| (1) | On June 30, 2023, the Registrant initially filed
a registration statement on Form F-3 (File No. 333-273058), which was declared
effective on July 11, 2023 (the “Prior Registration Statement”),
registering securities with a maximum aggregate offering price of $250,000,000,
for which the Registrant paid an aggregate registration fee of $27,550.00
(calculated at the filing fee rate of $110.20 per $1,000,000, which was in
effect at the time of the filing of the Prior Registration Statement).
Pursuant to Rule 415(a)(5) under the Securities
Act, the Prior Registration Statement has expired. At the time of the
expiration of the Prior Registration Statement, the Registrant had sold an
aggregate of $189,335,707.25 of securities thereunder (consisting of (i)
$29,993,250 of ordinary shares and pre-funded warrants sold in an underwritten
public offering completed in February 2025, (ii) $150,000,000 of ordinary
shares sold in an underwritten public offering completed in May 2026 and (iii)
$9,342,457.25 of ordinary shares sold under an at-the-market offering program),
and there remained unsold $60,664,292.75 of securities registered under the
Prior Registration Statement (the “Unsold Securities”), for which the
Registrant paid an aggregate registration fee of $6,685.21 (calculated at the
filing fee rate that was in effect at the time of the filing of the Prior
Registration Statement). |