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_CostOfGoodsAndServicesSoldAdjusted_019effb3-cbdb-78b7-b815-3f63f422d439" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019effb3-cbdb-7ea0-9927-e86d1bb514fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019effb3-cbdb-7ea0-9927-e86d1bb514fc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AdjustedOperatingIncome_019effb3-cbdb-7f77-8ffa-5fbe69620f6a" xlink:href="kvue-20260628.xsd#kvue_AdjustedOperatingIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_AdjustedOperatingIncome_019effb3-cbdb-7f77-8ffa-5fbe69620f6a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019effb3-cbdb-7c37-b3fc-dec1216b69f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_Depreciation_019effb3-cbdb-7c37-b3fc-dec1216b69f6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019effb3-cbdb-74d0-8a07-4b4f1e1ef905" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019effb3-cbdb-74d0-8a07-4b4f1e1ef905" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SeparationRelatedCosts_019effb3-cbdb-7612-a6e2-c23ffad884aa" xlink:href="kvue-20260628.xsd#kvue_SeparationRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_SeparationRelatedCosts_019effb3-cbdb-7612-a6e2-c23ffad884aa" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringAndOperatingModelOptimizationInitiatives_019effb3-cbdb-7a48-86dc-26b9998de3ad" xlink:href="kvue-20260628.xsd#kvue_RestructuringAndOperatingModelOptimizationInitiatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_RestructuringAndOperatingModelOptimizationInitiatives_019effb3-cbdb-7a48-86dc-26b9998de3ad" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_IncomeFromConversionOfShareBasedAwards_019effb3-cbdb-7012-af34-d04c1b0c979c" xlink:href="kvue-20260628.xsd#kvue_IncomeFromConversionOfShareBasedAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_IncomeFromConversionOfShareBasedAwards_019effb3-cbdb-7012-af34-d04c1b0c979c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FoundersShareBasedAwardsExpense_019effb3-cbdb-79b8-959c-e6529a6cfa3d" xlink:href="kvue-20260628.xsd#kvue_FoundersShareBasedAwardsExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_FoundersShareBasedAwardsExpense_019effb3-cbdb-79b8-959c-e6529a6cfa3d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PendingTransactionAndOtherRelatedCosts_019effb3-cbdb-784b-8dc7-27c3cdeada6f" xlink:href="kvue-20260628.xsd#kvue_PendingTransactionAndOtherRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_PendingTransactionAndOtherRelatedCosts_019effb3-cbdb-784b-8dc7-27c3cdeada6f" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SaleAndLeasebackTransactionRelatedExpense_019effb3-cbdb-7738-8846-7e65f3914760" xlink:href="kvue-20260628.xsd#kvue_SaleAndLeasebackTransactionRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_kvue_SaleAndLeasebackTransactionRelatedExpense_019effb3-cbdb-7738-8846-7e65f3914760" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_019effb3-cbdb-7e07-b486-3219d7c020a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_019effb3-cbdb-7e07-b486-3219d7c020a1" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherGeneralExpense_019effb3-cbdb-7724-8df1-832ed659d179" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherGeneralExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_OtherGeneralExpense_019effb3-cbdb-7724-8df1-832ed659d179" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019effb3-cbdb-715c-acdb-ee13470bf740" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_OperatingIncomeLoss_019effb3-cbdb-715c-acdb-ee13470bf740" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019effb3-cbdb-7d72-bcd6-8df2128fcadb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019effb3-cbdb-7d72-bcd6-8df2128fcadb" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019effb3-cbdb-735a-aae5-38633e94de35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019effb3-cbdb-735a-aae5-38633e94de35" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019effb3-cbdb-70fe-b834-eef3a2f500ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019effb3-cbdb-761d-8006-a2cf3bb12732" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019effb3-cbdb-70fe-b834-eef3a2f500ac" xlink:type="arc" order="18"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessDepreciationandAmortizationbySegmentDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#SegmentsofBusinessDepreciationandAmortizationbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessDepreciationandAmortizationbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7f97-96a6-381291b5f535" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-758a-8944-c4e6d52922d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7f97-96a6-381291b5f535" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-758a-8944-c4e6d52922d3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-744f-8004-787346bfb409" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019effb3-cbdb-758a-8944-c4e6d52922d3" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-744f-8004-787346bfb409" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-744f-8004-787346bfb409_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-744f-8004-787346bfb409" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-744f-8004-787346bfb409_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019effb3-cbdb-7a3e-8104-ab6c37eb57e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019effb3-cbdb-744f-8004-787346bfb409" xlink:to="loc_us-gaap_SegmentDomain_019effb3-cbdb-7a3e-8104-ab6c37eb57e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019effb3-cbdb-7453-b54c-812540969cb6" xlink:href="kvue-20260628.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7a3e-8104-ab6c37eb57e4" xlink:to="loc_kvue_SelfCareMember_019effb3-cbdb-7453-b54c-812540969cb6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-7a5b-a28e-f4c49bb4e3c6" xlink:href="kvue-20260628.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7a3e-8104-ab6c37eb57e4" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019effb3-cbdb-7a5b-a28e-f4c49bb4e3c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019effb3-cbdb-7dca-89f4-f29e71365116" xlink:href="kvue-20260628.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019effb3-cbdb-7a3e-8104-ab6c37eb57e4" xlink:to="loc_kvue_EssentialHealthMember_019effb3-cbdb-7dca-89f4-f29e71365116" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_DepreciationDepletionAndAmortizationAdjusted_019fb9e0-5e40-7ffa-a182-b1519acc8b1f" xlink:href="kvue-20260628.xsd#kvue_DepreciationDepletionAndAmortizationAdjusted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019effb3-cbdb-7f97-96a6-381291b5f535" xlink:to="loc_kvue_DepreciationDepletionAndAmortizationAdjusted_019fb9e0-5e40-7ffa-a182-b1519acc8b1f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7046-b3aa-d6952b6ff814" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-701f-83c9-06e3da72f1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7046-b3aa-d6952b6ff814" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-701f-83c9-06e3da72f1d4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-737e-9466-d58552f62bef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-701f-83c9-06e3da72f1d4" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-737e-9466-d58552f62bef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-737e-9466-d58552f62bef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-737e-9466-d58552f62bef" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-737e-9466-d58552f62bef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7bfe-a522-6d6abdab6845" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-737e-9466-d58552f62bef" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7bfe-a522-6d6abdab6845" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019effb3-cbdb-7ae1-910f-d71036f7b83d" xlink:href="kvue-20260628.xsd#kvue_InformationTechnologyAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7bfe-a522-6d6abdab6845" xlink:to="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019effb3-cbdb-7ae1-910f-d71036f7b83d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-7f0b-8f95-0dc055a32086" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7bfe-a522-6d6abdab6845" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-7f0b-8f95-0dc055a32086" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_019effb3-cbdb-7233-ac77-c88b314f9de7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7bfe-a522-6d6abdab6845" xlink:to="loc_us-gaap_OtherRestructuringMember_019effb3-cbdb-7233-ac77-c88b314f9de7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-701f-83c9-06e3da72f1d4" xlink:to="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7e4d-8519-1b226af0607e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7f1e-81b5-6e06d83b0e5e" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7e4d-8519-1b226af0607e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019effb3-cbdb-7f65-9328-17bc4524d33e" xlink:href="kvue-20260628.xsd#kvue_A2024MultiYearRestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7e4d-8519-1b226af0607e" xlink:to="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019effb3-cbdb-7f65-9328-17bc4524d33e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-79f8-8129-857f1a4801f4" xlink:href="kvue-20260628.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7e4d-8519-1b226af0607e" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-79f8-8129-857f1a4801f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019effb3-cbdb-7924-9f7c-5c5bd9130f97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostCostIncurredToDate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7046-b3aa-d6952b6ff814" xlink:to="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019effb3-cbdb-7924-9f7c-5c5bd9130f97" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019effb3-cbdb-7779-acfe-978b7507554b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostExpectedCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7046-b3aa-d6952b6ff814" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019effb3-cbdb-7779-acfe-978b7507554b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringAndRelatedCostExpectedCostPercent_019effb3-cbdb-7852-845a-ee494ee7f4b5" xlink:href="kvue-20260628.xsd#kvue_RestructuringAndRelatedCostExpectedCostPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7046-b3aa-d6952b6ff814" xlink:to="loc_kvue_RestructuringAndRelatedCostExpectedCostPercent_019effb3-cbdb-7852-845a-ee494ee7f4b5" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7dee-b29a-fc5991213ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7dee-b29a-fc5991213ac6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7fe8-8515-f24ffc6b21ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7dee-b29a-fc5991213ac6" xlink:to="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7fe8-8515-f24ffc6b21ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7fe8-8515-f24ffc6b21ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7fe8-8515-f24ffc6b21ef" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7fe8-8515-f24ffc6b21ef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7789-93d0-ca1739b5713f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-7fe8-8515-f24ffc6b21ef" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7789-93d0-ca1739b5713f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019effb3-cbdb-711b-96b9-111c4c30180f" xlink:href="kvue-20260628.xsd#kvue_A2024MultiYearRestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7789-93d0-ca1739b5713f" xlink:to="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019effb3-cbdb-711b-96b9-111c4c30180f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-787a-bf89-48693234ea40" xlink:href="kvue-20260628.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7789-93d0-ca1739b5713f" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-787a-bf89-48693234ea40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019effb3-cbdb-7c97-a34a-726e08e266ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:to="loc_us-gaap_RestructuringCharges_019effb3-cbdb-7c97-a34a-726e08e266ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019effb3-cbdb-74c2-8a31-03c28ef7bb53" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019effb3-cbdb-74c2-8a31-03c28ef7bb53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019effb3-cbdb-7239-b1db-9a5fda8ca922" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019effb3-cbdb-7239-b1db-9a5fda8ca922" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-7ac1-a066-5329a88f4aec" xlink:href="kvue-20260628.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7fd6-8549-23fef17db36a" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-7ac1-a066-5329a88f4aec" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-791d-9897-69e8b3d18e11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7cac-8d0a-43ebac3e7194" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-791d-9897-69e8b3d18e11" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7cac-8d0a-43ebac3e7194" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-72ae-ac9b-49a04bdaacf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7cac-8d0a-43ebac3e7194" xlink:to="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-72ae-ac9b-49a04bdaacf1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-72ae-ac9b-49a04bdaacf1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-72ae-ac9b-49a04bdaacf1" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-72ae-ac9b-49a04bdaacf1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7a71-98c0-dbcb59be9d6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-72ae-ac9b-49a04bdaacf1" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7a71-98c0-dbcb59be9d6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-7180-a6af-f86687882fea" xlink:href="kvue-20260628.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7a71-98c0-dbcb59be9d6a" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-7180-a6af-f86687882fea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-7230-815f-18dbe8bd90eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-7cac-8d0a-43ebac3e7194" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-7230-815f-18dbe8bd90eb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7230-815f-18dbe8bd90eb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-7230-815f-18dbe8bd90eb" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7230-815f-18dbe8bd90eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7f63-ab20-8ac04d9ce88a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-7230-815f-18dbe8bd90eb" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7f63-ab20-8ac04d9ce88a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-7bbe-8400-6e5f588b31c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7f63-ab20-8ac04d9ce88a" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-7bbe-8400-6e5f588b31c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ITAndProjectRelatedCostsMember_019effb3-cbdb-7290-b48b-3b032a75d544" xlink:href="kvue-20260628.xsd#kvue_ITAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7f63-ab20-8ac04d9ce88a" xlink:to="loc_kvue_ITAndProjectRelatedCostsMember_019effb3-cbdb-7290-b48b-3b032a75d544" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_019effe2-4be4-7b1d-883d-8ef27550374e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7f63-ab20-8ac04d9ce88a" xlink:to="loc_us-gaap_OtherRestructuringMember_019effe2-4be4-7b1d-883d-8ef27550374e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-708e-b9b2-779b50978c52" xlink:href="kvue-20260628.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-791d-9897-69e8b3d18e11" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-708e-b9b2-779b50978c52" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019effb3-cbdb-7cb0-9b2c-7de432c9b0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostCostIncurredToDate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-791d-9897-69e8b3d18e11" xlink:to="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019effb3-cbdb-7cb0-9b2c-7de432c9b0dc" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails" xlink:type="simple" xlink:href="kvue-20260628.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7145-802d-1efb81572605" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-74f8-bdbc-b79219371edc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7145-802d-1efb81572605" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-74f8-bdbc-b79219371edc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-756e-9d8d-ce2f620746b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-74f8-bdbc-b79219371edc" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-756e-9d8d-ce2f620746b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-756e-9d8d-ce2f620746b3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-756e-9d8d-ce2f620746b3" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-756e-9d8d-ce2f620746b3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7c6a-8e8e-f8c2864b7f96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019effb3-cbdb-756e-9d8d-ce2f620746b3" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7c6a-8e8e-f8c2864b7f96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-74fb-99b3-062233dfe11b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7c6a-8e8e-f8c2864b7f96" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019effb3-cbdb-74fb-99b3-062233dfe11b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019effb3-cbdb-7f64-8489-2ec0cae5a68e" xlink:href="kvue-20260628.xsd#kvue_InformationTechnologyAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019effb3-cbdb-7c6a-8e8e-f8c2864b7f96" xlink:to="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019effb3-cbdb-7f64-8489-2ec0cae5a68e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-754e-81db-5d294c2f371c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019effb3-cbdb-74f8-bdbc-b79219371edc" xlink:to="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-754e-81db-5d294c2f371c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-754e-81db-5d294c2f371c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-754e-81db-5d294c2f371c" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-754e-81db-5d294c2f371c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7214-a4ec-4e93363651ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019effb3-cbdb-754e-81db-5d294c2f371c" xlink:to="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7214-a4ec-4e93363651ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-7e1c-b6ce-cdbdfbf68bb4" xlink:href="kvue-20260628.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019effb3-cbdb-7214-a4ec-4e93363651ad" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019effb3-cbdb-7e1c-b6ce-cdbdfbf68bb4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019effb3-cbdb-7145-802d-1efb81572605" xlink:to="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019effb3-cbdb-7572-99f2-26250b3893d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:to="loc_us-gaap_RestructuringReserve_019effb3-cbdb-7572-99f2-26250b3893d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-7217-8865-84098a13bd97" xlink:href="kvue-20260628.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019effb3-cbdb-7217-8865-84098a13bd97" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_019effb3-cbdb-79bd-844c-ede9dcfdbd71" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:to="loc_us-gaap_PaymentsForRestructuring_019effb3-cbdb-79bd-844c-ede9dcfdbd71" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveSettledWithoutCash2_019efff6-b820-7e02-b217-62f007ca0f46" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveSettledWithoutCash2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019effb3-cbdb-783d-b9a7-98ec77f3c11a" xlink:to="loc_us-gaap_RestructuringReserveSettledWithoutCash2_019efff6-b820-7e02-b217-62f007ca0f46" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019effb3-cbdb-701f-8057-7d41ed9180e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
  </link:definitionLink>
</link:linkbase>
