v3.26.1
SEGMENT REPORTING (Tables)
 6 Months Ended
Jun. 30, 2026
Segment Reporting [Abstract]  
Summary of Significant Research and Development and General and Administrative Expense to CODM
The tables below summarize the significant research and development and general and administrative expense categories regularly provided to the CODM for the three months ended June 30, 2026 and June 30, 2025 and the six months ended June 30, 2026 and June 30, 2025. Due to the pause in development of the PBGENE-3243 program to prioritize the Company’s two lead programs, PBGENE-HBV and PBGENE-DMD, expenses for PBGENE-3243 have been recast for the periods presented below. The amounts previously reported under “PBGENE-3243 external development costs” are now reported within the “Platform development and early-stage research expense” line items:
Three months ended June 30,
(in thousands)20262025
Revenue$— $18 
Operating expenses
Research and development
Direct research and development expenses by product candidate:
PBGENE-HBV external development costs2,031 1,378 
PBGENE-DMD external development costs4,259 4,163 
Platform development and early-stage research expenses:
Employee-related costs (including share-based compensation)4,733 4,766 
Laboratory supplies and services309 570 
CMOs and outsourced research and development204 239 
Facility-related costs, laboratory equipment, and maintenance600 807 
Depreciation and amortization229 330 
Licensing fees and other research and development costs29 515 
Total research and development expenses$12,394 $12,768 
General and administrative expense
Employee-related costs (including share-based compensation)3,986 5,730 
Consulting and professional services1,500 1,665 
Other operating expenses and all other costs1,281 1,732 
Total general and administrative expenses$6,767 $9,127 
Total operating expenses$19,161 $21,895 
Operating loss(19,161)(21,877)
Total other (expense) income(13,491)(1,643)
Net loss$(32,652)$(23,520)
Six months ended June 30,
(in thousands)20262025
Revenue$10,838 $47 
Operating expenses
Research and development
Direct research and development expenses by product candidate:
PBGENE-HBV external development costs3,866 2,979 
PBGENE-DMD external development costs8,257 6,601 
Platform development and early-stage research expenses:
Employee-related costs (including share-based compensation)9,239 10,066 
Laboratory supplies and services682 1,108 
CMOs and outsourced research and development257 2,348 
Facility-related costs, laboratory equipment, and maintenance1,346 1,535 
Depreciation and amortization505 670 
Licensing fees and other research and development costs1,352 1,049 
Total research and development expenses$25,504 $26,356 
General and administrative expense
Employee-related costs (including share-based compensation)7,814 11,190 
Consulting and professional services2,936 3,201 
Other operating expenses and all other costs2,820 3,289 
Total general and administrative expenses$13,570 $17,680 
Total operating expenses$39,074 $44,036 
Operating loss(28,236)(43,989)
Total other (expense) income(22,857)(96)
(Loss) income from operations$(51,093)$(44,085)
Net (loss) income$(51,093)$(44,085)