Summary of Significant Accounting Policies - Segments (Details) $ in Thousands |
3 Months Ended | 6 Months Ended | ||||
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Jun. 30, 2026
USD ($)
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Mar. 31, 2026
USD ($)
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Jun. 30, 2025
USD ($)
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Mar. 31, 2025
USD ($)
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Jun. 30, 2026
USD ($)
segment
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Jun. 30, 2025
USD ($)
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| Summary of Significant Accounting Policies | ||||||
| Number of reportable segments | segment | 1 | |||||
| Number of operating segments | segment | 1 | |||||
| Operating expenses: | ||||||
| General and administrative | $ 18,573 | $ 15,741 | $ 41,445 | $ 29,185 | ||
| Total operating expenses | 118,630 | 70,451 | 208,009 | 126,762 | ||
| Loss from operations | (118,630) | (70,451) | (208,009) | (126,762) | ||
| Interest and other income, net | 12,705 | 8,929 | 26,306 | 18,505 | ||
| Loss before provision for income taxes | (105,925) | (61,522) | (181,703) | (108,257) | ||
| Provision for income taxes | 234 | 139 | 424 | 237 | ||
| Net loss attributable to ordinary shareholders | (106,159) | $ (75,968) | (61,661) | $ (46,833) | (182,127) | (108,494) |
| Single Reporting Segment | ||||||
| Operating expenses: | ||||||
| Discovery research and development | 23,079 | 26,244 | 41,596 | 48,031 | ||
| Manufacturing | 15,278 | 133 | 19,548 | 133 | ||
| Clinical research and development | 49,859 | 23,016 | 85,055 | 40,173 | ||
| Other research and development expenses | 11,841 | 5,317 | 20,365 | 9,240 | ||
| General and administrative | 18,573 | 15,741 | 41,445 | 29,185 | ||
| Total operating expenses | 118,630 | 70,451 | 208,009 | 126,762 | ||
| Loss from operations | (118,630) | (70,451) | (208,009) | (126,762) | ||
| Interest and other income, net | 12,705 | 8,929 | 26,306 | 18,505 | ||
| Loss before provision for income taxes | (105,925) | (61,522) | (181,703) | (108,257) | ||
| Provision for income taxes | 234 | 139 | 424 | 237 | ||
| Net loss attributable to ordinary shareholders | $ (106,159) | $ (61,661) | $ (182,127) | $ (108,494) | ||
| X | ||||||||||
- Definition Amount of expense for clinical research and development. No definition available.
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| X | ||||||||||
- Definition Amount of expense for discovery research and development. No definition available.
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| X | ||||||||||
- Definition The amount of interest and other income (expense) net. No definition available.
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| X | ||||||||||
- Definition Amount of expense for manufacturing. No definition available.
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| X | ||||||||||
- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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| X | ||||||||||
- Definition Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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| X | ||||||||||
- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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| X | ||||||||||
- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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| X | ||||||||||
- Definition Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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| X | ||||||||||
- Definition Number of segments reported by the entity. A reportable segment is a component of an entity for which there is an accounting requirement to report separate financial information on that component in the entity's financial statements. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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| X | ||||||||||
- Definition Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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| X | ||||||||||
- References No definition available.
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| X | ||||||||||
- Definition The net result for the period of deducting operating expenses from operating revenues. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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| X | ||||||||||
- Definition Amount of other research and development expense. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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| X | ||||||||||
- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Details
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