S-8 S-8 EX-FILING FEES 0001517022 Akebia Therapeutics, Inc. N/A Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid 0001517022 2026-08-03 2026-08-03 0001517022 1 2026-08-03 2026-08-03 0001517022 2 2026-08-03 2026-08-03 0001517022 3 2026-08-03 2026-08-03 0001517022 4 2026-08-03 2026-08-03 0001517022 5 2026-08-03 2026-08-03 0001517022 6 2026-08-03 2026-08-03 0001517022 7 2026-08-03 2026-08-03 0001517022 8 2026-08-03 2026-08-03 0001517022 9 2026-08-03 2026-08-03 0001517022 10 2026-08-03 2026-08-03 0001517022 11 2026-08-03 2026-08-03 0001517022 12 2026-08-03 2026-08-03 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-8

Akebia Therapeutics, Inc.

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

1 Equity Common Stock, $0.00001 par value per share Other 90,600 $ 3.14 $ 284,484.00 0.0001381 $ 39.29
2 Equity Common Stock, $0.00001 par value per share Other 190,063 $ 2.73 $ 518,871.99 0.0001381 $ 71.66
3 Equity Common Stock, $0.00001 par value per share Other 51,825 $ 2.21 $ 114,533.25 0.0001381 $ 15.82
4 Equity Common Stock, $0.00001 par value per share Other 22,576 $ 1.58 $ 35,670.08 0.0001381 $ 4.93
5 Equity Common Stock, $0.00001 par value per share Other 61,843 $ 1.61 $ 99,567.23 0.0001381 $ 13.76
6 Equity Common Stock, $0.00001 par value per share Other 32,675 $ 1.41 $ 46,071.75 0.0001381 $ 6.37
7 Equity Common Stock, $0.00001 par value per share Other 46,200 $ 1.31 $ 60,522.00 0.0001381 $ 8.36
8 Equity Common Stock, $0.00001 par value per share Other 631,600 $ 1.39 $ 877,924.00 0.0001381 $ 121.25
9 Equity Common Stock, $0.00001 par value per share Other 200,400 $ 1.38 $ 276,552.00 0.0001381 $ 38.20
10 Equity Common Stock, $0.00001 par value per share Other 8,400 $ 1.02 $ 8,568.00 0.0001381 $ 1.19
11 Equity Common Stock, $0.00001 par value per share Other 125,600 $ 1.14 $ 143,184.00 0.0001381 $ 19.78
12 Equity Common Stock, $0.00001 par value per share Other 61,000 $ 1.32 $ 80,520.00 0.0001381 $ 11.12

Total Offering Amounts:

$ 2,546,468.30

$ 351.73

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 351.73

Offering Note

1

Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on August 29, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

2

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on September 30, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

3

Pursuant to Rule 416 under the Securities Act , this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on October 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

4

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on November 28, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

5

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on December 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

6

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on January 30, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

7

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted February 27, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

8

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted March 31, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

9

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted April 30, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

10

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on May 29, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

11

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on June 30, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

12

Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted on July 31, 2026 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims
Fee Offset Sources