Oculis Holding AG
Bahnhofstrasse 20
6300 Zug
August 6, 2026
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Oculis Holding AG – Registration Statement on Form S-8
Dear Sir or Madam,
We have acted as special Swiss counsel to Oculis Holding AG (the "Company"), a company incorporated under the laws of Switzerland with a share capital of CHF 677,921.76 and 67,792,176 outstanding registered shares with a par value of CHF 0.01 each (the "Registered Shares"), in connection with the Company's registration statement on Form S-8, as amended or supplemented (the "Registration Statement"), filed with the United States Securities and Exchange Commission with respect to the registration under the U.S. Securities Act of 1933, as amended (the "Securities Act") relating to (i) the registration of up to 12,677,700 registered shares of the Company each with a par value of CHF 0.01 (the "Plan Shares") that are issuable under the Company's Stock Option and Incentive Plan Regulation dated January 2023 (the "2023 Stock Option Plan").
As such counsel, we have been requested to render an opinion as to certain matters of Swiss law.
This opinion is confined to and given on the basis of the laws of Switzerland in force at the date hereof and as currently applied by Swiss courts. Such laws and the interpretation thereof are subject to change. In the absence of explicit statutory law, we base our opinion on our independent professional judgement.
This opinion is also confined to the matters stated herein and is not to be read as extending, by implication or otherwise, to any document referred to in the Documents (other than listed below) or any other matter.
For purposes of this opinion we have not conducted any due diligence or similar investigation as to factual circumstances, which are or may be referred to in the Documents, and we express no opinion as to the accuracy of representations and warranties of facts set out in the Documents or the factual background assumed therein.
For the purpose of giving this opinion, we have examined originals or copies, certified or otherwise identified to our satisfaction, of

