| Schedule of changes in Stockholders' Equity |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | Accumulated | | | | | | | | | Common | | Common | | Additional | | Other | | | | | Total | | | Stock | | Stock Par | | Paid-In | | Comprehensive | | Accumulated | | Stockholders’ | | | Shares | | Value | | Capital | | Income | | Deficit | | Equity | | | | (In thousands, except share amounts) | Consolidated balance at December 31, 2025 | | 66,549,442 | | $ | 67 | | $ | 2,337,453 | | $ | 3,626 | | $ | (1,813,981) | | $ | 527,165 | Shares issued under stock option and employee stock purchase plans | | 19,529 | | | — | | | 327 | | | — | | | — | | | 327 | Stock-based compensation | | — | | | — | | | 8,523 | | | — | | | — | | | 8,523 | Unrealized loss on marketable securities | | — | | | — | | | — | | | (1,104) | | | — | | | (1,104) | Net loss | | — | | | — | | | — | | | — | | | (78,685) | | | (78,685) | Consolidated balance at March 31, 2026 | | 66,568,971 | | $ | 67 | | $ | 2,346,303 | | $ | 2,522 | | $ | (1,892,666) | | $ | 456,226 | Shares issued under stock option and employee stock purchase plans | | 34,452 | | | — | | | 825 | | | — | | | — | | | 825 | Shares issued in underwritten offering, net | | 11,896,750 | | | 12 | | | 323,820 | | | — | | | — | | | 323,832 | Stock-based compensation | | — | | | — | | | 8,408 | | | — | | | — | | | 8,408 | Unrealized loss on marketable securities | | — | | | — | | | — | | | (1,224) | | | — | | | (1,224) | Net loss | | — | | | — | | | — | | | — | | | (73,503) | | | (73,503) | Consolidated balance at June 30, 2026 | | 78,500,173 | | $ | 79 | | $ | 2,679,356 | | $ | 1,298 | | $ | (1,966,169) | | $ | 714,564 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Accumulated | | | | | | | | | Common | | Common | | Additional | | Other | | | | | Total | | | Stock | | Stock Par | | Paid-In | | Comprehensive | | Accumulated | | Stockholders’ | | | Shares | | Value | | Capital | | Income | | Deficit | | Equity | | | | (In thousands, except share amounts) | Consolidated balance at December 31, 2024 | | 66,374,549 | | $ | 66 | | $ | 2,298,849 | | $ | 3,314 | | $ | (1,555,224) | | $ | 747,005 | Shares issued under stock option and employee stock purchase plans | | 9,642 | | | — | | | 202 | | | — | | | — | | | 202 | Stock-based compensation | | — | | | — | | | 9,316 | | | — | | | — | | | 9,316 | Unrealized gain on marketable securities | | — | | | — | | | — | | | 254 | | | — | | | 254 | Net loss | | — | | | — | | | — | | | — | | | (53,796) | | | (53,796) | Consolidated balance at March 31, 2025 | | 66,384,191 | | $ | 66 | | $ | 2,308,367 | | $ | 3,568 | | $ | (1,609,020) | | $ | 702,981 | Shares issued under stock option and employee stock purchase plans | | 10,050 | | | — | | | 63 | | | — | | | — | | | 63 | Stock-based compensation | | — | | | — | | | 9,191 | | | — | | | — | | | 9,191 | Unrealized loss on marketable securities | | — | | | — | | | — | | | (229) | | | — | | | (229) | Net loss | | — | | | — | | | — | | | — | | | (56,600) | | | (56,600) | Consolidated balance at June 30, 2025 | | 66,394,241 | | $ | 66 | | $ | 2,317,621 | | $ | 3,339 | | $ | (1,665,620) | | $ | 655,406 |
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