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  <xs:element id="toi_AccruedSubCapitationCurrent" abstract="false" name="AccruedSubCapitationCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_NumberOfInstalmentsPayable" abstract="false" name="NumberOfInstalmentsPayable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_LesseeOperatingLeaseNumberOfLeasesExtended" abstract="false" name="LesseeOperatingLeaseNumberOfLeasesExtended" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_LesseeOperatingLeaseIncreaseInLiabilityAndRightOfUseAsset" abstract="false" name="LesseeOperatingLeaseIncreaseInLiabilityAndRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_LesseeOperatingLeaseLiabilityToBePaidThereafter" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidThereafter" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_FinanceLeaseLiabilityToBePaidThereafter" abstract="false" name="FinanceLeaseLiabilityToBePaidThereafter" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_WeightedAverageRemainingLeaseTermAbstract" abstract="true" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="toi_WeightedAverageDiscountRateAbstract" abstract="true" name="WeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="toi_CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" abstract="true" name="CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="toi_RepaymentsForFinanceLease" abstract="false" name="RepaymentsForFinanceLease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNet" abstract="false" name="RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_FacilityAgreementMember" abstract="true" name="FacilityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ConvertibleNoteWarrantMember" abstract="true" name="ConvertibleNoteWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_OptionalRedemptionMember" abstract="true" name="OptionalRedemptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_EmbeddedConversionOptionFeatureMember" abstract="true" name="EmbeddedConversionOptionFeatureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ExchangeAgreementUnitsWithoutWarrantsMember" abstract="true" name="ExchangeAgreementUnitsWithoutWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_CertainConvertibleDebtLendersMember" abstract="true" name="CertainConvertibleDebtLendersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_CommonWarrantsMember" abstract="true" name="CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_DebtInstrumentCovenantMinimumNetQuarterlyRevenues" abstract="false" name="DebtInstrumentCovenantMinimumNetQuarterlyRevenues" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_DebtInstrumentCovenantMinimumCashThresholdRemoval" abstract="false" name="DebtInstrumentCovenantMinimumCashThresholdRemoval" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_NumberOfEquityOfferings" abstract="false" name="NumberOfEquityOfferings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_CommonStockConvertibleSharesIssuable" abstract="false" name="CommonStockConvertibleSharesIssuable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="toi_DebtInstrumentConvertibleConversionCapShares" abstract="false" name="DebtInstrumentConvertibleConversionCapShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="toi_DebtInstrumentConvertibleDiscountAmortizationPeriod" abstract="false" name="DebtInstrumentConvertibleDiscountAmortizationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="toi_DebtInstrumentDebtDiscountRemainingDiscountAmortizationPeriod" abstract="false" name="DebtInstrumentDebtDiscountRemainingDiscountAmortizationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="toi_DebtInstrumentDebtIssuanceCostAmortizationPeriod" abstract="false" name="DebtInstrumentDebtIssuanceCostAmortizationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="toi_DebtInstrumentAccruedInterest" abstract="false" name="DebtInstrumentAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_PublicAndPrivateWarrantsMember" abstract="true" name="PublicAndPrivateWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_PublicWarrantsMember" abstract="true" name="PublicWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_PrivateWarrantsMember" abstract="true" name="PrivateWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_PreFundedWarrantsMember" abstract="true" name="PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_AtTheMarketOfferingMember" abstract="true" name="AtTheMarketOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_B.RileySecuritiesMember" abstract="true" name="B.RileySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_BTIGMember" abstract="true" name="BTIGMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_CommonStockVotesPerShare" abstract="false" name="CommonStockVotesPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_PreferredStockMaximumPercentOfCommonStockAllowed" abstract="false" name="PreferredStockMaximumPercentOfCommonStockAllowed" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightExercisableTermFromClosingOfInitialPublicOffering" abstract="false" name="ClassOfWarrantOrRightExercisableTermFromClosingOfInitialPublicOffering" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightWarrantRedemptionConditionMaximumCommonSharePrice" abstract="false" name="ClassOfWarrantOrRightWarrantRedemptionConditionMaximumCommonSharePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" abstract="false" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdConsecutiveTradingDays" abstract="false" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightThresholdNumberOfBusinessDaysBeforeSendingNoticeOfRedemptionToWarrantHolders" abstract="false" name="ClassOfWarrantOrRightThresholdNumberOfBusinessDaysBeforeSendingNoticeOfRedemptionToWarrantHolders" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" abstract="false" name="ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightRedemptionPeriodWrittenNotice" abstract="false" name="ClassOfWarrantOrRightRedemptionPeriodWrittenNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="toi_SaleOfStockSharesIssuedPerUnit" abstract="false" name="SaleOfStockSharesIssuedPerUnit" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="toi_ClassOfWarrantOrRightOwnershipThresholdPercentage" abstract="false" name="ClassOfWarrantOrRightOwnershipThresholdPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="toi_RestrictedStockUnitsAndAwardsMember" abstract="true" name="RestrictedStockUnitsAndAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_MedicalRestrictedStockUnitsRSUsMember" abstract="true" name="MedicalRestrictedStockUnitsRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_TwoThousandAndTwentyOnePlanMember" abstract="true" name="TwoThousandAndTwentyOnePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueVested" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueVested" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationFairValueOfTheLiabilityClassifiedMedicalRSUOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationFairValueOfTheLiabilityClassifiedMedicalRSUOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpiredInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpiredInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="toi_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpiredInPeriodWeightedAverageExercisePrice" abstract="false" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpiredInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="toi_RestrictedStockUnitsAndRestrictedStockAwardsMember" abstract="true" name="RestrictedStockUnitsAndRestrictedStockAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ClinicalContractsAndNoncompeteAgreementsMember" abstract="true" name="ClinicalContractsAndNoncompeteAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_PatientServicesSegmentMember" abstract="true" name="PatientServicesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_SpecialtyPharmacyMember" abstract="true" name="SpecialtyPharmacyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ClinicalTrialsAndOtherSegmentMember" abstract="true" name="ClinicalTrialsAndOtherSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_CommonWarrantsWithPrivatePlacementMember" abstract="true" name="CommonWarrantsWithPrivatePlacementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_SpecialtyPharmacySegmentMember" abstract="true" name="SpecialtyPharmacySegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_IntravenousIVDrugCostsSegmentMember" abstract="true" name="IntravenousIVDrugCostsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_ClinicianSalariesAndBenefitsSegmentMember" abstract="true" name="ClinicianSalariesAndBenefitsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_NetworkMedicalExpensesMember" abstract="true" name="NetworkMedicalExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_MedicalSuppliesAndOtherSegmentMember" abstract="true" name="MedicalSuppliesAndOtherSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_CapitatedAccountsReceivableSegmentMember" abstract="true" name="CapitatedAccountsReceivableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_FFSAccountsReceivableSegmentMember" abstract="true" name="FFSAccountsReceivableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_IVDrugInventorySegmentMember" abstract="true" name="IVDrugInventorySegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_OtherAssetsSegmentMember" abstract="true" name="OtherAssetsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_OralDrugAccountsReceivableSegmentMember" abstract="true" name="OralDrugAccountsReceivableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_OralDrugInventorySegmentMember" abstract="true" name="OralDrugInventorySegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_TermLoanAgreementMember" abstract="true" name="TermLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_VariableRateComponentAxis" abstract="true" name="VariableRateComponentAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="toi_VariableRateComponentDomain" abstract="true" name="VariableRateComponentDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_VariableRateComponentOneMember" abstract="true" name="VariableRateComponentOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_VariableRateComponentTwoMember" abstract="true" name="VariableRateComponentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="toi_DebtInstrumentCovenantMinimumNetRevenue" abstract="false" name="DebtInstrumentCovenantMinimumNetRevenue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="toi_DebtInstrumentQuarterlyAmortizationRate" abstract="false" name="DebtInstrumentQuarterlyAmortizationRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
</xs:schema>
