75000 - Document - Document and Entity Information
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75010 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS
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75020 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical)
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75030 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited)
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75040 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)
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75050 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)
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995457 - Disclosure - Nature of the Business
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995467 - Disclosure - Summary of Significant Accounting Policies
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995477 - Disclosure - Fair Value of Financial Assets and Liabilities
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995497 - Disclosure - Prepaid Expenses and Other Current Assets
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995507 - Disclosure - Accrued Expenses
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995517 - Disclosure - Common Stock
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995527 - Disclosure - Equity-Based Compensation
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995537 - Disclosure - Leases
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995547 - Disclosure - Commitments and Contingencies
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995557 - Disclosure - Debt
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995567 - Disclosure - Net Loss per Share
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995577 - Disclosure - Segment Reporting
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995587 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995597 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995607 - Disclosure - Fair Value of Financial Assets and Liabilities (Tables)
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995627 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)
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995637 - Disclosure - Accrued Expenses (Tables)
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995647 - Disclosure - Common Stock (Tables)
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995657 - Disclosure - Equity-Based Compensation (Tables)
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995667 - Disclosure - Leases (Tables)
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995677 - Disclosure - Net Loss per Share (Tables)
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995687 - Disclosure - Segment Reporting (Tables)
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995697 - Disclosure - Nature of the Business (Additional Information) (Details)
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995707 - Disclosure - Summary of Significant Accounting Policies - Schedule of reconciliation of cash, cash equivalents and restricted cash (Details)
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995717 - Disclosure - Fair Value of Financial Assets and Liabilities - Schedule of summary of the assets and liabilities measured at fair value on a recurring basis (Details)
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995727 - Disclosure - Fair Value of Financial Assets and Liabilities (Additional Information) (Details)
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995747 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Details)
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995757 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Other Long-term Assets (Details)
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995767 - Disclosure - Accrued Expenses (Details)
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995777 - Disclosure - Common Stock (Additional Information) (Details)
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995787 - Disclosure - Common Stock - Reserved (Details)
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995797 - Disclosure - Equity-Based Compensation (Additional Information) (Details)
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995807 - Disclosure - Equity-Based Compensation - Summary of Company's Unrecognized Expense - (Details)
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995817 - Disclosure - Equity-Based Compensation - Summary of Unrecognized Equity-Based Compensation Expense - (Details)
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995827 - Disclosure - Equity-Based Compensation - Summary of Performance Stock Units (Details)
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995837 - Disclosure - Equity-Based Compensation - Summary of Restricted Units (Details)
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995847 - Disclosure - Equity-Based Compensation - Summary of Stock Options (Details)
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995857 - Disclosure - Equity-Based Compensation - Summary of Weighted Average Assumptions in Fair Value (Details)
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995867 - Disclosure - Leases (Additional Information) (Details)
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995877 - Disclosure - Leases - Schedule of Other Information Related to The Leases Cost (Details)
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995887 - Disclosure - Debt (Additional Information) (Details)
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995897 - Disclosure - Net Loss per Share - Antidilutive (Details)
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995907 - Disclosure - Segment Reporting - Summary of Operating Segment Expenses (Details)
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995917 - Disclosure - Segment Reporting (Additional Information) (Details)
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999009 - Disclosure - Anchoring
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This name represents a member of the board.
Joshua Reed [Member]
Joshua Reed
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested (in dollars per share)
Segments [Domain]
Schedule of Revenues from External Customers and Long-Lived Assets [Table]
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued
Preferred stock, shares issued
Increase (Decrease) in Accounts Payable
Accounts payable
Long-Term Debt, Excluding Current Maturities
Long-term debt
Plan Name [Axis]
Entity Current Reporting Status
Proceeds from Warrant Exercises
Proceeds from pre-funded and common warrant exercises
Operating Expenses [Abstract]
Operating expenses:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted Average Exercise Price
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, shares authorized
Product and Service [Axis]
Document Fiscal Period Focus
Debt Instrument, Interest Rate, Stated Percentage
Interest rate
Entity Shell Company
Other Accrued Liabilities, Current
Accrued other
Cash and Cash Equivalent
Cash and cash equivalents
Subsidiary, Sale of Stock [Line Items]
Common Stock
Common Stock, Shares, Issued
Common stock, shares issued
It represents the amount of transfer of assets between fair value measurement levels.
Transfer Of Assets Between Fair Value Measurement Levels
Transfer of assets between fair value measurement levels
Statement [Table]
Entity single operating segment.
Single Reportable Segment [Member]
Operating segment
Restricted Cash, Noncurrent
Restricted cash
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets obtained in exchange for operating lease liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value (in dollars per share)
The amount of prepaid external research and development expense as of the balance sheet date. Used to reflect the noncurrent portion of the asset (due after one year or outside the normal operating cycle if longer).
Prepaid External Research And Development Expense, Noncurrent
Prepaid external research and development expenses
Statement [Line Items]
Statement
Warrant [Member]
Warrants
Entity Filer Category
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Units
Liabilities and Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Debt
Accrued Expenses
Share-Based Payment Arrangement, Nonvested Award, Cost [Table Text Block]
Summary of Unrecognized Equity-Based Compensation Expense
Payments to Acquire Marketable Securities
Purchases of marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options exercisable, end (in dollars per share)
Proceeds from Issuance of Debt
Proceeds from debt facility
Proceeds from credit facility
Shares Issued, Shares, Share-Based Payment Arrangement, before Forfeiture
Issuance of common shares upon vesting of restricted stock units ("RSUs") and performance stock units ("PSUs") (in shares)
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents
Stock options
Geographical [Domain]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents and Restricted Cash
Represents the information pertaining to incremental term loan facility.
Incremental Term Loan [Member]
Incremental Term Loan
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Summary of Operating Segment Expenses
Amount of base rent for initial period under the lease.
Lessee Operating Lease Base Rent
Base rent
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Leased assets
This name represents a member of the board.
Jeffrey Flier [Member]
Jeffrey Flier
Represents the information pertaining to Non-Employee Service Warrants.
Non-Employee Service Warrant [Member]
Non-Employee Services Warrant
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted (in shares)
Represents information related to 2020 Loan and Security Agreement with Oxford Finance LLC and Silicon Valley Bank.
Loan And Security Agreement 2020 With Oxford Finance L L C And Silicon Valley Bank [Member]
2020 Loan and Security Agreement with Oxford
Earnings Per Share, Basic
Net loss per share, basic
Repayments of Long-Term Debt
Payment of long-term debt
Represents information related to the 2026 Loan Agreement.
Loan Agreement 2026 [Member]
2026 Loan Agreement
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation adjustments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Outstanding, end (in shares)
Outstanding, beginning (in shares)
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Loss on disposal of property and equipment
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Warrants issued
Number of warrants or rights issued.
Class of Warrant or Right, Warrants Issued
Payments of Debt Issuance Costs
Payment of debt issuance costs
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Entity Small Business
Increase (Decrease) in Accrued Liabilities
Accrued expenses
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Subsidiary or Equity Method Investee, Sale of Stock, Type [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Cancelled (in shares)
Share-Based Payment Arrangement [Text Block]
Equity-Based Compensation
Nature of the Business
Leases
Amendment Flag
Product and Service [Domain]
Delayed Draw Term Loan (DDTL) [Member]
Delayed Draw Term Loan (DDTL)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrant to purchase (in shares)
Liabilities and Equity [Abstract]
Liabilities and Stockholders' Equity
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Common Stock [Member]
Common Stock
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted (in dollars per share)
Debt Securities, Available-for-Sale [Line Items]
Marketable Securities
Entity Address, Address Line One
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Weighted Average Assumptions in Fair Value
Fair Value Hierarchy and NAV [Axis]
Net Loss per Share
Supplemental Cash Flow Information [Abstract]
Supplemental cash flow information:
Name of Property [Axis]
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Unrealized loss on marketable securities
This name represents a member of the board.
Kristina Burrow [Member]
Kristina Burrow
Class of Warrant or Right [Axis]
Document Type
Amount of asset related to consideration paid in advance for insurance that provides economic benefits after a future period of one year or the normal operating cycle, if longer.
Prepaid Insurance, Noncurrent
Prepaid insurance
Related to R&D expense - SRK-181.
R&D expense - SRK-181 [Member]
SRK-181
Entity Central Index Key
Marketable Securities
Restricted Cash and Cash Equivalent [Abstract]
Cash and cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Net increase (decrease) in cash, cash equivalents and restricted cash
Represents the information pertaining to the common warrants.
Common Warrant [Member]
Common Warrants
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities excluded from the calculation of net loss per share
SWITZERLAND
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Equity-based compensation expense
Common Stock, Par or Stated Value Per Share
Common stock, par value
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total other comprehensive income (loss)
Represents information pertaining to 2018 Employee Stock Purchase Plan.
Employee Stock Purchase Plan 2018 [Member]
2018 ESPP
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash operating lease expense
Base Rate [Member]
Base Rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted average remaining contractual term
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Debt Securities, Available-for-Sale
Estimated Fair Value
Number of collaborative arrangements entered by the company.
Collaborative Arrangement, Number Of Activities
Collaborative arrangement
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of stock options (in shares)
Exercised (in shares)
Other Prepaid Expense, Current
Prepaid other
Debt
Accrued Liabilities, Current
Accrued expenses
Accrued expenses
Stock Issued During Period, Value, Restricted Stock Award, Gross
Issuance of common shares upon RSU vesting
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Equity-based compensation
This category includes information about debt securities issued by the United States Department of the Treasury and backed by the United States government, plus securities issued by other government agencies.
U.S. Treasury And Government Agency Securities [Member]
U.S. treasury obligations and government agency securities
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Document Quarterly Report
Entity Address, State or Province
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Outstanding, end (in shares)
Outstanding, beginning (in shares)
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for future issuance
Equity impact of shares issued during period on exercise of warrants.
Stock Issued During Period, Value, Exercise Of Warrants
Exercise of common warrants
Class of Warrant or Right [Domain]
Geographical [Axis]
Marketable Securities, Current
Marketable securities
Other General and Administrative Expense
External expense - G&A
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Company's Unrecognized Expense
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Performance Shares [Member]
PSUs
Performance Stock Units [Member]
Proceeds from Sale and Maturity of Marketable Securities
Sales and maturities of marketable securities
Other Assets, Noncurrent
Other long-term assets
Total other long-term assets
Antidilutive Securities [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Fair value of non-option awards vested
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Amount of cash outflow for payment of debt plus accrued, unpaid interest.
Repayments Of Debt Plus Accrued Interest
Gross Debt Repayment
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Assumptions used in determining the fair value of options
Cash and Cash Equivalents [Domain]
Represents information related to 2026 Loan Agreement with Blue Owl.
Loan Agreement 2026 With Blue Owl [Member]
2026 Loan Agreement with Blue Owl
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued and outstanding at June 30, 2026 and December 31, 2025
Minimum [Member]
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted (in dollars per share)
Financial Instrument [Axis]
Assets, Current [Abstract]
Current assets:
RSUs and unvested PSUs under the Two Thousand Seventeen And Two Thousand Eighteen Plan [Member]
RSUs and unvested PSUs under the Two Thousand Seventeen And Two Thousand Eighteen Plan [Member]
2017 and 2018 Plan
Segment Reporting
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of summary of the assets and liabilities measured at fair value on a recurring basis
Liabilities, Current [Abstract]
Current liabilities:
Amount of asset related to consideration paid in advance for professional and / or consulting within a future period of one year or the normal operating cycle, if longer.
Prepaid Professional Consulting
Prepaid professional services expense
Segment Reporting, Other Segment Item, Composition, Description
Description-Other segment related expense
Shares, Outstanding
Balance at end (in shares)
Balance at beginning (in shares)
Lessee, Operating Lease, Renewal Term
Renewal term
Commitments and Contingencies
Commitments and contingencies (Note 10)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Outstanding, end (in dollars per share)
Outstanding, beginning (in dollars per share)
Weighted average grant date fair value
Debt Instrument, Basis Spread on Variable Rate
Variable rate (as a percent)
Debt Issuance Costs, Noncurrent, Net
Deferred financing costs related to undrawn debt
Debt Issuance Costs, Noncurrent, Net, Total
Lessee, Lease, Description [Table]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract]
Marketable securities available-for-sale
Long-Term Debt, Type [Domain]
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic
The annual upward lease adjustment percentage.
Annual Lease Adjustment Percent
Annual upward adjustment (as a percent)
The entire disclosure of common stock.
Common Stock [Text Block]
Common Stock
This name represents a member of the board.
Michael Gilman [Member]
Michael Gilman
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate intrinsic value, exercisable
Share-Based Payment Arrangement, Plan Modification, Incremental Cost
Modification of equity awards expense
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Incentive to Lessee
Incentive to lease
Segments [Axis]
Long-Term Debt
Total borrowings
Variable Rate [Domain]
Equity, Attributable to Parent
Balance at end
Balance at beginning
Total stockholders' equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Lessee, Operating Lease, Existence of Option to Extend [true false]
Option to extend the term
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Fair Value Disclosures [Text Block]
Fair Value of Financial Assets and Liabilities
Represents information pertaining to 2018 Stock option and incentive plan.
Stock Option and Incentive Plan 2018 [Member]
2018 Plan
UNITED STATES
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Number of Units
Schedule of Accrued Liabilities [Table Text Block]
Summary of accrued expenses
Debt Instrument, Name [Domain]
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure for non-cash items:
Segment Reporting, Other Segment Item, Amount
Other segment items
Plan Name [Domain]
The amount of prepaid software expense as of the balance sheet date. Used to reflect the current portion of the asset (due within one year or within the normal operating cycle if longer).
Prepaid Software Expense, Current
Prepaid software
Related to early research and other activity.
Early Research [Member]
Early research and other
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets and financial liabilities measured at fair value on a recurring basis:
Stock Issued During Period, Value, Other
Other
Represents the information pertaining o second tranche of term loan.
Term Loan Second Tranche [Member]
Term loan second tranche
Business Description and Basis of Presentation [Text Block]
Nature of the Business
Class of Warrant or Right, Outstanding
Outstanding warrants (in shares)
Entity Address, City or Town
Lessor, Operating Leases [Text Block]
Leases
Number of Reportable Segments
Number of reportable segment
Security Exchange Name
Debt Issuance Costs Incurred During Noncash or Partial Noncash Transaction
Debt issuance costs in accrued expenses
Prepaid Expenses and Other Current Assets
Antidilutive Securities, Name [Domain]
The tabular disclosure of reserved common stock.
Schedule of Reserved Common Stock [Table Text Block]
Schedule of reserved common stock
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash, end of period
Cash, cash equivalents and restricted cash, beginning of period
Total
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Statistical Measurement [Domain]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrant exercise price (in dollars per share)
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Equity-based compensation expense
Noncash or Part Noncash Acquisition, Fixed Assets Acquired
Property and equipment purchases in accounts payable & accrued expenses
Document Period End Date
Fair Value Hierarchy and NAV [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Options exercisable, end (in shares)
CONDENSED CONSOLIDATED BALANCE SHEETS
Restricted Stock Units (RSUs) [Member]
RSUs
Restricted Stock Units [Member]
Antidilutive Security, Excluded EPS Calculation [Table]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive income (loss):
Represents information related to the 2026 Initial Term Loan.
Initial Term Loan [Member]
Initial Term Loan
Liabilities
Total liabilities
Financial Instruments [Domain]
Variable Rate [Axis]
Prepaid Expense and Other Assets, Current [Abstract]
Prepaid expenses and other current assets
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares outstanding, diluted
Securities Act File Number
Document and Entity Information
Investment Income, Nonoperating
Interest income
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited (in shares)
Unrealized Gain (Loss), Foreign Currency Transaction, before Tax
Unrealized foreign currency exchange rate losses
US Treasury Securities [Member]
U.S. Treasury obligations
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and Administrative Expense
General and administrative
Payments of Debt Restructuring Costs
Debt modification payment
Debt modification payment
Marketable Securities [Abstract]
Marketable securities:
Gain (Loss) on Extinguishment of Debt
Loss on extinguishment of debt
Loss on extinguishment of debt
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Stock options
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Issued Accounting Pronouncements
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Units
Proceeds from Issuance of Long-Term Debt
Proceeds from debt refinancing
Other Receivables, Net, Current
Other receivables
Lessee, Operating Lease, Term of Contract
Term of lease
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Operating Lease, Liability, Current
Operating lease liability
Document Transition Report
Operating Expenses
Total operating expenses
Research and Development Expense
Research and development
External R&D expense
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted Average Grant Date Fair Value
Represents information relating to At the market offering.
At Market Offering [Member]
ATM Offering
Stock Issued During Period, Value, New Issues
Sale of common shares, net of issuance costs
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of stock option activity
Assets, Fair Value Disclosure [Abstract]
Assets:
Earnings Per Share [Text Block]
Net Loss per Share
Related to R&D expense - Apitegromab.
Apitegromab [Member]
Apitegromab
Net loss
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate intrinsic value, end
Aggregate intrinsic value, beginning
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid
Periodic payment terms
Operating Lease, Cost
Operating lease cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Proceeds from (Payment for) Other Financing Activity
Other
Accrued payroll and related expenses
Accrued Payroll Taxes
Operating Lease, Payments
Operating cash flows used for operating leases
Assets [Abstract]
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Repayments of Debt
Repayments of debt
Name of Property [Domain]
Document Fiscal Year Focus
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Accounts Payable, Current
Accounts payable
Vested fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Interest Expense, Nonoperating
Interest expense
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Increase (Decrease) in Other Noncurrent Assets
Other assets
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Fair Value of Financial Assets and Liabilities
Commitments and Contingencies.
Debt Instrument [Axis]
Equity-Based Compensation
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized Expense
Assets, Fair Value Disclosure
Total assets
Sale of Stock [Axis]
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by (used in) investing activities
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Other information [Abstract]
Other information [Abstract]
Other information:
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Cancelled (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited (in dollars per share)
Money Market Funds [Member]
Money market funds
The number of warrants exercised during the period.
Class of Warrant or Right, Number of Warrants Exercised
Number of warrants exercised
Represents information pertaining to the 2022 Inducement Plan.
Inducement Plan 2022 [Member]
2022 Plan
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Change in operating assets and liabilities:
Letters of Credit Outstanding, Amount
Letter of credit
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding, end (in dollars per share)
Outstanding, beginning (in dollars per share)
Fair Value, Recurring and Nonrecurring [Table]
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Measurement Frequency [Domain]
Statement of Income Location, Balance [Axis]
Trading Symbol
Represents the Loan and Security Agreement.
Loan and Security Agreement [Member]
Loan and Security Agreement
Employee-related Liabilities, Current
Accrued external research and development expense
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Recurring [Member]
Recurring
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Accrued Expenses
Equity Components [Axis]
Nonoperating Income (Expense)
Total other income (expense), net
Equity Component [Domain]
Prepaid Expense Other, Noncurrent
Prepaid other
Prepaid Insurance
Prepaid insurance
Shares Issued, Value, Share-Based Payment Arrangement, before Forfeiture
Issuance of common shares upon vesting of restricted stock units ("RSUs") and performance stock units ("PSUs")
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization
Depreciation and amortization expense
Represents information pertaining to office space in Zug, Switzerland
Office Space In Zug Switzerland [Member]
Switzerland Lease
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
Statistical Measurement [Axis]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Common Stock, Value, Issued
Common stock, $0.001 par value; 300,000,000 shares authorized; 121,600,396 and 108,461,354 shares issued and outstanding as of June 30, 2026 and December 31, 2025, respectively
This name represents a member of the board.
Katie Peng [Member]
Katie Peng
Secured Overnight Financing Rate (SOFR) [Member]
Secured Overnight Financing Rate (SOFR)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
Amortization of Debt Issuance Costs
Amortization of debt discount and debt issuance costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Entity Registrant Name
Debt Disclosure [Text Block]
Debt
Represents the information pertaining to the pre-funded warrants.
Pre Funded Warrant [Member]
Pre-funded warrants
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Gross Unrealized Losses
Other Nonoperating Income (Expense)
Other expense, net
Other non-operating expense/(income), net
Additional Paid in Capital
Additional paid-in capital
Other Assets Disclosure [Text Block]
Prepaid Expenses and Other Current Assets
Measurement Frequency [Axis]
Proceeds from Issuance of Common Stock
Proceeds from sale of common shares, net
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Equity-Based Compensation
Related to R&D expense - SRK-439.
R&D expense - SRK-439 [Member]
SRK-439
The amount of prepaid external research and development expense as of the balance sheet date. Used to reflect the current portion of the asset (due within one year or within the normal operating cycle if longer).
Prepaid External Research And Development Expense, Current
Prepaid external research and development expenses
Entity Common Stock, Shares Outstanding
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted (in shares)
Restrictions on Cash and Cash Equivalents [Table Text Block]
Schedule of reconciliation of cash, cash equivalents and restricted cash
Assets
Total assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted average remaining contractual term, exercisable
Amount of asset related to consideration paid in advance for compensation expense that provide economic benefits within a future period of one year or the normal operating cycle, if longer.
Prepaid Compensation Expense
Prepaid compensation expense
Stock Issued During Period, Shares, New Issues
Sale of common shares, net of issuance costs (in shares)
Sale of common shares, net of issuance costs (in shares)
Lease, Cost [Abstract]
Lease cost:
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested (in shares)
Earnings Per Share, Diluted
Net loss per share, diluted
City Area Code
Represents the Loan and Security Agreement with Silicon Valley Bank entered into by the entity.
Loan and Security Agreement with Silicon Valley Bank [Member]
SVB-Equipment
Debt Instrument, Fee Amount
Prepayment fee
Amount receivable from exercise of stock options and related withholding taxes within a future period of one year or the normal operating cycle, if longer.
Receivables From Exercise of Stock Options And Related Withholding Taxes, Current
Stock options exercised and related withholding taxes receivable
Line of Credit Facility, Maximum Borrowing Capacity
Line of credit maximum
Variable Lease, Cost
Variable lease cost
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term
Segment Reporting Information [Line Items]
Segment Reporting
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Issuance of common shares upon RSU vesting (in shares)
Lease, Cost
Total lease cost
Property, Plant and Equipment, Net
Property and equipment, net
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Cash and Cash Equivalents [Axis]
Employee Benefits and Share-Based Compensation
Equity-based compensation expense
Number of shares issued during period on exercise of warrants.
Stock Issued During Period, Shares, Exercise Of Warrants
Exercise of warrants (in shares)
Exercise of common warrants (in shares)
Share-Based Payment Arrangement, Noncash Expense
Equity-based compensation
Equity-based compensation expense
The minimum unrestricted cash balance represented as percentage on outstanding principal amount.
Minimum Unrestricted Cash Balance , Percentage
Percentage of unrestricted cash balance
Operating Lease, Weighted Average Discount Rate, Percent
Weighted average incremental borrowing rate
Operating Lease, Liability, Noncurrent
Long-term portion of operating lease liability
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Common Stock
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Lease, Cost [Table Text Block]
Schedule of Other Information Related to The Leases Cost
Investments, Fair Value Disclosure
U.S. treasury obligations and government agency securities
Schedule of Other Current Assets [Table Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Marketable Securities [Table Text Block]
Summary of investments
The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt, till date.
Proceeds From Issuance Of Debt, Till Date
Issuance of debt
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of anti-dilutive securities
Amount receivable from sale of stock, within a future period of one year or the normal operating cycle, if longer.
Receivables From Sale of Stock, Current
Receivable from ATM sale
Debt Securities, Available-for-Sale [Table]
Entity Interactive Data Current
Statement of Income Location, Balance [Domain]
Disclosure of accounting policy for unaudited interim financial information.
Unaudited Interim Financial Information [Policy Text Block]
Unaudited Interim Financial Information
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Accretion of investment securities
Accretion (Amortization) of Discounts and Premiums, Investments
Entity Tax Identification Number
Long-Term Debt, Type [Axis]
General and Administrative Expenses [Member]
General and Administrative Expenses [Member]
General and administrative expense
Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Effect of exchange rate on cash, cash equivalents and restricted cash
Local Phone Number
Long-Lived Assets
Long-lived assets
Summary of Significant Accounting Policies
Common Stock.
Revenue from Contract with Customer, Excluding Assessed Tax
Revenues
Schedule of Other Assets, Noncurrent [Table Text Block]
Schedule of Other Long-term Assets
Labor and Related Expense
Employee related expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted Average Remaining Period of Recognition
Research and Development Expenses [Member]
Research and Development Expenses [Member]
Research and development expense
Accrued Professional Fees, Current
Accrued professional services expense
Stock, Class of Stock [Table]
Entity Emerging Growth Company