<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019eb280-b07a-73cb-a4a4-4e3208d00f1e,g:46453bb7-c84f-4150-960e-0956ede37928-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:irtc="http://www.irhythmtec.com/20260630" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.irhythmtec.com/20260630">
  <xs:import namespace="http://fasb.org/srt/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="irtc-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="irtc-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="irtc-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="irtc-20260630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="CoverPage" roleURI="http://www.irhythmtec.com/role/CoverPage">
        <link:definition>0000001 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheets" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedBalanceSheets">
        <link:definition>9952151 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsParenthetical" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofOperations" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedStatementsofOperations">
        <link:definition>9952153 - Statement - Condensed Consolidated Statements of Operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofComprehensiveLoss" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedStatementsofComprehensiveLoss">
        <link:definition>9952154 - Statement - Condensed Consolidated Statements of Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofCashFlows" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedStatementsofCashFlows">
        <link:definition>9952155 - Statement - Condensed Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofStockholdersEquity" roleURI="http://www.irhythmtec.com/role/CondensedConsolidatedStatementsofStockholdersEquity">
        <link:definition>9952156 - Statement - Condensed Consolidated Statements of Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ORGANIZATIONANDDESCRIPTIONOFBUSINESS" roleURI="http://www.irhythmtec.com/role/ORGANIZATIONANDDESCRIPTIONOFBUSINESS">
        <link:definition>9952157 - Disclosure - ORGANIZATION AND DESCRIPTION OF BUSINESS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES" roleURI="http://www.irhythmtec.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES">
        <link:definition>9952158 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUE" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUE">
        <link:definition>9952159 - Disclosure - BUSINESS SEGMENT AND REVENUE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CASHEQUIVALENTSANDMARKETABLESECURITIES" roleURI="http://www.irhythmtec.com/role/CASHEQUIVALENTSANDMARKETABLESECURITIES">
        <link:definition>9952160 - Disclosure - CASH EQUIVALENTS AND MARKETABLE SECURITIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTS" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTS">
        <link:definition>9952161 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTS" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTS">
        <link:definition>9952162 - Disclosure - BALANCE SHEET COMPONENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIES" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIES">
        <link:definition>9952163 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBT" roleURI="http://www.irhythmtec.com/role/DEBT">
        <link:definition>9952164 - Disclosure - DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXES" roleURI="http://www.irhythmtec.com/role/INCOMETAXES">
        <link:definition>9952165 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATION" roleURI="http://www.irhythmtec.com/role/STOCKBASEDCOMPENSATION">
        <link:definition>9952166 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERCOMMONSHARE" roleURI="http://www.irhythmtec.com/role/NETLOSSPERCOMMONSHARE">
        <link:definition>9952167 - Disclosure - NET LOSS PER COMMON SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENTS" roleURI="http://www.irhythmtec.com/role/SUBSEQUENTEVENTS">
        <link:definition>9952168 - Disclosure - SUBSEQUENT EVENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies" roleURI="http://www.irhythmtec.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies">
        <link:definition>9955511 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables" roleURI="http://www.irhythmtec.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables">
        <link:definition>9955512 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUETables" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUETables">
        <link:definition>9955513 - Disclosure - BUSINESS SEGMENT AND REVENUE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CASHEQUIVALENTSANDMARKETABLESECURITIESTables" roleURI="http://www.irhythmtec.com/role/CASHEQUIVALENTSANDMARKETABLESECURITIESTables">
        <link:definition>9955514 - Disclosure - CASH EQUIVALENTS AND MARKETABLE SECURITIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSTables" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSTables">
        <link:definition>9955515 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSTables" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSTables">
        <link:definition>9955516 - Disclosure - BALANCE SHEET COMPONENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESTables" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIESTables">
        <link:definition>9955517 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTTables" roleURI="http://www.irhythmtec.com/role/DEBTTables">
        <link:definition>9955518 - Disclosure - DEBT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONTables" roleURI="http://www.irhythmtec.com/role/STOCKBASEDCOMPENSATIONTables">
        <link:definition>9955519 - Disclosure - STOCK-BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERCOMMONSHARETables" roleURI="http://www.irhythmtec.com/role/NETLOSSPERCOMMONSHARETables">
        <link:definition>9955520 - Disclosure - NET LOSS PER COMMON SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESDetails" roleURI="http://www.irhythmtec.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESDetails">
        <link:definition>9955521 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUENarrativeDetails" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUENarrativeDetails">
        <link:definition>9955522 - Disclosure - BUSINESS SEGMENT AND REVENUE - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUEScheduleofDisaggregatedRevenuebyPayorTypeandMajorServiceDetails" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUEScheduleofDisaggregatedRevenuebyPayorTypeandMajorServiceDetails">
        <link:definition>9955523 - Disclosure - BUSINESS SEGMENT AND REVENUE - Schedule of Disaggregated Revenue by Payor Type and Major Service (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUEScheduleofChangesinProvisionforCreditLossesDetails" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUEScheduleofChangesinProvisionforCreditLossesDetails">
        <link:definition>9955524 - Disclosure - BUSINESS SEGMENT AND REVENUE - Schedule of Changes in Provision for Credit Losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BUSINESSSEGMENTANDREVENUEScheduleofChangesinContractualAllowanceDetails" roleURI="http://www.irhythmtec.com/role/BUSINESSSEGMENTANDREVENUEScheduleofChangesinContractualAllowanceDetails">
        <link:definition>9955525 - Disclosure - BUSINESS SEGMENT AND REVENUE - Schedule of Changes in Contractual Allowance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CASHEQUIVALENTSANDMARKETABLESECURITIESDetails" roleURI="http://www.irhythmtec.com/role/CASHEQUIVALENTSANDMARKETABLESECURITIESDetails">
        <link:definition>9955526 - Disclosure - CASH EQUIVALENTS AND MARKETABLE SECURITIES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofFairValueofCompanysFinancialAssetsandLiabilitiesDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueofCompanysFinancialAssetsandLiabilitiesDetails">
        <link:definition>9955527 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Fair Value of Company's Financial Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSFairValueofStrategicInvestmentsDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSFairValueofStrategicInvestmentsDetails">
        <link:definition>9955528 - Disclosure - FAIR VALUE MEASUREMENTS - Fair Value of Strategic Investments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofChangesinEstimatedFairValueofStrategicInvestmentsMeasuredonRecurringBasisDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofChangesinEstimatedFairValueofStrategicInvestmentsMeasuredonRecurringBasisDetails">
        <link:definition>9955529 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Changes in Estimated Fair Value of Strategic Investments Measured on Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSNarrativeDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSNarrativeDetails">
        <link:definition>9955530 - Disclosure - FAIR VALUE MEASUREMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofTheRecurringLevel3FairValueMeasurementsofTheLoanInvestmentDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofTheRecurringLevel3FairValueMeasurementsofTheLoanInvestmentDetails">
        <link:definition>9955531 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of The Recurring Level 3 Fair Value Measurements of The Loan Investment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofTheRecurringLevel3FairValueMeasurementsofContingentConsiderationLiabilitiesDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofTheRecurringLevel3FairValueMeasurementsofContingentConsiderationLiabilitiesDetails">
        <link:definition>9955532 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of The Recurring Level 3 Fair Value Measurements of Contingent Consideration Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofChangesinEstimatedFairValueofContingentConsiderationLiabilitiesMeasuredonaRecurringBasisLevel3Details" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofChangesinEstimatedFairValueofContingentConsiderationLiabilitiesMeasuredonaRecurringBasisLevel3Details">
        <link:definition>9955533 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Changes in Estimated Fair Value of Contingent Consideration Liabilities Measured on a Recurring Basis (Level 3) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofFairValueofSeniorConvertibleNotesDetails" roleURI="http://www.irhythmtec.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueofSeniorConvertibleNotesDetails">
        <link:definition>9955534 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Fair Value of Senior Convertible Notes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSScheduleofInventoryComponentsDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSScheduleofInventoryComponentsDetails">
        <link:definition>9955535 - Disclosure - BALANCE SHEET COMPONENTS - Schedule of Inventory Components (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSPrepaidExpensesandOtherCurrentAssetsDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSPrepaidExpensesandOtherCurrentAssetsDetails">
        <link:definition>9955536 - Disclosure - BALANCE SHEET COMPONENTS - Prepaid Expenses and Other Current Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSScheduleofOtherAssetsDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSScheduleofOtherAssetsDetails">
        <link:definition>9955537 - Disclosure - BALANCE SHEET COMPONENTS - Schedule of Other Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSNarrativeDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSNarrativeDetails">
        <link:definition>9955538 - Disclosure - BALANCE SHEET COMPONENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSScheduleofPropertyandEquipmentNetDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSScheduleofPropertyandEquipmentNetDetails">
        <link:definition>9955539 - Disclosure - BALANCE SHEET COMPONENTS - Schedule of Property and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETCOMPONENTSScheduleofAccruedLiabilitiesComponentsDetails" roleURI="http://www.irhythmtec.com/role/BALANCESHEETCOMPONENTSScheduleofAccruedLiabilitiesComponentsDetails">
        <link:definition>9955540 - Disclosure - BALANCE SHEET COMPONENTS - Schedule of Accrued Liabilities Components (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIESScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails">
        <link:definition>9955541 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Maturities of Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIESScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1">
        <link:definition>9955541 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Maturities of Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESNarrativeDetails" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails">
        <link:definition>9955542 - Disclosure - COMMITMENTS AND CONTINGENCIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESNarrativeDetails_1" roleURI="http://www.irhythmtec.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails_1">
        <link:definition>9955542 - Disclosure - COMMITMENTS AND CONTINGENCIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTNarrativeDetails" roleURI="http://www.irhythmtec.com/role/DEBTNarrativeDetails">
        <link:definition>9955543 - Disclosure - DEBT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTScheduleofConvertibleDebtDetails" roleURI="http://www.irhythmtec.com/role/DEBTScheduleofConvertibleDebtDetails">
        <link:definition>9955544 - Disclosure - DEBT - Schedule of Convertible Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTScheduleofComponentsofInterestExpenseandtheEffectiveInterestRatesDetails" roleURI="http://www.irhythmtec.com/role/DEBTScheduleofComponentsofInterestExpenseandtheEffectiveInterestRatesDetails">
        <link:definition>9955545 - Disclosure - DEBT - Schedule of Components of Interest Expense and the Effective Interest Rates (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESDetails" roleURI="http://www.irhythmtec.com/role/INCOMETAXESDetails">
        <link:definition>9955546 - Disclosure - INCOME TAXES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails" roleURI="http://www.irhythmtec.com/role/STOCKBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails">
        <link:definition>9955547 - Disclosure - STOCK-BASED COMPENSATION - Schedule of Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails_1" roleURI="http://www.irhythmtec.com/role/STOCKBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails_1">
        <link:definition>9955547 - Disclosure - STOCK-BASED COMPENSATION - Schedule of Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONNarrativeDetails" roleURI="http://www.irhythmtec.com/role/STOCKBASEDCOMPENSATIONNarrativeDetails">
        <link:definition>9955548 - Disclosure - STOCK-BASED COMPENSATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERCOMMONSHAREScheduleofComputationofBasicandDilutedNetLossperShareDetails" roleURI="http://www.irhythmtec.com/role/NETLOSSPERCOMMONSHAREScheduleofComputationofBasicandDilutedNetLossperShareDetails">
        <link:definition>9955549 - Disclosure - NET LOSS PER COMMON SHARE - Schedule of Computation of Basic and Diluted Net Loss per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERCOMMONSHAREScheduleofAntidilutiveSecuritiesExcludedfromDilutedNetLossperCommonShareDetails" roleURI="http://www.irhythmtec.com/role/NETLOSSPERCOMMONSHAREScheduleofAntidilutiveSecuritiesExcludedfromDilutedNetLossperCommonShareDetails">
        <link:definition>9955550 - Disclosure - NET LOSS PER COMMON SHARE - Schedule of Anti-dilutive Securities Excluded from Diluted Net Loss per Common Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEventsDetails" roleURI="http://www.irhythmtec.com/role/SubsequentEventsDetails">
        <link:definition>9955551 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="irtc_ProvisionForCreditLossesAndContractualAllowance" abstract="false" name="ProvisionForCreditLossesAndContractualAllowance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_IncreaseDecreaseInOperatingLeaseLiabilities" abstract="false" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_ProceedsFromMaturitiesPrepaymentsAndCallsOfMarketableSecurities" abstract="false" name="ProceedsFromMaturitiesPrepaymentsAndCallsOfMarketableSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_PaymentsToAcquireStrategicInvestments" abstract="false" name="PaymentsToAcquireStrategicInvestments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_CashEquivalentsAndInvestmentsAbstract" abstract="true" name="CashEquivalentsAndInvestmentsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="irtc_RiskAndUncertaintiesPolicyPolicyTextBlock" abstract="false" name="RiskAndUncertaintiesPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_ConcentrationRiskSupplyRiskPolicyPolicyTextBlock" abstract="false" name="ConcentrationRiskSupplyRiskPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_ContractLiabilityPolicyPolicyTextBlock" abstract="false" name="ContractLiabilityPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_ContractCostPolicyPolicyTextBlock" abstract="false" name="ContractCostPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_ScheduleOfChangeInContractualAllowanceTableTableTextBlock" abstract="false" name="ScheduleOfChangeInContractualAllowanceTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_ScheduleOfInventoryAndPrintedCircuitBoardAssembliesTableTableTextBlock" abstract="false" name="ScheduleOfInventoryAndPrintedCircuitBoardAssembliesTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="irtc_SummaryOfSignificantAccountingPoliciesTable" abstract="true" name="SummaryOfSignificantAccountingPoliciesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="irtc_CentersForMedicareMedicaidServicesMember" abstract="true" name="CentersForMedicareMedicaidServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_HealthcareInstitutionsMember" abstract="true" name="HealthcareInstitutionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_ContractedThirdPartyPayorsMember" abstract="true" name="ContractedThirdPartyPayorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_SummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="irtc_CommercialPayorsMember" abstract="true" name="CommercialPayorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_NonContractedThirdPartyPayorsMember" abstract="true" name="NonContractedThirdPartyPayorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_AllowanceForDoubtfulAccountsReceivableWriteOffsNetOfRecoveriesAndOtherAdjustments" abstract="false" name="AllowanceForDoubtfulAccountsReceivableWriteOffsNetOfRecoveriesAndOtherAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_AccountsReceivableForContractualAllowance" abstract="false" name="AccountsReceivableForContractualAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_AccountsReceivableAllowanceForContractualAdjustments" abstract="false" name="AccountsReceivableAllowanceForContractualAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_AccountsReceivableContractualAdjustments" abstract="false" name="AccountsReceivableContractualAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_CashCashEquivalentsAndShortTermInvestmentsAmortizedCost" abstract="false" name="CashCashEquivalentsAndShortTermInvestmentsAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_StrategicLoanInvestmentNoncurrent" abstract="false" name="StrategicLoanInvestmentNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_StrategicLoanInvestmentCurrent" abstract="false" name="StrategicLoanInvestmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_StrategicInvestments" abstract="false" name="StrategicInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_ChangeInFairValueOfStrategicInvestmentsRollForward" abstract="true" name="ChangeInFairValueOfStrategicInvestmentsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="irtc_StrategicInvestmentAdditions" abstract="false" name="StrategicInvestmentAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_StrategicInvestmentChangesInFairValue" abstract="false" name="StrategicInvestmentChangesInFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_BioIntelliSenseInc.Member" abstract="true" name="BioIntelliSenseInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_IncreaseDecreaseInFairValueOfStrategicLoanInvestments" abstract="false" name="IncreaseDecreaseInFairValueOfStrategicLoanInvestments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_FairValueOfStrategicLoanInvestment" abstract="false" name="FairValueOfStrategicLoanInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_IncreaseDecreaseInFairValueOfStrategicEquityInvestments" abstract="false" name="IncreaseDecreaseInFairValueOfStrategicEquityInvestments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_LoanInvestmentMeasurementInput" abstract="false" name="LoanInvestmentMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="irtc_LoanInvestmentTerm" abstract="false" name="LoanInvestmentTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="irtc_MeasurementInputProbabilityOfLoanForgivenessMember" abstract="true" name="MeasurementInputProbabilityOfLoanForgivenessMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_ContingentConsiderationMeasurementInput" abstract="false" name="ContingentConsiderationMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="irtc_ContingentConsiderationTerm" abstract="false" name="ContingentConsiderationTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="irtc_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityAdditions" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_ConvertibleNotesDue2029Member" abstract="true" name="ConvertibleNotesDue2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_PrintedCircuitBoardAssemblies" abstract="false" name="PrintedCircuitBoardAssemblies" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_CloudComputingArrangements" abstract="false" name="CloudComputingArrangements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_PrintedCircuitBoardAssembliesMember" abstract="true" name="PrintedCircuitBoardAssembliesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_AssetsPurchaseAccountingAdjustmentsOtherAssetsPCBAs" abstract="false" name="AssetsPurchaseAccountingAdjustmentsOtherAssetsPCBAs" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_LaboratoryAndManufacturingEquipmentMember" abstract="true" name="LaboratoryAndManufacturingEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_ComputerEquipmentAndSoftwareMember" abstract="true" name="ComputerEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_AccruedExpensesCurrent" abstract="false" name="AccruedExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_ClaimsPayableCurrent" abstract="false" name="ClaimsPayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_AccruedEmployeeStockPurchasePlanContribution" abstract="false" name="AccruedEmployeeStockPurchasePlanContribution" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_AccruedStateLocalAndForeignTaxes" abstract="false" name="AccruedStateLocalAndForeignTaxes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_ClassActionMember" abstract="true" name="ClassActionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_MilestoneNotesMember" abstract="true" name="MilestoneNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_AccruedHealthBenefitsLiability" abstract="false" name="AccruedHealthBenefitsLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_EstimatedInsuranceRecoveriesIncurred" abstract="false" name="EstimatedInsuranceRecoveriesIncurred" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_LitigationSettlementFeeExpenseNetOfInsuranceRecoveries" abstract="false" name="LitigationSettlementFeeExpenseNetOfInsuranceRecoveries" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_TechnologyLicenseAgreementUpfrontFee" abstract="false" name="TechnologyLicenseAgreementUpfrontFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_PaymentsToAcquireConvertibleDebt" abstract="false" name="PaymentsToAcquireConvertibleDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_SeniorConvertibleNotesDue2029Member" abstract="true" name="SeniorConvertibleNotesDue2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_DebtInstrumentConversionTermAxis" abstract="true" name="DebtInstrumentConversionTermAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="irtc_DebtInstrumentConversionTermDomain" abstract="true" name="DebtInstrumentConversionTermDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_DebtInstrumentConversionTermOneMember" abstract="true" name="DebtInstrumentConversionTermOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_DebtInstrumentConversionTermTwoMember" abstract="true" name="DebtInstrumentConversionTermTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_A2029CappedCallTransactionsMember" abstract="true" name="A2029CappedCallTransactionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_DebtInstrumentOptionToPurchaseConvertibleDebtAdditionalPurchaseAmount" abstract="false" name="DebtInstrumentOptionToPurchaseConvertibleDebtAdditionalPurchaseAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_DebtInstrumentCovenantRepurchasePricePercentage" abstract="false" name="DebtInstrumentCovenantRepurchasePricePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="irtc_DebtInstrumentTermsOfConversionFeatureConvertibleUnderCertainCircumstancesConversionAmount" abstract="false" name="DebtInstrumentTermsOfConversionFeatureConvertibleUnderCertainCircumstancesConversionAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_DebtInstrumentConvertibleRegardlessOfCircumstancesTermsOfConversionFeatureConversionAmount" abstract="false" name="DebtInstrumentConvertibleRegardlessOfCircumstancesTermsOfConversionFeatureConversionAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_DebtInstrumentConvertedAmount" abstract="false" name="DebtInstrumentConvertedAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_DebtInstrumentRedemptionCovenantPercentOfConversionPriceLastReportedSalePriceOfCommonStock" abstract="false" name="DebtInstrumentRedemptionCovenantPercentOfConversionPriceLastReportedSalePriceOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="irtc_DebtInstrumentCappedCallsPriceCap" abstract="false" name="DebtInstrumentCappedCallsPriceCap" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="irtc_DebtInstrumentCappedCallsPremiumPercentageOverClosingPrice" abstract="false" name="DebtInstrumentCappedCallsPremiumPercentageOverClosingPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="irtc_PurchasesOfCappedCallsTransactions" abstract="false" name="PurchasesOfCappedCallsTransactions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumCapacityPercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumCapacityPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="irtc_RestrictedStockUnitsAndPerformanceBasedRestrictedStockUnitsMember" abstract="true" name="RestrictedStockUnitsAndPerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_SeniorConvertibleNotesMember" abstract="true" name="SeniorConvertibleNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_BaxterSettlementAgreementMember" abstract="true" name="BaxterSettlementAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_VitalConnectMember" abstract="true" name="VitalConnectMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="irtc_LicensePaymentAmount" abstract="false" name="LicensePaymentAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_BusinessCombinationTerminationFee" abstract="false" name="BusinessCombinationTerminationFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_BusinessCombinationInterimFinancingInitialFundingAmount" abstract="false" name="BusinessCombinationInterimFinancingInitialFundingAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="irtc_BusinessCombinationInterimFinancingMaximumAmount" abstract="false" name="BusinessCombinationInterimFinancingMaximumAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
