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  <xs:element id="rprx_A2025NotesMember" abstract="true" name="A2025NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_A2024NotesMember" abstract="true" name="A2024NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_A2021NotesMember" abstract="true" name="A2021NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_A2020NotesMember" abstract="true" name="A2020NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_TheNotesMember" abstract="true" name="TheNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_SeniorUnsecuredRevolvingCreditFacilityMember" abstract="true" name="SeniorUnsecuredRevolvingCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_SeniorUnsecuredRevolvingCreditFacilityAndTermLoanMember" abstract="true" name="SeniorUnsecuredRevolvingCreditFacilityAndTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_UncommittedCreditFacilityMember" abstract="true" name="UncommittedCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_OvernightBankFundingRateMember" abstract="true" name="OvernightBankFundingRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_DebtInstrumentCovenantTermsMaximumConsolidatedLeverageRatio" abstract="false" name="DebtInstrumentCovenantTermsMaximumConsolidatedLeverageRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="rprx_DebtInstrumentCovenantTermsMaximumConsolidatedLeverageRatioFollowingQualifyingMaterialAcquisition" abstract="false" name="DebtInstrumentCovenantTermsMaximumConsolidatedLeverageRatioFollowingQualifyingMaterialAcquisition" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="rprx_DebtInstrumentCovenantTermsMinimumConsolidatedCoverageRatio" abstract="false" name="DebtInstrumentCovenantTermsMinimumConsolidatedCoverageRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="rprx_DebtInstrumentCovenantTermsMaximumConsolidatedCashFlowRatio" abstract="false" name="DebtInstrumentCovenantTermsMaximumConsolidatedCashFlowRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="rprx_DebtInstrumentCovenantTermsMaximumConsolidatedCashFlowRatioFollowingQualifyingMaterialAcquisition" abstract="false" name="DebtInstrumentCovenantTermsMaximumConsolidatedCashFlowRatioFollowingQualifyingMaterialAcquisition" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="rprx_TheNotesAndTermLoanMember" abstract="true" name="TheNotesAndTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_LongTermDebtMaturityAfterYearFour" abstract="false" name="LongTermDebtMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_ContinuingInvestorsPartnershipsMember" abstract="true" name="ContinuingInvestorsPartnershipsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_IncrementalCommonSharesAttributableToDilutiveEffectOfExchangeableShares" abstract="false" name="IncrementalCommonSharesAttributableToDilutiveEffectOfExchangeableShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="rprx_IncreaseDecreaseInFinancialRoyaltyAssets" abstract="false" name="IncreaseDecreaseInFinancialRoyaltyAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_AmortizationOfPrepaidExpenses" abstract="false" name="AmortizationOfPrepaidExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_IncreaseDecreaseInCashCollectionsOnFinancingReceivables" abstract="false" name="IncreaseDecreaseInCashCollectionsOnFinancingReceivables" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_IncreaseDecreaseInOtherRoyaltyIncomeReceivable" abstract="false" name="IncreaseDecreaseInOtherRoyaltyIncomeReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_RevolutionMedicinesFundingCommitmentsMember" abstract="true" name="RevolutionMedicinesFundingCommitmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_RevolutionMedicinesIncMember" abstract="true" name="RevolutionMedicinesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_RoyaltyPurchaseMember" abstract="true" name="RoyaltyPurchaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_SeniorSecuredTermLoanMember" abstract="true" name="SeniorSecuredTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_NumberOfPartsToFundingArrangement" abstract="false" name="NumberOfPartsToFundingArrangement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="rprx_LongTermFundingPartnershipRemainingUnfundedAmount" abstract="false" name="LongTermFundingPartnershipRemainingUnfundedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_CreditLossAllowance" abstract="false" name="CreditLossAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_LongTermFundingPartnershipRemainingAvailability" abstract="false" name="LongTermFundingPartnershipRemainingAvailability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_OperatingAndPersonnelPaymentsMember" abstract="true" name="OperatingAndPersonnelPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_FormerOperatingAndPersonnelPaymentsMember" abstract="true" name="FormerOperatingAndPersonnelPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_RateAdjustedCashReceipts" abstract="false" name="RateAdjustedCashReceipts" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="rprx_RateValueOfSecurityInvestments" abstract="false" name="RateValueOfSecurityInvestments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="rprx_NeurimmuneAGMember" abstract="true" name="NeurimmuneAGMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_UpfrontPaymentToAcquireFinanceReceivables" abstract="false" name="UpfrontPaymentToAcquireFinanceReceivables" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rprx_AccountingStandardsUpdate202512Member" abstract="true" name="AccountingStandardsUpdate202512Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rprx_MarshallUristMember" abstract="true" name="MarshallUristMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
